LOCUS       NM_175130               4245 bp    mRNA    linear   ROD 08-OCT-2024
DEFINITION  Mus musculus transient receptor potential cation channel, subfamily
            M, member 4 (Trpm4), mRNA.
ACCESSION   NM_175130
VERSION     NM_175130.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4245)
  AUTHORS   Guo,Y., Cheng,D., Yu,Z.Y., Schiatti,T., Chan,A.Y., Hill,A.P.,
            Peyronnet,R., Feneley,M.P., Cox,C.D. and Martinac,B.
  TITLE     Functional coupling between Piezo1 and TRPM4 influences the
            electrical activity of HL-1 atrial myocytes
  JOURNAL   J Physiol 602 (18), 4363-4386 (2024)
   PUBMED   38098265
  REMARK    GeneRIF: Functional coupling between Piezo1 and TRPM4 influences
            the electrical activity of HL-1 atrial myocytes.
REFERENCE   2  (bases 1 to 4245)
  AUTHORS   Mahapatra,C. and Thakkar,R.
  TITLE     In Silico Electrophysiological Investigation of Transient Receptor
            Potential Melastatin-4 Ion Channel Biophysics to Study Detrusor
            Overactivity
  JOURNAL   Int J Mol Sci 25 (13), 6875 (2024)
   PUBMED   38999984
  REMARK    GeneRIF: In Silico Electrophysiological Investigation of Transient
            Receptor Potential Melastatin-4 Ion Channel Biophysics to Study
            Detrusor Overactivity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4245)
  AUTHORS   Ascencio Gutierrez,V., Martin,L.E., Simental-Ramos,A., James,K.F.,
            Medler,K.F., Schier,L.A. and Torregrossa,A.M.
  TITLE     TRPM4 and PLCbeta3 contribute to normal behavioral responses to an
            array of sweeteners and carbohydrates but PLCbeta3 is not needed
            for taste-driven licking for glucose
  JOURNAL   Chem Senses 49 (2024)
   PUBMED   38183495
  REMARK    GeneRIF: TRPM4 and PLCbeta3 contribute to normal behavioral
            responses to an array of sweeteners and carbohydrates but PLCbeta3
            is not needed for taste-driven licking for glucose.
REFERENCE   4  (bases 1 to 4245)
  AUTHORS   Ghosh,S., Yang,R., Duraki,D., Zhu,J., Kim,J.E., Jabeen,M., Mao,C.,
            Dai,X., Livezey,M.R., Boudreau,M.W., Park,B.H., Nelson,E.R.,
            Hergenrother,P.J. and Shapiro,D.J.
  TITLE     Plasma Membrane Channel TRPM4 Mediates Immunogenic Therapy-Induced
            Necrosis
  JOURNAL   Cancer Res 83 (18), 3115-3130 (2023)
   PUBMED   37522838
  REMARK    GeneRIF: Plasma Membrane Channel TRPM4 Mediates Immunogenic
            Therapy-Induced Necrosis.
REFERENCE   5  (bases 1 to 4245)
  AUTHORS   Arullampalam,P., Essers,M.C., Boukenna,M., Guichard,S.,
            Rougier,J.S. and Abriel,H.
  TITLE     Knockdown of the TRPM4 channel alters cardiac electrophysiology and
            hemodynamics in a sex- and age-dependent manner in mice
  JOURNAL   Physiol Rep 11 (16), e15783 (2023)
   PUBMED   37604672
  REMARK    GeneRIF: Knockdown of the TRPM4 channel alters cardiac
            electrophysiology and hemodynamics in a sex- and age-dependent
            manner in mice.
REFERENCE   6  (bases 1 to 4245)
  AUTHORS   Ramsey,I.S., Delling,M. and Clapham,D.E.
  TITLE     An introduction to TRP channels
  JOURNAL   Annu Rev Physiol 68, 619-647 (2006)
   PUBMED   16460286
  REMARK    Review article
REFERENCE   7  (bases 1 to 4245)
  AUTHORS   Zhang,Z., Okawa,H., Wang,Y. and Liman,E.R.
  TITLE     Phosphatidylinositol 4,5-bisphosphate rescues TRPM4 channels from
            desensitization
  JOURNAL   J Biol Chem 280 (47), 39185-39192 (2005)
   PUBMED   16186107
  REMARK    GeneRIF: hydrolysis of PI(4,5)P(2) underlies desensitization of
            TRPM4, and PI(4,5)P(2) is a general regulator for the gating of
            TRPM ion channels
REFERENCE   8  (bases 1 to 4245)
  AUTHORS   Ullrich,N.D., Voets,T., Prenen,J., Vennekens,R., Talavera,K.,
            Droogmans,G. and Nilius,B.
  TITLE     Comparison of functional properties of the Ca2+-activated cation
            channels TRPM4 and TRPM5 from mice
  JOURNAL   Cell Calcium 37 (3), 267-278 (2005)
   PUBMED   15670874
  REMARK    GeneRIF: TRPM5 activated at lower Ca2+ concentration than TRPM4
            when [Ca2+]i was raised.  Different Ca2+ concentrations gave a
            difference in Ca2+ sensitivity between TRPM4 and TRPM5, with EC50
            values of 20.2+/-4.0 microM & 0.70+/-0.1 microM, respectively.
REFERENCE   9  (bases 1 to 4245)
  AUTHORS   Nilius,B., Prenen,J., Droogmans,G., Voets,T., Vennekens,R.,
            Freichel,M., Wissenbach,U. and Flockerzi,V.
  TITLE     Voltage dependence of the Ca2+-activated cation channel TRPM4
  JOURNAL   J Biol Chem 278 (33), 30813-30820 (2003)
   PUBMED   12799367
  REMARK    GeneRIF: Voltage dependence is not due to block by divalent cations
            or to voltage-dependent binding of intracellular Ca2+ to an
            activator site, indicating that TRPM4 is a transient receptor
            potential channel with an intrinsic voltage-sensing mechanism.
REFERENCE   10 (bases 1 to 4245)
  AUTHORS   Murakami,M., Xu,F., Miyoshi,I., Sato,E., Ono,K. and Iijima,T.
  TITLE     Identification and characterization of the murine TRPM4 channel
  JOURNAL   Biochem Biophys Res Commun 307 (3), 522-528 (2003)
   PUBMED   12893253
  REMARK    GeneRIF: Molecular cloning and characterization of TRPM4.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY097409.1, BY335443.1, AC150897.2, BY304579.1, BB840481.1,
            AK044094.1 and BC058632.1.
            
            [WARNING] On Dec 26, 2024 this sequence was replaced by
            NM_175130.5.
            
            On Oct 3, 2007 this sequence version replaced NM_175130.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC096475.1, AJ575814.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               BY097409.1         1-136
            137-282             BY335443.1         126-271
            283-283             AC150897.2         18672-18672
            284-358             BY335443.1         273-347
            359-468             BY304579.1         141-250
            469-656             BB840481.1         259-446
            657-1092            AK044094.1         264-699
            1093-4043           BC058632.1         1-2951
            4044-4245           AC150897.2         43094-43295
FEATURES             Location/Qualifiers
     source          1..4245
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.24 cM"
     gene            1..4245
                     /gene="Trpm4"
                     /gene_synonym="1110030C19Rik; LTrpC-4; LTRPC4; TRPM4B"
                     /note="transient receptor potential cation channel,
                     subfamily M, member 4"
                     /db_xref="GeneID:68667"
                     /db_xref="MGI:MGI:1915917"
     exon            1..94
                     /gene="Trpm4"
                     /gene_synonym="1110030C19Rik; LTrpC-4; LTRPC4; TRPM4B"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..3712
                     /gene="Trpm4"
                     /gene_synonym="1110030C19Rik; LTrpC-4; LTRPC4; TRPM4B"
                     /note="transient receptor potential ion channel melastatin
                     subgroup member 4; long transient receptor potential
                     channel 4; calcium-activated non-selective cation channel
                     1"
                     /codon_start=1
                     /product="transient receptor potential cation channel
                     subfamily M member 4"
                     /protein_id="NP_780339.2"
                     /db_xref="CCDS:CCDS52245.1"
                     /db_xref="GeneID:68667"
                     /db_xref="MGI:MGI:1915917"
                     /translation="MVGPEKEQSWIPKIFRKKVCTTFIVDLSDDAGGTLCQCGQPRDA
                     HPSVAVEDAFGAAVVTEWNSDEHTTEKPTDAYGDLDFTYSGRKHSNFLRLSDRTDPAT
                     VYSLVTRSWGFRAPNLVVSVLGGSGGPVLQTWLQDLLRRGLVRAAQSTGAWIVTGGLH
                     TGIGRHVGVAVRDHQTASTGSSKVVAMGVAPWGVVRNRDMLINPKGSFPARYRWRGDP
                     EDGVEFPLDYNYSAFFLVDDGTYGRLGGENRFRLRFESYVAQQKTGVGGTGIDIPVLL
                     LLIDGDEKMLKRIEDATQAQLPCLLVAGSGGAADCLVETLEDTLAPGSGGLRRGEARD
                     RIRRYFPKGDPEVLQAQVERIMTRKELLTVYSSEDGSEEFETIVLRALVKACGSSEAS
                     AYLDELRLAVAWNRVDIAQSELFRGDIQWRSFHLEASLMDALLNDRPEFVRLLISHGL
                     SLGHFLTPVRLAQLYSAVSPNSLIRNLLDQASHASSSKSPPVNGTVELRPPNVGQVLR
                     TLLGETCAPRYPARNTRDSYLGQDHRENDSLLMDWANKQPSTDASFEQAPWSDLLIWA
                     LLLNRAQMAIYFWEKGSNSVASALGACLLLRVMARLESEAEEAARRKDLAATFESMSV
                     DLFGECYHNSEERAARLLLRRCPLWGEATCLQLAMQADARAFFAQDGVQSLLTQKWWG
                     EMDSTTPIWALLLAFFCPPLIYTNLIVFRKSEEEPTQKDLDFDMDSSINGAGPPGTVE
                     PSAKVALERRQRRRPGRALCCGKFSKRWSDFWGAPVTAFLGNVVSYLLFLLLFAHVLL
                     VDFQPTKPSVSELLLYFWAFTLLCEELRQGLGGGWGSLASGGRGPDRAPLRHRLHLYL
                     SDTWNQCDLLALTCFLLGVGCRLTPGLFDLGRTVLCLDFMIFTLRLLHIFTVNKQLGP
                     KIVIVSKMMKDVFFFLFFLCVWLVAYGVATEGILRPQDRSLPSILRRVFYRPYLQIFG
                     QIPQEEMDVALMIPGNCSMERGSWAHPEGPVAGSCVSQYANWLVVLLLIVFLLVANIL
                     LLNLLIAMFSYTFSKVHGNSDLYWKAQRYSLIREFHSRPALAPPLIIISHVRLLIKWL
                     RRCRRCRRANLPASPVFEHFRVCLSKEAERKLLTWESVHKENFLLAQARDKRDSDSER
                     LKRTSQKVDTALKQLGQIREYDRRLRGLEREVQHCSRVLTWMAEALSHSALLPPGAPP
                     PPSPTGSKD"
     exon            95..165
                     /gene="Trpm4"
                     /gene_synonym="1110030C19Rik; LTrpC-4; LTRPC4; TRPM4B"
                     /inference="alignment:Splign:2.1.0"
     exon            166..340
                     /gene="Trpm4"
                     /gene_synonym="1110030C19Rik; LTrpC-4; LTRPC4; TRPM4B"
                     /inference="alignment:Splign:2.1.0"
     exon            341..521
                     /gene="Trpm4"
                     /gene_synonym="1110030C19Rik; LTrpC-4; LTRPC4; TRPM4B"
                     /inference="alignment:Splign:2.1.0"
     exon            522..685
                     /gene="Trpm4"
                     /gene_synonym="1110030C19Rik; LTrpC-4; LTRPC4; TRPM4B"
                     /inference="alignment:Splign:2.1.0"
     exon            686..869
                     /gene="Trpm4"
                     /gene_synonym="1110030C19Rik; LTrpC-4; LTRPC4; TRPM4B"
                     /inference="alignment:Splign:2.1.0"
     exon            870..931
                     /gene="Trpm4"
                     /gene_synonym="1110030C19Rik; LTrpC-4; LTRPC4; TRPM4B"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1123
                     /gene="Trpm4"
                     /gene_synonym="1110030C19Rik; LTrpC-4; LTRPC4; TRPM4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1223
                     /gene="Trpm4"
                     /gene_synonym="1110030C19Rik; LTrpC-4; LTRPC4; TRPM4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1336
                     /gene="Trpm4"
                     /gene_synonym="1110030C19Rik; LTrpC-4; LTRPC4; TRPM4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1678
                     /gene="Trpm4"
                     /gene_synonym="1110030C19Rik; LTrpC-4; LTRPC4; TRPM4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1813
                     /gene="Trpm4"
                     /gene_synonym="1110030C19Rik; LTrpC-4; LTRPC4; TRPM4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1943
                     /gene="Trpm4"
                     /gene_synonym="1110030C19Rik; LTrpC-4; LTRPC4; TRPM4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2089
                     /gene="Trpm4"
                     /gene_synonym="1110030C19Rik; LTrpC-4; LTRPC4; TRPM4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2202
                     /gene="Trpm4"
                     /gene_synonym="1110030C19Rik; LTrpC-4; LTRPC4; TRPM4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2280
                     /gene="Trpm4"
                     /gene_synonym="1110030C19Rik; LTrpC-4; LTRPC4; TRPM4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2703
                     /gene="Trpm4"
                     /gene_synonym="1110030C19Rik; LTrpC-4; LTRPC4; TRPM4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2704..2836
                     /gene="Trpm4"
                     /gene_synonym="1110030C19Rik; LTrpC-4; LTRPC4; TRPM4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2837..3011
                     /gene="Trpm4"
                     /gene_synonym="1110030C19Rik; LTrpC-4; LTRPC4; TRPM4B"
                     /inference="alignment:Splign:2.1.0"
     exon            3012..3189
                     /gene="Trpm4"
                     /gene_synonym="1110030C19Rik; LTrpC-4; LTRPC4; TRPM4B"
                     /inference="alignment:Splign:2.1.0"
     exon            3190..3395
                     /gene="Trpm4"
                     /gene_synonym="1110030C19Rik; LTrpC-4; LTRPC4; TRPM4B"
                     /inference="alignment:Splign:2.1.0"
     exon            3396..3528
                     /gene="Trpm4"
                     /gene_synonym="1110030C19Rik; LTrpC-4; LTRPC4; TRPM4B"
                     /inference="alignment:Splign:2.1.0"
     exon            3529..3601
                     /gene="Trpm4"
                     /gene_synonym="1110030C19Rik; LTrpC-4; LTRPC4; TRPM4B"
                     /inference="alignment:Splign:2.1.0"
     exon            3602..3707
                     /gene="Trpm4"
                     /gene_synonym="1110030C19Rik; LTrpC-4; LTRPC4; TRPM4B"
                     /inference="alignment:Splign:2.1.0"
     exon            3708..4245
                     /gene="Trpm4"
                     /gene_synonym="1110030C19Rik; LTrpC-4; LTRPC4; TRPM4B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4023..4028
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trpm4"
                     /gene_synonym="1110030C19Rik; LTrpC-4; LTRPC4; TRPM4B"
                     /note="hexamer: AATAAA"
     polyA_site      4043
                     /gene="Trpm4"
                     /gene_synonym="1110030C19Rik; LTrpC-4; LTRPC4; TRPM4B"
                     /note="major polyA site"
ORIGIN      
        1 ggatccggtt tggtcgggcg ggtcggcggc tggaggaaat acacggagcc tcaggggctg
       61 cggcagcagc atggtggggc cggagaagga gcagagctgg atccctaaga tcttcaggaa
      121 gaaggtgtgc acgacgttca tagtggacct ctccgatgat gcgggaggga ccttgtgcca
      181 gtgtgggcaa cctcgggatg cccacccttc tgtggctgtg gaggatgcct ttggggcagc
      241 cgtagttacc gagtggaaca gtgatgagca caccacggag aagcccacag atgcctatgg
      301 ggacctggac ttcacgtact ctggccgaaa gcacagcaac tttctccggc tgtctgaccg
      361 cacggatccg gccactgtgt acagtctcgt tacccgctct tggggctttc gtgccccaaa
      421 cttggtggtg tcggtgctgg gggggtcggg gggccccgtg ctccagacct ggctgcagga
      481 ccttctgcgt cgcgggctgg tgagagccgc ccagagcaca ggggcctgga tcgtcactgg
      541 gggactgcac acaggcattg gccggcacgt gggtgtggct gtaagggacc accagacagc
      601 cagcactggg agcagcaagg tggtggccat gggtgtggcc ccctggggag tggtccggaa
      661 cagagacatg ctgatcaacc ccaagggctc attccccgca aggtaccggt ggcgtggtga
      721 ccctgaggat ggtgttgagt tccccctgga ctataactat tctgctttct tcttggtgga
      781 tgatggcacc tatggccgcc tgggtggtga gaaccgcttc cgccttcggt ttgagtccta
      841 tgtggctcag cagaagaccg gagtgggagg gactggaatt gacatcccag tgctccttct
      901 tctcatcgat ggagatgaga agatgttaaa gcggatagag gatgccaccc aagctcagct
      961 cccctgcctc ttggtggcgg gctctggggg tgctgcagac tgtctggtgg agaccctgga
     1021 agatactctg gccccaggga gtgggggact taggcgaggc gaagcccggg atcggattag
     1081 gcgatacttc cctaaaggag accctgaggt tcttcaggcc caggtagaga ggatcatgac
     1141 ccgaaaggag ttgctgacgg tctattcatc agaagacggc tccgaggagt ttgagactat
     1201 cgttttgagg gctcttgtga aagcctgtgg gagctctgag gcctcagcct acctggatga
     1261 gctgcgtttg gctgtggctt ggaaccgcgt ggacatcgcc caaagtgaac ttttccgtgg
     1321 ggacatccaa tggcggtcct tccacctgga ggcatctctc atggatgctc tgctgaatga
     1381 ccggcctgaa tttgtgcgcc tgctcatctc ccatggcctt agcctgggac acttcctgac
     1441 ccccgtgcgt ctggcccagc tgtacagcgc ggtgtcccct aactcactga tccgaaatct
     1501 tctggaccag gcgtcccatg ctagtagcag caaatcccct cctgtaaatg gaactgtaga
     1561 gctccggcct cccaatgtgg ggcaagtgct gaggactctg ttgggagaaa cgtgtgcacc
     1621 acggtaccct gccaggaaca cccgagactc ctatctgggc caggaccaca gagagaatga
     1681 ctctctgctt atggactggg ccaacaagca accatcaacg gatgcaagct ttgaacaagc
     1741 cccctggagt gacctgctta tttgggctct gttgctgaac cgggcccaga tggctatcta
     1801 tttctgggag aagggctcca actcagtggc ctctgctctt ggggcttgtc ttttactccg
     1861 agtgatggct cgcctagagt cggaggctga ggaggccgcg cggcggaagg atcttgctgc
     1921 cacgtttgaa agcatgagcg tggacctctt tggagagtgt taccacaaca gtgaagagcg
     1981 agcagcccgc cttcttctgc gccgctgtcc cctctgggga gaggccacct gcctccagct
     2041 tgccatgcag gctgatgccc gagcgttctt tgcccaggat ggagtccagt ctcttctgac
     2101 acagaagtgg tggggggaga tggacagcac aactcccatc tgggccctgc ttctcgcctt
     2161 cttctgcccg cctctcatct acaccaacct tatcgtcttc aggaagtcag aggaggagcc
     2221 cacacagaag gatcttgact ttgatatgga cagcagcatc aatggagcag gtcctcctgg
     2281 gactgtagaa ccctctgcaa aggtggccct tgagaggcgg cagcggcgac ggccaggacg
     2341 tgccctctgc tgtggcaagt tctccaagcg ctggtcggac ttctggggtg ccccagtgac
     2401 tgccttcctg ggtaatgtgg tcagttacct gctgttcctg ctgctgtttg cccacgtgtt
     2461 gctggtggat ttccagccca caaagccaag tgtctccgag ctgctgctgt acttctgggc
     2521 cttcacgttg ctgtgcgagg agctgcgcca gggcctgggt ggtggctggg gtagcctggc
     2581 cagtggggga cgtggtccgg acagagctcc cctgcgccat cggctgcacc tctacctctc
     2641 agatacctgg aaccaatgtg acctgctggc actcacctgc ttcctgctgg gcgtaggctg
     2701 ccggctgacc cctgggctct ttgacttggg acgcaccgtc ctctgccttg acttcatgat
     2761 cttcacactg cgcctgctgc acatcttcac ggtgaacaag cagctggggc ccaagattgt
     2821 catagtgagc aaaatgatga aggatgtatt cttcttcctc ttcttcctct gcgtgtggct
     2881 tgtagcttat ggggtggcca cagaggggat cctgaggccc caggaccgca gtctaccgag
     2941 tatcctgcgc agggtcttct accgaccgta tctgcagatc ttcggacaaa ttccccagga
     3001 ggaaatggac gtggccctca tgattccagg taactgctca atggagcggg gctcctgggc
     3061 tcatccggag gggcccgtcg caggctcctg tgtgtcccag tatgccaact ggctggtggt
     3121 gttgctcctt atcgtcttct tgctggtggc caatatcctg ttgctcaacc tgctcatcgc
     3181 catgttcagc tacaccttca gcaaagtgca cggcaacagc gacctctact ggaaggcaca
     3241 gcgctacagc ctcatccggg aattccattc gaggcctgcc ctggccccac ccctcatcat
     3301 catctctcat gtgcgcctcc tcatcaagtg gctgcgcagg tgtcgcaggt gtcgcagggc
     3361 taacttgccc gcctccccag tcttcgagca cttccgtgtc tgtctctcta aggaagcaga
     3421 gcggaagctg ctgacttggg agtctgtgca caaagagaac ttcctgttgg cacaagctcg
     3481 ggacaagcga gacagtgact cggagcgttt gaaacgcacg tctcagaagg tggacactgc
     3541 actgaagcag ctgggacaga tcagagagta cgatcggcgt ctgagggggc tggagagaga
     3601 ggtccaacac tgttctcgag tcctgacttg gatggctgag gcccttagcc actctgcctt
     3661 gctgcctcca ggggccccac cccctccgag ccccactggt tccaaagact gagtgttcct
     3721 ggtggatgtc taggtgtttg catccagaga gggttcattc ctcaagctgg gcccagtctg
     3781 cctcaagcga cacaactggt ggccttatcc tcaccacgaa tcccatgctt atgggttgct
     3841 gtccagacac actgcgagta tcaccgaggg actccttccc agagcagcct caccttgggt
     3901 gaatcaagct ctgagctggc aaagttggcc tctttgtggg cccagccaca cagcagagga
     3961 agcaggaggg tcctggggtg caggaaccac agaccctaca cacagcttcc ccacaatggg
     4021 gaaataaaac catttgatga ggattttcgc acatgcttgg ctcctgtgga gcaggtgtgt
     4081 gatgttggga atctgtcctt ccccagacca ttgcagctgc cgacttagac ccagagcctc
     4141 tgtttgggtg gctttccctg caggagacag gggcgtctga gcccctgccg ctttctgctt
     4201 tcccgtggga acataacagg gtggtaataa agagagctgg tccca
//
