LOCUS       NM_019510               3659 bp    mRNA    linear   ROD 13-DEC-2024
DEFINITION  Mus musculus transient receptor potential cation channel, subfamily
            C, member 3 (Trpc3), transcript variant 1, mRNA.
ACCESSION   NM_019510
VERSION     NM_019510.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3659)
  AUTHORS   Wang,B., Yu,W., Zhang,W., Zhang,M., Niu,Y., Jin,X., Zhang,J.,
            Sun,D., Li,H., Zhang,Z., Luo,Q., Cheng,X., Niu,J., Cai,G., Chen,X.
            and Chen,Y.
  TITLE     Enhanced TRPC3 transcription through AT1R/PKA/CREB signaling
            contributes to mitochondrial dysfunction in renal tubular
            epithelial cells in D-galactose-induced accelerated aging mice
  JOURNAL   Aging Cell 23 (6), e14130 (2024)
   PUBMED   38415902
  REMARK    GeneRIF: Enhanced TRPC3 transcription through AT1R/PKA/CREB
            signaling contributes to mitochondrial dysfunction in renal tubular
            epithelial cells in D-galactose-induced accelerated aging mice.
REFERENCE   2  (bases 1 to 3659)
  AUTHORS   Lin,Y., Gao,R., Jing,D., Liu,Y., Da,H., Birnbaumer,L., Yang,Y.,
            Gao,X., Gao,Z. and Cao,Q.
  TITLE     TRPC absence induces pro-inflammatory macrophage polarization to
            promote obesity and exacerbate colorectal cancer
  JOURNAL   Front Pharmacol 15, 1392328 (2024)
   PUBMED   38835669
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3659)
  AUTHORS   Gombedza,F.C., Shin,S., Sadiua,J., Stackhouse,G.B. and
            Bandyopadhyay,B.C.
  TITLE     The Rise in Tubular pH during Hypercalciuria Exacerbates Calcium
            Stone Formation
  JOURNAL   Int J Mol Sci 25 (9), 4787 (2024)
   PUBMED   38732005
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3659)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 3659)
  AUTHORS   Ming,Z., Bagheri-Fam,S., Frost,E.R., Ryan,J.M. and Harley,V.R.
  TITLE     A role for TRPC3 in mammalian testis development
  JOURNAL   Front Cell Dev Biol 12, 1337714 (2024)
   PUBMED   38425503
  REMARK    Erratum:[Front Cell Dev Biol. 2024 Oct 15;12:1484634. doi:
            10.3389/fcell.2024.1484634. PMID: 39474354]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3659)
  AUTHORS   Ohki,G., Miyoshi,T., Murata,M., Ishibashi,K., Imai,M. and Suzuki,M.
  TITLE     A calcium-activated cation current by an alternatively spliced form
            of Trp3 in the heart
  JOURNAL   J Biol Chem 275 (50), 39055-39060 (2000)
   PUBMED   10984475
REFERENCE   7  (bases 1 to 3659)
  AUTHORS   Zhu,X. and Birnbaumer,L.
  TITLE     Calcium Channels Formed by Mammalian Trp Homologues
  JOURNAL   News Physiol Sci 13, 211-217 (1998)
   PUBMED   11390792
REFERENCE   8  (bases 1 to 3659)
  AUTHORS   Yamazaki,K., Okada,T., Mori,Y. and Tanaka,I.
  TITLE     Genetic mapping of mouse transient receptor potential (Trrp) genes
            responsible for capacitative calcium entry channels to chromosomes
            3, 7, 9, and X
  JOURNAL   Genomics 51 (2), 303-305 (1998)
   PUBMED   9722956
REFERENCE   9  (bases 1 to 3659)
  AUTHORS   Mori,Y., Takada,N., Okada,T., Wakamori,M., Imoto,K., Wanifuchi,H.,
            Oka,H., Oba,A., Ikenaka,K. and Kurosaki,T.
  TITLE     Differential distribution of TRP Ca2+ channel isoforms in mouse
            brain
  JOURNAL   Neuroreport 9 (3), 507-515 (1998)
   PUBMED   9512398
REFERENCE   10 (bases 1 to 3659)
  AUTHORS   Zhu,X., Jiang,M., Peyton,M., Boulay,G., Hurst,R., Stefani,E. and
            Birnbaumer,L.
  TITLE     trp, a novel mammalian gene family essential for agonist-activated
            capacitative Ca2+ entry
  JOURNAL   Cell 85 (5), 661-671 (1996)
   PUBMED   8646775
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117584.11.
            
            On Apr 5, 2022 this sequence version replaced NM_019510.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK080619.1, AK032317.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-330               AC117584.11        283-612
            331-1102            AC117584.11        18767-19538
            1103-1291           AC117584.11        27477-27665
            1292-1456           AC117584.11        35228-35392
            1457-1673           AC117584.11        38674-38890
            1674-1907           AC117584.11        40129-40362
            1908-2172           AC117584.11        46061-46325
            2173-2368           AC117584.11        49631-49826
            2369-2578           AC117584.11        51789-51998
            2579-2662           AC117584.11        55952-56035
            2663-2738           AC117584.11        65990-66065
            2739-3659           AC117584.11        69013-69933
FEATURES             Location/Qualifiers
     source          1..3659
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 17.93 cM"
     gene            1..3659
                     /gene="Trpc3"
                     /gene_synonym="Mwk; Trcp3; Trp3; Trrp3"
                     /note="transient receptor potential cation channel,
                     subfamily C, member 3"
                     /db_xref="GeneID:22065"
                     /db_xref="MGI:MGI:109526"
     exon            1..330
                     /gene="Trpc3"
                     /gene_synonym="Mwk; Trcp3; Trp3; Trrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            331..1102
                     /gene="Trpc3"
                     /gene_synonym="Mwk; Trcp3; Trp3; Trrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1291
                     /gene="Trpc3"
                     /gene_synonym="Mwk; Trcp3; Trp3; Trrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1456
                     /gene="Trpc3"
                     /gene_synonym="Mwk; Trcp3; Trp3; Trrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1673
                     /gene="Trpc3"
                     /gene_synonym="Mwk; Trcp3; Trp3; Trrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1907
                     /gene="Trpc3"
                     /gene_synonym="Mwk; Trcp3; Trp3; Trrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2172
                     /gene="Trpc3"
                     /gene_synonym="Mwk; Trcp3; Trp3; Trrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2368
                     /gene="Trpc3"
                     /gene_synonym="Mwk; Trcp3; Trp3; Trrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2369..2578
                     /gene="Trpc3"
                     /gene_synonym="Mwk; Trcp3; Trp3; Trrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2579..2662
                     /gene="Trpc3"
                     /gene_synonym="Mwk; Trcp3; Trp3; Trrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2663..2738
                     /gene="Trpc3"
                     /gene_synonym="Mwk; Trcp3; Trp3; Trrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2739..3659
                     /gene="Trpc3"
                     /gene_synonym="Mwk; Trcp3; Trp3; Trrp3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3557..3562
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trpc3"
                     /gene_synonym="Mwk; Trcp3; Trp3; Trrp3"
                     /note="hexamer: ATTAAA"
     polyA_site      3578
                     /gene="Trpc3"
                     /gene_synonym="Mwk; Trcp3; Trp3; Trrp3"
                     /note="major polyA site"
     regulatory      3633..3638
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trpc3"
                     /gene_synonym="Mwk; Trcp3; Trp3; Trrp3"
                     /note="hexamer: AATAAA"
     polyA_site      3659
                     /gene="Trpc3"
                     /gene_synonym="Mwk; Trcp3; Trp3; Trrp3"
ORIGIN      
        1 agaccgcgca cagccggcag cgcggccgcg gaccccaagc tccgctgcag gtcgcgcgct
       61 ccgcccgggc gtccccagct ccgcgggccc ggtgcttgac ccggggcagc tgggctgctg
      121 actgcgggcg gcagggagct tggccgctat gtccaccaag gtcaagaagt gccgggagcc
      181 cgcgagggtg accttgcccg ctccggagga ggaggaggat ggcgaggccg agggaggcga
      241 gtcgcagcgc cgccgccggg gctggagggg cgtcaacggc gggctggagc cgccctgccc
      301 gcgcgcgccg ccgtccccgg ggcccgacgc gtcgtcggag ggcagcccat ccaggtggcg
      361 cactgcgggg atgcgtgaca agggccggcg ccaggcagtg cgtggcccgg ccttcatgtt
      421 cggtgctcgt gggcccagcc tcacagctga ggaggagcgc ttcctggatg ctgcggagta
      481 cggcaacatc cctgtggtgc gcaagatgct ggaggagtct cgcacgctca atgtcaactg
      541 cgtggactac atgggccaga acgcactgca gctggctgta ggcaatgagc atctggaggt
      601 gaccgagctg ctgctgaaga aggagaacct ggcgcggatc ggtgatgcgc tgctgctagc
      661 catcagcaag ggctatgtgc gcatcgtgga ggccatcctg ggccacccag gctttgcagc
      721 cagccggcgc ctgaccctca gcccttgcga gcaagaactg cgagatgatg acttctatgc
      781 ttacgacgag gatggcacac gcttctcgcc tgacatcacg cccatcatcc tggctgcaca
      841 ctgccataag tacgaggtgg tgcacctgct gctactcaag ggtgcacgca tcgagaggcc
      901 acacgactac ttctgtcgct gctctgactg cgctgagaaa caaaggcttg acgccttcag
      961 ccactcaagg tctaggatca atgcctacaa gggactggcc agcccagcat acttgtcgct
     1021 gtccagcgag gaccccgtgc tcacagcact ggagctcagc aatgagctgg ccaagctggc
     1081 caacatagag aaggagttca agaatgacta caggaaactc tccatgcaat gcaaagactt
     1141 cgtagtgggt gtgctggacc tgtgtcggga ctcggaggag gtggaagcca ttctgaatgg
     1201 agatctggaa tcagccgagc ccctggaaag acacgggcac aaagcgtcac tgagtcgtgt
     1261 caaacttgcc attaagtatg aagtcaaaaa gtttgtggct caccccaact gccaacagca
     1321 gcttttgaca atctggtatg agaacctttc cggcctccgg gagcagacca tcgctatcaa
     1381 gtgtctggtc gtgttggtcg tggccttggg tcttccattc ctcgccatcg gctattggat
     1441 tgcaccttgt agcaggctgg ggaagattct tcgaagcccc ttcatgaagt ttgtggccca
     1501 cgctgcctcc ttcatcatct ttctgggtct gcttgtattc aacgcctcgg acagatttga
     1561 aggcatcacc acgctgccaa acatcactgt tatcgactac cccaagcaaa tcttcagggt
     1621 gaagaccacc cagttcacgt ggacggaaat gttaattatg gtctgggttc ttgggatgat
     1681 gtggtctgag tgcaaggagc tgtggctgga ggggccccgg gagtacatcg tgcagttgtg
     1741 gaatgtgctt gatttcggca tgctctccat cttcatcgcc gcgttcacag ccaggttcct
     1801 cgctttcctg caggccacga aggcgcagca gtatgtggat agtcacgtgc aggagagcga
     1861 tctgagcgaa gtcacgctcc cacctgaggt tcaatatttc acctatgcta gagacaaatg
     1921 gctcccctca gaccctcaga tcatatctga agggctctat gccatagctg tggtgctcag
     1981 cttctcccgg attgcgtaca tcctccctgc aaacgagagc tttgggccct tgcagatctc
     2041 tcttggaagg actgtgaagg acatattcaa gttcatggtt ctcttcatta tggtgttcct
     2101 ggctttcatg attggcatgt tcatacttta ttcttactac cttggggcca aagtaaatcc
     2161 tgcttttacc acggttgaag aaagtttcaa gactttgttt tggtccatat ttggactgtc
     2221 tgaagtgact tctgttgtcc tcaaatatga tcacaaattc atagagaata ttggctatgt
     2281 tctttatggg atatataatg taactatggt ggtcgtttta ctcaacatgc taattgctat
     2341 gattaatagc tcataccaag agatcgagga tgacagtgat gtagaatgga agtttgctcg
     2401 ttccaaactt tggctctcct acttcgatga tggaaaaaca ttacctccac ccttcagtct
     2461 ggtccctagt ccaaaatcat ttgtttactt catcatgagg atcactaact tttccaaatg
     2521 caggaggaga agactgcaga aggatctgga actgggcatg ggtaactcaa agtccaggtt
     2581 aaacctcttc acacagtcta actcgagagt ttttgaatca cacagtttta acagcattct
     2641 caatcagcca acacgatatc agcagataat gaaaagactc ataaaacggt atgttttgaa
     2701 agcacaagta gacaaagaaa acgatgaggt gaatgaaggt gaactgaaag aaatcaagca
     2761 ggatatctcc agccttcgtt atgaactttt agaagataag agccaagcga cggaggaatt
     2821 agccatcttg attcataaac tcagtgagaa actgaacccc agtgtgctga gatgtgagtg
     2881 aggcagccac ctgcagtcaa gccttgacta tagcacaacg tgggcaataa tactcctaag
     2941 tatgaaatac ttgaaaaact atggtgtaga gctctagtgt tccctacctt tatcatgcga
     3001 aactttaaaa ttaagctagg cggtcatgat tcccattaca tgaaatggtt ccagcagttg
     3061 acctcggcac tgtacgcagt gagatgctat tgtacttaga agcccagtat taatgtcact
     3121 gacagttttt gtcattcttg tctttatgtc acctgttggc ctccaagagt tccttggggg
     3181 acagggtcca cagcgatctc atcttcatgt ctcccacatt tagtacagtg cctgatacat
     3241 agtaggtgct tggtgaatgt gaaaccaaat ggccgtccag ccagttgcat ccaagagcag
     3301 acgagagacc atcactgagt agcatacgtt ctcatccaaa cgctgaagca ggtttttgtt
     3361 ttttgttttt ttaaatagaa actgaagatg ttttacaacc agctatgact tgtggagatc
     3421 tttcttagac ttttagatgc tgctgacaat tctaggatgt tggaaatgca agtgaagaat
     3481 ttaacaggga aatgagctaa ttgaaagtac ggttacacta catatttaaa tttcatgggg
     3541 ttgttcaaaa attatcatta aagatttttt ctaaaatata cgcttgtgtc ttttctcttt
     3601 gtatttgtgg tttctgatgt gaatatttag tcaataaaga ttttttttaa gttgggtta
//
