LOCUS       NM_001127259            5382 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus transformation related protein 63 (Trp63), transcript
            variant 1, mRNA.
ACCESSION   NM_001127259
VERSION     NM_001127259.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5382)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 5382)
  AUTHORS   Ito,M., Yun,Y., Kulkarni,D.S., Lee,S., Sandhu,S., Nunez,B., Hu,L.,
            Lee,K., Lim,N., Hirota,R.M., Prendergast,R., Huang,C., Huang,I. and
            Hunter,N.
  TITLE     Distinct and interdependent functions of three RING proteins
            regulate recombination during mammalian meiosis
  JOURNAL   Proc Natl Acad Sci U S A 122 (2), e2412961121 (2025)
   PUBMED   39761402
REFERENCE   3  (bases 1 to 5382)
  AUTHORS   Warren,R., Klinkhammer,K., Lyu,H., Knopp,J., Yuan,T., Yao,C.,
            Stripp,B. and De Langhe,S.P.
  TITLE     Cell competition drives bronchiolization and pulmonary fibrosis
  JOURNAL   Nat Commun 15 (1), 10624 (2024)
   PUBMED   39639058
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5382)
  AUTHORS   Cai,S. and Yin,N.
  TITLE     Single-cell transcriptome and chromatin accessibility mapping of
            upper lip and primary palate fusion
  JOURNAL   J Cell Mol Med 28 (19), e70128 (2024)
   PUBMED   39392189
REFERENCE   5  (bases 1 to 5382)
  AUTHORS   Mills,A.A., Zheng,B., Wang,X.J., Vogel,H., Roop,D.R. and Bradley,A.
  TITLE     p63 is a p53 homologue required for limb and epidermal
            morphogenesis
  JOURNAL   Nature 398 (6729), 708-713 (1999)
   PUBMED   10227293
REFERENCE   6  (bases 1 to 5382)
  AUTHORS   Kaelin,W.G. Jr.
  TITLE     The emerging p53 gene family
  JOURNAL   J Natl Cancer Inst 91 (7), 594-598 (1999)
   PUBMED   10203277
  REMARK    Review article
REFERENCE   7  (bases 1 to 5382)
  AUTHORS   Augustin,M., Bamberger,C., Paul,D. and Schmale,H.
  TITLE     Cloning and chromosomal mapping of the human p53-related KET gene
            to chromosome 3q27 and its murine homolog Ket to mouse chromosome
            16
  JOURNAL   Mamm Genome 9 (11), 899-902 (1998)
   PUBMED   9799841
REFERENCE   8  (bases 1 to 5382)
  AUTHORS   Yang,A., Kaghad,M., Wang,Y., Gillett,E., Fleming,M.D., Dotsch,V.,
            Andrews,N.C., Caput,D. and McKeon,F.
  TITLE     p63, a p53 homolog at 3q27-29, encodes multiple products with
            transactivating, death-inducing, and dominant-negative activities
  JOURNAL   Mol Cell 2 (3), 305-316 (1998)
   PUBMED   9774969
REFERENCE   9  (bases 1 to 5382)
  AUTHORS   Senoo,M., Seki,N., Ohira,M., Sugano,S., Watanabe,M., Inuzuka,S.,
            Okamoto,T., Tachibana,M., Tanaka,T., Shinkai,Y. and Kato,H.
  TITLE     A second p53-related protein, p73L, with high homology to p73
  JOURNAL   Biochem Biophys Res Commun 248 (3), 603-607 (1998)
   PUBMED   9703973
  REMARK    Erratum:[Biochem Biophys Res Commun 1998 Sep 18;250(2):536]
REFERENCE   10 (bases 1 to 5382)
  AUTHORS   Schmale,H. and Bamberger,C.
  TITLE     A novel protein with strong homology to the tumor suppressor p53
  JOURNAL   Oncogene 15 (11), 1363-1367 (1997)
   PUBMED   9315105
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK138305.1, AF075436.1 and
            BC090649.1.
            
            Summary: This gene encodes tumor protein p63, a member of the p53
            family of transcription factors involved in cellular responses to
            stress and development. The family members include tumor proteins
            p53, p63, and p73, which have high sequence similarity to one
            another. This similarity allows p63 and p73 to transactivate
            p53-responsive genes causing cell cycle arrest and apoptosis. The
            family members can interact with each other in many ways, including
            direct and indirect protein interactions. This results in mutual
            regulation of target gene promoters. Tumor protein p63 -/- mice
            have several developmental defects which include the lack of limbs
            and other tissues, such as teeth and mammary glands, which develop
            as a result of interactions between mesenchyme and epithelium. Both
            alternative splicing and the use of alternative promoters result in
            multiple transcript variants encoding different protein
            isoforms.[provided by RefSeq, Dec 2009].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a, also known as TAp63alpha).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF075436.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-525               AK138305.1         5-529
            526-2568            AF075436.1         1-2043
            2569-5382           BC090649.1         1876-4689
FEATURES             Location/Qualifiers
     source          1..5382
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 17.37 cM"
     gene            1..5382
                     /gene="Trp63"
                     /gene_synonym="Ket; P51/P63; P63; P73l; Tp63; Trp53rp1"
                     /note="transformation related protein 63"
                     /db_xref="GeneID:22061"
                     /db_xref="MGI:MGI:1330810"
     exon            1..587
                     /gene="Trp63"
                     /gene_synonym="Ket; P51/P63; P63; P73l; Tp63; Trp53rp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             526..2568
                     /gene="Trp63"
                     /gene_synonym="Ket; P51/P63; P63; P73l; Tp63; Trp53rp1"
                     /note="isoform a is encoded by transcript variant 1; tumor
                     protein 63"
                     /codon_start=1
                     /product="tumor protein 63 isoform a"
                     /protein_id="NP_001120731.1"
                     /db_xref="CCDS:CCDS49809.1"
                     /db_xref="GeneID:22061"
                     /db_xref="MGI:MGI:1330810"
                     /translation="MNFETSRCATLQYCPDPYIQRFIETPAHFSWKESYYRSAMSQST
                     QTSEFLSPEVFQHIWDFLEQPICSVQPIELNFVDEPSENGATNKIEISMDCIRMQDSD
                     LSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALS
                     PSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTP
                     PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYV
                     EDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQV
                     LGRRCFEARICACPGRDRKADEDSIRKQQVSDSAKNGDGTKRPFRQNTHGIQMTSIKK
                     RRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQ
                     TSMQSQSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTMPEGMGANIPMMGT
                     HMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFT
                     TQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHDFSSPPHLLRTPSGAS
                     TVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDSRRNKQQRIKEEGE"
     exon            588..716
                     /gene="Trp63"
                     /gene_synonym="Ket; P51/P63; P63; P73l; Tp63; Trp53rp1"
                     /inference="alignment:Splign:2.1.0"
     exon            717..849
                     /gene="Trp63"
                     /gene_synonym="Ket; P51/P63; P63; P73l; Tp63; Trp53rp1"
                     /inference="alignment:Splign:2.1.0"
     exon            850..1104
                     /gene="Trp63"
                     /gene_synonym="Ket; P51/P63; P63; P73l; Tp63; Trp53rp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1291
                     /gene="Trp63"
                     /gene_synonym="Ket; P51/P63; P63; P73l; Tp63; Trp53rp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1407
                     /gene="Trp63"
                     /gene_synonym="Ket; P51/P63; P63; P73l; Tp63; Trp53rp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1517
                     /gene="Trp63"
                     /gene_synonym="Ket; P51/P63; P63; P73l; Tp63; Trp53rp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1654
                     /gene="Trp63"
                     /gene_synonym="Ket; P51/P63; P63; P73l; Tp63; Trp53rp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1737
                     /gene="Trp63"
                     /gene_synonym="Ket; P51/P63; P63; P73l; Tp63; Trp53rp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1874
                     /gene="Trp63"
                     /gene_synonym="Ket; P51/P63; P63; P73l; Tp63; Trp53rp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..2032
                     /gene="Trp63"
                     /gene_synonym="Ket; P51/P63; P63; P73l; Tp63; Trp53rp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2177
                     /gene="Trp63"
                     /gene_synonym="Ket; P51/P63; P63; P73l; Tp63; Trp53rp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..2271
                     /gene="Trp63"
                     /gene_synonym="Ket; P51/P63; P63; P73l; Tp63; Trp53rp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2272..5352
                     /gene="Trp63"
                     /gene_synonym="Ket; P51/P63; P63; P73l; Tp63; Trp53rp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5320..5325
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trp63"
                     /gene_synonym="Ket; P51/P63; P63; P73l; Tp63; Trp53rp1"
                     /note="hexamer: AATAAA"
     polyA_site      5344
                     /gene="Trp63"
                     /gene_synonym="Ket; P51/P63; P63; P73l; Tp63; Trp53rp1"
                     /note="major polyA site"
ORIGIN      
        1 aaaacattgt agccacagca gaactgacag gagctctcaa atcaagtcag aatacagata
       61 caaggagatg ttattcagtt ggagcaaggg ggacatttat tagctcagtg acaagtcctg
      121 gcttctgtga ttaaactctg atgccattca taccagcacc caatcccaag caagatcaga
      181 agttcagaga tgcctacaaa ttgccaacaa gtgtggccac tctacgtcaa gggctctaaa
      241 actgtggcag agaggaagaa cagctttaca gggggtgccc agctggtaag aattgacggt
      301 ttatgatgct ctggttactt gaagactctc attggctgaa aggaagaaac gccccgcctc
      361 tttgcaaatc tgagtaaagg ggggaagtgt ctaaacttct atgtctgatg gcatttgacc
      421 ctattgcttt cagcctcctg gctacatacc tagatattct caggtgtata tgtatatttt
      481 atagaattgc ttcccatctg ttggtatcaa agagagttga aggaaatgaa ttttgaaact
      541 tcacggtgtg ccaccctaca gtactgcccc gacccttaca tccagcgttt catagaaacc
      601 ccagctcatt tctcgtggaa agaaagttat tacagatctg ccatgtcgca gagcacccag
      661 acaagcgagt tcctcagccc agaggtcttc cagcatatct gggattttct ggaacagcct
      721 atatgctcag tacagcccat cgagttgaac tttgtggatg aaccttccga aaatggtgca
      781 acaaacaaga ttgagattag catggattgt atccgcatgc aagactcaga cctcagtgac
      841 cccatgtggc cacagtacac gaacctgggg ctcctgaaca gcatggacca gcagattcag
      901 aacggctcct cgtccaccag cccctacaac acagaccacg cacagaatag cgtgacggcg
      961 ccctcgccct atgcacagcc cagctccacc tttgatgccc tctctccatc ccctgccatt
     1021 ccctccaaca cagattaccc gggcccacac agcttcgatg tgtccttcca gcagtcaagc
     1081 actgccaagt cagccacctg gacgtattcc accgaactga agaagctgta ctgccagatt
     1141 gcgaagacat gccccatcca gatcaaggtg atgaccccac ccccacaggg cgctgttatc
     1201 cgtgccatgc ctgtctacaa gaaagctgag catgtcaccg aggttgtgaa acgatgccct
     1261 aaccatgagc tgagccgtga gttcaatgag ggacagattg cccctcccag tcatctgatt
     1321 cgagtagaag ggaacagcca tgcccagtat gtagaagatc ctatcacggg aaggcagagc
     1381 gtgctggtcc cttatgagcc accacaggtt ggcactgaat tcacaacagt cctgtacaat
     1441 ttcatgtgta acagcagctg cgtcggagga atgaacagac gtccaatttt aatcatcgtt
     1501 actctggaaa ccagagatgg gcaagtcctg ggccgacggt gctttgaggc ccggatctgt
     1561 gcttgcccag gaagagaccg gaaggcagat gaagacagca tcagaaagca gcaagtatcg
     1621 gacagcgcaa agaacggcga tggtacgaag cgccctttcc gtcagaatac acacggaatc
     1681 cagatgactt ccatcaagaa acggagatcc ccagatgatg agctgctgta cctaccagtg
     1741 agaggtcgtg agacgtacga gatgttgctg aagatcaaag agtcactgga gctcatgcag
     1801 tacctccctc agcacacgat cgaaacgtac aggcagcagc agcagcagca gcaccagcac
     1861 ctacttcaga aacagacctc gatgcagtct cagtcttcat atggcaacag ttccccacct
     1921 ctgaacaaaa tgaacagcat gaacaagctg ccttccgtga gccagcttat caacccacag
     1981 cagcgcaatg ccctcactcc caccaccatg cctgagggca tgggagccaa cattcctatg
     2041 atgggcactc acatgccaat ggctggagac atgaatggac tcagccctac ccaagctctc
     2101 cctcctccac tctccatgcc ctccacctcc cactgcaccc caccaccgcc ctaccccaca
     2161 gactgcagca ttgtcagttt cttagcaagg ttgggctgct catcatgcct ggactatttc
     2221 acgacccagg ggctgaccac catctatcag attgagcatt actccatgga tgatttggca
     2281 agtctgaaga tccctgaaca gttccgacat gccatctgga agggcatcct ggaccacagg
     2341 cagctgcacg acttctcctc acctcctcat ctcctgagga ccccaagtgg tgcctctacc
     2401 gtcagtgtgg gctccagtga gacccgtggt gaacgtgtga tcgatgccgt gcgctttacc
     2461 ctccgccaga ccatctcttt tccaccccgt gacgagtgga atgatttcaa ctttgacatg
     2521 gattctcgtc gcaacaagca gcagcgtatc aaagaggaag gagaatgagc gcccattgcg
     2581 gggttcttcc tgtcttcttc cacctcccag cccctacagg gcacgcctgc ttgatcctca
     2641 gagccttctc gttagctctt ctccttctcc ttctcagtct ggtttctaaa gggacggaga
     2701 attaggaggc tgcctgttac ctaaagtctg acctgtcacc tgattctgat tctggcttta
     2761 agccttcaat actcttgctt gcaagatgca ttgacattgc tagatagaag ttagcaaaga
     2821 agcagtaggt ctctttaagc agtggagatc tctcattgac ttttataaag cattttcagc
     2881 cttatagtct aagactatat atataaatat ataaatatcc gatatatatt ttgggtgtgg
     2941 ggggtattga gtattgttta aatgtaattt aatggaaatt gagttgcact tatcatcctt
     3001 ctttggaatt tgcttgtttc ggatggctga gctgtactcc tttctcaggg gtatcatgta
     3061 tggtgacaga tatctagagt tgaatggtct atgtgagtaa caatgacgta taggacctct
     3121 cctcatcctt tggatggtta ttgtttagca catcaaacct gtggatgcat ccagtgtgtt
     3181 taccattgct tcctatgagg taaaactgta tatatgtaca cagttttctc tgtcagtata
     3241 ttttatgtta ctggtgtcca ttccagttag gctggttcac tctgtggcta ttacaagcca
     3301 cattttaggt ttgctttgtc acacactata agacagggca ttgtctcttg cttttgtttg
     3361 agaatgagga atgcagttgt gttgtggttt gttttgtttt attttgtttt gttttctgga
     3421 aactcttaaa tggttcaagt cagccattcc aaatatctga tgaaatttag cccaatatag
     3481 cagtagctct ttgaaattta aggcccaaca ccctagtatt tattagaaaa ataaacattt
     3541 gctgttgtta gaatagtctt aaaaataaat ttctctgcta gattgactaa gtaaaataga
     3601 cattctctgc tgttgtgaga atttgggcca attagaatga atgaaattcg tctagttttc
     3661 atggggagtt gtaatgtcta ttagaaagat tcaggaaaaa taagaatgat tcagaaatac
     3721 tgaatttcca tgaaaaggaa aacagaaagc gattcatccc accaaactct gaattgaagt
     3781 tccttttgaa gggtggagtg atgcttggga agtggacctt ttaaagactt tcctatctat
     3841 gagacactgc atgcacaggc aagtttctct ctccccaagg gctaaaataa gaataatggc
     3901 ttggaaaata caaacttcgt agtgtagttt tcacatagca tgagctgaac cactgttatc
     3961 ttcctcttga tcatcaaagc ttcattgttt tagaaagcag aggtgaagac ccagttttcc
     4021 gcctgacact ttccaagcta gtgtagacca agacctgtct acaaacccac gacaaacctt
     4081 ttcacctgtt taatccatat ccagaaagac ttgtttcata ccttgggaaa gcatgcaaca
     4141 gtattcccct tagatatttt ggaaacattt tgagacaagt atattttttt tcctgcctaa
     4201 accaagtgtt gtttgtatgc taatgagctc tacaatcttc ccacacattt tgttaaatga
     4261 ctttcattgc acatgagctc ccatttttta ttttaaagtg caaatgggct aataggcctt
     4321 tgacgtgtaa tgtatgagtt ttgccagaaa atcatatctt gtgtatatgc gtgtgtgtga
     4381 aattgcttac tatgctggtt ttgtttgtta tggctttctc tttgggatag ttgggttttc
     4441 cagaaccaca gatgaaactt tttttgttgc tatttttata tttttgcaga aacaccgttt
     4501 agtgagaatt caatgtcaaa tatgacatga taccttaatt gtaagaagaa ggtgggaagg
     4561 gaaagttggt ttattaattt ttttaaattt tgtatgcaaa agcaaatgag tccttaattt
     4621 caacattttg ttgtgtttaa ataatgataa gcatcattaa cttctgtaac aaactcacag
     4681 ctttacaaat tcaatgggtg gagaagaaag ctgtgtctta gccatgttag gaagacaaat
     4741 ggcttcctgt gtgttgtaag tatttgggct gtttcagcag tgttggtgtg gcacagggga
     4801 ctctgtggca tttcagcact atttaggtgg cactagggac tctgaaattc ctgtactgta
     4861 tctgatgatt ttggcattag ccataggtag gcacagtttg tctcctcaca ccagtgttta
     4921 gtgtgtgaat agccagagct gtggggaaga acacagagaa cagacatctg ctggatgcct
     4981 ctcagtggag aatgggattc cttcacttgg tggtgaagca gataggatag aaagcaggat
     5041 tctctttgtt aatccagtta gcttttgttt tcttgatatc ccccctgaat acgttgagta
     5101 tgagagatat gtgggttttt tttattttta taattgtaca aaattaagca aatatcaaat
     5161 gttttatata ctttattaat gttttttttc aaaaggtact ttcttataga catgatactt
     5221 ttttacagct tcagttgctt gtcttctggt atttttgtgt tatgggctat ggtgagccag
     5281 aggcaaatct ataagccatt tttgtttgcc aggacatgca ataaaattta aaaataaatg
     5341 aaaatacact gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
