LOCUS       NM_177781               4267 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus transient receptor potential cation channel, subfamily
            A, member 1 (Trpa1), transcript variant 1, mRNA.
ACCESSION   NM_177781
VERSION     NM_177781.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4267)
  AUTHORS   Titiz,M., Landini,L., Souza Monteiro de Araujo,D., Marini,M.,
            Seravalli,V., Chieca,M., Pensieri,P., Montini,M., De Siena,G.,
            Pasquini,B., Vannuccini,S., Iannone,L.F., Cunha,T.M.,
            Brancolini,G., Bellantoni,E., Scuffi,I., Mastricci,A., Tesi,M., Di
            Tommaso,M., Petraglia,F., Geppetti,P., Nassini,R. and De Logu,F.
  TITLE     Schwann cell C5aR1 co-opts inflammasome NLRP1 to sustain pain in a
            mouse model of endometriosis
  JOURNAL   Nat Commun 15 (1), 10142 (2024)
   PUBMED   39587068
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4267)
  AUTHORS   Singh,K., Jayaram,M., Hanumantharaju,A., Tonissoo,T., Jagomae,T.,
            Mikheim,K., Muthuraman,S., Gilbert,S.F., Plaas,M., Schafer,M.K.E.,
            Innos,J., Lillevali,K., Philips,M.A. and Vasar,E.
  TITLE     The IgLON family of cell adhesion molecules expressed in developing
            neural circuits ensure the proper functioning of the sensory system
            in mice
  JOURNAL   Sci Rep 14 (1), 22593 (2024)
   PUBMED   39349721
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4267)
  AUTHORS   Yadav,M., Chaudhary,P.P., Ratley,G., D'Souza,B., Kaur,M.,
            Ganesan,S., Kabat,J. and Myles,I.A.
  TITLE     TRPA1 Influences Staphylococcus aureus Skin Infection in Mice and
            Associates with HIF-1a and MAPK Pathway Modulation
  JOURNAL   Int J Mol Sci 25 (18), 9933 (2024)
   PUBMED   39337422
  REMARK    GeneRIF: TRPA1 Influences Staphylococcus aureus Skin Infection in
            Mice and Associates with HIF-1a and MAPK Pathway Modulation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4267)
  AUTHORS   Zhu,P., Tao,H., Chen,K., Chu,M., Wang,Q., Yang,X., Zhou,J., Yang,H.
            and Geng,D.
  TITLE     TRPA1 aggravates osteoclastogenesis and osteoporosis through
            activating endoplasmic reticulum stress mediated by SRXN1
  JOURNAL   Cell Death Dis 15 (8), 624 (2024)
   PUBMED   39191723
  REMARK    GeneRIF: TRPA1 aggravates osteoclastogenesis and osteoporosis
            through activating endoplasmic reticulum stress mediated by SRXN1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4267)
  AUTHORS   Yang,Y., Xiao,Z., Yang,W., Sun,Y., Sui,X., Lin,X., Yang,X., Bao,Z.,
            Cui,Z., Ma,Y., Li,W., Wang,S., Yang,J., Wang,Y. and Luo,Y.
  TITLE     Role of transient receptor potential ankyrin 1 in idiopathic
            pulmonary fibrosis: modulation of M2 macrophage polarization
  JOURNAL   Cell Mol Life Sci 81 (1), 187 (2024)
   PUBMED   38635081
  REMARK    GeneRIF: Role of transient receptor potential ankyrin 1 in
            idiopathic pulmonary fibrosis: modulation of M2 macrophage
            polarization.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4267)
  AUTHORS   Corey,D.P., Garcia-Anoveros,J., Holt,J.R., Kwan,K.Y., Lin,S.Y.,
            Vollrath,M.A., Amalfitano,A., Cheung,E.L., Derfler,B.H., Duggan,A.,
            Geleoc,G.S., Gray,P.A., Hoffman,M.P., Rehm,H.L., Tamasauskas,D. and
            Zhang,D.S.
  TITLE     TRPA1 is a candidate for the mechanosensitive transduction channel
            of vertebrate hair cells
  JOURNAL   Nature 432 (7018), 723-730 (2004)
   PUBMED   15483558
  REMARK    GeneRIF: Inhibition of TRPA1 protein expression in zebrafish and
            mouse inner ears inhibits receptor cell function [TRPA1]
REFERENCE   7  (bases 1 to 4267)
  AUTHORS   Smith,M.P., Beacham,D., Ensor,E. and Koltzenburg,M.
  TITLE     Cold-sensitive, menthol-insensitive neurons in the murine
            sympathetic nervous system
  JOURNAL   Neuroreport 15 (9), 1399-1403 (2004)
   PUBMED   15194861
REFERENCE   8  (bases 1 to 4267)
  AUTHORS   Bandell,M., Story,G.M., Hwang,S.W., Viswanath,V., Eid,S.R.,
            Petrus,M.J., Earley,T.J. and Patapoutian,A.
  TITLE     Noxious cold ion channel TRPA1 is activated by pungent compounds
            and bradykinin
  JOURNAL   Neuron 41 (6), 849-857 (2004)
   PUBMED   15046718
  REMARK    GeneRIF: TRPA1 activation elicits a painful sensation and provide a
            potential molecular model for why noxious cold can paradoxically be
            perceived as burning pain.
REFERENCE   9  (bases 1 to 4267)
  AUTHORS   Viswanath,V., Story,G.M., Peier,A.M., Petrus,M.J., Lee,V.M.,
            Hwang,S.W., Patapoutian,A. and Jegla,T.
  TITLE     Opposite thermosensor in fruitfly and mouse
  JOURNAL   Nature 423 (6942), 822-823 (2003)
   PUBMED   12815418
  REMARK    GeneRIF: functional comparison with Drosophila protein homologue
REFERENCE   10 (bases 1 to 4267)
  AUTHORS   Story,G.M., Peier,A.M., Reeve,A.J., Eid,S.R., Mosbacher,J.,
            Hricik,T.R., Earley,T.J., Hergarden,A.C., Andersson,D.A.,
            Hwang,S.W., McIntyre,P., Jegla,T., Bevan,S. and Patapoutian,A.
  TITLE     ANKTM1, a TRP-like channel expressed in nociceptive neurons, is
            activated by cold temperatures
  JOURNAL   Cell 112 (6), 819-829 (2003)
   PUBMED   12654248
  REMARK    GeneRIF: This protein was found only in dorsal root ganglia and
            responds to cold temperatures.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK045771.1 and AC121789.2.
            
            On Feb 8, 2017 this sequence version replaced NM_177781.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK045771.1, BC131963.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4159              AK045771.1         2-4160
            4160-4160           AC121789.2         129066-129066       c
            4161-4263           AK045771.1         4162-4264
            4264-4267           AC121789.2         128959-128962       c
FEATURES             Location/Qualifiers
     source          1..4267
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 4.5 cM"
     gene            1..4267
                     /gene="Trpa1"
                     /gene_synonym="Anktm1; TRPA1b"
                     /note="transient receptor potential cation channel,
                     subfamily A, member 1"
                     /db_xref="GeneID:277328"
                     /db_xref="MGI:MGI:3522699"
     exon            1..138
                     /gene="Trpa1"
                     /gene_synonym="Anktm1; TRPA1b"
                     /inference="alignment:Splign:2.1.0"
     exon            139..298
                     /gene="Trpa1"
                     /gene_synonym="Anktm1; TRPA1b"
                     /inference="alignment:Splign:2.1.0"
     exon            299..474
                     /gene="Trpa1"
                     /gene_synonym="Anktm1; TRPA1b"
                     /inference="alignment:Splign:2.1.0"
     exon            475..582
                     /gene="Trpa1"
                     /gene_synonym="Anktm1; TRPA1b"
                     /inference="alignment:Splign:2.1.0"
     exon            583..691
                     /gene="Trpa1"
                     /gene_synonym="Anktm1; TRPA1b"
                     /inference="alignment:Splign:2.1.0"
     exon            692..837
                     /gene="Trpa1"
                     /gene_synonym="Anktm1; TRPA1b"
                     /inference="alignment:Splign:2.1.0"
     exon            838..974
                     /gene="Trpa1"
                     /gene_synonym="Anktm1; TRPA1b"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1023
                     /gene="Trpa1"
                     /gene_synonym="Anktm1; TRPA1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1123
                     /gene="Trpa1"
                     /gene_synonym="Anktm1; TRPA1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1224
                     /gene="Trpa1"
                     /gene_synonym="Anktm1; TRPA1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1394
                     /gene="Trpa1"
                     /gene_synonym="Anktm1; TRPA1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1559
                     /gene="Trpa1"
                     /gene_synonym="Anktm1; TRPA1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1674
                     /gene="Trpa1"
                     /gene_synonym="Anktm1; TRPA1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1841
                     /gene="Trpa1"
                     /gene_synonym="Anktm1; TRPA1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..1935
                     /gene="Trpa1"
                     /gene_synonym="Anktm1; TRPA1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..1995
                     /gene="Trpa1"
                     /gene_synonym="Anktm1; TRPA1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..2094
                     /gene="Trpa1"
                     /gene_synonym="Anktm1; TRPA1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2165
                     /gene="Trpa1"
                     /gene_synonym="Anktm1; TRPA1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2331
                     /gene="Trpa1"
                     /gene_synonym="Anktm1; TRPA1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2421
                     /gene="Trpa1"
                     /gene_synonym="Anktm1; TRPA1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2422..2591
                     /gene="Trpa1"
                     /gene_synonym="Anktm1; TRPA1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2592..2721
                     /gene="Trpa1"
                     /gene_synonym="Anktm1; TRPA1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2722..2904
                     /gene="Trpa1"
                     /gene_synonym="Anktm1; TRPA1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2905..2973
                     /gene="Trpa1"
                     /gene_synonym="Anktm1; TRPA1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2974..3084
                     /gene="Trpa1"
                     /gene_synonym="Anktm1; TRPA1b"
                     /inference="alignment:Splign:2.1.0"
     exon            3085..3182
                     /gene="Trpa1"
                     /gene_synonym="Anktm1; TRPA1b"
                     /inference="alignment:Splign:2.1.0"
     exon            3183..4267
                     /gene="Trpa1"
                     /gene_synonym="Anktm1; TRPA1b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4239..4244
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trpa1"
                     /gene_synonym="Anktm1; TRPA1b"
                     /note="hexamer: AATAAA"
     polyA_site      4264
                     /gene="Trpa1"
                     /gene_synonym="Anktm1; TRPA1b"
                     /note="major polyA site"
ORIGIN      
        1 gcgccagccg gcgtccaggt ggagtcaatg aagcgcggct tgaggaggat tctgctcccg
       61 gaggaaagga aggaggtcca gggcgttgtc tatcgcggcg tcggggaaga catggactgc
      121 tccaaggaat cctttaaggt ggacattgaa ggagatatgt gtagattaga agacttcatc
      181 aagaaccgaa gaaaactaag caaatatgag gatgaaaatc tctgtcctct gcatcacgca
      241 gcagcagaag gtcaagttga actgatggaa ctgatcatca atggttcttc gtgtgaagtg
      301 ctgaatataa tggatggtta tggaaatacc ccactgcatt gtgctgcaga aaaaaatcaa
      361 gttgaaagtg taaagtttct tctcagccaa ggagcaaatc caaacctccg aaatagaaac
      421 atgatgtcac cccttcacat agctgtgcat ggcatgtaca acgaagtgat caaggtgttg
      481 actgagcaca aggccactaa catcaattta gaaggagaga atgggaacac ggctttgatg
      541 tccacgtgtg ccaaagacaa cagtgaagct ttgcaaattt tgttagaaaa aggagctaag
      601 ctgtgtaaat caaataagtg gggagactac cctgtgcacc aggcagcatt ttcaggtgcc
      661 aaaaaatgca tggaattaat cttagcatat ggtgaaaaga acggctacag cagggagact
      721 cacattaatt ttgtgaatca caagaaagcc agccctctcc acctagcagt tcaaagcgga
      781 gacttggaca tgattaagat gtgcctggac aacggtgcac acatcgacat gatggagaat
      841 gccaaatgca tggccctcca ttttgctgca acccagggag ccactgacat cgttaagctc
      901 atgatctcat cctataccgg aagtagtgat attgtgaatg cagttgatgg caatcaggag
      961 accctgcttc acagagcctc gttatttgat caccatgacc tggcagaata cctaatatca
     1021 gtgggagcag acatcaacag cactgattct gaaggacgct ctccacttat tttagcaaca
     1081 gcttctgcat cctggaacat tgtgaatttg ctcctctgta aaggtgccaa agtagacata
     1141 aaagatcatc ttggacgtaa ctttttgcat ttgactgtgc agcagcctta tggactaaga
     1201 aatttgcggc ctgagtttat gcagatgcaa cacatcaaag agctggtgat ggatgaagac
     1261 aatgacggat gcacacctct ccattatgcc tgtaggcagg gggttcctgt ctctgtaaat
     1321 aacctccttg gcttcaatgt gtccattcat agcaaaagta aagataagaa gtcgcccctg
     1381 cattttgcag ccagttatgg gcgcatcaat acatgtcaga gacttctgca agacataagt
     1441 gatacgaggc ttttgaatga aggggatctc catgggatga cccctctcca cctggcagca
     1501 aaaaatgggc atgataaagt cgttcaactc cttctgaaga aaggggcctt atttctcagt
     1561 gaccacaatg gctggactgc tttgcatcac gcctccatgg gtgggtacac tcagaccatg
     1621 aaggtcattc ttgatactaa cttgaaatgc acagaccgac tagatgaaga agggaacaca
     1681 gcactccact ttgcagcacg ggaaggccat gccaaggctg ttgcaatgct tttgagctac
     1741 aatgctgaca tcctcctgaa caagaagcaa gcttcctttc tgcatattgc cctgcacaat
     1801 aagcgcaagg aagtggttct cacaaccatc agaaataaaa gatgggatga gtgtcttcaa
     1861 gttttcactc ataattctcc aagcaatcga tgtccaatca tggagatggt agaatacctc
     1921 cccgagtgca tgaaagttct tttagatttc tgcatgatac cttccacaga agacaagtcc
     1981 tgtcaagact accatattga gtataatttc aagtatctcc aatgcccatt atccatgacc
     2041 aaaaaagtag cacctaccca ggatgtggta tatgagcctc ttacaatcct caatgtcatg
     2101 gtccaacata accgcataga actcctcaac caccctgtgt gtagggagta cttactcatg
     2161 aaatggtgtg cctatggatt cagagcccat atgatgaacc taggatctta ttgtcttggt
     2221 ctcataccca tgacccttct tgttgtcaaa atacagcctg gaatggcctt caattctact
     2281 ggaataatca atggaactag tagtactcat gaggaaagaa tagacactct gaattcattt
     2341 ccaataaaaa tatgtatgat tctagttttt ttatcaagta tatttggata ttgcaaagaa
     2401 gtgatccaaa ttttccaaca gaaaaggaat tacttcctgg attacaacaa tgctctggaa
     2461 tgggttatct atacaactag tatcatcttc gtgttgccct tgttcctcaa catcccagcg
     2521 tatatgcagt ggcaatgtgg agcaatagcg atattcttct actggatgaa cttcctactg
     2581 tatcttcaaa ggtttgagaa ctgtggaatt ttcattgtta tgttggaggt gatttttaaa
     2641 acattgctga gatcgaccgg agtgtttatc ttcctcctac tggcttttgg cctcagcttt
     2701 tatgttctcc tgaatttcca agatgccttc agcaccccat tgctttcctt aatccagaca
     2761 ttcagtatga tgctaggaga catcaattat cgagatgcct tcctagaacc attgtttaga
     2821 aatgagttgg catacccagt cctgaccttt gggcagctta ttgccttcac aatgtttgtc
     2881 ccaattgttc tcatgaactt actgattggc ttggcggttg gggacattgc tgaggtccag
     2941 aagcatgcgt cattgaagag gattgctatg caggtggaac ttcataccaa cttagaaaaa
     3001 aagctgccac tctggtactt acgcaaagtg gatcagaggt ccaccatcgt gtatccaaat
     3061 agacccaggc acggcaggat gctacggttt tttcattact ttcttaatat gcaagaaaca
     3121 cgacaagaag taccaaacat tgacacatgc ttggaaatgg aaatattgaa acagaaatat
     3181 cggctgaagg acctcacttc cctcttggaa aagcagcatg agctcatcaa actcatcatc
     3241 cagaagatgg agatcatctc agagacagaa gatgaagata accattgctc tttccaagac
     3301 aggttcaaga aggagaggct ggaacagatg cacagcaagt ggaattttgt cttaaacgca
     3361 gttaagacta aaacacattg ttctattagc cacccggact tttagttctg tgtcttatgg
     3421 gagtgggaga ctgctttaca tacttatttc agtgaatttc agtttggaaa agagcaaaga
     3481 aacagaaagt tgactaacat tgctgcatgg agatcctagt tcctgcaacc tcacccatac
     3541 atatgctcat atttcctgtc aattactatg tattgagaag atcctttctg acatgttcaa
     3601 tttgaacatg aaggatagtc tctttcgagt gaataaaaac cagggttgtt ggaatgcata
     3661 ttatggagga taagaattaa tgtaactatt aaggcagaac acaactacat aatacaagat
     3721 gcatataatt ccaagtatta tatttaatct cctaccatgt taaaccttcc tgtgttataa
     3781 cctgtctggg acactataat ctctgttcct actatgatta gatcatagtc tcaccctcct
     3841 cgtcccatca cacatgacat cattttgagc cacatgacag aagtcctagt tagtagactg
     3901 tgataagtat gaatgttaca atagaaatgt gttcccttag tgttcatcag ttgtgatggt
     3961 ttaaatgaga aacgttgccc acagactcat acatttaaac ccttagtccc agttgttgct
     4021 gctgcttagg ggggccacac agccttgctt gctctctcct ttctgagtgt ggagagaaat
     4081 gtgatcagta agactcctgc tcctgctgcc atgctcttta ttccattatg gacttcttct
     4141 gaaactgcaa gcagaaattc actgttcctt cctcaaattt cttttggtca tggtattata
     4201 tcatagcaac agaaactaac ttatgtacca atggtcttaa taaagaataa agcctgtaca
     4261 gtcactc
//
