LOCUS       NM_020277               4383 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus transient receptor potential cation channel, subfamily
            M, member 5 (Trpm5), mRNA.
ACCESSION   NM_020277
VERSION     NM_020277.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4383)
  AUTHORS   Billipp,T.E., Fung,C., Webeck,L.M., Sargent,D.B., Gologorsky,M.B.,
            Chen,Z., McDaniel,M.M., Kasal,D.N., McGinty,J.W., Barrow,K.A.,
            Rich,L.M., Barilli,A., Sabat,M., Debley,J.S., Wu,C., Myers,R.,
            Howitt,M.R. and von Moltke,J.
  TITLE     Tuft cell-derived acetylcholine promotes epithelial chloride
            secretion and intestinal helminth clearance
  JOURNAL   Immunity 57 (6), 1243-1259 (2024)
   PUBMED   38744291
REFERENCE   2  (bases 1 to 4383)
  AUTHORS   Gerrick,E.R., Zlitni,S., West,P.T., Carter,M.M., Mechler,C.M.,
            Olm,M.R., Caffrey,E.B., Li,J.A., Higginbottom,S.K., Severyn,C.J.,
            Kracke,F., Spormann,A.M., Sonnenburg,J.L., Bhatt,A.S. and
            Howitt,M.R.
  TITLE     Metabolic diversity in commensal protists regulates intestinal
            immunity and trans-kingdom competition
  JOURNAL   Cell 187 (1), 62-78 (2024)
   PUBMED   38096822
REFERENCE   3  (bases 1 to 4383)
  AUTHORS   Ascencio Gutierrez,V., Martin,L.E., Simental-Ramos,A., James,K.F.,
            Medler,K.F., Schier,L.A. and Torregrossa,A.M.
  TITLE     TRPM4 and PLCbeta3 contribute to normal behavioral responses to an
            array of sweeteners and carbohydrates but PLCbeta3 is not needed
            for taste-driven licking for glucose
  JOURNAL   Chem Senses 49 (2024)
   PUBMED   38183495
REFERENCE   4  (bases 1 to 4383)
  AUTHORS   Zhang,Y., Pool,A.H., Wang,T., Liu,L., Kang,E., Zhang,B., Ding,L.,
            Frieda,K., Palmiter,R. and Oka,Y.
  TITLE     Parallel neural pathways control sodium consumption and taste
            valence
  JOURNAL   Cell 186 (26), 5751-5765 (2023)
   PUBMED   37989313
REFERENCE   5  (bases 1 to 4383)
  AUTHORS   Ly,T., Oh,J.Y., Sivakumar,N., Shehata,S., La Santa Medina,N.,
            Huang,H., Liu,Z., Fang,W., Barnes,C., Dundar,N., Jarvie,B.C.,
            Ravi,A., Barnhill,O.K., Li,C., Lee,G.R., Choi,J., Jang,H. and
            Knight,Z.A.
  TITLE     Sequential appetite suppression by oral and visceral feedback to
            the brainstem
  JOURNAL   Nature 624 (7990), 130-137 (2023)
   PUBMED   37993711
REFERENCE   6  (bases 1 to 4383)
  AUTHORS   Engemann,S., Strodicke,M., Paulsen,M., Franck,O., Reinhardt,R.,
            Lane,N., Reik,W. and Walter,J.
  TITLE     Sequence and functional comparison in the Beckwith-Wiedemann
            region: implications for a novel imprinting centre and extended
            imprinting
  JOURNAL   Hum Mol Genet 9 (18), 2691-2706 (2000)
   PUBMED   11063728
REFERENCE   7  (bases 1 to 4383)
  AUTHORS   Onyango,P., Miller,W., Lehoczky,J., Leung,C.T., Birren,B.,
            Wheelan,S., Dewar,K. and Feinberg,A.P.
  TITLE     Sequence and comparative analysis of the mouse 1-megabase region
            orthologous to the human 11p15 imprinted domain
  JOURNAL   Genome Res 10 (11), 1697-1710 (2000)
   PUBMED   11076855
  REMARK    Erratum:[Genome Res 2001 Feb;11(2):308]
REFERENCE   8  (bases 1 to 4383)
  AUTHORS   Paulsen,M., El-Maarri,O., Engemann,S., Strodicke,M., Franck,O.,
            Davies,K., Reinhardt,R., Reik,W. and Walter,J.
  TITLE     Sequence conservation and variability of imprinting in the
            Beckwith-Wiedemann syndrome gene cluster in human and mouse
  JOURNAL   Hum Mol Genet 9 (12), 1829-1841 (2000)
   PUBMED   10915772
REFERENCE   9  (bases 1 to 4383)
  AUTHORS   Enklaar,T., Esswein,M., Oswald,M., Hilbert,K., Winterpacht,A.,
            Higgins,M., Zabel,B. and Prawitt,D.
  TITLE     Mtr1, a novel biallelically expressed gene in the center of the
            mouse distal chromosome 7 imprinting cluster, is a member of the
            Trp gene family
  JOURNAL   Genomics 67 (2), 179-187 (2000)
   PUBMED   10903843
REFERENCE   10 (bases 1 to 4383)
  AUTHORS   Yatsuki,H., Watanabe,H., Hattori,M., Joh,K., Soejima,H., Komoda,H.,
            Xin,Z., Zhu,X., Higashimoto,K., Nishimura,M., Kuratomi,S.,
            Sasaki,H., Sakaki,Y. and Mukai,T.
  TITLE     Sequence-based structural features between Kvlqt1 and Tapa1 on
            mouse chromosome 7F4/F5 corresponding to the Beckwith-Wiedemann
            syndrome region on human 11p15.5: long-stretches of unusually well
            conserved intronic sequences of kvlqt1 between mouse and human
  JOURNAL   DNA Res 7 (3), 195-206 (2000)
   PUBMED   10907850
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF228681.1, AB039952.1 and AK044908.1.
            
            On May 23, 2007 this sequence version replaced NM_020277.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF228681.1, AY280364.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2250              AF228681.1         1-2250
            2251-4267           AB039952.1         2168-4184
            4268-4383           AK044908.1         3883-3998
FEATURES             Location/Qualifiers
     source          1..4383
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 88.11 cM"
     gene            1..4383
                     /gene="Trpm5"
                     /gene_synonym="9430099A16Rik; LTrpC-5; Ltrpc5; Mtr1"
                     /note="transient receptor potential cation channel,
                     subfamily M, member 5"
                     /db_xref="GeneID:56843"
                     /db_xref="MGI:MGI:1861718"
     exon            1..77
                     /gene="Trpm5"
                     /gene_synonym="9430099A16Rik; LTrpC-5; Ltrpc5; Mtr1"
                     /inference="alignment:Splign:2.1.0"
     exon            78..204
                     /gene="Trpm5"
                     /gene_synonym="9430099A16Rik; LTrpC-5; Ltrpc5; Mtr1"
                     /inference="alignment:Splign:2.1.0"
     exon            205..385
                     /gene="Trpm5"
                     /gene_synonym="9430099A16Rik; LTrpC-5; Ltrpc5; Mtr1"
                     /inference="alignment:Splign:2.1.0"
     exon            386..558
                     /gene="Trpm5"
                     /gene_synonym="9430099A16Rik; LTrpC-5; Ltrpc5; Mtr1"
                     /inference="alignment:Splign:2.1.0"
     exon            559..745
                     /gene="Trpm5"
                     /gene_synonym="9430099A16Rik; LTrpC-5; Ltrpc5; Mtr1"
                     /inference="alignment:Splign:2.1.0"
     exon            746..810
                     /gene="Trpm5"
                     /gene_synonym="9430099A16Rik; LTrpC-5; Ltrpc5; Mtr1"
                     /inference="alignment:Splign:2.1.0"
     exon            811..1002
                     /gene="Trpm5"
                     /gene_synonym="9430099A16Rik; LTrpC-5; Ltrpc5; Mtr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1105
                     /gene="Trpm5"
                     /gene_synonym="9430099A16Rik; LTrpC-5; Ltrpc5; Mtr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1224
                     /gene="Trpm5"
                     /gene_synonym="9430099A16Rik; LTrpC-5; Ltrpc5; Mtr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1563
                     /gene="Trpm5"
                     /gene_synonym="9430099A16Rik; LTrpC-5; Ltrpc5; Mtr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1704
                     /gene="Trpm5"
                     /gene_synonym="9430099A16Rik; LTrpC-5; Ltrpc5; Mtr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1828
                     /gene="Trpm5"
                     /gene_synonym="9430099A16Rik; LTrpC-5; Ltrpc5; Mtr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1974
                     /gene="Trpm5"
                     /gene_synonym="9430099A16Rik; LTrpC-5; Ltrpc5; Mtr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2087
                     /gene="Trpm5"
                     /gene_synonym="9430099A16Rik; LTrpC-5; Ltrpc5; Mtr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2180
                     /gene="Trpm5"
                     /gene_synonym="9430099A16Rik; LTrpC-5; Ltrpc5; Mtr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2439
                     /gene="Trpm5"
                     /gene_synonym="9430099A16Rik; LTrpC-5; Ltrpc5; Mtr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2558
                     /gene="Trpm5"
                     /gene_synonym="9430099A16Rik; LTrpC-5; Ltrpc5; Mtr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2559..2691
                     /gene="Trpm5"
                     /gene_synonym="9430099A16Rik; LTrpC-5; Ltrpc5; Mtr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2692..2866
                     /gene="Trpm5"
                     /gene_synonym="9430099A16Rik; LTrpC-5; Ltrpc5; Mtr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2867..3020
                     /gene="Trpm5"
                     /gene_synonym="9430099A16Rik; LTrpC-5; Ltrpc5; Mtr1"
                     /inference="alignment:Splign:2.1.0"
     exon            3021..3202
                     /gene="Trpm5"
                     /gene_synonym="9430099A16Rik; LTrpC-5; Ltrpc5; Mtr1"
                     /inference="alignment:Splign:2.1.0"
     exon            3203..3335
                     /gene="Trpm5"
                     /gene_synonym="9430099A16Rik; LTrpC-5; Ltrpc5; Mtr1"
                     /inference="alignment:Splign:2.1.0"
     exon            3336..3408
                     /gene="Trpm5"
                     /gene_synonym="9430099A16Rik; LTrpC-5; Ltrpc5; Mtr1"
                     /inference="alignment:Splign:2.1.0"
     exon            3409..3475
                     /gene="Trpm5"
                     /gene_synonym="9430099A16Rik; LTrpC-5; Ltrpc5; Mtr1"
                     /inference="alignment:Splign:2.1.0"
     exon            3476..4383
                     /gene="Trpm5"
                     /gene_synonym="9430099A16Rik; LTrpC-5; Ltrpc5; Mtr1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3711..3716
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trpm5"
                     /gene_synonym="9430099A16Rik; LTrpC-5; Ltrpc5; Mtr1"
                     /note="hexamer: AATGAA"
     polyA_site      3736
                     /gene="Trpm5"
                     /gene_synonym="9430099A16Rik; LTrpC-5; Ltrpc5; Mtr1"
                     /note="major polyA site"
     regulatory      4099..4104
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trpm5"
                     /gene_synonym="9430099A16Rik; LTrpC-5; Ltrpc5; Mtr1"
                     /note="hexamer: TATAAA"
     polyA_site      4123
                     /gene="Trpm5"
                     /gene_synonym="9430099A16Rik; LTrpC-5; Ltrpc5; Mtr1"
                     /note="major polyA site"
ORIGIN      
        1 aagcatcacg agcaacagcc ctgagcctca atttggaggc agtcctcatg cagtccaagg
       61 cactgactgc ctgactggaa agccaccatg caaacaaccc agagctcctg ccccggcagc
      121 cccccagata ctgaggatgg ctgggagccc atcctatgca ggggagagat caacttcgga
      181 gggtctggga agaagcgagg caagtttgtg aaggtgccaa gcagtgtggc cccctccgtg
      241 ctttttgaac tcctgctcac cgagtggcac ctgccagccc ccaacctggt ggtgtccctg
      301 gtgggtgagg aacgaccttt ggctatgaag tcgtggcttc gggatgtcct gcgcaagggg
      361 ctggtgaaag cagctcagag cacaggtgcc tggatcctga ccagtgccct ccacgtgggc
      421 ctggcccgcc atgttggaca agctgtacgt gatcactctc tggctagcac atccaccaag
      481 atccgtgtag tggccatcgg aatggcctct ctggatcgaa tccttcaccg tcaacttcta
      541 gatggtgtcc accaaaagga ggatactccc atccactacc cagcagatga gggcaacatt
      601 cagggacccc tctgccccct ggacagcaat ctctcccact tcatccttgt ggagtcaggc
      661 gcccttggga gtgggaacga cgggctgaca gagctgcagc tgagcctgga gaagcacatc
      721 tctcagcaga ggacaggtta tgggggcacc agctgcatcc agatacctgt cctttgcctg
      781 ttggtcaatg gtgaccccaa caccctagag aggatttcca gggcagtgga gcaggctgcc
      841 ccatggctga tcctggcagg ttctggtggc attgctgatg tactcgctgc cctggtgagc
      901 cagcctcatc tcctggtgcc ccaggtggct gagaagcagt tcagagagaa attccccagc
      961 gagtgtttct cttgggaagc cattgtacac tggacagagc tgttacagaa cattgctgca
     1021 cacccccacc tgctcacagt atatgacttc gagcaggagg gttcggagga cctggacact
     1081 gtcatcctca aggcacttgt gaaagcctgc aagagccaca gccaagaagc ccaagactac
     1141 ctagatgagc tcaagttagc agtggcctgg gatcgcgtgg acattgccaa gagtgaaatc
     1201 ttcaatgggg acgtggaatg gaagtcctgt gacttggaag aggtgatgac agatgccctc
     1261 gtgagcaaca agcctgactt tgtccgcctc tttgtggaca gcggtgctga catggccgag
     1321 ttcttgacct atgggcggct gcagcagctt taccattctg tgtcccccaa gagcctcctc
     1381 tttgaactgc tgcagcgtaa gcatgaggag ggtaggctga cactggccgg cctgggtgcc
     1441 cagcaggctc gggagctgcc cattggtctg cctgccttct cactccacga ggtctcccgc
     1501 gtactcaaag acttcctgca tgacgcctgc cgtggcttct accaggacgg gcgcaggatg
     1561 gaggagagag ggccacctaa gcggcccgca ggccagaagt ggctgccaga cctcagtagg
     1621 aagagtgaag acccttggag ggacctgttc ctctgggctg tgctgcagaa tcgttatgag
     1681 atggccacat acttctgggc catgggccgg gagggtgtgg ctgctgctct ggctgcctgc
     1741 aagatcataa aggaaatgtc ccacctggag aaagaggcag aggtggcccg caccatgcgt
     1801 gaggccaagt atgagcagct ggccctggat cttttctcag agtgctacgg caacagtgag
     1861 gaccgtgcct ttgccctgct ggtgcgaagg aaccacagct ggagcaggac cacgtgcctg
     1921 cacctggcca ctgaagctga tgccaaggcc ttctttgccc atgacggtgt gcaagcattc
     1981 ctgaccaaga tctggtgggg agacatggcc acaggcacac ccatcctacg gcttctgggt
     2041 gccttcacct gcccagccct catctacaca aacctcatct ccttcagtga ggatgccccg
     2101 cagaggatgg acctagaaga tctgcaggag ccagacagct tggatatgga aaagagcttc
     2161 ctatgcagcc ggggtggcca attggagaag ctaacagagg caccaagggc tccaggcgat
     2221 ctaggcccac aagctgcctt cctgctcaca cggtggagga agttctgggg cgctcctgtg
     2281 actgtgttcc tggggaatgt ggtcatgtac ttcgcattcc tcttcctgtt cacctatgtc
     2341 ctgctggtgg acttcaggcc accaccccag gggccgtctg gatccgaggt taccctctat
     2401 ttctgggtgt tcacactggt gctggaggaa atccgacagg gcttcttcac agatgaggac
     2461 acgcacctgg tgaagaaatt cactctgtat gtggaagaca actggaacaa gtgtgacatg
     2521 gtggccatct tcctgttcat tgtgggagtc acctgtagaa tggtgccctc ggtgtttgag
     2581 gctggcagga ccgttctggc cattgacttc atggtgttca cacttcggct catccacatc
     2641 tttgctattc acaagcagtt gggtcctaag atcatcattg tagagcgaat gatgaaggat
     2701 gtcttctttt tcctcttctt cctgagcgta tggcttgtgg cctatggtgt gaccactcag
     2761 gccctgctgc atccccatga tggccgtttg gagtggattt tccgccgtgt gctatacagg
     2821 ccttacctgc agatctttgg gcaaatccct ctggatgaaa ttgatgaggc tcgtgtgaac
     2881 tgttctcttc accctctgct gctggaaagc tcggcttcct gccctaatct ctatgccaac
     2941 tggctggtca ttctcctgct ggttaccttc ctgcttgtca ctaatgtgct gctcatgaac
     3001 cttctgatcg ccatgttcag ctacacattc caggtggtgc aaggcaatgc agacatgttc
     3061 tggaagtttc aacgctacca cctcatcgtt gaataccatg gaagaccagc tctggccccg
     3121 cccttcatcc tgctcagcca cctgagcctg gtgctcaagc aggtcttcag gaaggaagcc
     3181 cagcataagc gacaacatct ggagagagac ttgcctgacc ccttggacca gaagatcatt
     3241 acctgggaaa cggttcaaaa ggagaacttc ctgagtacca tggagaaacg gaggagggac
     3301 agcgaggggg aggtgctgag gaaaacggca cacagagtgg acttgattgc caaatacatc
     3361 ggggggctga gagagcaaga aaagaggatc aagtgtctgg aatcacaggc caactactgt
     3421 atgctcctct tgtcctctat gacggataca ctggctccag gaggcaccta ctcaagctct
     3481 cagaactgtg gttgcaggag tcagccagcc tctgctagag acagggagta cctagagtct
     3541 ggcttgccac cctctgacac ctgaaatgga gaaaccactt gctctagagc cccagacctg
     3601 gccacatcga gtttttgggg cacatcaacc ttcccccact cccagcagcc ccaagaaatg
     3661 gtcttcaagg ccttgctaca gatcacttct tggacatccc ttcctaagag aatgaaactc
     3721 atgtctttgg catctattcg ggagcctcag aagtatcctc tccagcaggg caagattttt
     3781 catgtcccac taaagctttc actggcttgg actggacagc tggatctggc caagtcctac
     3841 ataggacacc atctgcctgg atggggctat ttaggtctaa cccctgtctt accctgagtt
     3901 cctaagaagc caacctctta aacactaggt ttctttctga cccctgaccc actcattagc
     3961 tgaccagctc ctagagggca ggactcagat ctattgtaat tacctcccat ctttcacccc
     4021 ccacagcatt atctgtctga tcattctggc agaaacccca agatattgct caagggtacc
     4081 caatgctact ttactttcta taaagcctgt agaccacctc aaatcagcta aactgggcca
     4141 caatggtggc taaacgggac atttcaaaca cccggggaat atggaggatt gtctgaccta
     4201 gtgaaaggca tctccgttcc ttccactgct cctcaaatta aatgaccatc caggtccttt
     4261 ttagaggaac tcagagaatg gggactacag aggctggggc agacctgggt cttagcaggt
     4321 ctagctaact tggtccaagt ccctggcctc cacaggaaac attcgctcat gcatcctccc
     4381 tgc
//
