LOCUS       NM_001109897            3342 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus transient receptor potential cation channel, subfamily
            C, member 2 (Trpc2), mRNA.
ACCESSION   NM_001109897
VERSION     NM_001109897.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3342)
  AUTHORS   Lin,Y., Gao,R., Jing,D., Liu,Y., Da,H., Birnbaumer,L., Yang,Y.,
            Gao,X., Gao,Z. and Cao,Q.
  TITLE     TRPC absence induces pro-inflammatory macrophage polarization to
            promote obesity and exacerbate colorectal cancer
  JOURNAL   Front Pharmacol 15, 1392328 (2024)
   PUBMED   38835669
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3342)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3342)
  AUTHORS   Pfau,D.R., Baribeau,S., Brown,F., Khetarpal,N., Marc Breedlove,S.
            and Jordan,C.L.
  TITLE     Loss of TRPC2 function in mice alters sex differences in brain
            regions regulating social behaviors
  JOURNAL   J Comp Neurol 531 (15), 1550-1561 (2023)
   PUBMED   37496437
  REMARK    GeneRIF: Loss of TRPC2 function in mice alters sex differences in
            brain regions regulating social behaviors.
REFERENCE   4  (bases 1 to 3342)
  AUTHORS   Weiss,J., Vacher,H., Trouillet,A.C., Leinders-Zufall,T., Zufall,F.
            and Chamero,P.
  TITLE     Sensing and avoiding sick conspecifics requires Galphai2+
            vomeronasal neurons
  JOURNAL   BMC Biol 21 (1), 152 (2023)
   PUBMED   37424020
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3342)
  AUTHORS   Yang,T., Bayless,D.W., Wei,Y., Landayan,D., Marcelo,I.M., Wang,Y.,
            DeNardo,L.A., Luo,L., Druckmann,S. and Shah,N.M.
  TITLE     Hypothalamic neurons that mirror aggression
  JOURNAL   Cell 186 (6), 1195-1211 (2023)
   PUBMED   36796363
  REMARK    Erratum:[Cell. 2024 Jul 11;187(14):3782. doi:
            10.1016/j.cell.2024.05.046.. PMID: 38815581]
REFERENCE   6  (bases 1 to 3342)
  AUTHORS   Morsli,H., Tuorto,F., Choo,D., Postiglione,M.P., Simeone,A. and
            Wu,D.K.
  TITLE     Otx1 and Otx2 activities are required for the normal development of
            the mouse inner ear
  JOURNAL   Development 126 (11), 2335-2343 (1999)
   PUBMED   10225993
REFERENCE   7  (bases 1 to 3342)
  AUTHORS   Liman,E.R., Corey,D.P. and Dulac,C.
  TITLE     TRP2: a candidate transduction channel for mammalian pheromone
            sensory signaling
  JOURNAL   Proc Natl Acad Sci U S A 96 (10), 5791-5796 (1999)
   PUBMED   10318963
  REMARK    GeneRIF: channel expressed specifically in sensory microvilli of
            the vomeronasal organ and likely to mediate pheromone sensory
            transduction.
REFERENCE   8  (bases 1 to 3342)
  AUTHORS   Vannier,B., Peyton,M., Boulay,G., Brown,D., Qin,N., Jiang,M.,
            Zhu,X. and Birnbaumer,L.
  TITLE     Mouse trp2, the homologue of the human trpc2 pseudogene, encodes
            mTrp2, a store depletion-activated capacitative Ca2+ entry channel
  JOURNAL   Proc Natl Acad Sci U S A 96 (5), 2060-2064 (1999)
   PUBMED   10051594
REFERENCE   9  (bases 1 to 3342)
  AUTHORS   Yamazaki,K., Okada,T., Mori,Y. and Tanaka,I.
  TITLE     Genetic mapping of mouse transient receptor potential (Trrp) genes
            responsible for capacitative calcium entry channels to chromosomes
            3, 7, 9, and X
  JOURNAL   Genomics 51 (2), 303-305 (1998)
   PUBMED   9722956
REFERENCE   10 (bases 1 to 3342)
  AUTHORS   Zhu,X., Jiang,M., Peyton,M., Boulay,G., Hurst,R., Stefani,E. and
            Birnbaumer,L.
  TITLE     trp, a novel mammalian gene family essential for agonist-activated
            capacitative Ca2+ entry
  JOURNAL   Cell 85 (5), 661-671 (1996)
   PUBMED   8646775
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC150275.2 and AC132297.4.
            
            On Nov 13, 2013 this sequence version replaced NM_001109897.1.
            
            Sequence Note: The RefSeq transcript was derived from the reference
            genome assembly. The genomic coordinates were determined from
            alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF230803.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                AC150275.2         220804-220874
            72-791              AC150275.2         221549-222268
            792-1004            AC150275.2         224086-224298
            1005-1169           AC132297.4         128626-128790
            1170-1344           AC132297.4         129226-129400
            1345-1545           AC132297.4         130211-130411
            1546-1708           AC132297.4         131023-131185
            1709-1801           AC132297.4         131633-131725
            1802-1994           AC132297.4         134640-134832
            1995-2122           AC132297.4         135338-135465
            2123-2201           AC132297.4         135605-135683
            2202-2334           AC132297.4         136278-136410
            2335-3342           AC132297.4         136967-137974
FEATURES             Location/Qualifiers
     source          1..3342
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.71 cM"
     gene            1..3342
                     /gene="Trpc2"
                     /gene_synonym="3010009O07Rik; mTrp2; smTRPC2; trp2;
                     TRPC2a; TRPC2b; Trrp2"
                     /note="transient receptor potential cation channel,
                     subfamily C, member 2"
                     /db_xref="GeneID:22064"
                     /db_xref="MGI:MGI:109527"
     exon            1..71
                     /gene="Trpc2"
                     /gene_synonym="3010009O07Rik; mTrp2; smTRPC2; trp2;
                     TRPC2a; TRPC2b; Trrp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..2729
                     /gene="Trpc2"
                     /gene_synonym="3010009O07Rik; mTrp2; smTRPC2; trp2;
                     TRPC2a; TRPC2b; Trrp2"
                     /note="transient receptor potential 2-like protein"
                     /codon_start=1
                     /product="short transient receptor potential channel 2"
                     /protein_id="NP_001103367.1"
                     /db_xref="CCDS:CCDS52333.1"
                     /db_xref="GeneID:22064"
                     /db_xref="MGI:MGI:109527"
                     /translation="MDPLSPQPNWTEIVNKKLKFPPTLLRAIQEGQLGLVQQLLESSS
                     DASGAGPGGPLRNVEESEDRSWREALNLAIRLGHEVITDVLLANVKFDFRQIHEALLV
                     AVDTNQPAVVRRLLARLEREKGRKVDTKSFSLAFFDSSIDGSRFAPGVTPLTLACQKD
                     LYEIAQLLMDQGHTIARPHPVSCACLECSNARRYDLLKFSLSRINTYRGIASRAHLSL
                     ASEDAMLAAFQLSRELRRLARKEPEFKPQYIALESLCQDYGFELLGMCRNQSEVTAVL
                     NDLGEDSETEPEAEGLGQAFEEGIPNLARLRLAVNYNQKQFVAHPICQQVLSSIWCGN
                     LAGWRGSTTIWKLFVAFLIFLTMPFLCIGYWLAPKSQLGRLLKIPVLKFLLHSASYLW
                     FLIFLLGESLVMETQLSTFKGRSQSVWETSLHMIWVTGFLWFECKEVWIEGLRSYLLD
                     WWNFLDVVILSLYLASFALRLLLAGLAYMHCRDASDSTTCRYFTTAERSEWRTEDPQF
                     LAEVLFAVTSMLSFTRLAYILPAHESLGTLQISIGKMIDDMIRFMFILMIILTAFLCG
                     LNNIYVPYQESEKLGNFNETFQFLFWTMFGMEEHTVVDMPQFLVPEFVGRAMYGIFTI
                     VMVIVLLNMLIAMITNSFQKIEDDADVEWKFARSKLYLSYFREGLTLPVPFNILPSPK
                     AAFYLVRRIFRFLCCGSSCCKAKKSDYPPIGTFTNPGARAGSAGEGERVSYRLRVIKA
                     LVQRYIETARREFEETRRKDLGNRLTELTKTVSRLQSEVASVQKNLAAGGAPRPPDGA
                     SILSRYITRVRNSFQNLGPPTSDTPAELTMPGIVETEVSLGDGLDGTGEAGAPAPGEP
                     GSSSSAHVLVHREQEAEGSGDLLLEGDLETKGES"
     exon            72..791
                     /gene="Trpc2"
                     /gene_synonym="3010009O07Rik; mTrp2; smTRPC2; trp2;
                     TRPC2a; TRPC2b; Trrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            792..1004
                     /gene="Trpc2"
                     /gene_synonym="3010009O07Rik; mTrp2; smTRPC2; trp2;
                     TRPC2a; TRPC2b; Trrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1169
                     /gene="Trpc2"
                     /gene_synonym="3010009O07Rik; mTrp2; smTRPC2; trp2;
                     TRPC2a; TRPC2b; Trrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1344
                     /gene="Trpc2"
                     /gene_synonym="3010009O07Rik; mTrp2; smTRPC2; trp2;
                     TRPC2a; TRPC2b; Trrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1545
                     /gene="Trpc2"
                     /gene_synonym="3010009O07Rik; mTrp2; smTRPC2; trp2;
                     TRPC2a; TRPC2b; Trrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1708
                     /gene="Trpc2"
                     /gene_synonym="3010009O07Rik; mTrp2; smTRPC2; trp2;
                     TRPC2a; TRPC2b; Trrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1801
                     /gene="Trpc2"
                     /gene_synonym="3010009O07Rik; mTrp2; smTRPC2; trp2;
                     TRPC2a; TRPC2b; Trrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..1994
                     /gene="Trpc2"
                     /gene_synonym="3010009O07Rik; mTrp2; smTRPC2; trp2;
                     TRPC2a; TRPC2b; Trrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2122
                     /gene="Trpc2"
                     /gene_synonym="3010009O07Rik; mTrp2; smTRPC2; trp2;
                     TRPC2a; TRPC2b; Trrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2201
                     /gene="Trpc2"
                     /gene_synonym="3010009O07Rik; mTrp2; smTRPC2; trp2;
                     TRPC2a; TRPC2b; Trrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2202..2334
                     /gene="Trpc2"
                     /gene_synonym="3010009O07Rik; mTrp2; smTRPC2; trp2;
                     TRPC2a; TRPC2b; Trrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2335..3342
                     /gene="Trpc2"
                     /gene_synonym="3010009O07Rik; mTrp2; smTRPC2; trp2;
                     TRPC2a; TRPC2b; Trrp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaggcagag ctggagttca agcattcagc ccctgcccac agaggtgggt gcagccatgg
       61 accccctttc gccacagccc aactggactg agattgtgaa caaaaagctc aaattccccc
      121 ccacactcct gcgtgccatc caggagggcc agctgggtct tgtgcagcag ctgctggaat
      181 ccagttccga tgcctcgggt gctgggccag gtggtcctct gcggaatgtg gaagagtctg
      241 aggaccgctc ctggagggaa gccctcaacc tggccatccg cctgggccac gaggtcatca
      301 ctgatgttct gctggccaat gtcaaattcg actttcggca gatccacgaa gccctgctag
      361 tggctgtgga cacaaaccag ccagcagtgg tgcgtcgcct gctagcgcgg ctggagcggg
      421 agaaaggtcg aaaagtagac accaagtctt tctctctagc cttctttgac tcatcgattg
      481 atggctcccg ctttgcccct ggtgtcactc cactcacact ggcctgccag aaggacctgt
      541 atgagattgc ccagctgctt atggaccagg gccataccat tgctcggccc cacccagttt
      601 cctgtgcctg cctcgagtgc agcaatgccc gccgatacga cctgctgaag ttctcactat
      661 cccgaatcaa cacctaccga ggcattgcaa gccgggctca cctctcgctg gccagtgagg
      721 atgccatgct ggccgctttt cagctcagcc gggagctcag gcgccttgca cgaaaggagc
      781 ctgagtttaa gcctcagtac attgccctgg agtctctctg ccaggactat ggcttcgagt
      841 tgctgggcat gtgccgaaat cagagtgagg tcaccgcagt gctcaatgac ctgggtgagg
      901 atagtgagac tgagcctgag gctgagggcc tgggtcaggc ctttgaggag ggcatcccca
      961 acctggcaag actgcggttg gctgtcaact acaaccagaa acagtttgta gcacatccca
     1021 tctgccagca agttctgtct tccatctggt gtgggaacct ggctggctgg cgtggaagca
     1081 ccaccatctg gaagctcttt gttgccttcc tcatcttcct caccatgccc ttcctctgca
     1141 ttggctactg gctggcgccc aagtcccagc tgggccgcct gctgaagatc ccggtgctga
     1201 agttcctgct gcattctgcc tcctacctgt ggttccttat cttcttgctg ggagagtctc
     1261 tggtcatgga gacccagctg agcaccttca aaggccgcag ccagagtgtc tgggagactt
     1321 cactacatat gatctgggtc acaggcttcc tatggtttga atgcaaggag gtgtggatcg
     1381 agggcttgcg gagctacctc ctggactggt ggaacttcct ggacgtggtc atcctgtccc
     1441 tgtacttggc atcctttgca ctgcgcctcc tcctggctgg gcttgcctac atgcactgcc
     1501 gtgatgcctc agacagcacc acctgccgct atttcaccac agctgagaga agtgagtggc
     1561 gtacagagga cccccagttt ctggctgagg tgctctttgc tgtcaccagc atgctcagct
     1621 tcacccgact ggcatatatt ctgccagctc acgaatcgct gggcacactg cagatctcca
     1681 tcggcaagat gattgacgac atgatccggt tcatgttcat cctcatgatc atcctgactg
     1741 ccttcctctg tggcctcaac aacatctatg tgccctacca ggaatccgag aagctaggca
     1801 atttcaacga aacgttccag tttctctttt ggaccatgtt cggcatggaa gagcacacag
     1861 tggtggacat gcctcagttc ctggtgcctg agttcgtggg cagggccatg tacggcatct
     1921 ttaccatcgt catggtcatt gtgctactta acatgcttat tgccatgatc accaactcct
     1981 tccagaagat cgaggatgat gctgatgtgg agtggaagtt tgctcgctcc aagctctacc
     2041 tgtcctactt ccgagagggt ctgacgctgc ctgtgccctt taacatcctg ccatccccaa
     2101 aggccgcctt ctacctcgtc aggagaattt tccggttcct ttgctgtggc tcctcctgct
     2161 gcaaagccaa gaagtcggac tacccgccca tcgggacctt taccaacccc ggggcaaggg
     2221 cgggctccgc cggggaagga gaacgcgtgt cctaccgcct tcgagtcatc aaggctctgg
     2281 tgcagcgcta catagagact gcccggcgcg agttcgagga gacccgtcgg aaagacctgg
     2341 gcaacagact gacagagctg accaagactg tgtctcgact gcaaagcgag gtggccagtg
     2401 tgcagaagaa cctggcggcg ggaggggcac cacggcctcc ggatggtgcc agcatcctca
     2461 gtagatacat cacccgagtg cgcaacagct tccagaacct gggcccccct acctctgaca
     2521 ccccagcaga gctgactatg cctgggattg tggagaccga agtctcttta ggagatggcc
     2581 ttgatggcac aggtgaagct ggagctcccg ctcctggaga gcccggctct tcctcctctg
     2641 cccatgtgct ggttcacagg gagcaagaag cagaggggtc aggggacttg ctcctggaag
     2701 gagatctgga gaccaagggc gagtcctaag gcaacagaag ggtctcttct gtcactaagt
     2761 gcagctgctg tgttgggtag agccagggtc tcacagtaga agaccatggt gctttttaat
     2821 attattatta tttattttat tttattttat tttatttgtt tttttgcctc agtaaaattt
     2881 ctgctgtgga agtcagatgg tagtctccat ctcttggcat cctaagattc cttcctttac
     2941 ttcccctaaa atggacgctg tgggaggagg gaagagagaa acagcttgct ttgagttctg
     3001 gggtttagaa tcctactttt gggattcctt aggtctttag tgaaaaacgt tctggcctag
     3061 gagactggaa gactgggagc taggaggcca gagaagcagg agacctgagt gggtaggtct
     3121 gagagatggg aggcctggag gtggtgccct ttcttggcct ggcattctct tcagggatgg
     3181 gtatcaatct atcccctccc tgacttcatg aggcccctgt ggctgttaag aagcatcagg
     3241 cacagaggct acaatgtgtg acccggatga ctgggaaatt agtttccatc cctcgacttt
     3301 caagcttgtc aaggacaaat gacgtcatgc aataaaccag tc
//
