LOCUS       NM_138301               7292 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus transient receptor potential cation channel, subfamily
            M, member 2 (Trpm2), mRNA.
ACCESSION   NM_138301
VERSION     NM_138301.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7292)
  AUTHORS   Ferreira,A.F.F., Ulrich,H., Feng,Z.P., Sun,H.S. and Britto,L.R.
  TITLE     Neurodegeneration and glial morphological changes are both
            prevented by TRPM2 inhibition during the progression of a
            Parkinson's disease mouse model
  JOURNAL   Exp Neurol 377, 114780 (2024)
   PUBMED   38649091
  REMARK    GeneRIF: Neurodegeneration and glial morphological changes are both
            prevented by TRPM2 inhibition during the progression of a
            Parkinson's disease mouse model.
REFERENCE   2  (bases 1 to 7292)
  AUTHORS   Hinz,F.I., Villegas,C.L.M., Roberts,J.T., Yao,H., Gaddam,S.,
            Delwig,A., Green,S.A., Fredrickson,C., Adrian,M., Asuncion,R.R.,
            Cheung,T.K., Hayne,M., Hackos,D.H., Rose,C.M., Richmond,D. and
            Hoogenraad,C.C.
  TITLE     Context-Specific Stress Causes Compartmentalized SARM1 Activation
            and Local Degeneration in Cortical Neurons
  JOURNAL   J Neurosci 44 (24), e2424232024 (2024)
   PUBMED   38692735
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7292)
  AUTHORS   Burch,A.M., Garcia,J.D., O'Leary,H., Haas,A., Orfila,J.E.,
            Tiemeier,E., Chalmers,N., Smith,K.R., Quillinan,N. and Herson,P.S.
  TITLE     TRPM2 and CaMKII Signaling Drives Excessive GABAergic Synaptic
            Inhibition Following Ischemia
  JOURNAL   J Neurosci 44 (19), e1762232024 (2024)
   PUBMED   38565288
  REMARK    GeneRIF: TRPM2 and CaMKII Signaling Drives Excessive GABAergic
            Synaptic Inhibition Following Ischemia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7292)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 7292)
  AUTHORS   Benzi,A., Heine,M., Spinelli,S., Salis,A., Worthmann,A.,
            Diercks,B., Astigiano,C., Perez Mato,R., Memushaj,A., Sturla,L.,
            Vellone,V., Damonte,G., Jaeckstein,M.Y., Koch-Nolte,F.,
            Mittrucker,H.W., Guse,A.H., De Flora,A., Heeren,J. and Bruzzone,S.
  TITLE     The TRPM2 ion channel regulates metabolic and thermogenic
            adaptations in adipose tissue of cold-exposed mice
  JOURNAL   Front Endocrinol (Lausanne) 14, 1251351 (2024)
   PUBMED   38390373
  REMARK    GeneRIF: The TRPM2 ion channel regulates metabolic and thermogenic
            adaptations in adipose tissue of cold-exposed mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7292)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   7  (bases 1 to 7292)
  AUTHORS   Vennekens,R., Voets,T., Bindels,R.J., Droogmans,G. and Nilius,B.
  TITLE     Current understanding of mammalian TRP homologues
  JOURNAL   Cell Calcium 31 (6), 253-264 (2002)
   PUBMED   12098215
  REMARK    Review article
REFERENCE   8  (bases 1 to 7292)
  AUTHORS   Hara,Y., Wakamori,M., Ishii,M., Maeno,E., Nishida,M., Yoshida,T.,
            Yamada,H., Shimizu,S., Mori,E., Kudoh,J., Shimizu,N., Kurose,H.,
            Okada,Y., Imoto,K. and Mori,Y.
  TITLE     LTRPC2 Ca2+-permeable channel activated by changes in redox status
            confers susceptibility to cell death
  JOURNAL   Mol Cell 9 (1), 163-173 (2002)
   PUBMED   11804595
REFERENCE   9  (bases 1 to 7292)
  AUTHORS   Wiltshire,T., Pletcher,M., Cole,S.E., Villanueva,M., Birren,B.,
            Lehoczky,J., Dewar,K. and Reeves,R.H.
  TITLE     Perfect conserved linkage across the entire mouse chromosome 10
            region homologous to human chromosome 21
  JOURNAL   Genome Res 9 (12), 1214-1222 (1999)
   PUBMED   10613844
REFERENCE   10 (bases 1 to 7292)
  AUTHORS   Keino,H., Masaki,S., Kawarada,Y. and Naruse,I.
  TITLE     Apoptotic degeneration in the arhinencephalic brain of the mouse
            mutant Pdn/Pdn
  JOURNAL   Brain Res Dev Brain Res 78 (2), 161-168 (1994)
   PUBMED   8026071
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ108999.1, AC153507.11, AC158612.7, AK134735.1, AK036731.1 and
            AK136905.1.
            
            On Oct 23, 2009 this sequence version replaced NM_138301.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB166747.1, SRR9219382.27859.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-521               CJ108999.1         2-522
            522-568             AC153507.11        162901-162947
            569-737             AC153507.11        168886-169054
            738-918             AC153507.11        179562-179742
            919-1085            AC153507.11        180890-181056
            1086-1266           AC153507.11        182911-183091
            1267-1328           AC153507.11        184943-185004
            1329-1529           AC153507.11        185807-186007
            1530-1632           AC153507.11        187677-187779
            1633-1754           AC158612.7         108720-108841       c
            1755-1859           AC158612.7         108431-108535       c
            1860-3945           AK134735.1         1-2086
            3946-5342           AK036731.1         2225-3621
            5343-5653           AK136905.1         4198-4508
            5654-7292           AC158612.7         78115-79753         c
FEATURES             Location/Qualifiers
     source          1..7292
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..7292
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
                     /note="transient receptor potential cation channel,
                     subfamily M, member 2"
                     /db_xref="GeneID:28240"
                     /db_xref="MGI:MGI:1351901"
     exon            1..90
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
                     /inference="alignment:Splign:2.1.0"
     exon            91..233
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
                     /inference="alignment:Splign:2.1.0"
     exon            234..479
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
                     /inference="alignment:Splign:2.1.0"
     CDS             318..4838
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
                     /EC_number="3.6.1.13"
                     /note="LTrpC-2; long transient receptor potential channel
                     2; transient receptor protein 7; transient receptor
                     potential channel 7"
                     /codon_start=1
                     /product="transient receptor potential cation channel
                     subfamily M member 2"
                     /protein_id="NP_612174.2"
                     /db_xref="CCDS:CCDS48611.1"
                     /db_xref="GeneID:28240"
                     /db_xref="MGI:MGI:1351901"
                     /translation="MESLDRRRTGSEQEEGFGVQSRRATDLGMVPNLRRSNSSLCKSR
                     RFLCSFSSEKQENLSSWIPENIKKKECVYFVESSKLSDAGKVVCACGYTHEQHLEVAI
                     KPHTFQGKEWDPKKHVQEMPTDAFGDIVFTDLSQKVGKYVRVSQDTPSSVIYQLMTQH
                     WGLDVPNLLISVTGGAKNFNMKLRLKSIFRRGLVKVAQTTGAWIITGGSHTGVMKQVG
                     EAVRDFSLSSSCKEGEVITIGVATWGTIHNREGLIHPMGGFPAEYMLDEEGQGNLTCL
                     DSNHSHFILVDDGTHGQYGVEIPLRTKLEKFISEQTKERGGVAIKIPIVCVVLEGGPG
                     TLHTIYNAINNGTPCVIVEGSGRVADVIAQVATLPVSEITISLIQQKLSIFFQEMFET
                     FTENQIVEWTKKIQDIVRRRQLLTIFREGKDGQQDVDVAILQALLKASRSQDHFGHEN
                     WDHQLKLAVAWNRVDIARSEIFTDEWQWKPADLHPMMTAALISNKPEFVRLFLENGVR
                     LKEFVTWDTLLCLYENLEPSCLFHSKLQKVLAEEQRLAYASATPRLHMHHVAQVLREL
                     LGDSTQLLYPRPRYTDRPRLSMTVPHIKLNVQGVSLRSLYKRSTGHVTFTIDPVRDLL
                     IWAVIQNHRELAGIIWAQSQDCTAAALACSKILKELSKEEEDTDSSEEMLALADEFEH
                     RAIGVFTECYRKDEERAQKLLVRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKV
                     WWGQLCVDNGLWRIILCMLAFPLLFTGFISFREKRLQALCRPARVRAFFNAPVVIFHM
                     NILSYFAFLCLFAYVLMVDFQPSPSWCEYLIYLWLFSLVCEETRQLFYDPDGCGLMKM
                     ASLYFSDFWNKLDVGAILLFIVGLTCRLIPATLYPGRIILSLDFIMFCLRLMHIFTIS
                     KTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHNESRVDWIFRGVVYHSY
                     LTIFGQIPTYIDGVNFSMDQCSPNGTDPYKPKCPESDWTGQAPAFPEWLTVTLLCLYL
                     LFANILLLNLLIAMFNYTFQEVQEHTDQIWKFQRHDLIEEYHGRPPAPPPLILLSHLQ
                     LLIKRIVLKIPAKRHKQLKNKLEKNEETALLSWELYLKENYLQNQQYQQKQRPEQKIQ
                     DISEKVDTMVDLLDMDQVKRSGSTEQRLASLEEQVTQVTRALHWIVTTLKDSGFGSGA
                     GALTLAPQRAFDEPDAELSIRRKVEEPGDGYHVSARHLLYPNARIMRFPVPNEKVPWA
                     AEFLIYDPPFYTAEKDVALTDPVGDTAEPLSKISYNVVDGPTDRRSFHGVYVVEYGFP
                     LNPMGRTGLRGRGSLSWFGPNHTLQPVVTRWKRNQGGAICRKSVRKMLEVLVMKLPRS
                     EHWALPGGSREPGEMLPRKLKRVLRQEFWVAFETLLMQGTEVYKGYVDDPRNTDNAWI
                     ETVAVSIHFQDQNDMELKRLEENLHTHDPKELTRDLKLSTEWQVVDRRIPLYANHKTI
                     LQKVASLFGAHF"
     exon            480..568
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
                     /inference="alignment:Splign:2.1.0"
     exon            569..737
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
                     /inference="alignment:Splign:2.1.0"
     exon            738..918
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1085
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1266
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1328
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1529
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1632
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1754
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..2105
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2243
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
                     /inference="alignment:Splign:2.1.0"
     exon            2244..2373
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2519
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..2632
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
                     /inference="alignment:Splign:2.1.0"
     exon            2633..2846
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
                     /inference="alignment:Splign:2.1.0"
     exon            2847..2965
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
                     /inference="alignment:Splign:2.1.0"
     exon            2966..3098
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
                     /inference="alignment:Splign:2.1.0"
     exon            3099..3270
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
                     /inference="alignment:Splign:2.1.0"
     exon            3271..3454
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
                     /inference="alignment:Splign:2.1.0"
     exon            3455..3636
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
                     /inference="alignment:Splign:2.1.0"
     exon            3637..3769
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
                     /inference="alignment:Splign:2.1.0"
     exon            3770..3857
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
                     /inference="alignment:Splign:2.1.0"
     exon            3858..3945
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
                     /inference="alignment:Splign:2.1.0"
     exon            3946..4103
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
                     /inference="alignment:Splign:2.1.0"
     exon            4104..4177
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
                     /inference="alignment:Splign:2.1.0"
     exon            4178..4279
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
                     /inference="alignment:Splign:2.1.0"
     exon            4280..4366
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
                     /inference="alignment:Splign:2.1.0"
     exon            4367..4472
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
                     /inference="alignment:Splign:2.1.0"
     exon            4473..4574
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
                     /inference="alignment:Splign:2.1.0"
     exon            4575..4691
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
                     /inference="alignment:Splign:2.1.0"
     exon            4692..7292
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5604..5609
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
                     /note="hexamer: AATGAA"
     regulatory      5636..5641
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
                     /note="hexamer: AATGAA"
     polyA_site      5646
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
     polyA_site      5656
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
                     /note="major polyA site"
     regulatory      7274..7279
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
                     /note="hexamer: AATAAA"
     polyA_site      7292
                     /gene="Trpm2"
                     /gene_synonym="9830168K16Rik; LTRPC2; Trp7; TRPC7; Trrp7"
ORIGIN      
        1 ttcaggctgc gcctagcgat gagatgcggg tgagagcggc tgtcctgcgc agctgcgcgt
       61 gtgacgctgg ggtgcgcggc ctctgagcag accagtatgt ccaggatgcc tgggagcaag
      121 cagagagcta ctgggaagcc tgagagatgc agaatttttc agtgagtgag gtaaagaagg
      181 tgccacatgc cccagccccc agccagggct cataagccct ccctcccaat aaaaatcccc
      241 agtctcacaa atgagaagag atttccctga aggcatctag aggtctctgt cctcgggtga
      301 atctggagcc gtggaggatg gagtccttgg accggagaag aactggctct gagcaggagg
      361 agggctttgg ggtgcagtca aggagggcca ctgacctggg catggtcccc aatctccgac
      421 gaagcaatag cagcctttgc aagagcagga gatttctgtg ctctttcagc agtgagaagc
      481 aagaaaacct tagctcatgg attcccgaga atatcaagaa gaaggagtgt gtgtacttcg
      541 tggaaagttc caaactctcg gacgcaggga aggtagtgtg tgcgtgtggt tatacccacg
      601 agcaacactt ggaggtggcc atcaagccac acaccttcca gggcaaggag tgggatccaa
      661 agaaacacgt ccaagagatg cccacagatg cctttggtga catcgttttc acagacctga
      721 gccagaaagt ggggaagtat gtccgggtct cccaggacac gccctccagt gtcatctacc
      781 agctcatgac ccagcactgg ggcctagatg tccccaacct cctcatctcc gtgaccggtg
      841 gggccaagaa cttcaacatg aagctgaggc tgaagagcat cttccggaga ggcttggtca
      901 aggtggctca aaccacgggg gcctggatca tcactggagg atcccacaca ggcgtgatga
      961 agcaggtggg cgaagcggta cgggacttca gtctgagcag cagctgcaaa gaaggtgaag
     1021 tcatcactat tggcgtagcc acgtggggca ccatccacaa ccgcgaggga ctgatccatc
     1081 ccatgggagg cttccccgcc gagtacatgc tggatgagga aggccaaggg aacctgacct
     1141 gcttggacag caaccattcc cacttcatct tggtggatga tgggacccac gggcaatatg
     1201 gtgtggagat tccgctgagg actaagctgg aaaagttcat ctcagagcaa acgaaggaaa
     1261 ggggaggtgt ggccatcaag atccccattg tctgcgtggt gttggagggt ggccctggca
     1321 ctctgcatac aatctacaat gccatcaaca atggcacacc ctgcgtgata gtggagggct
     1381 ctggccgagt ggctgacgtc atcgctcagg tagctactct gcctgtctct gagatcacca
     1441 tctccttgat ccagcagaag ctcagcatat tcttccagga gatgtttgag actttcaccg
     1501 aaaaccagat tgtggaatgg accaaaaaga tccaagacat tgtccggagg cggcagctgc
     1561 tgacgatctt ccgggaaggc aaggatggtc agcaggatgt ggatgtggcc attctgcagg
     1621 cgttactgaa agcctctcga agccaagacc actttggcca cgagaactgg gaccaccaac
     1681 tgaagttggc tgtggcctgg aaccgcgtgg acatcgctcg cagtgagatc ttcaccgatg
     1741 aatggcagtg gaagcctgca gatctgcatc ccatgatgac ggccgctctc atctccaaca
     1801 agcctgagtt cgtgaggctc tttctggaga atggggtgcg gctcaaggag tttgtcactt
     1861 gggatactct tctctgcctg tacgagaacc tggagccgtc ctgtctcttc cacagcaagc
     1921 tacagaaggt gctggccgaa gaacagcgct tagcctatgc atctgcaaca ccccgcctgc
     1981 acatgcacca tgtggcccag gtgcttcgtg aactcctggg ggactccacg cagctgctgt
     2041 acccccggcc ccggtacact gacaggccac ggctctcgat gaccgtgcca cacatcaagc
     2101 tgaacgtgca gggagtgagc ctccggtccc tctataagcg atcaacaggc cacgttacct
     2161 tcaccattga cccagtccgt gaccttctca tttgggccgt tatccagaac cacagggagc
     2221 tggcaggcat catctgggct cagagtcagg actgtactgc cgcagcactg gcctgtagca
     2281 agatcctgaa ggagctgtcc aaggaggagg aagatacaga cagctctgag gagatgctgg
     2341 cactggcaga cgagtttgag cacagagcta taggcgtctt cactgagtgc tacaggaagg
     2401 atgaggaaag agcccagaag ctgcttgtcc gtgtgtctga ggcctggggg aagaccacct
     2461 gcctgcagct ggccctagag gccaaggaca tgaaattcgt gtctcatgga ggcatccagg
     2521 ctttcctaac caaggtgtgg tggggccagc tctgtgtgga caatggcctg tggaggatca
     2581 tcctgtgcat gctggccttc ccgctgctct tcaccggctt catctccttc agggaaaaga
     2641 ggctgcaggc actgtgtcgc ccagcccgcg tccgcgcctt cttcaatgcg cctgtggtca
     2701 tcttccacat gaatatcctc tcctactttg ccttcctctg cctgttcgcc tacgtgctca
     2761 tggtggactt ccagccttct ccatcctggt gcgagtacct catctacctg tggctcttct
     2821 ccctggtgtg cgaagagact cggcagctat tctatgatcc tgatggctgt ggactaatga
     2881 agatggcgtc cctgtacttc agtgacttct ggaacaaact ggacgttggg gccattctgc
     2941 tcttcatagt aggactgacc tgtcggctca tcccagcgac gctgtaccct gggcgcatca
     3001 tcctgtcttt ggacttcatc atgttctgtc tccgtctcat gcacatcttc actattagca
     3061 agacactggg gcccaagata atcatcgtga agcggatgat gaaggacgtc ttcttcttcc
     3121 tctttctcct ggcggtgtgg gtggtgtcct tcggcgtagc taagcaggcc attctcatac
     3181 ataacgagag ccgcgtggac tggatcttcc gtggggttgt ctatcactct tacctgacca
     3241 tctttggcca gatcccaacc tacattgacg gtgtgaattt cagcatggac cagtgcagcc
     3301 ccaatggcac ggacccctac aagcctaagt gtcctgagag cgactggacg ggacaggcac
     3361 ctgccttccc cgagtggctg actgtcaccc tgctctgcct ctacctgctc tttgccaaca
     3421 tcctgctgct taacctgctc atcgccatgt tcaactacac cttccaggag gtgcaggaac
     3481 acacagacca gatctggaaa ttccagcgcc acgacctgat cgaggagtac catggccgtc
     3541 ccccggcacc tcccccactc atcctcctca gccacctgca gctcctgatc aagaggattg
     3601 tcctgaagat ccctgccaag aggcataagc agctcaagaa caagctggag aagaacgagg
     3661 agacagcgct cctgtcttgg gaactgtacc tgaaggagaa ctacctgcag aaccagcagt
     3721 accagcagaa acagcgtcca gagcagaaaa tccaagacat cagtgagaaa gtggacacca
     3781 tggtggatct gctggacatg gaccaggtga agaggtcagg ctccacagag cagagactgg
     3841 cttccctgga ggaacaggtg actcaggtga ccagagcttt gcactggatc gtgacaaccc
     3901 tgaaggacag tggctttggc tcaggagcag gtgcgctgac cctggcaccc cagagggcct
     3961 tcgatgagcc agatgctgag ctgagtatca ggaggaaagt agaggaacca ggagatggtt
     4021 accacgtgag cgcccggcat ctcctctatc ccaatgcccg catcatgcgc ttccccgtgc
     4081 ctaacgagaa ggtgccttgg gcggcagagt ttctgatcta cgatcctccc ttttacaccg
     4141 ctgagaagga tgtggctctc acagaccccg tgggagacac tgcagaacct ctgtctaaga
     4201 tcagttacaa cgtcgtggat ggaccgacgg accgtcgcag cttccatgga gtctacgtgg
     4261 tcgagtatgg gttcccgttg aaccccatgg gccgcacagg gttgcgtggt cgtgggagcc
     4321 tcagctggtt tggtcccaac cacactctgc agccagttgt cacccggtgg aagaggaacc
     4381 agggtggagc catctgccgg aagagtgtca ggaagatgct ggaggtgcta gtgatgaagc
     4441 tgcctcgctc tgagcactgg gccttgcctg ggggctctag ggagccaggg gagatgctac
     4501 cacggaagct gaaacgggtc ctccggcagg agttctgggt ggcctttgag accttgctga
     4561 tgcaaggtac agaggtatac aaagggtacg tggatgaccc aaggaacaca gacaatgcct
     4621 ggatcgagac agtggctgtc agcatccatt ttcaggacca gaatgatatg gagctgaaga
     4681 ggctggaaga gaacctgcac actcatgatc caaaggagtt gacccgtgac ctgaagctgt
     4741 ctactgaatg gcaggtggta gaccggcgga tccctctgta tgcgaaccac aagaccatcc
     4801 tccagaaggt ggcctcactg tttggagctc acttctgact gtggcttctg ggccacaatg
     4861 gccccccaag acttggactg ctgtcttggg ctggatggct ggttggggta ctgggttggg
     4921 gtgggtggta ggttgtaggg ctgggttggg tgaccacagg gatcttaata agtccccaga
     4981 ggtgatgtcc tgaaagccac ttctgccaca acaggaaggt cacaagcata aggacagaag
     5041 tgtattcagt ggctcctgct acctatgtcc tcaagtgcca tgctttgact agggtttatg
     5101 gggccctgac cagcaagatg ctgccactac ccataagcct gcctggaagt gctctctctg
     5161 ggacaggcac tttcccctgg agggacctct gtcctcattg tgggagactt ctgtcctagg
     5221 cattaggtag atagaggctg tgcctccttc aggaagagac actgtcctta taacttctgg
     5281 tcagtgctga gtcacaggca ttgagggagg agggcttggg gctgggatca ctgtcatccc
     5341 tagactatag aagtgctctt ctgaagacac tcaggcagga gcatgccctc cctcagcact
     5401 agctgacctg ctggtcacag aaagtactgg aagaagacaa cggggcatcc tgtcatggct
     5461 tctaagagga aagtacaatt gagaatgata ggctttctct gacagggtag gtgactcagg
     5521 gattggtact gtggctagga gatgaactct gtagccgagg tgggtgtggg gatgagcaat
     5581 accgggcttt aatgggatag gacaatgaag aacatgtatg atcaatctat ctaaaaatga
     5641 atcttggaaa acttcaggac tcaactgggg tcactgggaa caaagttctg cggtgtctgg
     5701 ggtctgtcct gaactgctcg aggtcacctg gtttcccaga cagtaggtat ccctggttcc
     5761 cagaaaggga ggtggtctga ttagcttctt ttgacaagca acaaaggggt ctctgggaat
     5821 ggagaggtag cccagtgaac gctgctgtgt ggatccatgg aagctggagg acacggtcct
     5881 agactgtctt ttctccagtt caggcttcaa aacaacgcag agagccagga attctggacg
     5941 atccaggaat ccctggagat ccaagaatcc cgggagatct aggatttctg ggaaaaacaa
     6001 ggattatagt ggcacagagg aggtcgcctg gctcaaactg ttgaagaaaa aaaaaaagga
     6061 tataaaaagc aaccggctct gctctggctg gcctggcagc tccttgtcca ccttatgtca
     6121 tgcgattaag tcactgcatg cattaatatc atgatggtgc acagatgggg gtggggtgag
     6181 cacgtgggag caaaacaaac caatctcatg cccaccagct gagagattca ctgagagatg
     6241 caggtcatgg tttcctccaa gggtacctct gcaatgactg gagacacccc ctattccaat
     6301 tcagttccac ctcctgaagg tcccaccacc ttccagaagc accgtgtcag gggtgaagcc
     6361 tccaacattc aaggtatgaa cccaaatcac agtcccatgc ctagtccaag aaggcagaca
     6421 aggaaacaaa gacatgctga gagatttctt aagagctcct ctgcttccag gtcatccctt
     6481 aaccaagcca gtgatgccag gagacaccac aggccttaac agctatggtc tggccctcat
     6541 gctgacccgc tctctctgga tttctcctgg ctgtcatttg tcttaggagc tcattatact
     6601 gatgcaggct ggttgacact gacttcttag cttcccctac ctgcagcagg gcctcagacg
     6661 tctgtttgtc tgtagcgacc ttttcagtgt tgagcatcct gtgtattcag ttccagtgtg
     6721 tctgctgcct tcccacagct gcgtggactt gctggacagg acatttttag tggcacttta
     6781 aaaggtgtgt tacagttttc cccttaccca gttggctccc aaataattga gactgagcta
     6841 ttacatttat tttacagctg tgagggcaca ataactgagc agttattact ctattttaat
     6901 ctatcctaat ctggctacct cccaggcaaa atccctgtgc tacttgcatt ttatggtttt
     6961 ctctgcttca agtgttttct catgaactat cctggaccca ctttctctct tctcttctct
     7021 tctcttctct tcctcttcct cttcctcttc ctcttcctct tcctcttcct cttcctcttc
     7081 ctcttcctct tcctcttcct cctcccctct ctgccctggg tgtaaaccca gccctattct
     7141 ctcccatgtt cagccactag cggatcagct agctttattg atcaatcagg gaataattgg
     7201 ggagcaatgt ttacacaaca tcgatacagg agattcttag aataaggact gcaaccagat
     7261 acagtggcac agaaataaac atttgaataa ta
//
