LOCUS       NM_011642               4710 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus transformation related protein 73 (Trp73), transcript
            variant 1, mRNA.
ACCESSION   NM_011642 XM_989340
VERSION     NM_011642.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4710)
  AUTHORS   Ohyama,K., Shinohara,H.M., Takayama,N., Ogawa,R., Omura,S.,
            Hayashida,M. and Takahashi,T.
  TITLE     Differentiation stage-specific expression of transcriptional
            regulators for epithelial mesenchymal transition in dentate granule
            progenitors
  JOURNAL   Front Neurosci 18, 1425849 (2024)
   PUBMED   39268037
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4710)
  AUTHORS   Pastor-Morate,D., Amigo-Moran,L., Garranzo-Asensio,M.,
            Rejas-Gonzalez,R., Carnicero,P., Rodriguez,N., Perez-Robledo,J.P.,
            Barderas,R., Prieto-Nieto,I. and Dominguez,G.
  TITLE     DeltaNp73 and its effector targets promote colorectal peritoneal
            carcinosis and predict survival
  JOURNAL   J Pathol 263 (3), 328-337 (2024)
   PUBMED   38629257
  REMARK    GeneRIF: DeltaNp73 and its effector targets promote colorectal
            peritoneal carcinosis and predict survival.
REFERENCE   3  (bases 1 to 4710)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4710)
  AUTHORS   Richmond,B.W., Marshall,C.B., Blackburn,J.B., Tufenkjian,T.S.,
            Lehmann,B.D., Han,W., Newcomb,D., Gutor,S.S., Hunt,R.P.,
            Michell,D.L., Vickers,K.C., Polosukhin,V.V., Blackwell,T.S. and
            Pietenpol,J.A.
  TITLE     Loss of p73 Expression Contributes to Chronic Obstructive Pulmonary
            Disease
  JOURNAL   Am J Respir Crit Care Med 209 (2), 153-163 (2024)
   PUBMED   37931077
  REMARK    GeneRIF: Loss of p73 Expression Contributes to Chronic Obstructive
            Pulmonary Disease.
REFERENCE   5  (bases 1 to 4710)
  AUTHORS   Ho,K.H., Candat,A., Scarpetta,V., Faucourt,M., Weill,S., Salio,C.,
            D'Este,E., Meschkat,M., Wurm,C.A., Kneussel,M., Janke,C.,
            Magiera,M.M., Genovesio,A., Meunier,A., Sassoe-Pognetto,M.,
            Brill,M.S., Spassky,N. and Patrizi,A.
  TITLE     Choroid plexuses carry nodal-like cilia that undergo axoneme
            regression from early adult stage
  JOURNAL   Dev Cell 58 (23), 2641-2651 (2023)
   PUBMED   37890489
REFERENCE   6  (bases 1 to 4710)
  AUTHORS   Pozniak,C.D., Radinovic,S., Yang,A., McKeon,F., Kaplan,D.R. and
            Miller,F.D.
  TITLE     An anti-apoptotic role for the p53 family member, p73, during
            developmental neuron death
  JOURNAL   Science 289 (5477), 304-306 (2000)
   PUBMED   10894779
REFERENCE   7  (bases 1 to 4710)
  AUTHORS   Lohrum,M.A. and Vousden,K.H.
  TITLE     Regulation and function of the p53-related proteins: same family,
            different rules
  JOURNAL   Trends Cell Biol 10 (5), 197-202 (2000)
   PUBMED   10754563
  REMARK    Review article
REFERENCE   8  (bases 1 to 4710)
  AUTHORS   Yang,A., Walker,N., Bronson,R., Kaghad,M., Oosterwegel,M.,
            Bonnin,J., Vagner,C., Bonnet,H., Dikkes,P., Sharpe,A., McKeon,F.
            and Caput,D.
  TITLE     p73-deficient mice have neurological, pheromonal and inflammatory
            defects but lack spontaneous tumours
  JOURNAL   Nature 404 (6773), 99-103 (2000)
   PUBMED   10716451
REFERENCE   9  (bases 1 to 4710)
  AUTHORS   Herranz,M., Santos,J., Salido,E., Fernandez-Piqueras,J. and
            Serrano,M.
  TITLE     Mouse p73 gene maps to the distal part of chromosome 4 and might be
            involved in the progression of gamma-radiation-induced T-cell
            lymphomas
  JOURNAL   Cancer Res 59 (9), 2068-2071 (1999)
   PUBMED   10232589
REFERENCE   10 (bases 1 to 4710)
  AUTHORS   Kaelin,W.G. Jr.
  TITLE     The emerging p53 gene family
  JOURNAL   J Natl Cancer Inst 91 (7), 594-598 (1999)
   PUBMED   10203277
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL806525.23.
            
            On Mar 26, 2019 this sequence version replaced NM_011642.3.
            
            Summary: This gene encodes tumor protein p73, which is a member of
            the p53 family of transcription factors involved in cellular
            responses to stress and development. The family members include
            p53, p63, and p73 and have high sequence similarity to one another,
            which allows p63 and p73 to transactivate p53-responsive genes
            causing cell cycle arrest and apoptosis. The family members can
            interact with each other in many ways involving direct or indirect
            protein interactions, resulting in regulation of the same target
            gene promoters or regulation of each other's promoters. The p73
            protein is expressed at very low levels in normal tissues and is
            differentially expressed in a number of tumors. The p73 gene
            expresses at least 35 mRNA variants due to the use of alternate
            promoters, alternate translation initiation sites, and multiple
            splice variations. Theoretically this can account for 29 different
            p73 isoforms; however, the biological validity and the full-length
            nature of most variants have not been determined. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes isoform a, also known
            as TAp73alpha.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y19234.1, SRR7345562.3010791.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AL806525.23        189063-189115       c
            54-131              AL806525.23        154059-154136       c
            132-237             AL806525.23        153560-153665       c
            238-480             AL806525.23        130569-130811       c
            481-667             AL806525.23        116817-117003       c
            668-783             AL806525.23        116250-116365       c
            784-893             AL806525.23        113878-113987       c
            894-1036            AL806525.23        113553-113695       c
            1037-1125           AL806525.23        113125-113213       c
            1126-1253           AL806525.23        111752-111879       c
            1254-1402           AL806525.23        111193-111341       c
            1403-1541           AL806525.23        110602-110740       c
            1542-1635           AL806525.23        109828-109921       c
            1636-4710           AL806525.23        105492-108566       c
FEATURES             Location/Qualifiers
     source          1..4710
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 83.79 cM"
     gene            1..4710
                     /gene="Trp73"
                     /gene_synonym="deltaNp73; p73; TAp73; Tp73"
                     /note="transformation related protein 73"
                     /db_xref="GeneID:22062"
                     /db_xref="MGI:MGI:1336991"
     exon            1..53
                     /gene="Trp73"
                     /gene_synonym="deltaNp73; p73; TAp73; Tp73"
                     /inference="alignment:Splign:2.1.0"
     exon            54..131
                     /gene="Trp73"
                     /gene_synonym="deltaNp73; p73; TAp73; Tp73"
                     /inference="alignment:Splign:2.1.0"
     exon            132..237
                     /gene="Trp73"
                     /gene_synonym="deltaNp73; p73; TAp73; Tp73"
                     /inference="alignment:Splign:2.1.0"
     exon            238..480
                     /gene="Trp73"
                     /gene_synonym="deltaNp73; p73; TAp73; Tp73"
                     /inference="alignment:Splign:2.1.0"
     exon            481..667
                     /gene="Trp73"
                     /gene_synonym="deltaNp73; p73; TAp73; Tp73"
                     /inference="alignment:Splign:2.1.0"
     exon            668..783
                     /gene="Trp73"
                     /gene_synonym="deltaNp73; p73; TAp73; Tp73"
                     /inference="alignment:Splign:2.1.0"
     exon            784..893
                     /gene="Trp73"
                     /gene_synonym="deltaNp73; p73; TAp73; Tp73"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1036
                     /gene="Trp73"
                     /gene_synonym="deltaNp73; p73; TAp73; Tp73"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1125
                     /gene="Trp73"
                     /gene_synonym="deltaNp73; p73; TAp73; Tp73"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1253
                     /gene="Trp73"
                     /gene_synonym="deltaNp73; p73; TAp73; Tp73"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1402
                     /gene="Trp73"
                     /gene_synonym="deltaNp73; p73; TAp73; Tp73"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1541
                     /gene="Trp73"
                     /gene_synonym="deltaNp73; p73; TAp73; Tp73"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1635
                     /gene="Trp73"
                     /gene_synonym="deltaNp73; p73; TAp73; Tp73"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..4710
                     /gene="Trp73"
                     /gene_synonym="deltaNp73; p73; TAp73; Tp73"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2661..2666
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trp73"
                     /gene_synonym="deltaNp73; p73; TAp73; Tp73"
                     /note="hexamer: GATAAA"
     polyA_site      2681
                     /gene="Trp73"
                     /gene_synonym="deltaNp73; p73; TAp73; Tp73"
                     /note="major polyA site"
     regulatory      4689..4694
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trp73"
                     /gene_synonym="deltaNp73; p73; TAp73; Tp73"
                     /note="hexamer: AATAAA"
     polyA_site      4709
                     /gene="Trp73"
                     /gene_synonym="deltaNp73; p73; TAp73; Tp73"
ORIGIN      
        1 gaggcaacgc tgcagcccag ccctcgccga cgccgacgcc cggcccggag cagaatgagc
       61 ggcagcgttg gggagatggc ccagacctct tcttcctcct cctccacctt cgagcacctg
      121 tggagttctc tagagccaga cagcacctac tttgacctcc cccagcccag ccaagggact
      181 agcgaggcat caggcagcga ggagtccaac atggatgtct tccacctgca aggcatggcc
      241 cagttcaatt tgctcagcag tgccatggac cagatgggca gccgtgcggc cccggcgagc
      301 ccctacaccc cggagcacgc cgccagcgcg cccacccact cgccctacgc gcagcccagc
      361 tccaccttcg acaccatgtc tccggcgcct gtcatccctt ccaataccga ctaccccggc
      421 ccccaccact tcgaggtcac cttccagcag tcgagcactg ccaagtcggc cacctggaca
      481 tactccccac tcttgaagaa gttgtactgt cagattgcta agacatgccc catccagatc
      541 aaagtgtcca caccaccacc cccgggcacg gccatccggg ccatgcctgt ctacaagaag
      601 gcagagcatg tgaccgacat tgttaagcgc tgccccaacc acgagcttgg aagggacttc
      661 aatgaaggac agtctgcccc ggctagccac ctcatccgtg tagaaggcaa caacctcgcc
      721 cagtacgtgg atgaccctgt caccggaagg cagagtgtgg ttgtgccgta tgaaccccca
      781 caggtgggaa cagaatttac caccatcctg tacaacttca tgtgtaacag cagctgtgtg
      841 gggggcatga atcggaggcc catccttgtc atcatcaccc tggagacccg ggatggacag
      901 gtcctgggcc gccggtcttt cgagggtcgc atctgtgcct gtcctggccg tgaccgcaaa
      961 gctgatgaag accattaccg ggagcaacag gctctgaatg aaagtaccac caaaaatgga
     1021 gctgccagca aacgtgcatt caagcagagc ccccctgcca tccctgccct gggtaccaac
     1081 gtgaagaaga gacgccacgg ggacgaggac atgttctaca tgcacgtgcg aggccgggag
     1141 aactttgaga tcttgatgaa agtcaaggag agcctagaac tgatggagct tgtgccccag
     1201 cctttggttg actcctatcg acagcagcag cagcagcagc tcctacagag gccgagtcac
     1261 ctgcagcctc catcctatgg gcccgtgctc tccccaatga acaaggtaca cggtggtgtc
     1321 aacaaactgc cctccgtcaa ccagctggtg ggccagcctc ccccgcacag ctcagcagct
     1381 gggcccaacc tggggcccat gggctccggg atgctcaaca gccacggcca cagcatgccg
     1441 gccaatggtg agatgaatgg aggccacagc tcccagacca tggtttcggg atcccactgc
     1501 accccgccac ccccctatca tgcagacccc agcctcgtca gttttttgac agggttgggg
     1561 tgtccaaact gcatcgagtg cttcacttcc caagggttgc agagcatcta ccacctgcag
     1621 aaccttacca tcgaggacct tggggctctg aaggtccctg accagtaccg tatgaccatc
     1681 tggaggggcc tacaggacct gaagcagagc catgactgcg gccagcaact gctacgctcc
     1741 agcagcaacg cggccaccat ctccatcggc ggctctggcg agctgcagcg gcagcgggtc
     1801 atggaagccg tgcatttccg tgtgcgccac accatcacga tccccaaccg tggaggcgca
     1861 ggtgcggtga caggtcccga cgagtgggcg gactttggct ttgacctgcc tgactgcaag
     1921 tcccgtaagc agcccatcaa agaggagttc acagagacag agagccactg aggaacgtac
     1981 cttcttctcc tgtccttcct ctgtgagaaa ctgctcttgg aagtgggacc tgttggctgt
     2041 gcccacagaa accagcaagg accttctgcc ggatgccatt cctgaaggga agtcgctcat
     2101 gaactaactc cctcttggaa acttctggaa ctgcccttag ctacatatac acaagggcag
     2161 gtggtgagcc aagtgctgag acagggagct gtccctttgt gggtgggtat gcagcaccca
     2221 tttgcttctc ccgttctcta ttgaggactc tgccacctcc aggacagagc agcatccttc
     2281 acttgctcac cctctgccac aaagtattcc aacatcttct gttcctgcta accatgcaca
     2341 gcccagcctc tgtgtcatca gcgcttacgt acaggtcgat tccactgtgt cttgaaagtg
     2401 aattcagggc cagagacatc ttctgcagga tgtgtggaca gatctgtccc taatgtaggt
     2461 cattctgccg ttaccccttg tctcccgagt cttgattgct ggggtcaggg aagactgtgg
     2521 cagagcaggg gaagccgctg gccctccgcc tctagccagc accctgaaca tgctggctgt
     2581 agcagcctct agggacctct ctggtcagac aaagggacag aatgagtctc agactaccga
     2641 aaattgaatt gtcaatattt gataaaaggt tactctttct acttggtggg gtcagcttgc
     2701 tttttccccc ctctctgact ctctcagcat tcctttctga gatcagccta gtgtgtccac
     2761 acgtacttct caacaagtct aaaacgccga gcatcaatcc aggaagggtc cttacctgtt
     2821 accaggatgg ttggaaggga aagagactca gagagagcat agccgtggga gtgcaggtca
     2881 gacagacccc agctgtgagg aacatctgtt ctcactaagt gctcagagtc tgggctctgt
     2941 gcctgagtgc tagcccatcc tcgtggcctg gaactggagt ggctgctggg ggccctggtc
     3001 ttcatgattc atccccaaag agtcagtggc tagagaaaca gctcctgcat gcattcagcc
     3061 aatggggccc tgtacctgcc agaagctttg tgaacttctg caatgagagc ccccagcagt
     3121 ccctgccagg agtggagaag cacagaggag cccctgccaa cagtaaagcc caacatctgc
     3181 cgagtcactt tggagccatc ctctttaggc ttggctttca ttagcaaggc ccaacagagg
     3241 cagtgacgtc cgtgggatag cctcagagtc agcactacca gggctggcgt catatcaggg
     3301 ctgcctcctc gaagcccagg gacaatgttg ccaatcttag caatcttagc aagctctgca
     3361 aacttaggtg gttaccaccc atgctatgct tcatgaatct ctgaggggca ggatttgggt
     3421 gcacttaggg taggtgcagg catcacattg tcagagacca gtgctgacca tacaggcctt
     3481 tccaacttga cagatgttga cagcttaggc tctggggggg tggggggttc ctgcacccag
     3541 atgggccgtt aacagctgca gcatcaggct tgcttcttgg gtgtaggttg tggccctccc
     3601 agtgagtggt aacacacttc acaaagcctg aggttgacta cacacttctt gttgctgctc
     3661 agatgaggaa gctgaggcta gacagactga gtgccctgcc tcgggcatca gctcattgca
     3721 gaagtgggtg ttcactcctg aggtacatgc tgccccatgc tacctcagaa actaggcagc
     3781 acattctcac tcctaggcct gtgaacccca ctgagatgcg cttgcgttct gggatctcac
     3841 ataagtatgt ctcaggcatt gtccaggagg gaccatccta agcgccccac cacatgctcc
     3901 tgggaaggag gagtggttag gaggagtggt tgtcaccagg catctgagga gggaagagcc
     3961 cccctccagc aaggacccag ggcttgtgtc tccctagacc ctgcctcaag tgccaaagct
     4021 gtctcgtgag cttccaggat cctgacaggc ctggagggaa ctgcaaaggg ccatctgcca
     4081 ggaaataaac gtcacagagg caatgcttgc agtgcctgag aagctctcca ggaaccagcc
     4141 tttgggtctg aaccaaactt tgttctacaa aacacagaaa gcaagagaaa gcaaatcttc
     4201 cagccaccaa ctttcccagg agcactggag tactagtttg gaaacaagtt tgggggtgcc
     4261 ctggaagaca tctgttgagc aagggcaggt tgagcagggc tgtaaaagca ggccactcca
     4321 gcctcagtct gtatggtccc atccagcttt gtgcatccaa ttaacagcag ctcccatgtc
     4381 ccttcctggc cttgcttacc gtgcctgaca gctctacctt gggctgcttt gagcttgtga
     4441 gttcgcagaa ccagcacccc tacgcaagaa tcctgcaagg gtcaaaagtt gccacttagt
     4501 tgcatttcag atgggagaca aaaaccaaaa ctaaattgtc catgtttcaa tgtgatgaaa
     4561 tgcttctcca agcagtattg atggatacag tctagtgact ctattaactg ttttgggtga
     4621 tgtcatttta gaaaaatgtg ttattttttt tagctgtgtt tcggtgggaa tttttgtttt
     4681 tgtaatataa taaaaatcac atgttcccat
//
