LOCUS       NM_012035               3550 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus transient receptor potential cation channel, subfamily
            C, member 7 (Trpc7), transcript variant 1, mRNA.
ACCESSION   NM_012035
VERSION     NM_012035.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3550)
  AUTHORS   Lin,Y., Gao,R., Jing,D., Liu,Y., Da,H., Birnbaumer,L., Yang,Y.,
            Gao,X., Gao,Z. and Cao,Q.
  TITLE     TRPC absence induces pro-inflammatory macrophage polarization to
            promote obesity and exacerbate colorectal cancer
  JOURNAL   Front Pharmacol 15, 1392328 (2024)
   PUBMED   38835669
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3550)
  AUTHORS   Li,G., Chen,L., Jiang,Z. and Yau,K.W.
  TITLE     Coexistence within one cell of microvillous and ciliary
            phototransductions across M1- through M6-IpRGCs
  JOURNAL   Proc Natl Acad Sci U S A 120 (52), e2315282120 (2023)
   PUBMED   38109525
REFERENCE   3  (bases 1 to 3550)
  AUTHORS   Lin,Y., Cui,X., Cao,Q., Bi,R., Liu,Y., Jing,D., Yue,C., Zhao,Q.,
            Wang,Y., Liu,S., Su,Y., Formoso,K., Susperreguy,S., Birnbaumer,L.,
            Freichel,M., Yang,Y., You,L. and Gao,X.
  TITLE     TRPC absence induces pro-inflammatory macrophages and gut microbe
            disorder, sensitizing mice to colitis
  JOURNAL   Int Immunopharmacol 115, 109655 (2023)
   PUBMED   36592529
REFERENCE   4  (bases 1 to 3550)
  AUTHORS   Kollewe,A., Schwarz,Y., Oleinikov,K., Raza,A., Haupt,A.,
            Wartenberg,P., Wyatt,A., Boehm,U., Ectors,F., Bildl,W., Zolles,G.,
            Schulte,U., Bruns,D., Flockerzi,V. and Fakler,B.
  TITLE     Subunit composition, molecular environment, and activation of
            native TRPC channels encoded by their interactomes
  JOURNAL   Neuron 110 (24), 4162-4175 (2022)
   PUBMED   36257322
REFERENCE   5  (bases 1 to 3550)
  AUTHORS   Phelan,K.D., Shwe,U.T., Abramowitz,J., Birnbaumer,L. and Zheng,F.
  TITLE     Critical role of canonical transient receptor potential channel 7
            in initiation of seizures
  JOURNAL   Proc Natl Acad Sci U S A 111 (31), 11533-11538 (2014)
   PUBMED   25049394
  REMARK    GeneRIF: TRPC7 is intimately involved in the initiation of seizures
            both in vitro and in vivo.
REFERENCE   6  (bases 1 to 3550)
  AUTHORS   Boisseau,S., Kunert-Keil,C., Lucke,S. and Bouron,A.
  TITLE     Heterogeneous distribution of TRPC proteins in the embryonic cortex
  JOURNAL   Histochem Cell Biol 131 (3), 355-363 (2009)
   PUBMED   18989690
REFERENCE   7  (bases 1 to 3550)
  AUTHORS   Elg,S., Marmigere,F., Mattsson,J.P. and Ernfors,P.
  TITLE     Cellular subtype distribution and developmental regulation of TRPC
            channel members in the mouse dorsal root ganglion
  JOURNAL   J Comp Neurol 503 (1), 35-46 (2007)
   PUBMED   17480026
REFERENCE   8  (bases 1 to 3550)
  AUTHORS   Ramsey,I.S., Delling,M. and Clapham,D.E.
  TITLE     An introduction to TRP channels
  JOURNAL   Annu Rev Physiol 68, 619-647 (2006)
   PUBMED   16460286
  REMARK    Review article
REFERENCE   9  (bases 1 to 3550)
  AUTHORS   Freichel,M., Vennekens,R., Olausson,J., Hoffmann,M., Muller,C.,
            Stolz,S., Scheunemann,J., Weissgerber,P. and Flockerzi,V.
  TITLE     Functional role of TRPC proteins in vivo: lessons from
            TRPC-deficient mouse models
  JOURNAL   Biochem Biophys Res Commun 322 (4), 1352-1358 (2004)
   PUBMED   15336983
  REMARK    Review article
REFERENCE   10 (bases 1 to 3550)
  AUTHORS   Okada,T., Inoue,R., Yamazaki,K., Maeda,A., Kurosaki,T.,
            Yamakuni,T., Tanaka,I., Shimizu,S., Ikenaka,K., Imoto,K. and
            Mori,Y.
  TITLE     Molecular and functional characterization of a novel mouse
            transient receptor potential protein homologue TRP7.
            Ca(2+)-permeable cation channel that is constitutively activated
            and enhanced by stimulation of G protein-coupled receptor
  JOURNAL   J Biol Chem 274 (39), 27359-27370 (1999)
   PUBMED   10488066
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK137418.1, AK135153.1,
            AC132322.3 and AC132886.18.
            
            On Oct 16, 2014 this sequence version replaced NM_012035.2.
            
            Summary: The protein encoded by this gene is a member of the
            transient receptor potential channel family of proteins, which form
            six-transmembrane cation-permeable channels that are calcium
            permeant. Knock out mice are viable but display a reduction in the
            gamma wave activity that precedes seizure induction in response to
            a muscrarinic agonist, suggesting a functional role for this
            protein in initiation of seizures. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Oct 2014].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF139923.1, BC117995.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849377,
                                           SAMN00849378 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AK137418.1         1-13
            14-1912             AK135153.1         2-1900
            1913-1913           AC132322.3         60045-60045         c
            1914-2557           AK135153.1         1902-2545
            2558-2560           AC132886.18        170950-170952       c
            2561-3535           AK135153.1         2546-3520
            3536-3550           AC132886.18        161459-161473       c
FEATURES             Location/Qualifiers
     source          1..3550
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 30.27 cM"
     gene            1..3550
                     /gene="Trpc7"
                     /gene_synonym="TRP7; Trrp8"
                     /note="transient receptor potential cation channel,
                     subfamily C, member 7"
                     /db_xref="GeneID:26946"
                     /db_xref="MGI:MGI:1349470"
     exon            1..297
                     /gene="Trpc7"
                     /gene_synonym="TRP7; Trrp8"
                     /inference="alignment:Splign:2.1.0"
     CDS             296..2884
                     /gene="Trpc7"
                     /gene_synonym="TRP7; Trrp8"
                     /EC_number="3.6.1.13"
                     /note="isoform 1 is encoded by transcript variant 1; short
                     transient receptor potential channel 7; transient receptor
                     protein 7; transient receptor potential protein homologue
                     TRP7; transient receptor protein 8"
                     /codon_start=1
                     /product="short transient receptor potential channel 7
                     isoform 1"
                     /protein_id="NP_036165.1"
                     /db_xref="CCDS:CCDS26566.1"
                     /db_xref="GeneID:26946"
                     /db_xref="MGI:MGI:1349470"
                     /translation="MLGSNTFKNMQRRHTTLREKGRRQAIRGPAYMFNEKGTSLTPEE
                     ERFLDSAEYGNIPVVRKMLEESKTLNFNCVDYMGQNALQLAVGNEHLEVTELLLKKEN
                     LARVGDALLLAISKGYVRIVEAILSHPAFAQGQRLTLSPLEQELRDDDFYAYDEDGTR
                     FSHDITPIILAAHCQEYEIVHILLLKGARIERPHDYFCKCNECTEKQRKDSFSHSRSR
                     MNAYKGLASAAYLSLSSEDPVLTALELSNELARLANIETEFKNDYRKLSMQCKDFVVG
                     VLDLCRDTEEVEAILNGDVNLQVWSDHHRPSLSRIKLAIKYEVKKFVAHPNCQQQLLT
                     MWYENLSGLRQQSIAVKFLAVFGVSIGLPFLAIAYWIAPCSKLGQTLRSPFMKFVAHA
                     VSFTIFLGLLVVNASDRFEGVKTLPNETFTDYPKQIFRVKTTQFSWTEMLIMKWVLGM
                     IWSECKEIWEEGPREYVLHLWNLLDFGMLSIFVASFTARFMAFLKASEAQLYVDQYVQ
                     DVTLHNVSLPPEVAYFTYARDKWWPSDPQIISEGLYAIAVVLSFSRIAYILPANESFG
                     PLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYRGAKYNPAFTTVEESFKTLF
                     WSIFGLSEVISVVLKYDHKFIENIGYVLYGVYNVTMVVVLLNMLIAMINNSYQEIEED
                     ADVEWKFARAKLWLSYFDEGRTLPAPFNLVPSPKSFYYLIMRIKMCLIELCQSKAKRC
                     ENDLEMGMLNSKFRKTRYQAGMRNSENLTANSTFSKPTRYQKIMKRLIKRYVLKAQVD
                     RENDEVNEGELKEIKQDISSLRYELLEEKSQATGELADLIQQLSEKFGKNLNKDHLRV
                     NQGKDI"
     exon            298..1075
                     /gene="Trpc7"
                     /gene_synonym="TRP7; Trrp8"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1258
                     /gene="Trpc7"
                     /gene_synonym="TRP7; Trrp8"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1423
                     /gene="Trpc7"
                     /gene_synonym="TRP7; Trrp8"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1640
                     /gene="Trpc7"
                     /gene_synonym="TRP7; Trrp8"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1874
                     /gene="Trpc7"
                     /gene_synonym="TRP7; Trrp8"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..2139
                     /gene="Trpc7"
                     /gene_synonym="TRP7; Trrp8"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2335
                     /gene="Trpc7"
                     /gene_synonym="TRP7; Trrp8"
                     /inference="alignment:Splign:2.1.0"
     exon            2336..2557
                     /gene="Trpc7"
                     /gene_synonym="TRP7; Trrp8"
                     /inference="alignment:Splign:2.1.0"
     exon            2558..2638
                     /gene="Trpc7"
                     /gene_synonym="TRP7; Trrp8"
                     /inference="alignment:Splign:2.1.0"
     exon            2639..2714
                     /gene="Trpc7"
                     /gene_synonym="TRP7; Trrp8"
                     /inference="alignment:Splign:2.1.0"
     exon            2715..3550
                     /gene="Trpc7"
                     /gene_synonym="TRP7; Trrp8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3522..3527
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trpc7"
                     /gene_synonym="TRP7; Trrp8"
                     /note="hexamer: AATAAA"
     polyA_site      3548
                     /gene="Trpc7"
                     /gene_synonym="TRP7; Trrp8"
                     /note="major polyA site"
ORIGIN      
        1 gccagtctca cacacggatg cttctccttc acattctctg ggaaatttcc cccagattag
       61 gaaaaggaca ggaaggcaag tcggccacaa aaggcgagtt ttcaccattc cccacaaagg
      121 aaagcagagc gcacctccac acaatcgcaa ctccgctctc tggagcagat ctcgacttca
      181 gcaccacgga gagcggcacc tccgcctcgg ccacccatgg ggagccagat cccggagact
      241 ccgttcagga ttcgggtcat ctagaggagg gacaagcctg cgtattctac tctcgatgtt
      301 ggggagcaac accttcaaaa acatgcagcg ccggcacacc accttgaggg agaaggggcg
      361 ccgccaggcc atccggggtc ctgcctacat gttcaacgag aagggcacga gcctgacccc
      421 tgaggaggag cgcttcctgg actcggctga gtatggcaac ataccagtgg tcagaaaaat
      481 gctggaggaa tccaagaccc tcaatttcaa ctgcgtggac tacatggggc agaacgcgct
      541 gcagctggcc gtgggcaacg agcacttgga ggtcactgaa ctgttgctga agaaagagaa
      601 cttggcgcgg gtgggcgacg cgctgctgct ggccatcagc aagggctatg tgcgcattgt
      661 ggaggccatc ctcagccatc cggccttcgc gcagggccag cgcctgacgc tcagcccgct
      721 ggagcaggag ctgcgggatg atgacttcta tgcctacgac gaggatggca cgcgcttctc
      781 ccacgacatc acacccatca tcctggcggc ccactgccag gagtatgaga ttgtgcatat
      841 cttgctgctc aagggtgcgc gcattgagcg gccccatgac tacttctgca agtgcaatga
      901 gtgcacggag aagcagcgca aggactcctt cagtcactcg cgctcccgga tgaatgccta
      961 caaaggactg gccagtgccg cctacctgtc cctatccagt gaagaccctg tcctcactgc
     1021 gctggagcta agcaacgagt tagcccgact ggccaacatt gagactgaat ttaagaatga
     1081 ttacaggaag ttatctatgc aatgcaagga ttttgtggtg ggcgtgctgg acctgtgccg
     1141 agacacagaa gaggtggaag caattttaaa tggcgatgtg aacttgcaag tctggtccga
     1201 ccaccaccgt ccaagtctga gccgaatcaa actcgccatt aagtacgaag tcaagaagtt
     1261 cgttgctcac cctaactgtc agcagcaatt gcttaccatg tggtatgaaa atctctcagg
     1321 cttacggcaa cagtctatcg ctgtgaaatt cctggctgtc tttggagtct ccataggcct
     1381 cccttttctc gccatagcct attggattgc tccgtgcagc aagctaggac aaaccctgag
     1441 gagccctttc atgaagtttg tggcccatgc agtgtctttt accatcttct tgggactgct
     1501 agttgtgaac gcctccgacc ggtttgaggg cgttaagact ctgcccaatg agaccttcac
     1561 agactacccc aaacagatct tcagagtgaa aaccacacag ttctcctgga cggagatgct
     1621 catcatgaag tgggtcttag gaatgatctg gtccgaatgc aaggagatct gggaggaggg
     1681 gccgcgggag tacgtgctac acttgtggaa ccttctggat tttggcatgc tgtccatctt
     1741 cgtggcctcc ttcactgcga ggttcatggc tttcctcaag gccagcgagg cccagctgta
     1801 cgtggaccag tacgtgcagg atgtaacgct gcacaacgtc tcacttccac cggaagtggc
     1861 ctacttcacc tacgccaggg ataagtggtg gccttcagac ccccagatca tctcggaagg
     1921 gctgtacgcc attgcggttg tcctcagctt ctcccggatc gcctacatcc tgccagccaa
     1981 tgagagcttc ggacctttgc agatctccct gggaagaact gtgaaagaca tcttcaagtt
     2041 catggtcatt tttatcatgg tatttgtggc ctttatgatc ggaatgttca acctgtactc
     2101 ctactaccga ggtgcaaagt acaacccagc gtttaccaca gttgaagaaa gctttaaaac
     2161 cttgttttgg tccatatttg gcttgtctga ggtcatctcg gtggtgctga aatacgacca
     2221 caagttcatc gagaatattg gctacgtgct gtatggggtt tataatgtca ccatggtggt
     2281 tgtactactc aacatgctga tagccatgat caacaactcc tatcaggaaa tcgaggaaga
     2341 cgcggacgtg gagtggaaat ttgctcgagc gaagctctgg ctttcttact ttgatgaagg
     2401 aagaactctc cctgctccct ttaacctggt gccgagccct aaatcctttt attatctcat
     2461 aatgagaatc aagatgtgcc tcatagagct ctgccaatct aaggccaaac gctgtgaaaa
     2521 cgacctggaa atgggcatgc tgaactccaa gttcaggaag actcgctacc aggctggcat
     2581 gaggaattct gaaaacctga cagccaatag caccttcagc aagcccacca gataccagaa
     2641 gatcatgaag cggctcataa agagatacgt gctgaaggcc caggtggaca gagagaacga
     2701 tgaagtcaat gaaggtgaac tcaaggagat caaacaagac atctcaagcc ttcgctatga
     2761 gctcctggag gagaagtctc aggctacagg agagctggca gacctgatcc agcagctcag
     2821 cgagaagttt gggaagaatc tgaacaaaga ccacctgcgg gtgaaccagg gcaaggacat
     2881 ttagggcctg actgcccgct tggcaggtgt gactgacgtc taacagcatt ccaaagccgg
     2941 gccaggtgtc ccagtctcag cccctctgag gaggaggaac cactggctct gtcctgggca
     3001 catgactgat atctatagcc caggaaccgc ctggatccag gattgtgaaa ctaagcccgt
     3061 gggagggaca agctacccca aggagggaaa aagtgccatc agatacacga gaccctcctg
     3121 tccagcctcc gtggccaaag caggaaacgg ccatcttgga tgcacatgtg tgtccgccca
     3181 cttgactcag gacgacagct gtgtcctggg aagtcagctc tctgcccctg agtcccttct
     3241 tattcctccc cgacacacac acacacacac acacacacac acacacacaa ccagaaccgg
     3301 gaggtgacct gtgacctact cttaagtgcc agatgagaac ccagatagcc taatagttaa
     3361 atagttctat ttgtttatat aaaaaaaaaa gtttaaaaaa cactaaatca aaaattgtac
     3421 tgtagagaaa agttgtcatt gtttagagaa caacaaaatc caaataatgt atttttacct
     3481 ttattatctt gtatttacta tttttaccta aaatgagaag aaataaaatt acctcataag
     3541 agcctggggg
//
