LOCUS       NM_011643               4549 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus transient receptor potential cation channel, subfamily
            C, member 1 (Trpc1), transcript variant 1, mRNA.
ACCESSION   NM_011643
VERSION     NM_011643.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4549)
  AUTHORS   Broker-Lai,J., Rego Terol,J., Richter,C., Mathar,I., Wirth,A.,
            Kopf,S., Moreno-Perez,A., Buttner,M., Tan,L.L., Makke,M.,
            Poschet,G., Hermann,J., Tsvilovskyy,V., Haberkorn,U.,
            Wartenberg,P., Susperreguy,S., Berlin,M., Ottenheijm,R.,
            Philippaert,K., Wu,M., Wiedemann,T., Herzig,S., Belkacemi,A.,
            Levinson,R.T., Agarwal,N., Camacho Londono,J.E., Klebl,B.,
            Dinkel,K., Zufall,F., Nussbaumer,P., Boehm,U., Hell,R., Nawroth,P.,
            Birnbaumer,L., Leinders-Zufall,T., Kuner,R., Zorn,M., Bruns,D.,
            Schwarz,Y. and Freichel,M.
  TITLE     TRPC5 controls the adrenaline-mediated counter regulation of
            hypoglycemia
  JOURNAL   EMBO J 43 (23), 5813-5836 (2024)
   PUBMED   39375537
REFERENCE   2  (bases 1 to 4549)
  AUTHORS   Atkins,R.M., Pantalia,M., Skaggs,C., Lau,A.K., Mahmood,M.B.,
            Anwar,M.M., Barron,L., Eby,B., Khan,U., Tsiokas,L. and Lau,K.
  TITLE     Normotensive metabolic syndrome in Transient Receptor Potential
            Canonical Channel type 1 Trpc1-/- mice
  JOURNAL   Biol Open 13 (7) (2024)
   PUBMED   38885005
  REMARK    GeneRIF: Normotensive metabolic syndrome in Transient Receptor
            Potential Canonical Channel type 1 Trpc1-/- mice.
REFERENCE   3  (bases 1 to 4549)
  AUTHORS   Naillat,F., Deshar,G., Hankkila,A., Rak-Raszewska,A., Sharma,A.,
            Prunskaite-Hyyrylainen,R., Railo,A., Shan,J. and Vainio,S.J.
  TITLE     Calcium signaling induces partial EMT and renal fibrosis in a
            Wnt4mCherry knock-in mouse model
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167180 (2024)
   PUBMED   38653356
REFERENCE   4  (bases 1 to 4549)
  AUTHORS   Lin,Y., Gao,R., Jing,D., Liu,Y., Da,H., Birnbaumer,L., Yang,Y.,
            Gao,X., Gao,Z. and Cao,Q.
  TITLE     TRPC absence induces pro-inflammatory macrophage polarization to
            promote obesity and exacerbate colorectal cancer
  JOURNAL   Front Pharmacol 15, 1392328 (2024)
   PUBMED   38835669
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4549)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 4549)
  AUTHORS   Schrick,J.J. and Lingrel,J.B.
  TITLE     cDNA cloning, mapping and expression of the mouse propionyl CoA
            carboxylase beta (pccb), the gene for human type II propionic
            acidaemia
  JOURNAL   Gene 264 (1), 147-152 (2001)
   PUBMED   11245989
REFERENCE   7  (bases 1 to 4549)
  AUTHORS   Zhu,X. and Birnbaumer,L.
  TITLE     Calcium Channels Formed by Mammalian Trp Homologues
  JOURNAL   News Physiol Sci 13, 211-217 (1998)
   PUBMED   11390792
REFERENCE   8  (bases 1 to 4549)
  AUTHORS   Yamazaki,K., Okada,T., Mori,Y. and Tanaka,I.
  TITLE     Genetic mapping of mouse transient receptor potential (Trrp) genes
            responsible for capacitative calcium entry channels to chromosomes
            3, 7, 9, and X
  JOURNAL   Genomics 51 (2), 303-305 (1998)
   PUBMED   9722956
REFERENCE   9  (bases 1 to 4549)
  AUTHORS   Sakura,H. and Ashcroft,F.M.
  TITLE     Identification of four trp1 gene variants murine pancreatic
            beta-cells
  JOURNAL   Diabetologia 40 (5), 528-532 (1997)
   PUBMED   9165220
REFERENCE   10 (bases 1 to 4549)
  AUTHORS   Zhu,X., Jiang,M., Peyton,M., Boulay,G., Hurst,R., Stefani,E. and
            Birnbaumer,L.
  TITLE     trp, a novel mammalian gene family essential for agonist-activated
            capacitative Ca2+ entry
  JOURNAL   Cell 85 (5), 661-671 (1996)
   PUBMED   8646775
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091531.9 and AC157947.2.
            
            On May 14, 2019 this sequence version replaced NM_011643.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC137581.1, U73625.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-681               AC091531.9         114629-115309
            682-836             AC157947.2         3603-3757
            837-938             AC157947.2         10033-10134
            939-1141            AC157947.2         14745-14947
            1142-1273           AC157947.2         20398-20529
            1274-1469           AC157947.2         23664-23859
            1470-1806           AC157947.2         25485-25821
            1807-1946           AC157947.2         29295-29434
            1947-2090           AC157947.2         30728-30871
            2091-2266           AC157947.2         36663-36838
            2267-2468           AC157947.2         38107-38308
            2469-2663           AC157947.2         38559-38753
            2664-4549           AC157947.2         39987-41872
FEATURES             Location/Qualifiers
     source          1..4549
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 50.2 cM"
     gene            1..4549
                     /gene="Trpc1"
                     /gene_synonym="Mtrp1; Trp1; Trrp1"
                     /note="transient receptor potential cation channel,
                     subfamily C, member 1"
                     /db_xref="GeneID:22063"
                     /db_xref="MGI:MGI:109528"
     exon            1..681
                     /gene="Trpc1"
                     /gene_synonym="Mtrp1; Trp1; Trrp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             510..2891
                     /gene="Trpc1"
                     /gene_synonym="Mtrp1; Trp1; Trrp1"
                     /note="isoform 1 is encoded by transcript variant 1; short
                     transient receptor potential channel 1; trp-related
                     protein 1; transient receptor protein 1"
                     /codon_start=1
                     /product="short transient receptor potential channel 1
                     isoform 1"
                     /protein_id="NP_035773.2"
                     /db_xref="CCDS:CCDS23411.1"
                     /db_xref="GeneID:22063"
                     /db_xref="MGI:MGI:109528"
                     /translation="MMAALYPSTDLSGVSSSSLPSSPSSSSPNEVMALKDVREVKEEN
                     TLNEKLFLLACDKGDYYMVKKILEENSSGDLNINCVDVLGRNAVTITIENESLDILQL
                     LLDYGCQSADALLVAIDSEVVGAVDILLNHRPKRSSRPTIVKLMERIQNPEYSTTMDV
                     APVILAAHRNNYEILTMLLKQDVSLPKPHAVGCECTLCSAKNKKDSLRHSRFRLDIYR
                     CLASPALIMLTEEDPILRAFELSADLKELSLVEVEFRNDYEELARQCKMFAKDLLAQA
                     RNSRELEVILNHTSSDEPLDKRGLLEERMNLSRLKLAIKYNQKEFVSQSNCQQFLNTV
                     WFGQMSGYRRKPTCKKIMTVLTVGIFWPVLSLCYLIAPKSQFGRIIHTPFMKFIIHGA
                     SYFTFLLLLNLYSLVYNEDKKNTMGPALERIDYLLILWIIGMIWSDIKRLWYEGLEDF
                     LEESRNQLSFVMNSLYLATFALKVVAHNKFHDFADRKDWDAFHPTLVAEGLFAFANVL
                     SYLRLFFMYTTSSILGPLQISMGQMLQDFGKFLGMFLLVLFSFTIGLTQLYDKGYTSK
                     EQKDCVGIFCEQQSNDTFHSFIGTCFALFWYIFSLAHVAIFVTRFSYGEELQSFVGAV
                     IVGTYNVVVVIVLTKLLVAMLHKSFQLIANHEDKEWKFARAKLWLSYFDDKCTLPPPF
                     NIIPSPKTICYMISSLSKWICSHTSKGKVKRQNSLKEWRNLKQKRDENYQKVMCCLVH
                     RYLTSMRQKMQSTDQATVENLNELRQDLSKFRNEIRDLLGFRTSKYAMFYPRN"
     exon            682..836
                     /gene="Trpc1"
                     /gene_synonym="Mtrp1; Trp1; Trrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            837..938
                     /gene="Trpc1"
                     /gene_synonym="Mtrp1; Trp1; Trrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1141
                     /gene="Trpc1"
                     /gene_synonym="Mtrp1; Trp1; Trrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1273
                     /gene="Trpc1"
                     /gene_synonym="Mtrp1; Trp1; Trrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1469
                     /gene="Trpc1"
                     /gene_synonym="Mtrp1; Trp1; Trrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1806
                     /gene="Trpc1"
                     /gene_synonym="Mtrp1; Trp1; Trrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1946
                     /gene="Trpc1"
                     /gene_synonym="Mtrp1; Trp1; Trrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2090
                     /gene="Trpc1"
                     /gene_synonym="Mtrp1; Trp1; Trrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2266
                     /gene="Trpc1"
                     /gene_synonym="Mtrp1; Trp1; Trrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..2468
                     /gene="Trpc1"
                     /gene_synonym="Mtrp1; Trp1; Trrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..2663
                     /gene="Trpc1"
                     /gene_synonym="Mtrp1; Trp1; Trrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2664..4549
                     /gene="Trpc1"
                     /gene_synonym="Mtrp1; Trp1; Trrp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4525..4530
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trpc1"
                     /gene_synonym="Mtrp1; Trp1; Trrp1"
                     /note="hexamer: AATAAA"
     polyA_site      4549
                     /gene="Trpc1"
                     /gene_synonym="Mtrp1; Trp1; Trrp1"
                     /note="major polyA site"
ORIGIN      
        1 gcggggctga ggatgacgtg aggagaaagc cgcgaacctc tgcctcctgt gggtgctgct
       61 gggccagcgg ttcccacagc cccggagcca gacgtgctgc gaagcgcacc gccgagctct
      121 ccggccggcg gccccctcac tccctcccag gccgggccgc tccctgtgcg gcccctgcgg
      181 ctcctggcac ggccccgcgc tcggctgccg ccctggcgcg ctccactctg tcgtccccgg
      241 acgggcgcgg accagctcga ccggggcgcc ggcggctggg cagagggcgc tggccccggg
      301 gccgcgccag cgcggccacc aacctggggc tgtccgtgga gggcgagtgc tggtttcggg
      361 gcgaggcgac gcccttcggg gccaacgggc cgcacgccga tgtggccgtg ggaacgactc
      421 acccgttttc cagctcgggg tcggggtcgg ggtcggcgcc catgggggcc ccgcctccgt
      481 ctcctggcct gcccccgtcg tgggccgcga tgatggcggc cctgtacccg agcacggacc
      541 tctcgggcgt ctcctcctcc tccctgcctt cctccccatc ctcctcgtcg cccaacgaag
      601 tgatggcgct gaaggatgtg cgagaggtga aggaggagaa caccttgaat gagaagcttt
      661 tcttgctggc gtgcgacaag ggtgactatt atatggttaa aaagattttg gaggaaaaca
      721 gttcaggtga cttgaacata aattgcgtag atgtgcttgg gagaaatgct gttaccataa
      781 ctattgaaaa cgaaagcttg gacatactgc agctgctttt ggactacggt tgtcagtccg
      841 cagatgcact tttggtggca atcgactctg aagtagtggg agctgttgat atactactta
      901 atcatcggcc aaaacgatca tcaagaccaa ccattgtaaa acttatggaa cgaattcaga
      961 atccagaata ttcaacaacg atggatgtcg cacctgttat tttagctgct catcgtaaca
     1021 actatgaaat ccttacaatg cttttaaagc aggatgtgtc tttgcccaag ccccatgctg
     1081 ttggctgtga atgcacactg tgttctgcaa aaaacaagaa ggacagcctc agacattcca
     1141 ggtttcgtct tgatatctat agatgtctgg ccagtccagc tctgataatg ttaacagagg
     1201 aagatccaat tctgagagcg tttgaactta gtgctgactt aaaggaactc agccttgtgg
     1261 aggtggaatt caggaatgat tatgaagagc tagcccgtca gtgcaaaatg tttgctaaag
     1321 atttgctcgc acaagcccgg aattctcgtg aactggaagt tatcctgaac catacatcta
     1381 gcgatgagcc tcttgacaaa cgaggactac tagaagaaag aatgaactta agtcgtctga
     1441 aacttgctat caaatataac cagaaggagt ttgtctccca gtcaaattgc cagcagttcc
     1501 tgaacacggt ttggtttgga cagatgtcag gttaccgccg taagcccacc tgtaagaaga
     1561 taatgactgt tttgacagtt ggcatcttct ggccagtttt gtcactatgc tatttgatag
     1621 ctcccaaatc tcaatttggc agaatcattc acacaccttt catgaaattc attattcatg
     1681 gagcatcgta tttcacattc ttgctgttac taaatctcta ctcacttgtc tacaatgagg
     1741 acaagaaaaa tacaatggga ccagccctgg agagaataga ttaccttctc atactgtgga
     1801 ttattgggat gatttggtca gacattaaga gactgtggta tgaagggttg gaagacttcc
     1861 tagaagaatc gcgtaaccag ctcagctttg ttatgaattc cctttacttg gcaacctttg
     1921 ccctcaaagt ggtggctcac aacaagtttc atgactttgc tgaccggaag gactgggatg
     1981 cattccaccc cacgcttgta gcagaagggc tttttgcttt tgcaaacgtt ctgagttacc
     2041 ttcgactctt ttttatgtat acaaccagct ctattttggg cccactgcag atttcaatgg
     2101 gacagatgtt acaagatttt gggaaatttc tgggaatgtt cctccttgtt ctgttttcct
     2161 tcacgattgg actgactcag ctctatgaca aagggtacac ttccaaagag cagaaggact
     2221 gtgtgggcat cttctgcgaa cagcaaagca atgacacctt ccactcgttc attggcacct
     2281 gctttgctct gttctggtac atcttctcct tagcgcacgt ggccatcttt gtcaccaggt
     2341 ttagctatgg ggaagagctg cagtccttcg ttggagctgt gattgttgga acttacaatg
     2401 ttgtggttgt gattgtgctg acgaagctgc tcgtggcgat gcttcacaag agcttccagc
     2461 tgatagcaaa tcatgaggat aaagaatgga agtttgctcg agcaaagcta tggcttagct
     2521 actttgatga caaatgtaca ctgcccccac ctttcaacat tattccttct ccaaagacga
     2581 tctgctatat gatcagtagc ctcagtaaat ggatttgctc gcatacctcg aaaggcaagg
     2641 tcaaacgtca aaacagttta aaggagtgga gaaacttgaa gcaaaagaga gacgagaact
     2701 accagaaggt gatgtgctgc ctggtgcacc gctacctgac gtccatgcga cagaagatgc
     2761 agagcacaga ccaggccacc gtggagaacc tcaatgaact gcgccaagat ctgtcaaaat
     2821 tccgaaatga aataagggat ttgcttggct ttcggacttc taaatatgct atgttttatc
     2881 caagaaatta accattttct aaatgttgta gaaataattt tccataacag atctgaaaga
     2941 ctgtatttgc atacttgcaa ttaaatcaat taagatctat atgggcataa acaattacac
     3001 aaaagccatt ctttaaatat ttatagcata aatatatgtc atgtaaaata tgtatataga
     3061 gttagttttt taaaacctgt ctatggcttt ttgtagaagc aaacccgttt tgttcgcatg
     3121 ctcttttgtt ttcttagttg gtcagtgctt aactccatca tgtttaagag gggcagctat
     3181 cagtgtacac atggcccact ccattttata aaacaaagat cagcaaatgc agctacctta
     3241 agacacactt gaaatgaaga gctcatggtg tttaaatctc ttgttttagg agttcacaca
     3301 gagttcagta tattgcttag gagtatagtt tcatctaaaa taccctattt tttcttttgt
     3361 tagaatctta agcagcagag aaaagttcta gtaaatattt gaatttaagc cagtcatggt
     3421 aatgcacgcc tttaatgcca gcatacagga ggcagaggca ggcagatctc tgagttcaag
     3481 gccagcctgg tctacagagt gagtttcagg atagccagga ctacacagag aaatcctgtc
     3541 ttggaaaaaa tttatttatt tatgtctatc taaattcatc ttggtatttg tagtgtacta
     3601 tatttacttt tacatggtta taataatttt atatttttaa ttttgttttg acacattatt
     3661 ttatatctag ttctctatat tgaggtagtt tatatgttca agtatttata gaagtctgtg
     3721 atttttgaaa actagtagcc atcttttact catagaatat ttgttcatat ttatacattt
     3781 gcaacgctac ttctctaggt atttggttag tttagctttt ccttctacgt ttccaagttg
     3841 gagtaaaact caccattaca aagttgaagc tgcttgtcac cattcatgtg gtcacatgct
     3901 ggtcacagtg ggcttggctg gagaggcctg gagccctgag gaaagctgct ttcctttcag
     3961 ctgaaggctc ttgagcaact cttgcaaagt gttttcctca gagcctacca tagcttccac
     4021 aaaaggggcc tcgtgctcgc tgctagagat gtaaagcact gtttattcca tttgaaatag
     4081 aaagagaatc tgactgcctt tcagtgttca tgtgagggtg tgactgaagg tttcccagct
     4141 gtcgcatgaa cattcttgaa gagcgcttgg tgaatgtgag ccggcattga ggccagagtg
     4201 cagacagccc tggtctgtga gcaccaccta ccctggggca gctgaggatt ctagtgttag
     4261 ctttcatctt gctttttaca tttgttttta atgttcaggt ttaagtgttc cctcttttgg
     4321 gcaaattctt ataaaaatgt ttattgtaaa attatatatt ttgtctacaa tgggattatg
     4381 cgcttccaag ttgggatttt acatcaggat ttttagtcat tctaaaaaaa tacctaatta
     4441 ttaaaaaatt tatagagtac ctatgtgtgc atgagtaact gatggggtat attttgaatg
     4501 acagcatatt gtaagaaaaa agtgaataaa agttgacatt agatcataa
//
