LOCUS       NM_001039104            5711 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus transient receptor potential cation channel, subfamily
            M, member 1 (Trpm1), transcript variant 2, mRNA.
ACCESSION   NM_001039104
VERSION     NM_001039104.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5711)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5711)
  AUTHORS   Cao,Y., Fajardo,D., Guerrero-Given,D., Samuel,M.A., Ohtsuka,T.,
            Boye,S.E., Kamasawa,N. and Martemyanov,K.A.
  TITLE     Post-developmental plasticity of the primary rod pathway allows
            restoration of visually guided behaviors
  JOURNAL   Curr Biol 32 (22), 4783-4796 (2022)
   PUBMED   36179691
REFERENCE   3  (bases 1 to 5711)
  AUTHORS   Chambers,S., Leftwich,T., Pamonag,M., Rice,J. and Walker,M.T.
  TITLE     Trpm1: Novel function at the intersection of light and pain
            response in the iris
  JOURNAL   Exp Eye Res 215, 108897 (2022)
   PUBMED   34954202
REFERENCE   4  (bases 1 to 5711)
  AUTHORS   Koike,C., Obara,T., Uriu,Y., Numata,T., Sanuki,R., Miyata,K.,
            Koyasu,T., Ueno,S., Funabiki,K., Tani,A., Ueda,H., Kondo,M.,
            Mori,Y., Tachibana,M. and Furukawa,T.
  TITLE     TRPM1 is a component of the retinal ON bipolar cell transduction
            channel in the mGluR6 cascade
  JOURNAL   Proc Natl Acad Sci U S A 107 (1), 332-337 (2010)
   PUBMED   19966281
  REMARK    GeneRIF: These results demonstrate that TRPM1-L is a component of
            the ON bipolar cell (BC) transduction channel downstream of mGluR6
            in ON BCs.
REFERENCE   5  (bases 1 to 5711)
  AUTHORS   Rowan,S., Chen,C.M., Young,T.L., Fisher,D.E. and Cepko,C.L.
  TITLE     Transdifferentiation of the retina into pigmented cells in ocular
            retardation mice defines a new function of the homeodomain gene
            Chx10
  JOURNAL   Development 131 (20), 5139-5152 (2004)
   PUBMED   15459106
REFERENCE   6  (bases 1 to 5711)
  AUTHORS   Miller,A.J., Du,J., Rowan,S., Hershey,C.L., Widlund,H.R. and
            Fisher,D.E.
  TITLE     Transcriptional regulation of the melanoma prognostic marker
            melastatin (TRPM1) by MITF in melanocytes and melanoma
  JOURNAL   Cancer Res 64 (2), 509-516 (2004)
   PUBMED   14744763
REFERENCE   7  (bases 1 to 5711)
  AUTHORS   Loftus,S.K., Larson,D.M., Baxter,L.L., Antonellis,A., Chen,Y.,
            Wu,X., Jiang,Y., Bittner,M., Hammer,J.A. 3rd and Pavan,W.J.
  TITLE     Mutation of melanosome protein RAB38 in chocolate mice
  JOURNAL   Proc Natl Acad Sci U S A 99 (7), 4471-4476 (2002)
   PUBMED   11917121
REFERENCE   8  (bases 1 to 5711)
  AUTHORS   Fang,D. and Setaluri,V.
  TITLE     Expression and Up-regulation of alternatively spliced transcripts
            of melastatin, a melanoma metastasis-related gene, in human
            melanoma cells
  JOURNAL   Biochem Biophys Res Commun 279 (1), 53-61 (2000)
   PUBMED   11112417
REFERENCE   9  (bases 1 to 5711)
  AUTHORS   Hunter,J.J., Shao,J., Smutko,J.S., Dussault,B.J., Nagle,D.L.,
            Woolf,E.A., Holmgren,L.M., Moore,K.J. and Shyjan,A.W.
  TITLE     Chromosomal localization and genomic characterization of the mouse
            melastatin gene (Mlsn1)
  JOURNAL   Genomics 54 (1), 116-123 (1998)
   PUBMED   9806836
REFERENCE   10 (bases 1 to 5711)
  AUTHORS   Duncan,L.M., Deeds,J., Hunter,J., Shao,J., Holmgren,L.M.,
            Woolf,E.A., Tepper,R.I. and Shyjan,A.W.
  TITLE     Down-regulation of the novel gene melastatin correlates with
            potential for melanoma metastasis
  JOURNAL   Cancer Res 58 (7), 1515-1520 (1998)
   PUBMED   9537257
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY180104.2.
            
            On Mar 14, 2008 this sequence version replaced NM_001039104.1.
            
            Transcript Variant: This variant (TRPM1-L, PMID: 19966281, also
            known as Trpm1delta189-1078) differs in the 5' UTR and 5' coding
            region, and includes several additional exons at the 3' end,
            compared to variant 1. The resulting isoform (2) has distinct N-
            and C-termini, and is longer than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY180104.2 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849388
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5711              AY180104.2         1-5711
FEATURES             Location/Qualifiers
     source          1..5711
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7"
     gene            1..5711
                     /gene="Trpm1"
                     /gene_synonym="4732499L03Rik; Ltrpc1; Mlsn1; rd15"
                     /note="transient receptor potential cation channel,
                     subfamily M, member 1"
                     /db_xref="GeneID:17364"
                     /db_xref="MGI:MGI:1330305"
     exon            1..272
                     /gene="Trpm1"
                     /gene_synonym="4732499L03Rik; Ltrpc1; Mlsn1; rd15"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..5066
                     /gene="Trpm1"
                     /gene_synonym="4732499L03Rik; Ltrpc1; Mlsn1; rd15"
                     /note="isoform 2 is encoded by transcript variant 2;
                     melastatin-1; long transient receptor potential channel 1"
                     /codon_start=1
                     /product="transient receptor potential cation channel
                     subfamily M member 1 isoform 2"
                     /protein_id="NP_001034193.2"
                     /db_xref="CCDS:CCDS21332.2"
                     /db_xref="GeneID:17364"
                     /db_xref="MGI:MGI:1330305"
                     /translation="MGSMRKMSSSFKRGSIKSSTSGSQKGQKAWIEKTFCKRECIFVI
                     PSTKDPNRCCCGQLTNQHIPPLPSGAPSTTGEDTKQADTQSGKWSVSKHTQSYPTDSY
                     GILEFQGGGYSNKAMYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQSFEMQP
                     KLKQVFGKGLIKAAMTTGAWIFTGGVSTGVVSHVGDALKDHSSKSRGRLCAIGIAPWG
                     MVENKEDLIGKDVTRVYQTMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVKLRRQL
                     EKHISLQKINTRLGQGVPVVGLVVEGGPNVVSIVLEYLKEDPPVPVVVCDGSGRASDI
                     LSFAHKYCDEGGVINESLRDQLLVTIQKTFNYSKSQSYQLFAIIMECMKKKELVTVFR
                     MGSEGQQDVEMAILTALLKGTNASAPDQLSLALAWNRVDIARSQIFVFGPHWPPLGSL
                     APPVDTKATEKEKKPPTATTKGRGKGKGKKKGKVKEEVEEETDPRKLELLNWVNALEQ
                     AMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEELYNTRLGPPNTLHLLVRDVKKSN
                     LPPDYHISLIDIGLVLEYLMGGAYRCNYTRKSFRTLYNNLFGPKRPKALKLLGMEDDE
                     PPAKGKKKKKKKKEEEIDIDVDDPAVSRFQYPFHELMVWAVLMKRQKMAVFLWQRGEE
                     CMAKALVACKLYKAMAHESSESELVDDISQDLDNNSKDFGQLAVELLDQSYKHDEQVA
                     MKLLTYELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNPGLKVIM
                     GILIPPTILFLEFRTYDDFSYQTSKENEDGKEKEEENVDANADAGSRKGDEENEHKKQ
                     RSIPIGTKICEFYNAPIVKFWFYTISYLGYLLLFNYVILVRMDGWPSPQEWIVISYIV
                     SLALEKIREILMSEPGKLSQKIKVWLQEYWNITDLVAISMFMVGAILRLQSQPYMGYG
                     RVIYCVDIILWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMSFGVARQ
                     AILHPEEKPSWKLARNIFYMPYWMIYGEVFADQIDLYAMEINPPCGENLYDEEGKRLP
                     PCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTF
                     HDRPVLPPPMIILSHIYIIIMRLSGRCRKKREGDQEERDRGLKLFLSDEELKKLHEFE
                     EQCVQEHFREKEDEQQSSSDERIRVTSERVENMSMRLEEINERENFMKTSLQTVDLRL
                     SQLEELSGRMVSALENLAGIDRSDLIQARSRASSECEATYLLRQSSINSADGYSLYRY
                     HFNGEELLFEEPALSTSPGTAFRKKTYSFRVKDEDAKSHLDQPSNLHHTPGPSPPATP
                     GRSRLALEGPLSTELRPGSDPGISAGEFDPRADFKSTEAAPSLNAAGVTGTQLTVEST
                     DSHPLRESKLVRYYPGDPNTYKTMKSRSFVYTEGRKLVRGLSNWSAEYSSIMDQAWNA
                     TEWRCQVQRITRSRSTDIPYIVSEAASQDELEDEHRGSLLDPQISRSALTVSDRPEKE
                     NLLSVKPHQTLGFPCLRSRSLHGRPRSAEPAPSKLDRAGHASSTSNLAVMSVVPEGQN
                     TQQEKRSAETEC"
     exon            273..352
                     /gene="Trpm1"
                     /gene_synonym="4732499L03Rik; Ltrpc1; Mlsn1; rd15"
                     /inference="alignment:Splign:2.1.0"
     exon            353..548
                     /gene="Trpm1"
                     /gene_synonym="4732499L03Rik; Ltrpc1; Mlsn1; rd15"
                     /inference="alignment:Splign:2.1.0"
     exon            549..762
                     /gene="Trpm1"
                     /gene_synonym="4732499L03Rik; Ltrpc1; Mlsn1; rd15"
                     /inference="alignment:Splign:2.1.0"
     exon            763..887
                     /gene="Trpm1"
                     /gene_synonym="4732499L03Rik; Ltrpc1; Mlsn1; rd15"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1059
                     /gene="Trpm1"
                     /gene_synonym="4732499L03Rik; Ltrpc1; Mlsn1; rd15"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1234
                     /gene="Trpm1"
                     /gene_synonym="4732499L03Rik; Ltrpc1; Mlsn1; rd15"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1358
                     /gene="Trpm1"
                     /gene_synonym="4732499L03Rik; Ltrpc1; Mlsn1; rd15"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1431
                     /gene="Trpm1"
                     /gene_synonym="4732499L03Rik; Ltrpc1; Mlsn1; rd15"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1532
                     /gene="Trpm1"
                     /gene_synonym="4732499L03Rik; Ltrpc1; Mlsn1; rd15"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1703
                     /gene="Trpm1"
                     /gene_synonym="4732499L03Rik; Ltrpc1; Mlsn1; rd15"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1838
                     /gene="Trpm1"
                     /gene_synonym="4732499L03Rik; Ltrpc1; Mlsn1; rd15"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..1889
                     /gene="Trpm1"
                     /gene_synonym="4732499L03Rik; Ltrpc1; Mlsn1; rd15"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..2030
                     /gene="Trpm1"
                     /gene_synonym="4732499L03Rik; Ltrpc1; Mlsn1; rd15"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2060
                     /gene="Trpm1"
                     /gene_synonym="4732499L03Rik; Ltrpc1; Mlsn1; rd15"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2353
                     /gene="Trpm1"
                     /gene_synonym="4732499L03Rik; Ltrpc1; Mlsn1; rd15"
                     /inference="alignment:Splign:2.1.0"
     exon            2354..2582
                     /gene="Trpm1"
                     /gene_synonym="4732499L03Rik; Ltrpc1; Mlsn1; rd15"
                     /inference="alignment:Splign:2.1.0"
     exon            2583..2705
                     /gene="Trpm1"
                     /gene_synonym="4732499L03Rik; Ltrpc1; Mlsn1; rd15"
                     /inference="alignment:Splign:2.1.0"
     exon            2706..2837
                     /gene="Trpm1"
                     /gene_synonym="4732499L03Rik; Ltrpc1; Mlsn1; rd15"
                     /inference="alignment:Splign:2.1.0"
     exon            2838..2966
                     /gene="Trpm1"
                     /gene_synonym="4732499L03Rik; Ltrpc1; Mlsn1; rd15"
                     /inference="alignment:Splign:2.1.0"
     exon            2967..3218
                     /gene="Trpm1"
                     /gene_synonym="4732499L03Rik; Ltrpc1; Mlsn1; rd15"
                     /inference="alignment:Splign:2.1.0"
     exon            3219..3393
                     /gene="Trpm1"
                     /gene_synonym="4732499L03Rik; Ltrpc1; Mlsn1; rd15"
                     /inference="alignment:Splign:2.1.0"
     exon            3394..3414
                     /gene="Trpm1"
                     /gene_synonym="4732499L03Rik; Ltrpc1; Mlsn1; rd15"
                     /inference="alignment:Splign:2.1.0"
     exon            3415..3559
                     /gene="Trpm1"
                     /gene_synonym="4732499L03Rik; Ltrpc1; Mlsn1; rd15"
                     /inference="alignment:Splign:2.1.0"
     exon            3560..3762
                     /gene="Trpm1"
                     /gene_synonym="4732499L03Rik; Ltrpc1; Mlsn1; rd15"
                     /inference="alignment:Splign:2.1.0"
     exon            3763..3895
                     /gene="Trpm1"
                     /gene_synonym="4732499L03Rik; Ltrpc1; Mlsn1; rd15"
                     /inference="alignment:Splign:2.1.0"
     exon            3896..5708
                     /gene="Trpm1"
                     /gene_synonym="4732499L03Rik; Ltrpc1; Mlsn1; rd15"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgtagtctct gagcactggg tgggagtcca gccggagggt gagaagcagt ccagctcctt
       61 ctgagctgac tgagccatca atatcatctc aaactctgag ccctgctgtc cagtctcata
      121 aagaggactc tcttacctca gctgaccagg gcctcccatg cagcaggctg gacctcacag
      181 ggaatgcaga agcacccatg gggtccatga ggaagatgag cagctccttc aagcgtggtt
      241 caatcaagag ctccacatca gggtcccaga agggtcagaa agcatggata gagaagacat
      301 tttgcaaaag ggaatgcatc tttgtaattc ccagtacaaa agaccctaac agatgttgct
      361 gtggtcagct cactaaccag cacatccccc ctctgccgag tggggctccc agcacaacag
      421 gagaggacac caagcaggca gacacgcagt ccgggaaatg gtctgtcagc aaacacaccc
      481 agagctaccc aacagactcc tatgggattc ttgaattcca gggtgggggt tactccaata
      541 aagccatgta catccgagtc tcctacgaca ccaagccaga ttccctgctc cacctcatgg
      601 tgaaggactg gcagctggag ctcccgaagc tcttgatatc tgtgcacgga ggcctccaaa
      661 gcttcgagat gcagcccaaa ctgaagcagg tgtttgggaa aggtctgatc aaggctgcca
      721 tgaccacggg ggcgtggatc ttcaccgggg gtgtgagcac tggtgtcgtc agccatgtgg
      781 gggatgcctt gaaagaccac tcctccaagt ccagaggccg gctctgtgct ataggaattg
      841 ctccctgggg catggtggag aacaaggaag acctgattgg aaaagatgta acaagagtct
      901 atcagaccat gtccaaccct ctgagcaagc tctctgtgct caacaattcc cacactcact
      961 tcatcttggc tgacaacggc accctgggca agtatggtgc tgaggtgaag cttcgaagac
     1021 agctggaaaa acacatctcc ctgcagaaga tcaacacaag gctgggccag ggtgtacctg
     1081 tcgtgggcct agtggtagaa ggtggtccta acgtggtttc tatcgtcctg gagtatctca
     1141 aagaagaccc tcctgtccct gtggtggttt gcgatggcag tggacgtgcc tctgacattt
     1201 tgtccttcgc acacaaatac tgcgacgaag gaggagtcat aaacgagtcc ctgcgggacc
     1261 agcttctagt taccattcag aaaacattta attacagcaa gtcccagtcg tatcagctgt
     1321 ttgcaattat catggagtgc atgaagaaga aagaactcgt cactgtgttt cggatgggtt
     1381 ccgagggtca gcaagatgtc gagatggcaa ttttaactgc cttgctcaaa ggaaccaacg
     1441 catcagctcc agatcagctg agcttggccc tggcttggaa ccgggtcgac atagcgcgaa
     1501 gccagatctt cgtctttggc ccacactggc cgccactggg aagcctggcc cctcctgtgg
     1561 acaccaaagc cacagagaag gaaaagaagc cacccacagc caccaccaag gggagaggaa
     1621 aaggaaaagg caagaagaaa ggcaaagtga aagaggaagt ggaggaagag acggaccccc
     1681 ggaagcttga gctgctcaac tgggtgaatg ccctggagca agccatgctg gatgctcttg
     1741 tcctagatcg ggtggacttt gtaaagctcc tgattgaaaa cggagtgaac atgcagcatt
     1801 tcctcaccat cccgaggctg gaggagctat acaacaccag actgggccca ccaaacaccc
     1861 ttcatctgct ggtgcgggat gtaaagaaga gcaaccttcc acctgattac cacatcagcc
     1921 tcattgatat aggactggtg ctggagtacc tcatgggcgg tgcctaccgc tgcaactaca
     1981 ctcggaaaag cttccggact ctctacaaca acttgtttgg ccctaagagg ccgaaagcac
     2041 ttaagcttct gggaatggaa gatgatgaac ccccagccaa aggcaagaag aaaaagaaga
     2101 agaagaaaga ggaagagatt gacatcgacg tggacgaccc cgccgtgagt aggttccagt
     2161 acccgttcca tgagctcatg gtatgggccg tgctcatgaa gcgccagaag atggcggtct
     2221 tcctgtggca gcgtggggaa gagtgcatgg cgaaggcctt ggtggcctgc aagctctaca
     2281 aggccatggc ccacgagtcc tccgagagcg agctggtgga tgacatctcc caggatctgg
     2341 acaacaattc caaagatttt ggccagctcg ctgtggagct gttagaccag tcttacaagc
     2401 acgatgagca ggttgccatg aaacttctga cctacgagct caagaactgg agcaactcaa
     2461 cctgcctgaa gctggctgtg gcagccaagc accgggactt cattgctcac acctgcagcc
     2521 agatgctgct gacagacatg tggatgggaa ggcttcgcat gaggaagaac cctggcctga
     2581 aggtcatcat ggggatcctt atcccaccca ccatcttgtt tttggaattc cgtacatatg
     2641 atgacttctc ctatcaaaca tccaaggaga acgaagatgg caaagaaaag gaagaagaga
     2701 atgtggatgc aaatgcagat gctggctcga gaaaggggga tgaggagaat gagcacaaaa
     2761 agcagaggag cattcccatt ggaacaaaga tctgtgaatt ctataatgcg cccattgtca
     2821 agttctggtt ttacacaatt tcctacttgg gctacttgct gctgttcaat tatgtcatcc
     2881 tggtgcggat ggatggatgg ccatcacccc aagaatggat tgtcatctcc tacattgtga
     2941 gccttgcatt ggagaaaata cgagagatcc tcatgtcgga accaggcaaa ctcagccaga
     3001 aaatcaaagt gtggctccag gagtactgga acatcacaga cctcgtggcc atctccatgt
     3061 tcatggttgg ggccatcctt cgtctccaga gccagccata catgggctat ggtcgggtca
     3121 tctactgtgt ggatatcatc ctctggtaca tccgagtgtt agacatcttt ggtgtcaaca
     3181 aatatcttgg tccctatgtg atgatgattg gaaagatgat gattgacatg ctctactttg
     3241 tggtcattat gctggttgta ctgatgagtt ttggagtggc tcggcaagcc atcttgcatc
     3301 cggaggagaa gccttcctgg aaactggccc gaaacatctt ctacatgcca tactggatga
     3361 tctacggaga ggtgtttgca gaccagatag acctctacgc catggaaatc aaccctcctt
     3421 gtggtgagaa tctctatgat gaggaaggca agaggctccc tccctgcatc cctggtgcct
     3481 ggctcacacc tgccctcatg gcctgttatc tcctggtggc caatatcctg ctggtcaacc
     3541 tactgattgc tgttttcaac aataccttct ttgaagtcaa gtcaatatcc aatcaagtgt
     3601 ggaagttcca gcgataccag ctgatcatga catttcatga caggccggtc ctgcccccac
     3661 caatgatcat cttaagtcac atctatatca tcattatgcg cctcagcggt cgctgcagaa
     3721 aaaagagaga gggggaccag gaggagcggg accgtgggtt gaagttgttc cttagcgacg
     3781 aagaactgaa aaaactgcat gagtttgagg agcagtgcgt gcaggagcac ttccgggaaa
     3841 aggaggatga gcagcagtcg tccagcgacg agcgcatccg ggtcacaagc gagagggttg
     3901 aaaatatgtc aatgagattg gaggaaatca acgaaagaga aaatttcatg aaaacttctc
     3961 tgcagactgt tgaccttcgg ctctctcagc tggaggagct atctggcagg atggtgagcg
     4021 ctctggagaa tctggcaggc atcgacaggt ctgatctgat ccaggctcga tctcgagcat
     4081 cctccgaatg cgaggccacc tacctgctgc ggcagagcag catcaacagt gccgacggct
     4141 acagcttgta ccgctaccat ttcaatggcg aggagcttct gtttgaggag cctgctctct
     4201 ccacttcgcc agggacagcg ttccggaaaa aaacctactc ctttcgtgtg aaggatgagg
     4261 atgcaaagtc gcacctggac cagcccagca acctgcacca cacccctggc cccagcccac
     4321 ctgccacgcc aggccgcagc cggctcgccc ttgaaggtcc cttgagcaca gagctgagac
     4381 ctggatcgga ccctggcatc tccgcaggcg agttcgatcc gcgggcggat ttcaagagca
     4441 cggaagctgc accaagtctg aacgcagcgg gtgttacagg cactcaactg actgtcgaaa
     4501 gcaccgattc ccaccctctg cgggagagca aactcgtgcg ctactacccc ggagacccta
     4561 acacctacaa aacaatgaag tccagaagct tcgtctatac tgaaggaaga aagctagtcc
     4621 gaggtcttag caactggagt gcagagtaca gttcaatcat ggaccaagca tggaacgcga
     4681 cagaatggag atgtcaagtt caaaggatca cgcgctcccg cagcacagac atcccataca
     4741 tcgtgtccga agcagcctcg caagacgagc ttgaagatga gcacagagga tctcttctgg
     4801 atcctcagat ctcccgttca gccctcaccg tctccgacag gccagaaaag gaaaacttac
     4861 tctctgtgaa gccacatcag actttaggat tcccctgcct acggtcaaga agtttacatg
     4921 gccgtcctag gagtgctgag cccgctccta gcaaattaga cagggcagga catgccagca
     4981 gcactagcaa cttagcagtt atgtcagttg ttccagaggg acaaaacacc cagcaagaga
     5041 aaagaagcgc ggaaactgag tgctgatggg ttttgcttct ttgattaaaa caaaaaccaa
     5101 gcactcaaca gccagaccat cgatggctgc catcttgacc atccaaaaca ttatcaagtt
     5161 taggaaatac attcattttg aacttagttt taaatttaaa ttgtaatgag ggtacagtaa
     5221 tgttctgtta agcacttttt agaaaactat gttgttttta gtagtagaag aagagaatga
     5281 aagccacact agagcaggct tgggctatag ctcagtaggt agaatgcctg ctcacagagt
     5341 acaaccaagt ccctggcttc aaacactagc agcacatgaa acgtgttgca gcatacacct
     5401 gtacagttgt aatcccagca ctcaggagaa tcagaaattt acagtcatcc ctggctacat
     5461 gggaggtttc aggctagcct gagccactta ataatgtcct aaacaaacaa acaaacaagt
     5521 taaatgtcag aagacactag gccagtgaag ctaattagtt catcactatc aagactgcct
     5581 gcgctctttg ctttgtgggc cacctactgt ctgacagagg ccttaaggta ctgacatcac
     5641 tactgagcca tttactaagt gacacagtga agttaaagag atagagtaga tgtaaaaaaa
     5701 aaaaaaaaaa a
//
