LOCUS       NM_001163452            3219 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus transient receptor potential cation channel, subfamily
            C, member 4 associated protein (Trpc4ap), transcript variant 1,
            mRNA.
ACCESSION   NM_001163452
VERSION     NM_001163452.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3219)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3219)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3219)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3219)
  AUTHORS   Zhu,Q., Zhu,Y.Y. and Wang,W.N.
  TITLE     TRUSS inhibition protects against high fat diet (HFD)-stimulated
            brain injury by alleviation of inflammatory response
  JOURNAL   Biochem Biophys Res Commun 511 (1), 41-48 (2019)
   PUBMED   30765221
  REMARK    GeneRIF: TRUSS ablation alleviates high fat diet -induced cognitive
            impairments and metabolic disorder.
REFERENCE   5  (bases 1 to 3219)
  AUTHORS   Yu,C.J., Wang,Q.S., Wu,M.M., Song,B.L., Liang,C., Lou,J.,
            Tang,L.L., Yu,X.D., Niu,N., Yang,X., Zhang,B.L., Qu,Y., Liu,Y.,
            Dong,Z.C. and Zhang,Z.R.
  TITLE     TRUSS Exacerbates NAFLD Development by Promoting IkappaBalpha
            Degradation in Mice
  JOURNAL   Hepatology 68 (5), 1769-1785 (2018)
   PUBMED   29704259
  REMARK    GeneRIF: Hepatocyte TRUSS promotes pathological stimuli-induced non
            alcoholic fatty liver disease and metabolic disorders, through
            activation of NF-kappaB by promoting ubiquitination and degradation
            of IkappaBalpha
REFERENCE   6  (bases 1 to 3219)
  AUTHORS   DiTommaso,T., Jones,L.K., Cottle,D.L., Gerdin,A.K., Vancollie,V.E.,
            Watt,F.M., Ramirez-Solis,R., Bradley,A., Steel,K.P., Sundberg,J.P.,
            White,J.K. and Smyth,I.M.
  CONSRTM   WTSI Mouse Genetics Program
  TITLE     Identification of genes important for cutaneous function revealed
            by a large scale reverse genetic screen in the mouse
  JOURNAL   PLoS Genet 10 (10), e1004705 (2014)
   PUBMED   25340873
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3219)
  AUTHORS   Soond,S.M., Terry,J.L., Colbert,J.D. and Riches,D.W.
  TITLE     TRUSS, a novel tumor necrosis factor receptor 1 scaffolding protein
            that mediates activation of the transcription factor NF-kappaB
  JOURNAL   Mol Cell Biol 23 (22), 8334-8344 (2003)
   PUBMED   14585990
  REMARK    GeneRIF: cloning and characterization of tumor necrosis factor
            receptor 1 (TNF-R1)-associated ubiquitous scaffolding and signaling
            protein (TRUSS)
REFERENCE   8  (bases 1 to 3219)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844852.11, AK171404.1 and BC057330.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057330.1, AK220239.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AL844852.11        256885-256936       c
            53-2369             AK171404.1         2-2318
            2370-3219           BC057330.1         2328-3177
FEATURES             Location/Qualifiers
     source          1..3219
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 77.26 cM"
     gene            1..3219
                     /gene="Trpc4ap"
                     /gene_synonym="4833429F06Rik; D2Ertd113e; mFLJ00177;
                     Trrp4ap; truss"
                     /note="transient receptor potential cation channel,
                     subfamily C, member 4 associated protein"
                     /db_xref="GeneID:56407"
                     /db_xref="MGI:MGI:1930751"
     exon            1..246
                     /gene="Trpc4ap"
                     /gene_synonym="4833429F06Rik; D2Ertd113e; mFLJ00177;
                     Trrp4ap; truss"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..2472
                     /gene="Trpc4ap"
                     /gene_synonym="4833429F06Rik; D2Ertd113e; mFLJ00177;
                     Trrp4ap; truss"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Trp4-associated protein TAP1; short transient receptor
                     potential channel 4-associated protein; transient receptor
                     protein 4, associated protein; TNF-receptor ubiquitous
                     scaffolding/signaling protein; trpc4-associated protein;
                     rabex-5/Rin2-interacting protein"
                     /codon_start=1
                     /product="short transient receptor potential channel
                     4-associated protein isoform 1"
                     /protein_id="NP_001156924.1"
                     /db_xref="CCDS:CCDS50769.1"
                     /db_xref="GeneID:56407"
                     /db_xref="MGI:MGI:1930751"
                     /translation="MAAAPAAAGAGASRGRRLAATAAAWGGWGGRPRPGNILLQLRQG
                     QLTGRGLVRAVQFTETFLTERDKLSKWSGIPQLLLKLYATSHLHSDFVECQSILKEIS
                     PLLSMEAMAFVTEDRKFTQEATYPNTYIFDLFGGVDLLVEILMRPTISIRGQKLKISD
                     EMSKDCLSILYNTCVCTEGVTKRLAEKNDFVIFLFTLMTSKKTFLQTATLIEDILGVK
                     KEMIRLDEVPNLSSLVSNFDQQQLANFCRILAVTISEMDTGNDDKHTLLAKNAQQKKS
                     LSLGPSAAEINQAALLSIPGFVERLCKLATRKVSESTGTASFLQELEEWYTWLDNALV
                     LDALMRVANEESEHNQAPTVFPSLGTSEEGGLPHTSARAQLPQSMKIMHEIMYKLEVL
                     YVLCVLLMGRQRNQVHRMIAEFKLIPGLNNLFDKLIWRKHSASALVLHGHNQNCDCSP
                     DITLKIQFLRLLQSFSDHHENKYLLLNNQELNELSAISLKANIPEVEAVLNTDRSLVC
                     DGKRGLLTRLLQVMKKEPAESSFRFWQARAVESFLRGTTSYADQMFLLKRGLLEHILY
                     CIVDSECKSRDVLQSYFDLLGELMKFNVDAFKRFNKYINTDAKFQVFLKQINSSLVDS
                     NMLVRCVTLSLDRFENQVDMKVAEVLSECRLLAYISQVPTQMSFLFRLINIIHVQTLT
                     QENVSCLNTSLVILMLARRKERLPLYLRLLQRMEHSKKYPGFLLNNFHNLLRFWQQHY
                     LHKDKDSTCLENSSCISFSYWKETVSILLNPDRQSPSALVSYIEEPYMDIDRDFTEE"
     exon            247..375
                     /gene="Trpc4ap"
                     /gene_synonym="4833429F06Rik; D2Ertd113e; mFLJ00177;
                     Trrp4ap; truss"
                     /inference="alignment:Splign:2.1.0"
     exon            376..492
                     /gene="Trpc4ap"
                     /gene_synonym="4833429F06Rik; D2Ertd113e; mFLJ00177;
                     Trrp4ap; truss"
                     /inference="alignment:Splign:2.1.0"
     exon            493..550
                     /gene="Trpc4ap"
                     /gene_synonym="4833429F06Rik; D2Ertd113e; mFLJ00177;
                     Trrp4ap; truss"
                     /inference="alignment:Splign:2.1.0"
     exon            551..606
                     /gene="Trpc4ap"
                     /gene_synonym="4833429F06Rik; D2Ertd113e; mFLJ00177;
                     Trrp4ap; truss"
                     /inference="alignment:Splign:2.1.0"
     exon            607..735
                     /gene="Trpc4ap"
                     /gene_synonym="4833429F06Rik; D2Ertd113e; mFLJ00177;
                     Trrp4ap; truss"
                     /inference="alignment:Splign:2.1.0"
     exon            736..943
                     /gene="Trpc4ap"
                     /gene_synonym="4833429F06Rik; D2Ertd113e; mFLJ00177;
                     Trrp4ap; truss"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1129
                     /gene="Trpc4ap"
                     /gene_synonym="4833429F06Rik; D2Ertd113e; mFLJ00177;
                     Trrp4ap; truss"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1296
                     /gene="Trpc4ap"
                     /gene_synonym="4833429F06Rik; D2Ertd113e; mFLJ00177;
                     Trrp4ap; truss"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1428
                     /gene="Trpc4ap"
                     /gene_synonym="4833429F06Rik; D2Ertd113e; mFLJ00177;
                     Trrp4ap; truss"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1487
                     /gene="Trpc4ap"
                     /gene_synonym="4833429F06Rik; D2Ertd113e; mFLJ00177;
                     Trrp4ap; truss"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1589
                     /gene="Trpc4ap"
                     /gene_synonym="4833429F06Rik; D2Ertd113e; mFLJ00177;
                     Trrp4ap; truss"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1673
                     /gene="Trpc4ap"
                     /gene_synonym="4833429F06Rik; D2Ertd113e; mFLJ00177;
                     Trrp4ap; truss"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1764
                     /gene="Trpc4ap"
                     /gene_synonym="4833429F06Rik; D2Ertd113e; mFLJ00177;
                     Trrp4ap; truss"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1905
                     /gene="Trpc4ap"
                     /gene_synonym="4833429F06Rik; D2Ertd113e; mFLJ00177;
                     Trrp4ap; truss"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2014
                     /gene="Trpc4ap"
                     /gene_synonym="4833429F06Rik; D2Ertd113e; mFLJ00177;
                     Trrp4ap; truss"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2127
                     /gene="Trpc4ap"
                     /gene_synonym="4833429F06Rik; D2Ertd113e; mFLJ00177;
                     Trrp4ap; truss"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2334
                     /gene="Trpc4ap"
                     /gene_synonym="4833429F06Rik; D2Ertd113e; mFLJ00177;
                     Trrp4ap; truss"
                     /inference="alignment:Splign:2.1.0"
     exon            2335..3198
                     /gene="Trpc4ap"
                     /gene_synonym="4833429F06Rik; D2Ertd113e; mFLJ00177;
                     Trrp4ap; truss"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3149..3154
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trpc4ap"
                     /gene_synonym="4833429F06Rik; D2Ertd113e; mFLJ00177;
                     Trrp4ap; truss"
                     /note="hexamer: AATAAA"
     polyA_site      3167
                     /gene="Trpc4ap"
                     /gene_synonym="4833429F06Rik; D2Ertd113e; mFLJ00177;
                     Trrp4ap; truss"
     regulatory      3172..3177
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trpc4ap"
                     /gene_synonym="4833429F06Rik; D2Ertd113e; mFLJ00177;
                     Trrp4ap; truss"
                     /note="hexamer: ATTAAA"
     polyA_site      3192
                     /gene="Trpc4ap"
                     /gene_synonym="4833429F06Rik; D2Ertd113e; mFLJ00177;
                     Trrp4ap; truss"
                     /note="major polyA site"
ORIGIN      
        1 gtagagagtc ctccgccgcc ccgtagaaat cgacacggct ccgggaccgc ttgcttcctg
       61 tttgtcggac gaggagacat ggcggcagcg cccgcagcgg ctggagctgg ggccagccgg
      121 gggaggcggt tggcagctac cgcggcggcg tggggcggct ggggaggtcg accgcggccg
      181 ggtaacatcc tgctgcagct gcggcagggc cagctcaccg gccgaggcct ggtccgggcg
      241 gtgcagttca ctgagacctt tttgaccgag agggacaaat tgtccaaatg gagtggaatt
      301 cctcagttgc tccttaagct gtatgccacc agccatctgc acagtgactt cgttgagtgc
      361 caaagcattc tcaaggagat ttctcctctt ctctctatgg aggctatggc gtttgtaact
      421 gaagacagga aatttactca agaagctaca tacccaaata catatatttt tgacttattt
      481 ggaggtgttg atcttcttgt agaaattctt atgaggccta ccatctctat ccggggacag
      541 aaactaaaaa taagtgacga gatgtcgaag gactgcttga gcatcctgta caatacctgt
      601 gtctgcacgg aaggagtaac gaagcgtttg gcagaaaaga atgattttgt gatttttctg
      661 ttcacactga tgacaagtaa gaagacattc ttacaaacag cgactctcat tgaagacatt
      721 ttgggtgtta agaaggaaat gatccggcta gatgaagttc ccaatctgag ttccttagta
      781 tccaatttcg atcagcagca gcttgctaac ttctgcagga tcctggctgt caccatttca
      841 gagatggaca cggggaatga cgacaaacac acgcttcttg ccaaaaatgc tcagcagaag
      901 aagagtttga gtttggggcc ttctgcagct gaaatcaacc aagctgctct tctcagcatc
      961 cctggctttg tggaacggct ttgcaaactg gcaactagga aagtgtcaga gtcaacgggc
     1021 acagccagct tccttcaaga actggaggag tggtacacat ggctcgacaa tgcgttggtg
     1081 ctagatgccc tgatgcgagt ggccaatgag gagtctgaac acaatcaagc ccccactgtg
     1141 ttcccttctc taggcacttc ggaggagggt gggctgccac acacctcggc cagggcgcag
     1201 ctgccccagt ccatgaagat tatgcatgag attatgtaca aactggaagt gctttatgtc
     1261 ctctgcgtgc tgctgatggg gcgtcagcga aaccaggtcc acaggatgat tgctgagttc
     1321 aagttgatcc caggactcaa taatttgttc gacaaactga tttggaggaa gcattcagca
     1381 tctgcccttg tcctccatgg ccacaaccag aactgtgact gtagcccgga catcaccttg
     1441 aagatccagt ttttgagact tctccagagt ttcagtgacc accatgagaa caagtacttg
     1501 ctgctcaaca accaggagct aaatgagctc agtgccatct cgctgaaagc caacatccct
     1561 gaggtggagg ctgtcctcaa cactgacagg agtctggtgt gtgacggcaa gaggggccta
     1621 ctaactcggc tgctgcaggt catgaagaag gagccagcgg agtcttcatt caggttttgg
     1681 caagcccggg ctgtggaaag tttcctccga gggaccacct cctatgcaga ccagatgttc
     1741 ctgctgaagc gaggccttct ggagcacatc ttatactgca ttgtggacag tgagtgcaag
     1801 tctagggatg tactccagag ctactttgat ctcctgggag agctgatgaa gttcaacgtc
     1861 gatgcattca agagattcaa taaatatatc aacactgatg caaagttcca ggtgttcctg
     1921 aaacagatca acagctcgct agtggactcc aacatgctgg tgcgctgtgt cactctgtca
     1981 ctggaccgat ttgaaaacca ggtggacatg aaagtggccg aggtcctgtc cgagtgccgc
     2041 ctgcttgcct acatatccca ggtgcccacg caaatgtcct tcctcttccg cctcatcaat
     2101 atcatccatg tgcagacgct aacccaggag aacgtcagct gcctcaacac cagcctggta
     2161 atcctgatgc tggcccgacg gaaagagcgg ctgcccctgt acctgcgact gctacagcga
     2221 atggagcaca gcaagaaata ccccggcttc ctgctcaaca acttccacaa cctgctgcgc
     2281 ttttggcagc agcactacct gcacaaggat aaggacagca cctgcctgga gaatagctcc
     2341 tgtatcagct tctcgtactg gaaggagaca gtgtccatct tgttgaaccc agaccgccag
     2401 tcgccctctg ccctcgtcag ctacattgag gagccctaca tggacataga cagagacttc
     2461 actgaggagt gaccttgagc caggcttcaa gaagctgcca ggcaggggcg agtgcagaga
     2521 gccagagtgc acgtgccgcc tcgcactctg cccatccctg tccctcttgc ctccccagtg
     2581 ctctgtccac cccgggtgtc caggtgcagg ctcagtggaa ggaacatcct agaagctctt
     2641 gtctcctggg tctgagggcc caggtcatgg ggagcctgtt tcttcactgt ccccagggta
     2701 aggacaatgg caccatgccc acctttccct cgcaatcctg gagccctggc ctgccagaga
     2761 aggggaacac gggaaaccat ctgtctgagc ttctcccatc agtcctgatg gagaggaaga
     2821 tgcagacccc tgtgagccaa acctccctgg cctcaggacg caggcagaga ggctcctgag
     2881 ccctgggcag gggtgggtat cggagaatgc tgccttcccc ggggtctgcc catctctccc
     2941 ttcctcacct cccttgtctt cctttagctc ctctggttct ttgctcattg gccactgtgt
     3001 tcatccagga ggctccctag aagtgggggg agccttttct ctccatccct tggggcatgg
     3061 agtgcctgtg cctgcctgag cccagacacg ggagcctggc tgagagctta cccttggctc
     3121 ctcctgtgtt gccagtttat taacagcaaa taaaccgatt aaatggagac tattaaagaa
     3181 ctttatttta aagactgaaa aaaaaaaaaa aaaaaaaaa
//
