LOCUS       NM_016984               3490 bp    mRNA    linear   ROD 06-FEB-2024
DEFINITION  Mus musculus transient receptor potential cation channel, subfamily
            C, member 4 (Trpc4), transcript variant 1, mRNA.
ACCESSION   NM_016984
VERSION     NM_016984.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3490)
  AUTHORS   Zhou,Q., Fu,X., Xu,J., Dong,S., Liu,C., Cheng,D., Gao,C., Huang,M.,
            Liu,Z., Ni,X., Hua,R., Tu,H., Sun,H., Shen,Q., Chen,B., Zhang,J.,
            Zhang,L., Yang,H., Hu,J., Yang,W., Pei,W., Yao,Q., Sheng,X.,
            Zhang,J., Yang,W.Z. and Shen,W.L.
  TITLE     Hypothalamic warm-sensitive neurons require TRPC4 channel for
            detecting internal warmth and regulating body temperature in mice
  JOURNAL   Neuron 111 (3), 387-404 (2023)
   PUBMED   36476978
  REMARK    GeneRIF: Hypothalamic warm-sensitive neurons require TRPC4 channel
            for detecting internal warmth and regulating body temperature in
            mice.
REFERENCE   2  (bases 1 to 3490)
  AUTHORS   Lin,Y., Cui,X., Cao,Q., Bi,R., Liu,Y., Jing,D., Yue,C., Zhao,Q.,
            Wang,Y., Liu,S., Su,Y., Formoso,K., Susperreguy,S., Birnbaumer,L.,
            Freichel,M., Yang,Y., You,L. and Gao,X.
  TITLE     TRPC absence induces pro-inflammatory macrophages and gut microbe
            disorder, sensitizing mice to colitis
  JOURNAL   Int Immunopharmacol 115, 109655 (2023)
   PUBMED   36592529
REFERENCE   3  (bases 1 to 3490)
  AUTHORS   Kollewe,A., Schwarz,Y., Oleinikov,K., Raza,A., Haupt,A.,
            Wartenberg,P., Wyatt,A., Boehm,U., Ectors,F., Bildl,W., Zolles,G.,
            Schulte,U., Bruns,D., Flockerzi,V. and Fakler,B.
  TITLE     Subunit composition, molecular environment, and activation of
            native TRPC channels encoded by their interactomes
  JOURNAL   Neuron 110 (24), 4162-4175 (2022)
   PUBMED   36257322
REFERENCE   4  (bases 1 to 3490)
  AUTHORS   Tian,J.B., Yang,J., Joslin,W.C., Flockerzi,V., Prescott,S.A.,
            Birnbaumer,L. and Zhu,M.X.
  TITLE     TRPC4 and GIRK channels underlie neuronal coding of firing patterns
            that reflect Gq/11-Gi/o coincidence signals of variable strengths
  JOURNAL   Proc Natl Acad Sci U S A 119 (20), e2120870119 (2022)
   PUBMED   35544691
  REMARK    GeneRIF: TRPC4 and GIRK channels underlie neuronal coding of firing
            patterns that reflect Gq/11-Gi/o coincidence signals of variable
            strengths.
REFERENCE   5  (bases 1 to 3490)
  AUTHORS   Turrero Garcia,M., Stegmann,S.K., Lacey,T.E., Reid,C.M.,
            Hrvatin,S., Weinreb,C., Adam,M.A., Nagy,M.A. and Harwell,C.C.
  TITLE     Transcriptional profiling of sequentially generated septal neuron
            fates
  JOURNAL   Elife 10, e71545 (2021)
   PUBMED   34851821
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3490)
  AUTHORS   Philipp,S., Hambrecht,J., Braslavski,L., Schroth,G., Freichel,M.,
            Murakami,M., Cavalie,A. and Flockerzi,V.
  TITLE     A novel capacitative calcium entry channel expressed in excitable
            cells
  JOURNAL   EMBO J 17 (15), 4274-4282 (1998)
   PUBMED   9687496
REFERENCE   7  (bases 1 to 3490)
  AUTHORS   Yamazaki,K., Okada,T., Mori,Y. and Tanaka,I.
  TITLE     Genetic mapping of mouse transient receptor potential (Trrp) genes
            responsible for capacitative calcium entry channels to chromosomes
            3, 7, 9, and X
  JOURNAL   Genomics 51 (2), 303-305 (1998)
   PUBMED   9722956
REFERENCE   8  (bases 1 to 3490)
  AUTHORS   Mori,Y., Takada,N., Okada,T., Wakamori,M., Imoto,K., Wanifuchi,H.,
            Oka,H., Oba,A., Ikenaka,K. and Kurosaki,T.
  TITLE     Differential distribution of TRP Ca2+ channel isoforms in mouse
            brain
  JOURNAL   Neuroreport 9 (3), 507-515 (1998)
   PUBMED   9512398
REFERENCE   9  (bases 1 to 3490)
  AUTHORS   Zhu,X., Jiang,M., Peyton,M., Boulay,G., Hurst,R., Stefani,E. and
            Birnbaumer,L.
  TITLE     trp, a novel mammalian gene family essential for agonist-activated
            capacitative Ca2+ entry
  JOURNAL   Cell 85 (5), 661-671 (1996)
   PUBMED   8646775
REFERENCE   10 (bases 1 to 3490)
  AUTHORS   Petersen,C.C., Berridge,M.J., Borgese,M.F. and Bennett,D.L.
  TITLE     Putative capacitative calcium entry channels: expression of
            Drosophila trp and evidence for the existence of vertebrate
            homologues
  JOURNAL   Biochem J 311 (Pt 1) (Pt 1), 41-44 (1995)
   PUBMED   7575478
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK080670.1, AC117594.8 and CO043592.1.
            
            [WARNING] On Mar 20, 2024 this sequence was replaced by
            NM_016984.4.
            
            On Nov 30, 2011 this sequence version replaced NM_016984.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK080670.1, U50922.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1331              AK080670.1         2-1332
            1332-1332           AC117594.8         93683-93683         c
            1333-3402           AK080670.1         1334-3403
            3403-3423           CO043592.1         69-89               c
            3424-3490           CO043592.1         1-67                c
FEATURES             Location/Qualifiers
     source          1..3490
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 25.43 cM"
     gene            1..3490
                     /gene="Trpc4"
                     /gene_synonym="CCE1; STRPC4; Trp4; Trrp4"
                     /note="transient receptor potential cation channel,
                     subfamily C, member 4"
                     /db_xref="GeneID:22066"
                     /db_xref="MGI:MGI:109525"
     exon            1..203
                     /gene="Trpc4"
                     /gene_synonym="CCE1; STRPC4; Trp4; Trrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            204..611
                     /gene="Trpc4"
                     /gene_synonym="CCE1; STRPC4; Trp4; Trrp4"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..3158
                     /gene="Trpc4"
                     /gene_synonym="CCE1; STRPC4; Trp4; Trrp4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     putative capacitative calcium entry channel; short
                     transient receptor potential channel 4; receptor-activated
                     cation channel TRP4; capacitative calcium entry channel
                     Trp4; transient receptor protein 4"
                     /codon_start=1
                     /product="short transient receptor potential channel 4
                     isoform 1"
                     /protein_id="NP_058680.1"
                     /db_xref="CCDS:CCDS17350.1"
                     /db_xref="GeneID:22066"
                     /db_xref="MGI:MGI:109525"
                     /translation="MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGD
                     YASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLH
                     AIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKL
                     LVQKGVSVPRPHEVRCNCVECVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFL
                     TAFQLSWELQELSKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNS
                     LIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCF
                     IIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDL
                     NRQGPPPTIVEWMILPWVLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATIS
                     LKIVAFVKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQIS
                     LGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLSCKGIRCEKQNNAFSTLFE
                     TLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSY
                     QLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLVKWIWTHLCKKKM
                     RRKPESFGTIGRRAADNLRRHHQYQEVMRNLVKRYVAAMIREAKTEEGLTEENVKELK
                     QDISSFRFEVLGLLRGSKLSTIQSANAASSADSDEKSQSEGNGKDKRKNLSLFDLTTL
                     IHPRSAAIASERHNLSNGSALVVQEPPREKQRKVNFVADIKNFGLFHRRSKQNAAEQN
                     ANQIFSVSEEITRQQAAGALERNIELESKGLASRGDRSIPGLNEQCVLVDHRERNTDT
                     LGLQVGKRVCSTFKSEKVVVEDTVPIIPKEKHAHEEDSSIDYDLSPTDTAAHEDYVTT
                     RL"
     exon            612..1130
                     /gene="Trpc4"
                     /gene_synonym="CCE1; STRPC4; Trp4; Trrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1467
                     /gene="Trpc4"
                     /gene_synonym="CCE1; STRPC4; Trp4; Trrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1607
                     /gene="Trpc4"
                     /gene_synonym="CCE1; STRPC4; Trp4; Trrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1921
                     /gene="Trpc4"
                     /gene_synonym="CCE1; STRPC4; Trp4; Trrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2117
                     /gene="Trpc4"
                     /gene_synonym="CCE1; STRPC4; Trp4; Trrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2118..2312
                     /gene="Trpc4"
                     /gene_synonym="CCE1; STRPC4; Trp4; Trrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..2354
                     /gene="Trpc4"
                     /gene_synonym="CCE1; STRPC4; Trp4; Trrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..2444
                     /gene="Trpc4"
                     /gene_synonym="CCE1; STRPC4; Trp4; Trrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2445..3473
                     /gene="Trpc4"
                     /gene_synonym="CCE1; STRPC4; Trp4; Trrp4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actccgccca gttctgtgcc agctgcgtgg gctctggttt cgtgcgggtt tttttccccc
       61 ttggaatgct ccaaaaaact cggtagcgac tacggaaacc ccatcggaac tgaccagctg
      121 cgctagcacc aggcacagca ctggtgctgc gcgctcgccg agcccacctc ggtcacttca
      181 accaccagat tgcaactttg cggagatgat gatggactag catggcctga agcatggctc
      241 agttctatta caaaagaaat gtcaacgccc cctacagaga ccgcatccca ctgaggattg
      301 tcagagcaga atctgagctc tcaccatcag agaaagccta cttgaatgct gtggagaagg
      361 gggactatgc aagcgtcaag aagtctctgg aggaagctga gatttatttt aaaatcaaca
      421 ttaactgcat cgaccccctg ggaaggaccg ccctcctcat tgccattgaa aatgagaatc
      481 tggagcttat tgaactattg ttgagtttca atgtctatgt aggcgatgcg ctgcttcacg
      541 ccatcagaaa agaggtggtt ggagccgtgg agctactgct gaaccacaaa aagccaagtg
      601 gagagaagca ggtgcctccc attctccttg ataaacagtt ctctgaattc actccggaca
      661 tcacacccat catcttggct gcacatacaa ataattacga gataatcaaa cttttggttc
      721 agaaaggtgt ctcagtgccc agaccccacg aggtccgctg taactgtgtt gagtgtgtct
      781 ccagctcgga tgtggacagc ctcaggcatt cacggtccag gctcaacatc tacaaggcct
      841 tggccagccc ctcgctcatt gccctgtcaa gcgaagaccc tttccttact gcctttcagt
      901 taagttggga gctgcaagaa ctcagcaagg tggagaacga attcaagtcg gagtatgagg
      961 agctgtctag acagtgcaaa caatttgcca aggacctcct agatcagaca cggagttcca
     1021 gagagctgga aatcattctt aattaccgtg atgacaatag tctgatcgaa gaacagagtg
     1081 gaaatgatct tgcaaggcta aaattagcca ttaagtaccg tcaaaaagag tttgttgctc
     1141 agcccaactg ccagcagctg ctcgcttccc gctggtacga tgagttccca ggctggagga
     1201 gaagacactg ggcggtgaag atggtgacgt gtttcataat aggactactc ttccccgtct
     1261 tctccgtgtg ctacctgata gctcccaaaa gcccacttgg actgttcatc agaaagccat
     1321 ttatcaagtt tatctgccac acagcctcct atctgacctt tttgtttctg ctgctgctag
     1381 cctctcagca catcgacagg tcagacttga acaggcaagg tccaccacca accatcgtgg
     1441 agtggatgat attaccgtgg gtcctgggtt ttatatgggg agagattaaa cagatgtggg
     1501 atggcggact ccaggattac atccatgact ggtggaatct aatggacttt gtgatgaact
     1561 ccttgtatct ggcaacaatc tccttgaaga ttgtcgcgtt tgtaaagtac agtgctctga
     1621 acccacggga atcatgggac atgtggcacc ccaccctggt ggcagaggca ttatttgcta
     1681 ttgcaaacat cttcagttcc ctccgcctga tctctctgtt cactgccaat tctcacctgg
     1741 ggcctctgca gatatctctg ggaaggatgc ttctggacat cctgaagttc ttgttcatct
     1801 actgcctcgt gctgctagct tttgcaaatg gcctaaatca gctgtacttt tactatgaag
     1861 aaacaaaggg gctaagctgc aaaggcatcc ggtgcgagaa acagaacaac gcgttttcca
     1921 cgttattcga gacactacag tccctgtttt ggtcaatatt tggactcatc aatctctatg
     1981 ttaccaatgt caaagcccag cacgagttca ctgagtttgt tggggccacc atgtttggca
     2041 catataatgt catctctctg gttgtcctgc tgaacatgtt aattgctatg atgaataatt
     2101 cttaccaact aattgccgac catgcagata tagaatggaa atttgctcga acaaagcttt
     2161 ggatgagcta ctttgaagaa ggaggtaccc tgcctacacc tttcaatgtc atcccaagcc
     2221 ccaagtccct gtggtacctg gtcaagtgga tatggacaca cttatgtaag aaaaaaatga
     2281 gaaggaagcc agaaagcttc gggacaattg ggcggcgtgc tgctgataac ttgagaagac
     2341 atcaccaata ccaagaggtg atgaggaacc tggtgaagcg gtacgtggca gccatgatca
     2401 gagaggcaaa aaccgaagaa ggcttgacgg aggagaatgt taaggaacta aagcaagaca
     2461 tttctagctt ccgcttcgaa gttctgggat tgctcagagg aagcaagctc tctacaatac
     2521 agtcagccaa cgcggcgagt tcagcggact ccgacgagaa gagccagagc gaaggtaatg
     2581 gcaaggacaa gagaaagaat ctcagcctct ttgatttaac cactctgatc cacccgcggt
     2641 cggcagccat tgcctccgag agacataacc taagcaatgg ttccgccctg gtggtgcagg
     2701 agccgcccag ggagaagcag aggaaagtga attttgtggc tgatatcaaa aacttcgggt
     2761 tatttcatag acggtcaaaa caaaatgctg ctgagcaaaa cgcaaaccaa atcttctctg
     2821 tttcagaaga aattactcgt caacaggcgg caggagcact tgagcgaaat atcgaactgg
     2881 aatccaaagg attagcttca cggggtgacc gcagcattcc tggtctcaat gaacagtgtg
     2941 tgctagtaga ccatagagaa aggaatacgg acactttggg tttacaggta ggcaagagag
     3001 tgtgctccac cttcaagtcg gagaaggtgg tggtggaaga caccgtccct attataccaa
     3061 aggagaaaca cgcccacgag gaggactcga gcatagacta tgacttaagc cccacggaca
     3121 cagctgccca cgaagattat gtgaccacaa gattgtgacc cttggaggag tgtttaccat
     3181 acctatacat attttccata gtgctctggg caggcaaaat gtttgaaatc ccattatcaa
     3241 atgctaattt ccactttcta atgtttatct gttgtggcat attaacctgt aatatgtttg
     3301 aacaaagcag aagtaatatg aaccctcctc ttttgtagcc tgcttttgct ttcaccgttg
     3361 attttacaag tgtttctgtt aaataaacgc accttttatc cttgtactgt tacaataacc
     3421 cacagaaaat ttttagctat ctttttcaat taaaaccaat gcaattgttt tcaaaaaaaa
     3481 aaaaaaaaaa
//
