LOCUS       NM_001362491           12337 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus transient receptor potential cation channel, subfamily
            M, member 3 (Trpm3), transcript variant 14, mRNA.
ACCESSION   NM_001362491
VERSION     NM_001362491.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 12337)
  AUTHORS   Singh,K., Jayaram,M., Hanumantharaju,A., Tonissoo,T., Jagomae,T.,
            Mikheim,K., Muthuraman,S., Gilbert,S.F., Plaas,M., Schafer,M.K.E.,
            Innos,J., Lillevali,K., Philips,M.A. and Vasar,E.
  TITLE     The IgLON family of cell adhesion molecules expressed in developing
            neural circuits ensure the proper functioning of the sensory system
            in mice
  JOURNAL   Sci Rep 14 (1), 22593 (2024)
   PUBMED   39349721
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12337)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 12337)
  AUTHORS   King,J.W., Bennett,A.S.W., Wood,H.M., Baker,C.C., Alsaadi,H.,
            Topley,M., Vanner,S.A., Reed,D.E. and Lomax,A.E.
  TITLE     Expression and function of transient receptor potential melastatin
            3 in the spinal afferent innervation of the mouse colon
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 326 (2), G176-G186 (2024)
   PUBMED   38084411
  REMARK    GeneRIF: Expression and function of transient receptor potential
            melastatin 3 in the spinal afferent innervation of the mouse colon.
REFERENCE   4  (bases 1 to 12337)
  AUTHORS   Zhou,Y., Bennett,T.M., Ruzycki,P.A., Guo,Z., Cao,Y.Q.,
            Shahidullah,M., Delamere,N.A. and Shiels,A.
  TITLE     A Cataract-Causing Mutation in the TRPM3 Cation Channel Disrupts
            Calcium Dynamics in the Lens
  JOURNAL   Cells 13 (3), 257 (2024)
   PUBMED   38334649
  REMARK    GeneRIF: A Cataract-Causing Mutation in the TRPM3 Cation Channel
            Disrupts Calcium Dynamics in the Lens.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 12337)
  AUTHORS   Alves-Lopes,R., Lacchini,S., Neves,K.B., Harvey,A., Montezano,A.C.
            and Touyz,R.M.
  TITLE     Vasoprotective effects of NOX4 are mediated via polymerase and
            transient receptor potential melastatin 2 cation channels in
            endothelial cells
  JOURNAL   J Hypertens 41 (9), 1389-1400 (2023)
   PUBMED   37272080
  REMARK    GeneRIF: Vasoprotective effects of NOX4 are mediated via polymerase
            and transient receptor potential melastatin 2 cation channels in
            endothelial cells.
REFERENCE   6  (bases 1 to 12337)
  AUTHORS   Deo,M., Yu,J.Y., Chung,K.H., Tippens,M. and Turner,D.L.
  TITLE     Detection of mammalian microRNA expression by in situ hybridization
            with RNA oligonucleotides
  JOURNAL   Dev Dyn 235 (9), 2538-2548 (2006)
   PUBMED   16736490
  REMARK    Erratum:[Dev Dyn. 2007 Mar;236(3):912]
REFERENCE   7  (bases 1 to 12337)
  AUTHORS   Ramsey,I.S., Delling,M. and Clapham,D.E.
  TITLE     An introduction to TRP channels
  JOURNAL   Annu Rev Physiol 68, 619-647 (2006)
   PUBMED   16460286
  REMARK    Review article
REFERENCE   8  (bases 1 to 12337)
  AUTHORS   Oberwinkler,J., Lis,A., Giehl,K.M., Flockerzi,V. and Philipp,S.E.
  TITLE     Alternative splicing switches the divalent cation selectivity of
            TRPM3 channels
  JOURNAL   J Biol Chem 280 (23), 22540-22548 (2005)
   PUBMED   15824111
  REMARK    GeneRIF: the divalent cation selectivity of TRPM3 channels is
            regulated by altenrative splicing
REFERENCE   9  (bases 1 to 12337)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   10 (bases 1 to 12337)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124513.3, AC164427.5, AC123066.4 and AC132389.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: JF706722.1, JX644972.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-252               AC124513.3         36714-36965
            253-332             AC164427.5         151746-151825
            333-537             AC164427.5         153053-153257
            538-751             AC164427.5         166036-166249
            752-876             AC164427.5         169553-169677
            877-1048            AC164427.5         187324-187495
            1049-1223           AC123066.4         172924-173098       c
            1224-1347           AC123066.4         146278-146401       c
            1348-1420           AC123066.4         82982-83054         c
            1421-1521           AC123066.4         55748-55848         c
            1522-1656           AC123066.4         54250-54384         c
            1657-1707           AC123066.4         50288-50338         c
            1708-1743           AC123066.4         42213-42248         c
            1744-1884           AC123066.4         41922-42062         c
            1885-1914           AC123066.4         39569-39598         c
            1915-2204           AC123066.4         38397-38686         c
            2205-2433           AC123066.4         37516-37744         c
            2434-2601           AC123066.4         34930-35097         c
            2602-2742           AC123066.4         29557-29697         c
            2743-2871           AC123066.4         25173-25301         c
            2872-3123           AC123066.4         20878-21129         c
            3124-3298           AC123066.4         13662-13836         c
            3299-3449           AC132389.3         82458-82608
            3450-3649           AC132389.3         82722-82921
            3650-3782           AC132389.3         86749-86881
            3783-12337          AC132389.3         91022-99576
FEATURES             Location/Qualifiers
     source          1..12337
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 16.05 cM"
     gene            1..12337
                     /gene="Trpm3"
                     /gene_synonym="6330504P12Rik; 9330180E14; B930001P07Rik;
                     LTRPC3; MLSN2"
                     /note="transient receptor potential cation channel,
                     subfamily M, member 3"
                     /db_xref="GeneID:226025"
                     /db_xref="MGI:MGI:2443101"
     exon            1..252
                     /gene="Trpm3"
                     /gene_synonym="6330504P12Rik; 9330180E14; B930001P07Rik;
                     LTRPC3; MLSN2"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..5235
                     /gene="Trpm3"
                     /gene_synonym="6330504P12Rik; 9330180E14; B930001P07Rik;
                     LTRPC3; MLSN2"
                     /note="isoform n is encoded by transcript variant 14;
                     melastatin 2; transient receptor potential melastatin 3
                     beta 1"
                     /codon_start=1
                     /product="transient receptor potential cation channel
                     subfamily M member 3 isoform n"
                     /protein_id="NP_001349420.1"
                     /db_xref="GeneID:226025"
                     /db_xref="MGI:MGI:2443101"
                     /translation="MPGPWGTVYFLGTAQICSFLSSRWNLEGVMNQTDASRPLNWTIR
                     KLCHAAFLPSVRLLKAQKSWIERAFYKRECVHIIPSTKDPHRCCCGRLIGQHVGLTPS
                     ISVLQNEKNESRLSRNDIQSEKWSISKHTQLSPTDAFGTIEFQGGGHSNKAMYVRVSF
                     DTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTTGAWI
                     FTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQTMS
                     NPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVVA
                     LIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQ
                     LLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGA
                     NASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIEN
                     GVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKREYPGFGWIYFKGNLPPDYRIS
                     LIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGMEDDIPLRRGRKT
                     TKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVAC
                     KLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELK
                     NWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSIL
                     SLEFKNKDDMPYMTQAQEIHLQEKEPEEPEKPTKEKDEEDMELTAMLGRSNGESSRKK
                     DEEEVQSRHRLIPVGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQ
                     EWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRL
                     QDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVV
                     LMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKT
                     IQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQL
                     IMTFHERPVLPPPLIIFSHMTMIFQHVCCRWRKHESDQDERDYGLKLFITDDELKKVH
                     DFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVD
                     IRLAQLEDLIGRMATALERLTGLERAESNKIRSRTSSDCTDAAYIVRQSSFNSQEGNT
                     FKLQESIDPAGEETISPTSPTLMPRMRSHSFYSVNVKDKGGIEKLESIFKERSLSLHR
                     ATSSHSVAKEPKAPAAPANTLAIVPDSRRPSSCIDIYVSAMDELHCDIEPLDNSMNIL
                     GLGEPSFSALAPSTTPSSSAYATLAPTDRPPSRSIDFEDLTSMDTRSFSSDYTHLPEC
                     QNPWDTDPPTYHTIERSKSSRYLATTPFLLEEAPIVKSHSFMFSPSRSYYANFGVPVK
                     TAEYTSITDCIDTRCVNAPQAIADRATFPGGLGDKVEDLSCCHPEREAELSHPSSDSE
                     ENEARGQRAANPISSQEAENADRTLSNNITVPKIERANSYSAEEPNVPYAHTRKSFSI
                     SDKLDRQRNTASLRNPFQRSKSSKPEGRGDSLSMRRLSRTSAFHSFESKHN"
     exon            253..332
                     /gene="Trpm3"
                     /gene_synonym="6330504P12Rik; 9330180E14; B930001P07Rik;
                     LTRPC3; MLSN2"
                     /inference="alignment:Splign:2.1.0"
     exon            333..537
                     /gene="Trpm3"
                     /gene_synonym="6330504P12Rik; 9330180E14; B930001P07Rik;
                     LTRPC3; MLSN2"
                     /inference="alignment:Splign:2.1.0"
     exon            538..751
                     /gene="Trpm3"
                     /gene_synonym="6330504P12Rik; 9330180E14; B930001P07Rik;
                     LTRPC3; MLSN2"
                     /inference="alignment:Splign:2.1.0"
     exon            752..876
                     /gene="Trpm3"
                     /gene_synonym="6330504P12Rik; 9330180E14; B930001P07Rik;
                     LTRPC3; MLSN2"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1048
                     /gene="Trpm3"
                     /gene_synonym="6330504P12Rik; 9330180E14; B930001P07Rik;
                     LTRPC3; MLSN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1223
                     /gene="Trpm3"
                     /gene_synonym="6330504P12Rik; 9330180E14; B930001P07Rik;
                     LTRPC3; MLSN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1347
                     /gene="Trpm3"
                     /gene_synonym="6330504P12Rik; 9330180E14; B930001P07Rik;
                     LTRPC3; MLSN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1420
                     /gene="Trpm3"
                     /gene_synonym="6330504P12Rik; 9330180E14; B930001P07Rik;
                     LTRPC3; MLSN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1521
                     /gene="Trpm3"
                     /gene_synonym="6330504P12Rik; 9330180E14; B930001P07Rik;
                     LTRPC3; MLSN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1656
                     /gene="Trpm3"
                     /gene_synonym="6330504P12Rik; 9330180E14; B930001P07Rik;
                     LTRPC3; MLSN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1707
                     /gene="Trpm3"
                     /gene_synonym="6330504P12Rik; 9330180E14; B930001P07Rik;
                     LTRPC3; MLSN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1743
                     /gene="Trpm3"
                     /gene_synonym="6330504P12Rik; 9330180E14; B930001P07Rik;
                     LTRPC3; MLSN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1884
                     /gene="Trpm3"
                     /gene_synonym="6330504P12Rik; 9330180E14; B930001P07Rik;
                     LTRPC3; MLSN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..1914
                     /gene="Trpm3"
                     /gene_synonym="6330504P12Rik; 9330180E14; B930001P07Rik;
                     LTRPC3; MLSN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2204
                     /gene="Trpm3"
                     /gene_synonym="6330504P12Rik; 9330180E14; B930001P07Rik;
                     LTRPC3; MLSN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2433
                     /gene="Trpm3"
                     /gene_synonym="6330504P12Rik; 9330180E14; B930001P07Rik;
                     LTRPC3; MLSN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..2601
                     /gene="Trpm3"
                     /gene_synonym="6330504P12Rik; 9330180E14; B930001P07Rik;
                     LTRPC3; MLSN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2602..2742
                     /gene="Trpm3"
                     /gene_synonym="6330504P12Rik; 9330180E14; B930001P07Rik;
                     LTRPC3; MLSN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2743..2871
                     /gene="Trpm3"
                     /gene_synonym="6330504P12Rik; 9330180E14; B930001P07Rik;
                     LTRPC3; MLSN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2872..3123
                     /gene="Trpm3"
                     /gene_synonym="6330504P12Rik; 9330180E14; B930001P07Rik;
                     LTRPC3; MLSN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3124..3298
                     /gene="Trpm3"
                     /gene_synonym="6330504P12Rik; 9330180E14; B930001P07Rik;
                     LTRPC3; MLSN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3299..3449
                     /gene="Trpm3"
                     /gene_synonym="6330504P12Rik; 9330180E14; B930001P07Rik;
                     LTRPC3; MLSN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3450..3649
                     /gene="Trpm3"
                     /gene_synonym="6330504P12Rik; 9330180E14; B930001P07Rik;
                     LTRPC3; MLSN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3650..3782
                     /gene="Trpm3"
                     /gene_synonym="6330504P12Rik; 9330180E14; B930001P07Rik;
                     LTRPC3; MLSN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3783..12337
                     /gene="Trpm3"
                     /gene_synonym="6330504P12Rik; 9330180E14; B930001P07Rik;
                     LTRPC3; MLSN2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6800..6805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trpm3"
                     /gene_synonym="6330504P12Rik; 9330180E14; B930001P07Rik;
                     LTRPC3; MLSN2"
                     /note="hexamer: ATTATA"
     polyA_site      6822
                     /gene="Trpm3"
                     /gene_synonym="6330504P12Rik; 9330180E14; B930001P07Rik;
                     LTRPC3; MLSN2"
                     /note="major polyA site"
     regulatory      9490..9495
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trpm3"
                     /gene_synonym="6330504P12Rik; 9330180E14; B930001P07Rik;
                     LTRPC3; MLSN2"
                     /note="hexamer: AATAAA"
     polyA_site      9518
                     /gene="Trpm3"
                     /gene_synonym="6330504P12Rik; 9330180E14; B930001P07Rik;
                     LTRPC3; MLSN2"
     regulatory      12305..12310
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trpm3"
                     /gene_synonym="6330504P12Rik; 9330180E14; B930001P07Rik;
                     LTRPC3; MLSN2"
                     /note="hexamer: AATAAA"
     regulatory      12315..12320
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trpm3"
                     /gene_synonym="6330504P12Rik; 9330180E14; B930001P07Rik;
                     LTRPC3; MLSN2"
                     /note="hexamer: AATACA"
     polyA_site      12322
                     /gene="Trpm3"
                     /gene_synonym="6330504P12Rik; 9330180E14; B930001P07Rik;
                     LTRPC3; MLSN2"
     polyA_site      12337
                     /gene="Trpm3"
                     /gene_synonym="6330504P12Rik; 9330180E14; B930001P07Rik;
                     LTRPC3; MLSN2"
ORIGIN      
        1 gccacttgac tagactccca agttccagga agcctctgcc ctaatggaat ttgcaggtgt
       61 ggagatgacc atgggatgcc agggccgtgg gggaccgttt attttctagg cactgcccag
      121 atttgcagtt tcttgtcttc ccggtggaat ttggaagggg tcatgaatca gactgatgct
      181 tctcgacccc taaattggac catccggaag ctatgccacg cagcctttct cccatctgtc
      241 agacttctca aggctcagaa atcctggatt gaaagagcat tttataaaag agaatgtgtt
      301 cacatcatac cgagcaccaa agacccccat aggtgttgct gtggacgcct cataggccag
      361 catgttggac tcactcccag tatctctgtg cttcagaatg agaaaaatga gagtcgcctc
      421 tcccgaaatg acatccagtc tgagaagtgg tctatcagca aacacactca gctcagccca
      481 acagacgctt ttgggaccat tgagttccaa ggaggtggcc attccaacaa agctatgtat
      541 gtccgagtat cttttgatac gaaacctgat ctcttgctac acctgatgac caaggaatgg
      601 caactggagc ttcccaaact tctcatctcc gtgcacggag ggctgcagaa ctttgaactc
      661 cagcccaaac tcaagcaagt cttcgggaag gggctcatca aagcagccat gacaactgga
      721 gcctggatct tcactggagg ggtcaacaca ggtgtcattc gtcatgttgg agatgccttg
      781 aaagaccatg catctaagtc tcgagggaag atatgtacca taggtatcgc cccctgggga
      841 attgtggaaa accaggaaga cctgattgga agagatgtag tccgaccata ccagaccatg
      901 tccaatccta tgagcaagct caccgttctc aatagcatgc actcccactt catcctggct
      961 gacaatggga ccacggggaa atacggagca gaggtgaaac tccgcagaca actggaaaag
     1021 cacatttcac tccagaagat aaacacaaga atcggtcaag gggttccagt ggtggctctc
     1081 atcgtggaag gaggacccaa tgtgatctca attgttttgg aataccttcg agacacccct
     1141 cctgtaccag tcgtggtctg tgatgggagt ggacgggcat ccgacatcct ggcatttggg
     1201 cataaatatt cagaagaagg cggacttatc aatgaatctt tgagggacca gctgttggtg
     1261 acaatacaga agaccttcac gtacactcga acccaagctc agcacctgtt catcatcctc
     1321 atggaatgca tgaagaagaa ggaactgatc acagtgtttc gaatggggtc agaaggccac
     1381 caggacattg atttagctat cctgacagca ttactcaaag gtgccaatgc atccgcccca
     1441 gaccaactga gcttagcttt agcctggaac agagttgaca tcgctcgcag ccagatcttt
     1501 atttacgggc agcagtggcc ggtagggtcc ctggagcaag ccatgctgga tgccctagtc
     1561 ctggacagag tggattttgt gaaattactc atagaaaatg gagtaagcat gcaccgtttt
     1621 ctcaccatct ccagactaga ggaactgtac aatacgagac atgggccctc aaatacattg
     1681 taccacttgg tcagggatgt caaaaagcga gagtatccag gtttcggttg gatctatttt
     1741 aagggaaacc tgcccccgga ctacagaatc agcctgatag acattggcct ggtgatcgag
     1801 tacctgatgg gcggggctta ccgctgcaac tacacgcgca agcgctttcg gaccctctac
     1861 cacaatctct ttggccccaa aaggcccaaa gccttgaaac tgctgggaat ggaggatgat
     1921 attcccttga ggagaggacg gaagacaact aagaagcgtg aggaagaggt ggacatcgac
     1981 ttggatgatc ctgagatcaa ccactttcca ttccccttcc atgagctgat ggtgtgggcc
     2041 gtcctcatga agagacaaaa gatggccctg ttcttctggc aacacggaga ggaggccatg
     2101 gccaaagccc tggtggcctg caagctctgc aaggccatgg ctcacgaggc ttctgagaat
     2161 gacatggtcg atgacatttc ccaggagctg aaccacaact ccagggactt tggccagctg
     2221 gctgtggagc tcctggacca gtcctacaaa caggatgagc agctggccat gaagctgctg
     2281 acgtatgagc tgaagaactg gagtaatgcc acatgcctgc agctggctgt ggctgccaag
     2341 caccgtgact tcattgcaca cacgtgcagc cagatgttac ttactgacat gtggatggga
     2401 cggctccgga tgagaaagaa ctcaggcctc aaggtaattc tgggaattct acttcctcct
     2461 tcaattctca gcttggagtt caagaacaaa gatgacatgc cctatatgac tcaggcccag
     2521 gagattcatc tccaagagaa ggagccggag gagccagaga agcccacaaa ggaaaaagat
     2581 gaagaggaca tggagctaac agcaatgttg gggcgaagca atggggaatc atccagaaag
     2641 aaagatgaag aagaagttca aagcaggcac cggctaatcc ccgtgggccg aaaaatctat
     2701 gagttctaca acgcacccat cgtgaagttc tggttctaca ctctggcgta tattggatac
     2761 ctgatgctct tcaactacat cgtgttagtg aagatggagc gctggccttc cactcaggaa
     2821 tggattgtca tctcctacat tttcactctg ggaatagaga agatgagaga gatcctgatg
     2881 tcggagccgg gcaagctgct gcagaaggtg aaggtgtggc ttcaggagta ctggaacgtc
     2941 acagacctca tcgccatcct tctcttctcg gtgggaatga tccttcgtct tcaagatcag
     3001 cccttcagga gtgacgggag ggtcatctac tgtgtgaaca tcatttattg gtatatccgt
     3061 ttgctggaca tcttcggcgt gaacaagtat ctgggcccat atgtgatgat gattgggaaa
     3121 atgatgatag acatgatgta ctttgtcatc attatgctgg tggtgctgat gagctttggg
     3181 gtcgccaggc aagccattct ctttcccaat gaggagccat cttggaaact ggccaagaat
     3241 atcttctaca tgccttattg gatgatttat ggggaagtgt ttgctgacca gatagaccct
     3301 ccctgtggac agaatgagac ccgagaggat ggcaagacaa tccagctgcc cccatgcaag
     3361 acaggagcat ggattgtccc ggccatcatg gcctgctacc tcttggtggc gaacatcctt
     3421 ctggtcaacc tccttattgc cgtcttcaac aatacatttt ttgaggtcaa gtcgatatcc
     3481 aaccaagtat ggaaatttca gaggtaccag ctcatcatga ctttccacga gaggccggtt
     3541 ctgcccccac cgctcatcat cttcagtcac atgaccatga tcttccagca tgtgtgctgc
     3601 cggtggagga agcatgagag tgaccaggac gaaagggact acggcctgaa actcttcata
     3661 actgacgatg agctcaagaa agtacacgat tttgaagagc agtgcataga ggaatatttc
     3721 cgagagaagg atgatcgctt caattcgtcc aacgatgaga ggatacgtgt tacatcagaa
     3781 agggtggaga acatgtccat gaggctggag gaagttaatg agagagaaca ttccatgaag
     3841 gcttcactcc agaccgtgga catccggcta gcacagctag aggacctcat cgggcgcatg
     3901 gccaccgccc tggagcgcct gactggtctg gagcgggcag agtctaacaa aatccgctca
     3961 aggacctcct cagactgcac agatgcagcc tacatcgtcc gccagagcag cttcaacagc
     4021 caggaaggga acaccttcaa acttcaagag agtatagacc ctgcaggtga ggagaccata
     4081 tccccaactt ctccaacctt aatgccccgt atgcgaagcc attctttcta ttcagtcaat
     4141 gtgaaagaca aaggtgggat agaaaagttg gaaagcattt tcaaagaaag gtccctgagc
     4201 ttacaccgag ctactagctc ccactcagta gccaaagaac ccaaagctcc tgcagcccct
     4261 gcaaacacct tggccattgt tcctgactcc agaagaccat catcttgcat agacatctat
     4321 gtctctgcca tggacgagct ccactgtgat atagagcctc tggataattc catgaacatc
     4381 cttgggctgg gtgagccaag cttttcagct ctagcacctt ccacaacccc gtcaagtagt
     4441 gcctatgcaa cgctcgcacc tacagaccga cctcccagta ggagcattga ttttgaagac
     4501 ctcacctcca tggacactag atctttttct tcagactata cacacctccc agaatgccaa
     4561 aacccctggg acacagaccc tccaacgtac cataccatcg agcgttccaa gagtagccgc
     4621 tacctagcca ccacgccctt tcttctggaa gaggctccca ttgtaaaatc ccatagcttt
     4681 atgttttctc cttcaaggag ctactacgcc aactttgggg tgcccgtgaa aacggcagaa
     4741 tacacaagta ttacagactg tatcgacaca agatgtgtca atgcccccca agcaatagct
     4801 gaccgagcca ccttccctgg aggtctcgga gacaaagtgg aagatttatc ttgttgccac
     4861 cctgagcgag aagcagagct gagccatcct agctctgaca gtgaggaaaa tgaggccaga
     4921 ggccagagag ctgccaatcc gatatcctct caggaggctg aaaatgcaga cagaacccta
     4981 tccaacaaca tcacagttcc caagatagag cgcgccaaca gctactcagc agaggagcca
     5041 aacgtgccat atgcacatac cagaaagagc ttctccatca gtgacaagct tgatagacag
     5101 aggaacacgg cgagcctccg aaatcccttc cagagaagta agtcctccaa gccggagggc
     5161 cgaggggaca gcctatccat gaggagactg tctagaacat cggcctttca tagctttgaa
     5221 agcaagcaca actaaaccgg cttaccgtgt gttgcaggag gctcgagaat ccagcgctaa
     5281 aattctcccc aatgcccacc accacgttcc cccttccttg agttagacct gctttattct
     5341 tagctgagca aaacaatggg agacattaac tcaaaggtaa cctctgggcc acaggtcaag
     5401 caagcattcc atctggtcca gtgcaaaaca caggggtcaa agcatgttcc tatctgttgg
     5461 gcagggaggg gtaaagacaa cagacagggg ctagagatga atgggtgtca ccaggcacca
     5521 gagaaagtca tgagctctgg gagccaatgg gcttcagcac tctccatgcc aacaggcatc
     5581 atgggatttc ggccctgtta tcaagagtcg agggctaaat tgcaaaatga aataagagta
     5641 ggcagcgtac aagatgagat attctaaact tccattctgt tttcttttca cattggttcc
     5701 atcactggtg actgatgaag aacatccttt ttattcagta taagccggca gcaagcagtt
     5761 ctacctaacg tcccacatcc ttctcatgcc aacacctctg taattggtca ttataaagaa
     5821 aaccaaggta acagtcatat atacagttca cctgtctctt atctattcac ctctggtgcc
     5881 acaactgttt atctctttag aagaaaataa gggaacagaa aaaaaatgcc tttttttttg
     5941 tcttgcgatc aaaatgaaag aagaattgat gttgaaagca aaagtcatat gatttataat
     6001 ataccacggg caatcaaata tagtcaagga agctcaggat gaatgtactc agatactttt
     6061 atatttgtaa gttattttgt atctcacctg tcatcaaaga attcactcgt caaatgtgta
     6121 atattgaact ttaaggaaaa ggtgggaaga tctaacatta agttgccagt gggatgttgt
     6181 cacagtctca ccgttcatag tgtgtgacgc tgctgtgtgg gccttcatca tctgcatgtc
     6241 tccactatgt cctccagaca cctccaagat gtaactgcca aatttccata ccgctcatca
     6301 tgtgaccatt ttgtatttga acacatggtt atatgtggat attttcatac ctagagtttt
     6361 agccatctaa tctgggctca gcataaattt aatcagagtt tttcaagggc tggtatcttt
     6421 tttatggaaa tgttccaaag tactttttaa ggaagtttaa aaaccataaa taaccttaga
     6481 tttgagtagg ggcttgatag caacccaaac ccatcagttg caggtaggcc atgaatatgt
     6541 ttcttattta caaagctata aaaaagatac agtagggcta aaatagaaag caattttacc
     6601 atatacagaa ttctatagtt tatgctgctt acatatacat ccacatacag actcatgttt
     6661 atatacagta tgtatacaga cagagatttc ttaaaaggct ttgactttct gtcatctgac
     6721 ggtataacta agattatttt ttagtgtcca agaagtttct ctggaaaaag tttattgtgc
     6781 tattggaccc actgttgaaa ttataatttt caaaagaaaa aatatctctg gtcttcttca
     6841 cctgtctttt cactgaacaa gaactgtcca aatggtctcc tccctccccc tccccccctc
     6901 cctccccctc cccccccccc cccaatctcc ttctatttgg aagcatccat tgtcatgaaa
     6961 tcccttttac tctggttgtt ctgacacaaa gctattacca ccaaatacac tctgaataga
     7021 tgagtgcttc taagccagtt tgtattacac catctaggat ggaggcatat gtttctagaa
     7081 tagaacctgg acttgaagtg ggataaagaa atcttgacca caaatctttg gattcctatt
     7141 tagatcactg aacacagagt ctttaagaaa aaaaatgatt tggggccagg aatagtggta
     7201 atgttcactg tgtgtgattc tgggcacttg ggaagaagag gaagaagatg aggaattgag
     7261 agtcaatctc tgctatgtag caagttcaag gccaacctgg actatatgag accctgttgc
     7321 agagagaagg ggagagagag agaaaaaaga cagagagaga aagagagaca gagacagaga
     7381 gagacagaga gggagggagg gagggagaga gagagagaga gagagagaga gagagaacat
     7441 aatttaatgt tcctggtccc aggtgttcct tattttgttt ttttcattgc agttctaaac
     7501 agcaaggtgc atatccctta gtgaaatcaa gtcagcaccc cacaaaacct gtagccttta
     7561 aatgtttttt tttttttaag aaaaaaatct tttcagcaga agagtggcaa gcatgtatcc
     7621 ataaggaatc ctttttcatc cttggtattt aggcaacacc caagctcttc actgataact
     7681 gcgctagaga cacttacttc ctaactggtg atctccctcc cagcagacat gctctgaacc
     7741 tggaaataaa tcatgtgtct ctaagcttcc tagagccatg agtccctgtg agaacccgat
     7801 agaaacgctg aaccctccca tacctcaaac tcacatccac atgaagcctc acgatagcgt
     7861 tgaggggttc gtgactggtg atgattaaag agactacact cattcttcat caatcacact
     7921 gcaacaggca ctatacactt ccagaccatt ttcctgtgat tctcaggagg gctgagtctc
     7981 agcaccagag tttgaaccaa ggtttcagca cttcaactct ttagattaga tatgactagc
     8041 tagatgtctt tatgccctaa catattcatg attttgagta gcaagcattc tccaaggcaa
     8101 agactctctg agggagtcca agatgagtcc acagatgtca gctgtgacaa tagaacagga
     8161 taccaagcac tctagagcct ggtttgggga ctcccttgga agcaagggag agaaagaaca
     8221 agcctacatg tctctgtttg ttgtgatcac ctgagagaac gaacatgacc tgggaaagga
     8281 aacactttac agtcctgagc tctcattctg catgaaaatt aagtgctaac ctctttggtg
     8341 aagtgtgtga agtctataag ccaaatgtaa acaacttcag acacaaactg tgtaggtctc
     8401 acaagccatg tcttccctgt gcgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     8461 gtgtgtgtgt gttattttca atcccacctc cttccatttc tgggttctct gtgtaccagt
     8521 gtggcattga ttctctagcc ttgtgcagac agcttgtgtt cagctcattt gttccaccat
     8581 tcccctgatg gaggggacct taattacctg cctctgtgaa ttaaacagct tgtgagtagc
     8641 cagtcattga agaccataca taaataaagt catagagggc tcaaggaaga gatagcttgt
     8701 ttaatcatcc ccttcatagg tgccaatttt tatatactac gatgtgtaat gatttgttct
     8761 aaattgcttg cttgttcctt ttgggaaaga aatgaagaat gttttataaa aatggccatg
     8821 aaggtttcct gattaaccgc catattttat atttacagtt agaaactgat agatttgaat
     8881 gaagtgctag aaagcaagag gataattgtc atgggcagtt tgtgtgtgtg caagccaaaa
     8941 ggagggcagt cagagtgtgg cactttagag gactggatgt ttctttaaag ttgaagcttc
     9001 cagggccagt tactatttag cactttgaaa gttccccctt taaaatatat ataaatatat
     9061 acatatacaa gaataatgaa atgggggggt tgtacttgtg aaaacacaaa atgtgtttct
     9121 tctgaatgtt acaattgtat tttaaaatct ggtttctata gataacatta tggtagatca
     9181 ctggatagta cgtttttttt ttcttttttt tctgcagctg tacagtctaa tcttcctgga
     9241 tgtttgggct gtttgatttc tttaaagata ataagcatta tccagttatc catcatgcta
     9301 tatctatagg ctatgccatg tgacatattg ggcaatgctg tattattaaa aaaaaaaaaa
     9361 aaaaaaaaaa aaaaaaaaca catgtaaacc tatttgtaac ctgtgtttaa ccagcatagt
     9421 tgtagcatgt ggttgtatta atgaacgtta caggacagct ttataatcat ttataaatct
     9481 gtaacattca ataaagaagc acatgtggca aggattaatt atgctcccat tttccatgtt
     9541 tttagcagcc tctagtaatg ggcatttttg ttcctgatct ctcttacact cttcacatct
     9601 ctcagacccc cgtgagatac ttatataagc tgatggtgcc tccgccacca ggtcccacaa
     9661 gctgggagag gcaaggtgtg gttttgtgtc tgacaagctg gcatgctatg caaaagacta
     9721 cctagcaaat gaactgaaag agtttaaact ccagttgaat tagctgcctg tttacgtcta
     9781 ctgaccccat aaggaagcag tgtgcagtgt tttataaatc cattcaatca gtagcactgt
     9841 ctgttataga taaagtgttg gtgttgtttg ggtggctgta tatttggcct agatgttgca
     9901 tccaacttgc taatctttac cataacgatg tggctcgact gaagtaatcc ctctccaaac
     9961 ccagtcctag ttttgtgtcg gcacaatgca cgcacgctat gctttatatg tgtctctttg
    10021 ccttcgtaag gcacttaagg ttttactctg gtctgctgca atccttaaac cagttatcga
    10081 gtcactcgaa ctgttgggct tcttaaactg gggactactt tcagttctca caaactaaaa
    10141 acaagtcatc aaggggttct tttctctttt tattttttta aagctctgag caaataatat
    10201 gaaataaagt atcaactaca agttgcaata gctcggggac ccagagatga caaggcagca
    10261 ccgctctgga gtcccaaggt ctaggtgtgg gggcaactgt aatataggaa agacacatct
    10321 tggattcttt agggcttcct gggtgcaaat tgctaaagcg gagataaaag tcaaggtgca
    10381 cggcgacaga gcagaaatgc acagatcaac tgtgagcgag cagtcccgtg gtaatgcatg
    10441 agacctccct tcttgtcctg tggctttcac accccgtggg tgagccaggc ccagaggtgg
    10501 gagtgggggt gatcgtttga tgaaacacca ggtgactctg aagagcttgt tctttcaaga
    10561 agttgccgct cggttgttat aagcccttca acatctggaa aggaatggat ccaagttgcc
    10621 tagtcaaaaa cgctcccaaa atgagcaggg aaaccgtttc tcagcatcag ctttgcccta
    10681 tatctaccag tccagcatcc tgtctctcag gagagagtcc ataagaaagg ggtctggctc
    10741 taactaaaga acaacttctt cttttctttt tctaattaat ttcaccgagt gtcgatggcg
    10801 ccctttgccc ttgtgacctc cttacattgg tcatccctag taaaatcaag atctactgat
    10861 tgctctgtgt catctaagag gggatagagg tgaccacatc ctctggattc atcaagagat
    10921 gatgataatt cctttcctaa ttttcctgga aaaactggcc aacttctgct ggcagcacac
    10981 gatccctgca tcatggtgtt ggaaacttga ccaactcgga ggggcatcag tgccggccat
    11041 gactctaatc cccaggggag gcagattgct aaagaatgtg agacacagga tgagatcagt
    11101 cttgggcctg agggcacggg attttttttt ttttttggtc tcccttcttc ctgtttttta
    11161 ttagttcaaa gccatctctt tctccccagt atgagtgtga gactaacaga ctcacccatt
    11221 acctcacatc cctgtggatc ccaacacagt aatgctaaac atcaactaca tggaagaagc
    11281 cagatgttct gacccagttc tggttgtcca tctgacttct cctgcaccca agttcttaat
    11341 gtggctggtg tggcacatgt cacatgcaat tctgaactgc ccgcctgact cctgaaaggc
    11401 tctctccacc ttcaccagct tcccatacat ggtcagaacc agttgcctaa ctctccatga
    11461 agggattgcc aactcaatcc aagacccaga tctagaaaga aatcaagagc aggatttgtt
    11521 aggcgtgaga gcatacgcat ctcacagaaa gactcaaatt tgggtttcca actcctatgc
    11581 tagtcacaca catgtgtctg cctgcagtat tcccaacggc catatttgga ggcctctgat
    11641 ttggagccaa gcagggtctg attcatggtt tttcacacag ttagcaaaca catcaaatac
    11701 actggagaat ttcaagtggg gagaagcagt ttgccctact aggggtgact cttagatcac
    11761 ttccatgtat gttgattagc atgtttttct ggatccaaac acaggaccag tgtgagggag
    11821 attcagagga aagatgtcgt agcactcgaa gacttacctg cttcctgtca ctggagcatc
    11881 tgacctgagt tcttattgct gctaccgctg tgtaagacag tccgtgtagt cagtaaacaa
    11941 ctccatagcc atttcataat ctagcactta gattcacact gtaaatgctc taaccatagt
    12001 ttataaaggg ggaagttatt cagatatcat ttttaaatga attcctataa atacaatgat
    12061 tttgaaattg ggtttactaa ctatatatac atcttttcct tctttcatgt atggatagac
    12121 agaggtttgc atatctactg acactatgaa tatatataga gagaagaact gttctttttt
    12181 aaaggtctct tactggattc acaatgcact ttgagcttgt ctgtttagat atataatttg
    12241 aagcagaagt tggcagattc tacaggcaac gaactttctg gaatttctgt aacaaatgtt
    12301 ttgcaataaa aaaaaataca aatagtttaa aacatga
//
