LOCUS       NM_009428               8502 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus transient receptor potential cation channel, subfamily
            C, member 5 (Trpc5), mRNA.
ACCESSION   NM_009428
VERSION     NM_009428.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8502)
  AUTHORS   Broker-Lai,J., Rego Terol,J., Richter,C., Mathar,I., Wirth,A.,
            Kopf,S., Moreno-Perez,A., Buttner,M., Tan,L.L., Makke,M.,
            Poschet,G., Hermann,J., Tsvilovskyy,V., Haberkorn,U.,
            Wartenberg,P., Susperreguy,S., Berlin,M., Ottenheijm,R.,
            Philippaert,K., Wu,M., Wiedemann,T., Herzig,S., Belkacemi,A.,
            Levinson,R.T., Agarwal,N., Camacho Londono,J.E., Klebl,B.,
            Dinkel,K., Zufall,F., Nussbaumer,P., Boehm,U., Hell,R., Nawroth,P.,
            Birnbaumer,L., Leinders-Zufall,T., Kuner,R., Zorn,M., Bruns,D.,
            Schwarz,Y. and Freichel,M.
  TITLE     TRPC5 controls the adrenaline-mediated counter regulation of
            hypoglycemia
  JOURNAL   EMBO J 43 (23), 5813-5836 (2024)
   PUBMED   39375537
REFERENCE   2  (bases 1 to 8502)
  AUTHORS   Ptakova,A. and Vlachova,V.
  TITLE     Thermosensing ability of TRPC5: current knowledge and unsettled
            questions
  JOURNAL   J Physiol Sci 74 (1), 50 (2024)
   PUBMED   39363236
  REMARK    GeneRIF: Thermosensing ability of TRPC5: current knowledge and
            unsettled questions.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8502)
  AUTHORS   Li,Y., Cacciottolo,T.M., Yin,N., He,Y., Liu,H., Liu,H., Yang,Y.,
            Henning,E., Keogh,J.M., Lawler,K., Mendes de Oliveira,E.,
            Gardner,E.J., Kentistou,K.A., Laouris,P., Bounds,R., Ong,K.K.,
            Perry,J.R.B., Barroso,I., Tu,L., Bean,J.C., Yu,M., Conde,K.M.,
            Wang,M., Ginnard,O., Fang,X., Tong,L., Han,J., Darwich,T.,
            Williams,K.W., Yang,Y., Wang,C., Joss,S., Firth,H.V., Xu,Y. and
            Farooqi,I.S.
  TITLE     Loss of transient receptor potential channel 5 causes obesity and
            postpartum depression
  JOURNAL   Cell 187 (16), 4176-4192 (2024)
   PUBMED   38959890
  REMARK    GeneRIF: Loss of transient receptor potential channel 5 causes
            obesity and postpartum depression.
REFERENCE   4  (bases 1 to 8502)
  AUTHORS   Lin,Y., Gao,R., Jing,D., Liu,Y., Da,H., Birnbaumer,L., Yang,Y.,
            Gao,X., Gao,Z. and Cao,Q.
  TITLE     TRPC absence induces pro-inflammatory macrophage polarization to
            promote obesity and exacerbate colorectal cancer
  JOURNAL   Front Pharmacol 15, 1392328 (2024)
   PUBMED   38835669
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8502)
  AUTHORS   Thakore,P., Clark,J.E., Aubdool,A.A., Thapa,D., Starr,A.,
            Fraser,P.A., Farrell-Dillon,K., Fernandes,E.S., McFadzean,I. and
            Brain,S.D.
  TITLE     Transient Receptor Potential Canonical 5 (TRPC5): Regulation of
            Heart Rate and Protection against Pathological Cardiac Hypertrophy
  JOURNAL   Biomolecules 14 (4), 442 (2024)
   PUBMED   38672459
  REMARK    GeneRIF: Transient Receptor Potential Canonical 5 (TRPC5):
            Regulation of Heart Rate and Protection against Pathological
            Cardiac Hypertrophy.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8502)
  AUTHORS   Sossey-Alaoui,K., Lyon,J.A., Jones,L., Abidi,F.E., Hartung,A.J.,
            Hane,B., Schwartz,C.E., Stevenson,R.E. and Srivastava,A.K.
  TITLE     Molecular cloning and characterization of TRPC5 (HTRP5), the human
            homologue of a mouse brain receptor-activated capacitative Ca2+
            entry channel
  JOURNAL   Genomics 60 (3), 330-340 (1999)
   PUBMED   10493832
REFERENCE   7  (bases 1 to 8502)
  AUTHORS   Philipp,S., Hambrecht,J., Braslavski,L., Schroth,G., Freichel,M.,
            Murakami,M., Cavalie,A. and Flockerzi,V.
  TITLE     A novel capacitative calcium entry channel expressed in excitable
            cells
  JOURNAL   EMBO J 17 (15), 4274-4282 (1998)
   PUBMED   9687496
REFERENCE   8  (bases 1 to 8502)
  AUTHORS   Yamazaki,K., Okada,T., Mori,Y. and Tanaka,I.
  TITLE     Genetic mapping of mouse transient receptor potential (Trrp) genes
            responsible for capacitative calcium entry channels to chromosomes
            3, 7, 9, and X
  JOURNAL   Genomics 51 (2), 303-305 (1998)
   PUBMED   9722956
REFERENCE   9  (bases 1 to 8502)
  AUTHORS   Okada,T., Shimizu,S., Wakamori,M., Maeda,A., Kurosaki,T.,
            Takada,N., Imoto,K. and Mori,Y.
  TITLE     Molecular cloning and functional characterization of a novel
            receptor-activated TRP Ca2+ channel from mouse brain
  JOURNAL   J Biol Chem 273 (17), 10279-10287 (1998)
   PUBMED   9553080
REFERENCE   10 (bases 1 to 8502)
  AUTHORS   Zhu,X., Jiang,M., Peyton,M., Boulay,G., Hurst,R., Stefani,E. and
            Birnbaumer,L.
  TITLE     trp, a novel mammalian gene family essential for agonist-activated
            capacitative Ca2+ entry
  JOURNAL   Cell 85 (5), 661-671 (1996)
   PUBMED   8646775
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731701.8, AK038531.1, AK047867.1 and AL713978.9.
            
            On Aug 25, 2015 this sequence version replaced NM_009428.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF060107.1, BC112972.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               AL731701.8         90408-90584         c
            178-2103            AK038531.1         2-1927
            2104-3416           AK047867.1         1125-2437
            3417-8502           AL713978.9         155814-160899       c
FEATURES             Location/Qualifiers
     source          1..8502
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 65.49 cM"
     gene            1..8502
                     /gene="Trpc5"
                     /gene_synonym="CCE2; TRP-5; TRP5; Trrp5"
                     /note="transient receptor potential cation channel,
                     subfamily C, member 5"
                     /db_xref="GeneID:22067"
                     /db_xref="MGI:MGI:109524"
     exon            1..382
                     /gene="Trpc5"
                     /gene_synonym="CCE2; TRP-5; TRP5; Trrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            383..781
                     /gene="Trpc5"
                     /gene_synonym="CCE2; TRP-5; TRP5; Trrp5"
                     /inference="alignment:Splign:2.1.0"
     CDS             404..3331
                     /gene="Trpc5"
                     /gene_synonym="CCE2; TRP-5; TRP5; Trrp5"
                     /note="vtransient receptor potential cation channel,
                     subfamily C, member 5; trp-related protein 5; capacitative
                     calcium entry channel 2; transient receptor protein 5"
                     /codon_start=1
                     /product="short transient receptor potential channel 5"
                     /protein_id="NP_033454.1"
                     /db_xref="CCDS:CCDS30457.1"
                     /db_xref="GeneID:22067"
                     /db_xref="MGI:MGI:109524"
                     /translation="MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLSAVEKGD
                     YATVKQALQEAEIYYNVNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLY
                     AIRKEVVGAVELLLSYRKPSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKL
                     LVQKRVTIPRPHQIRCNCVECVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPIL
                     TAFRLGWELKELSKVENEFKAEYEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHS
                     EELDPQKYHDLAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTC
                     MTIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICHTASYLTFLFMLLLASQHIVRTD
                     LHVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATI
                     SLKIVAYVKYNGSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQI
                     SLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFS
                     TLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMM
                     NNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNNTFC
                     PKRDPDGRRRRHNLRSFTERHADSLIQNQHYQEVIRNLVKRYVAAMIRNSKTNEGLTE
                     ENFKELKQDISSFRYEVLDLLGNRKHPRRSLSTSSADFSQRDDTNDGSGGARAKSKSV
                     SFNVGCKKKACHGAPLIRTVPRASGAQGKPKSESSSKRSFMGPSFKKLGLFFSKFNGQ
                     TSEPTSEPMYTISDGIAQQHCMWQDIRYSQMEKGKAEACSQSQMNLGEVELGEIRGAA
                     ARSSECPLACSSSLHCASGICSSNSKLLDSSEDVFETWGEACDLLMHKWGDGQEEQVT
                     TRL"
     exon            782..1303
                     /gene="Trpc5"
                     /gene_synonym="CCE2; TRP-5; TRP5; Trrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1640
                     /gene="Trpc5"
                     /gene_synonym="CCE2; TRP-5; TRP5; Trrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1780
                     /gene="Trpc5"
                     /gene_synonym="CCE2; TRP-5; TRP5; Trrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..2103
                     /gene="Trpc5"
                     /gene_synonym="CCE2; TRP-5; TRP5; Trrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..2299
                     /gene="Trpc5"
                     /gene_synonym="CCE2; TRP-5; TRP5; Trrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2503
                     /gene="Trpc5"
                     /gene_synonym="CCE2; TRP-5; TRP5; Trrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..2545
                     /gene="Trpc5"
                     /gene_synonym="CCE2; TRP-5; TRP5; Trrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2635
                     /gene="Trpc5"
                     /gene_synonym="CCE2; TRP-5; TRP5; Trrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..8502
                     /gene="Trpc5"
                     /gene_synonym="CCE2; TRP-5; TRP5; Trrp5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4283..4288
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trpc5"
                     /gene_synonym="CCE2; TRP-5; TRP5; Trrp5"
                     /note="hexamer: TATAAA"
     polyA_site      4306
                     /gene="Trpc5"
                     /gene_synonym="CCE2; TRP-5; TRP5; Trrp5"
                     /note="major polyA site"
     regulatory      8101..8106
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trpc5"
                     /gene_synonym="CCE2; TRP-5; TRP5; Trrp5"
                     /note="hexamer: AATAAA"
     polyA_site      8125
                     /gene="Trpc5"
                     /gene_synonym="CCE2; TRP-5; TRP5; Trrp5"
     regulatory      8195..8200
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trpc5"
                     /gene_synonym="CCE2; TRP-5; TRP5; Trrp5"
                     /note="hexamer: AATAAA"
     polyA_site      8215
                     /gene="Trpc5"
                     /gene_synonym="CCE2; TRP-5; TRP5; Trrp5"
                     /note="major polyA site"
ORIGIN      
        1 cgctgagggg ggacaagtga gagagaagag agagagaacc gggcaggagc acaccgggca
       61 gtcgggcgaa gagaagagtt tcgggcactg gcagaggcaa aaggtgagga gatctggcca
      121 gtcagaggga agtttggcag taactgaaga gcaaagaagg aagcccaggt aggagtcagt
      181 ccttgggctc ctctcagcat cctgattcct tcgccagtac tcaaccacca cccactcggc
      241 agcctccagg cccgggactg tcccaggtgg ctgccgcttg cgcggcgcgg aagaggagtc
      301 cagtaaggtt gccgcaccac gcgccggggt gctcggactc cagacaacac aaatctgaaa
      361 aaaaaaacac acttggcctg ggttttctaa attgttatga accatggccc agctgtacta
      421 caagaaggtc aattactcac catacagaga tcgcatcccc ctccaaatcg tgagggctga
      481 gactgagctg tctgctgagg agaaagcctt ccttagtgct gtggagaagg gggactatgc
      541 cacagtgaag caggcactgc aggaggccga gatctactac aatgtcaaca tcaactgcat
      601 ggatcctttg ggcaggagcg ccctgctcat tgccattgag aatgagaact tggagatcat
      661 ggagctactg ctgaaccaca gtgtgtatgt gggcgatgca ttactctacg ccatccgcaa
      721 ggaggtggta ggagctgtgg aacttctgct tagctacagg aagcccagtg gagagaagca
      781 ggttcccacg ctgatgatgg acacccagtt ctctgagttc acaccagaca tcactcccat
      841 tatgttggca gcccacacca acaactatga aatcatcaaa ttgcttgtcc aaaagagggt
      901 cactatccca aggccccacc agatccgctg caactgtgtg gagtgtgtat ccagttcgga
      961 ggtagatagt ctacgtcatt ctaggtcccg actgaatata tacaaggctc tggcaagccc
     1021 ctcgctcatt gccttatcaa gcgaggaccc catcctcacg gcctttcggc tgggctggga
     1081 actcaaggag ctgagcaaag tggaaaatga gttcaaggct gagtacgagg aactttccca
     1141 gcaatgtaag ctctttgcca aggatctctt ggaccaagct cggagctcca gagaactgga
     1201 gatcatcctc aaccatcgag atgaccacag tgaagaactt gacccacaga agtatcatga
     1261 cctggccaag ctgaaggtgg caatcaaata tcaccagaaa gagtttgtcg ctcagccaaa
     1321 ctgccaacaa ttgctagcca ccttgtggta cgatggcttc cctggatggc ggagaaaaca
     1381 ctgggtagtc aagcttctga cctgcatgac cattggattc ctgtttccta tgctgtccat
     1441 agcctatctg atctcaccca gaagcaacct tgggcttttc atcaagaaac cctttattaa
     1501 gttcatctgc cacacagcat cctatctgac cttcctcttc atgcttctcc tggcttctca
     1561 acatatcgtc agaacagacc tccatgttca aggacctccc ccaactgttg tggaatggat
     1621 gatactgcct tgggttctag gtttcatttg gggggagata aaggaaatgt gggatggtgg
     1681 attcacggaa tacatccatg attggtggaa cctgatggat tttgcaatga actccctcta
     1741 cctggcaact atttccttga agatcgtggc ctatgtcaag tataatggtt ctcgtccaag
     1801 ggaagaatgg gaaatgtggc acccgactct gattgcagaa gcactcttcg caatatccaa
     1861 cattttaagt tccttgcgtc tcatatcctt gttcacagcc aactcccatt tagggcctct
     1921 gcagatctct ttgggacgaa tgctgcttga tatactcaaa tttctcttta tctactgcct
     1981 agtactactg gcttttgcca acggactgaa ccagctttac ttttactatg agaccagagc
     2041 tattgatgaa cctaacaact gcaaggggat ccgatgtgaa aaacagaaca acgccttctc
     2101 cacgctcttt gaaacccttc agtcgctctt ctggtctgtc tttggcctcc taaatctcta
     2161 tgttaccaat gtgaaggccc gacatgagtt cactgagttt gtgggagcta cgatgtttgg
     2221 gacatacaac gtcatctccc tggtagtgct gctgaatatg ctcatcgcca tgatgaacaa
     2281 ctcctaccag ctcattgccg atcatgctga tattgagtgg aagtttgcga gaacaaagct
     2341 ctggatgagt tactttgatg aaggtggcac cttaccacct cctttcaaca ttattcccag
     2401 ccccaaatca tttctctatc ttggcaactg gttcaacaac accttctgtc ccaaaagaga
     2461 ccctgatgga agacgaagga ggcacaactt gagaagcttc acagaacgtc atgctgacag
     2521 cctgatacaa aatcaacatt atcaggaagt tatcagaaat ttagtcaaga gatatgtggc
     2581 tgcaatgata agaaactcca aaacaaatga ggggctaaca gaagaaaatt ttaaggaatt
     2641 aaagcaggac atttccagct ttcgatatga agtgcttgac ctcttgggaa acaggaaaca
     2701 tccaagaaga agcctctcca ccagcagtgc tgatttctct caaagggatg ataccaatga
     2761 cggcagtggt ggggctcggg ccaagtctaa gagtgtctct ttcaatgtag gctgcaagaa
     2821 aaaggcctgt cacggtgcac cgctcatcag aaccgtgcca agagctagtg gcgcccaagg
     2881 aaagccaaaa tccgagtcgt cgagcaaacg gtccttcatg ggtccgtctt tcaagaaatt
     2941 gggtctcttc ttctccaagt tcaatggtca aacatctgaa cctacttcgg agccaatgta
     3001 cacaatctct gatggcatcg cacagcagca ttgtatgtgg caggacatcc gctattctca
     3061 gatggagaaa gggaaggcag aggcctgttc tcaaagtcag atgaaccttg gcgaggtaga
     3121 gctaggtgaa atccgggggg ctgctgctcg gagcagtgag tgccccctag cctgttccag
     3181 ctcccttcac tgtgcatccg gcatctgctc ctcaaattcg aaacttttgg actcgtcaga
     3241 ggacgtattt gaaacttggg gagaggcttg tgacttgctc atgcacaaat ggggtgatgg
     3301 acaggaagaa caagttacaa ctcggctcta agtcaaatcc ccgtcatcta ttctggaatt
     3361 caagagaata tttgtaattt ccctgttctc agaggtgacc ccaaatttgg ttccctccct
     3421 gtccccaaca cacacacaca cacacacaca cacacacaca cacacacaca cacacaccaa
     3481 ggagtgaaac tcctattact ttcagtcttt tctagccaca ttcttcatgt tttgtttcac
     3541 tgtcattatc atttgccttt ttatatctat aaatactaaa tccatctcaa aagcaactga
     3601 aggggtcctg cccctaatga gcagaggtgc ggtcgggtgc tttaacccct ttgctttgct
     3661 ttgttcaccc ttgcctcctt gaagctccag gtgccacttt gctaccatag ctgccgcata
     3721 gattcctgac atgcctcagg atctcacacc catctcccca cagagctgag ggctacggtc
     3781 agcagtccct accagctatc agataaggct aatcaacctg cctgtcttcg ttgctcttca
     3841 gtgctacacg ctgcccatgc tggtccgatg aacagcatta aagggagact ccaaagaatt
     3901 gtcagcttgt ggtttctagg tagaactggc ctttccgttc cgtttttaaa cactacaagt
     3961 actaattgtg gggactgtag aggttttgtt tcgtaaatgt gtgttagttt cttaacgtgt
     4021 agcaatgaga tatttactgt acagtgcgta ccacataata agttagctaa tttcctgtgt
     4081 ttgtatattt cggttaactt accatacctt aaaatttgag agtatcaaaa ctagtattta
     4141 ggatgtgtac ttttttcaaa aaaaaaaaac ttttactgta ctttaactaa tagttactac
     4201 atctcataca ttggcaagaa aaataattag ttggtatatt tatagggtcc tatctactgt
     4261 ggatagtttt aatcatcatt gatataaaag catttctaag attaaagtct ggatttgaaa
     4321 tatttttatc agaaaaatga caatttattg aggtgttaaa atttgggggg aaaatgcacc
     4381 tcaatttaat taattgcttt ctggaaagaa aacccaacag atacaaatgt aggttcagat
     4441 aactgaattc agattgcagc tgcagtatct actgggggac agtggaaagc acatgtatga
     4501 gctcttggat atagaacata ataatcctag tggatttgta gaactatact tgtggtctaa
     4561 gttctgcctt ccaagaaagc tgcagttata cattccaatt ctttcccata ggcaaggagt
     4621 acttaatccg aatataagtt aaaaatgaag ctagtttgcg gatggtaatc accttagaac
     4681 tgagacccac caaacagctg agcaaacatg ggtttaccaa catatgctcg gcttgtagag
     4741 attaacaatg tctatggcag aaacgttaaa gaaggctgtt gagtaccact tggtcttttt
     4801 aaaggtcacc accaccaagg actccttcac atttttgtga tgtctgctag aggtgaaggg
     4861 ggaaactgtg aaacaatgta aatgtgtctg caagcttgct tttgacagag tagtttaagt
     4921 caaactgact ttccatctct atccctagca ttggtgaatg agggggaaaa tgtttcatgt
     4981 ggagatgagc caaattaggg gcaagggagg caggaagtgc tgctggatac aactcagata
     5041 cccagaaaaa ggaactagga gagtaagatc catcagcatc catttggctg gcaagggttt
     5101 gttccaaaat aatctatctt atctgaagtg ctcatttatt caaatccaac tgctgcccta
     5161 ctttttctaa gagcgcctat cacaaatagc tctgacacaa agacagctta ctttctaaaa
     5221 ggaagagatc taaagtcaca atttcaactt tcccaacagt aaattctatt cttaataata
     5281 aatggggctg gagagatggc tcagcagtta agagcactga gtgctctttc aaaggtcctg
     5341 agttcaaatc ccagcaacca caaggtggct cacaaccatc cataatgaga tctgacatcc
     5401 tcttctgatg tgtctgaaga cagctacagt gtacttatat ataaaatcaa taaattaatc
     5461 tttaaaaaaa tgacccttca gcccagtgat ggtggggcac acttttaatc ccagtactca
     5521 ggaggaggcc agcctggtct atagaatgat ttccaggaca gccagggcta cactgtgtat
     5581 aaataagcaa acaaacgaac aagtaaataa ataaaccttg agaaatactg tatagaaaat
     5641 atacaaacct aaactataat ccgaactcat actgccaaca aagccaacat aaaacatata
     5701 gtcaaaacat ttttctcacc aatacaccaa ctactgatga tctaggcata actgttctag
     5761 tgatcagaaa acagggtagc aagccatgaa gtcatgcttc aaagcagtct attatattct
     5821 gaaaggtgag gacagatata ccacaacagc caatctctgc tactgaaaga cactagtccc
     5881 atatttcctg ggaacacatt gcagtacaga tcacctcagg gttatcatgt ttgtgatgtg
     5941 gacttaggac atcattagct atgttgaggt ctcatttact atgaaggtta aaactaaaca
     6001 gggattgccc taagtaccat ataggtgata gcaacatatt aactttaagc taataccaag
     6061 taggagaaag gcatcattct accctgttaa tcagctactg tttaaaaaca tttcagggat
     6121 agagaacttt aacagtcagc cctgagttct gtctgcagta cctttttttt ttttctttta
     6181 agggggctgg agtgatggct tggtgcttaa aggcactcag tctaacaaag ggcctacccc
     6241 gattctattc ccagcaccca aatggcagct caatctgtct gtaactctag ttcaagggcc
     6301 tctgaccttg ctgttatcct acttgggaat tttgaatggt gaggaagcag tattaactta
     6361 gtactttttt cctggcatgt gctaaaatca atagccacaa gagcatcctc tgtagagctg
     6421 ttaaagcaaa agctatccaa tttagctttt ctacttctga ggacagaaga cacttagacc
     6481 agaaaaaact aacccaagga atatatacac tttggcaaag aaaatctaca tagacttatt
     6541 gtatacgtaa gacattacaa ttcctaatgc tgccacggga gcttagcagc tcgtcagtat
     6601 gttcagagaa ggtcctagtc ggtggctttg gagctttact ttgagaaagt ggggtgttga
     6661 agaaacagaa gaattaaatg ttagaatgat acaggcaaca agctaaggtg ctacatcatc
     6721 ttcacactca gaattgattt ttgcaactta aaatcaactt tcaatgtgct tggagtagtg
     6781 gcagctttac aaggataagt acaatgcctc ctagggaaat tttaaaggac aacagactta
     6841 agtagagacc ctccactgat tagggagcca tcaaaattta acccctgaaa tccttatatt
     6901 taaatagcaa attccatcaa gagttccaat agcccaagtt ctaaacaaac tgacaactgt
     6961 ctttctagat cttcagtaat ctaaaagaca aattttatca tgtacacatt ctacaagtag
     7021 gctgttagca ggattaacag gacaaatgaa tttttaaaaa gccctcaaga ttctacagaa
     7081 aaaaatggag aagacagttt ttggaccgga cattcatagt agcagatgta atgagacagg
     7141 gctcaaatag aaaggcagct agttgaattc tcaagtcatc taaaagtact atgttcaaag
     7201 taggtatttc tatagatgat ctaaccattt tatttacaac ttcaccatgt ctttaaacaa
     7261 tgagggcagt tgcctgtatt caataggaat gacaactaga cctgacatac ttgggaagga
     7321 gcagcagtca gaatttaaaa tggtttttat gacctctaga accaatggca ctaacatcca
     7381 tgttagtgta ggttcataag gagagttcta aacgcaggcc gtcaaccaca ttagtttact
     7441 taatgttaaa ggaaataatt tcataaagta ataacttcgg atttaactat ctgaattctc
     7501 cctttaaaca caatatggcc atgttcttat atttcagtgg tacaactata acagaccttg
     7561 tccaagatca tttcagttca gataagacta aacataactt tctccagaga aaatacatgg
     7621 atatgttttt attctttcat gtgcacacta ggggtaatat tcaagaagag aggaatattc
     7681 taactgctta cggattctat ttcttcaaga ttttataaaa gggggataag aagttgcttt
     7741 ctagtcagtg actgattgca atttggagct acagcctaac agttgatagg aaagaaaaac
     7801 tagaaaacag aggctatgct tatcaaattt tctccgcgta gtcccttaca tcaacataga
     7861 atgtttgtca aaattaaggt taaaatttta cctcctgagt ttaatttatg aaaagggaga
     7921 gaaatttcag tgtttgtgca aatggcattt tggctctctg gattatttta aaagctaaaa
     7981 acctgagtaa caacttttat ctaaatattt tctgtaagaa gtgtgaagtt agtgtcaacc
     8041 tgaaatgtgt gaaaaacttg tataataatt tcgtgtgttt ttagcttcag tatgaagaaa
     8101 aataaagcat ttccttgccc tcccacaaaa tgtatggcta tttagaaata aggtgtttgt
     8161 tcctcctttt ccaatgtaac catttatacc tattaataaa tgttcatgaa cagcattggg
     8221 tttcaaatga taatttaacc tgcaaaaaca ctaacagaag actactgtag ttcaaaatat
     8281 tctgaagtcc gactgagaag caacgttatc tcaatttcta tagttcctat gtaaaaagtt
     8341 tttactataa agtgctgaaa tagtaaaacc taatggttca ttcacctcaa tttcaactac
     8401 atgcttggac tatgtacttc aaaaaaagta gttttaccca gagctatgaa tatacctgag
     8461 acgtataaaa ctttaagtac tcaattaact atcccatcgc ct
//
