LOCUS       NM_023815               4389 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus transformation related protein 53 regulating kinase B
            (Trp53rkb), mRNA.
ACCESSION   NM_023815
VERSION     NM_023815.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4389)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4389)
  AUTHORS   Wu,M., Jin,Q., Xu,X., Fan,J., Chen,W., Miao,M., Gu,R., Zhang,S.,
            Guo,Y., Huang,S., Zhang,Y., Zhang,A. and Jia,Z.
  TITLE     TP53RK Drives the Progression of Chronic Kidney Disease by
            Phosphorylating Birc5
  JOURNAL   Adv Sci (Weinh) 10 (25), e2301753 (2023)
   PUBMED   37382161
REFERENCE   3  (bases 1 to 4389)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4389)
  AUTHORS   Braun,D.A., Rao,J., Mollet,G., Schapiro,D., Daugeron,M.C., Tan,W.,
            Gribouval,O., Boyer,O., Revy,P., Jobst-Schwan,T., Schmidt,J.M.,
            Lawson,J.A., Schanze,D., Ashraf,S., Ullmann,J.F.P.,
            Hoogstraten,C.A., Boddaert,N., Collinet,B., Martin,G., Liger,D.,
            Lovric,S., Furlano,M., Guerrera,I.C., Sanchez-Ferras,O., Hu,J.F.,
            Boschat,A.C., Sanquer,S., Menten,B., Vergult,S., De Rocker,N.,
            Airik,M., Hermle,T., Shril,S., Widmeier,E., Gee,H.Y., Choi,W.I.,
            Sadowski,C.E., Pabst,W.L., Warejko,J.K., Daga,A., Basta,T.,
            Matejas,V., Scharmann,K., Kienast,S.D., Behnam,B., Beeson,B.,
            Begtrup,A., Bruce,M., Ch'ng,G.S., Lin,S.P., Chang,J.H., Chen,C.H.,
            Cho,M.T., Gaffney,P.M., Gipson,P.E., Hsu,C.H., Kari,J.A., Ke,Y.Y.,
            Kiraly-Borri,C., Lai,W.M., Lemyre,E., Littlejohn,R.O., Masri,A.,
            Moghtaderi,M., Nakamura,K., Ozaltin,F., Praet,M., Prasad,C.,
            Prytula,A., Roeder,E.R., Rump,P., Schnur,R.E., Shiihara,T.,
            Sinha,M.D., Soliman,N.A., Soulami,K., Sweetser,D.A., Tsai,W.H.,
            Tsai,J.D., Topaloglu,R., Vester,U., Viskochil,D.H.,
            Vatanavicharn,N., Waxler,J.L., Wierenga,K.J., Wolf,M.T.F.,
            Wong,S.N., Leidel,S.A., Truglio,G., Dedon,P.C., Poduri,A., Mane,S.,
            Lifton,R.P., Bouchard,M., Kannu,P., Chitayat,D., Magen,D.,
            Callewaert,B., van Tilbeurgh,H., Zenker,M., Antignac,C. and
            Hildebrandt,F.
  TITLE     Mutations in KEOPS-complex genes cause nephrotic syndrome with
            primary microcephaly
  JOURNAL   Nat Genet 49 (10), 1529-1538 (2017)
   PUBMED   28805828
REFERENCE   5  (bases 1 to 4389)
  AUTHORS   Lewandowski,J.P., Du,F., Zhang,S., Powell,M.B., Falkenstein,K.N.,
            Ji,H. and Vokes,S.A.
  TITLE     Spatiotemporal regulation of GLI target genes in the mammalian limb
            bud
  JOURNAL   Dev Biol 406 (1), 92-103 (2015)
   PUBMED   26238476
REFERENCE   6  (bases 1 to 4389)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   7  (bases 1 to 4389)
  AUTHORS   Abe,Y., Matsumoto,S., Wei,S., Nezu,K., Miyoshi,A., Kito,K.,
            Ueda,N., Shigemoto,K., Hitsumoto,Y., Nikawa,J. and Enomoto,Y.
  TITLE     Cloning and characterization of a p53-related protein kinase
            expressed in interleukin-2-activated cytotoxic T-cells, epithelial
            tumor cell lines, and the testes
  JOURNAL   J Biol Chem 276 (47), 44003-44011 (2001)
   PUBMED   11546806
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591703.14.
            
            On Jan 18, 2022 this sequence version replaced NM_023815.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028411.1, AK046261.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-278               AL591703.14        72556-72833
            279-4389            AL591703.14        74147-78257
FEATURES             Location/Qualifiers
     source          1..4389
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 87.22 cM"
     gene            1..4389
                     /gene="Trp53rkb"
                     /gene_synonym="2810408M09Rik; 4933401B08Rik;
                     5630401H01Rik; mNori-2p; Nori-2; PRPK; Tp53rk; Tp53rkb;
                     Trp53rk; Trp53tk"
                     /note="transformation related protein 53 regulating kinase
                     B"
                     /db_xref="GeneID:76367"
                     /db_xref="MGI:MGI:1914050"
     exon            1..278
                     /gene="Trp53rkb"
                     /gene_synonym="2810408M09Rik; 4933401B08Rik;
                     5630401H01Rik; mNori-2p; Nori-2; PRPK; Tp53rk; Tp53rkb;
                     Trp53rk; Trp53tk"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..757
                     /gene="Trp53rkb"
                     /gene_synonym="2810408M09Rik; 4933401B08Rik;
                     5630401H01Rik; mNori-2p; Nori-2; PRPK; Tp53rk; Tp53rkb;
                     Trp53rk; Trp53tk"
                     /EC_number="2.7.11.1"
                     /note="TP53-regulating kinase; p53-related protein kinase;
                     Trp53 regulating kinase; EKC/KEOPS complex subunit Tp53rk;
                     atypical serine/threonine protein kinase Tp53rk"
                     /codon_start=1
                     /product="EKC/KEOPS complex subunit Tp53rkb"
                     /protein_id="NP_076304.2"
                     /db_xref="CCDS:CCDS17090.1"
                     /db_xref="GeneID:76367"
                     /db_xref="MGI:MGI:1914050"
                     /translation="MAGVSSEAEAEALAAARERSRLFLSGLELVQQGAEARVFRGRFQ
                     GRAAVVKHRFPKSYRHPELEARLGRRRTVQEARALLRCRRAGIAAPVVFFVDYASNCL
                     YMEEIEDSVTVRDYIQSTMETEKDPQCLLDLARRMGQVLAGMHDQDLIHGDLTTSNML
                     LRRPLAQLHIVLIDFGLSFVSGLPEDKGVDLYVLEKAFLSTHPHTETAFEAFLKSYGA
                     SSKKSSPVLKKLDEVRLRGRKRSMVG"
     exon            279..4389
                     /gene="Trp53rkb"
                     /gene_synonym="2810408M09Rik; 4933401B08Rik;
                     5630401H01Rik; mNori-2p; Nori-2; PRPK; Tp53rk; Tp53rkb;
                     Trp53rk; Trp53tk"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1030..1035
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trp53rkb"
                     /gene_synonym="2810408M09Rik; 4933401B08Rik;
                     5630401H01Rik; mNori-2p; Nori-2; PRPK; Tp53rk; Tp53rkb;
                     Trp53rk; Trp53tk"
                     /note="hexamer: AACAAA"
     polyA_site      1050
                     /gene="Trp53rkb"
                     /gene_synonym="2810408M09Rik; 4933401B08Rik;
                     5630401H01Rik; mNori-2p; Nori-2; PRPK; Tp53rk; Tp53rkb;
                     Trp53rk; Trp53tk"
                     /note="major polyA site"
     polyA_site      1131
                     /gene="Trp53rkb"
                     /gene_synonym="2810408M09Rik; 4933401B08Rik;
                     5630401H01Rik; mNori-2p; Nori-2; PRPK; Tp53rk; Tp53rkb;
                     Trp53rk; Trp53tk"
     regulatory      1203..1208
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trp53rkb"
                     /gene_synonym="2810408M09Rik; 4933401B08Rik;
                     5630401H01Rik; mNori-2p; Nori-2; PRPK; Tp53rk; Tp53rkb;
                     Trp53rk; Trp53tk"
                     /note="hexamer: CATAAA"
     polyA_site      1230
                     /gene="Trp53rkb"
                     /gene_synonym="2810408M09Rik; 4933401B08Rik;
                     5630401H01Rik; mNori-2p; Nori-2; PRPK; Tp53rk; Tp53rkb;
                     Trp53rk; Trp53tk"
     regulatory      1554..1559
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trp53rkb"
                     /gene_synonym="2810408M09Rik; 4933401B08Rik;
                     5630401H01Rik; mNori-2p; Nori-2; PRPK; Tp53rk; Tp53rkb;
                     Trp53rk; Trp53tk"
                     /note="hexamer: ATTAAA"
     polyA_site      1585
                     /gene="Trp53rkb"
                     /gene_synonym="2810408M09Rik; 4933401B08Rik;
                     5630401H01Rik; mNori-2p; Nori-2; PRPK; Tp53rk; Tp53rkb;
                     Trp53rk; Trp53tk"
     regulatory      1955..1960
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trp53rkb"
                     /gene_synonym="2810408M09Rik; 4933401B08Rik;
                     5630401H01Rik; mNori-2p; Nori-2; PRPK; Tp53rk; Tp53rkb;
                     Trp53rk; Trp53tk"
                     /note="hexamer: AATAAT"
     polyA_site      1976
                     /gene="Trp53rkb"
                     /gene_synonym="2810408M09Rik; 4933401B08Rik;
                     5630401H01Rik; mNori-2p; Nori-2; PRPK; Tp53rk; Tp53rkb;
                     Trp53rk; Trp53tk"
     regulatory      4363..4368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trp53rkb"
                     /gene_synonym="2810408M09Rik; 4933401B08Rik;
                     5630401H01Rik; mNori-2p; Nori-2; PRPK; Tp53rk; Tp53rkb;
                     Trp53rk; Trp53tk"
                     /note="hexamer: AATAAA"
     polyA_site      4389
                     /gene="Trp53rkb"
                     /gene_synonym="2810408M09Rik; 4933401B08Rik;
                     5630401H01Rik; mNori-2p; Nori-2; PRPK; Tp53rk; Tp53rkb;
                     Trp53rk; Trp53tk"
ORIGIN      
        1 agggtcggaa ggagtcggag gcatggctgg tgtgtcctcg gaggcggagg ccgaggcgct
       61 ggccgcggcg cgcgagcgga gccgcctctt cctgagcggc ctagagctgg tgcagcaggg
      121 cgccgaggcg cgcgttttcc gtggccgctt ccagggccgc gcggccgtgg tgaagcaccg
      181 cttcccgaag agttaccggc acccggagct ggaggcgcgg ctcggccgtc ggcggacggt
      241 gcaggaggcg cgcgcgctgc tccgctgccg ccgtgcgggg atagctgccc cagtcgtctt
      301 ctttgtggac tatgcgtcta actgcttata tatggaagaa atcgaagact cggtgactgt
      361 tcgggattat atccaatcca ctatggagac tgaaaaggac ccccagtgcc tcttggacct
      421 ggccaggagg atggggcagg ttctggccgg aatgcacgac caagacctca ttcacgggga
      481 cctcaccacc tccaacatgc tcctgaggcg gcccctggcg cagctgcaca tcgtgctcat
      541 cgactttggg ctgagctttg tctcaggact gccggaagat aaaggcgtcg acctctatgt
      601 cctggagaag gccttcctca gcacgcaccc ccacaccgag accgcgtttg aagcctttct
      661 gaagagttac ggggcctcgt ccaagaagtc cagtccagtg ctgaagaagt tagatgaggt
      721 gcgcctgaga gggcgaaagc ggtccatggt cgggtagtgg agctgtggtg aactggctca
      781 cggtgaagga tgatgtagac gaggctggac ccctcagcaa agcatgggtt gttaagtggt
      841 ctgtgatcgt gctgggccac caccatccat ggctcactgt tctcaggggc ttcatgtaca
      901 tgaggtttat tctgggcaga actgggtagg tagcccaggc tagccttgaa tttatggcaa
      961 catcctacct cagcttgctt ggaagaggtt ataagccacc atacctgact ttgcactgat
     1021 tctgtcagaa acaaaacaac tatgactcta tttgttttta tatcttctta tatttatttt
     1081 gtgtgtgtgc aaatgtgtcc atggaggtca gagaagaact tttgagagtt agctctctgg
     1141 atctgtgttg tagaatctgc catatggatt tcagggattg agttcaggtg attaggcttg
     1201 gccataaaat cctgtatccg gcgagccatc tcactggctc acaaaactat ttttatgtta
     1261 atgggcggaa tggagctagg acgtggggtg gtagctggcg ggggttgggc taagtctgat
     1321 tgaagcaggg ttacagaggc tacattagtg cctggtgtac atgtcctgcc atttgccaga
     1381 gcagcatgca ttgttaactg ctgagccatc tcttcagctt cctaaatttt tgttttgttt
     1441 tgtttttcaa gacagggttt ctctgtgtag ctctggctgt cccagaaact cactctgtaa
     1501 gctcaggctg gccttaaact cagagccacc tcctctgcct cctgagtgct gggattaaag
     1561 gtgtatgtca ctactgctta gctaagacat cttttaatat ttatttttac atgtgtatat
     1621 gcaggtgtct taagagggca ccagaacccc tgtagcctac gttacaatca gatgtgagct
     1681 gtcccgtgta ggtgctgaga aacactctgg tcctgtggaa aggcagcaca tatgcttttt
     1741 ctgttttttt tttttcccga tttatttatt ttatgtatgt gagtactatt tctgcgtgta
     1801 tacctgcatg ccagggaagg gaatcagatc ccattacggg tggttgtgag ccaccatgta
     1861 gtttctagga attgaactca ggacctcttg aagagcagcc agtgctctta gcccctgagc
     1921 cgtctcttca gcctgtctag acattttagc caataataat atccctacat tttaaagtgg
     1981 aaaattactt taacagagtt gagggctaca aaaatacagc ttatgggtgt gttttccccc
     2041 aggataccat gaagtgggaa agccaacaca ggaacatctt caaggactac agtctatgga
     2101 gagggaggga gggaggtgga cgatacccca gtctgagatg caggaaacag tcttccttca
     2161 ggcttttttg aggttctgag ggggattaaa aagccaggac aggtgtcaag aaggttgtta
     2221 gagagcagga gacagttctg catgggagtg tggggactgg ggatcaggcc agcaaggctt
     2281 cctacagact tgtgtggcag agatgaactc cagacccaga gtctgggaga tcacttagca
     2341 gaccagagag gacctgcatc tcctccaggc ttggtacttt tggagcagtc tgttgccagt
     2401 gatgcattcc attggggggt ccgtgaagac tgcggtttgg cgctctccag gtgagtggct
     2461 gcttgtagat gggctggagg gctgacgttg cgtagggcag ggctctcgtg acgatacaat
     2521 ctaaagcctg agcccagggt tcccttcaga agccagcttc tcctgtgtcc cctggcttgc
     2581 ttacacccaa ctcactttct taagaaacct acctcccgag gctgcagaga tggctatggt
     2641 taagagcacc ggctgttctt ccagaggacc tggattcact tcccaacacc acatagcagc
     2701 tcacaactgt ctgcaactcc agttccaggg aatctgacac cttcacacag atgtacaggc
     2761 aaattaccaa tgcacattaa aaaaaaaagc ctcccccctc cccccacatc ctacagtgtg
     2821 tgcagggact gcttcagctg ttagagtcag aatcttctgc agaggcctaa caaaacaaaa
     2881 ccacatcatg acacctggct tctatggggt ctgaaatacc tagactgaca tgtcttcagt
     2941 gtaatggggc ccaaagacca gtagaagaca gctgaactgg tgggtggtga aaccagacat
     3001 aactcttacc ttgaagagaa tcctcaagtc cattcacagt aatgctgctg ctttgaacct
     3061 gctctgaacc ccagtggcat gggaggggtg tgtgtgttta cgcactgaga aatacgctgg
     3121 tgaaatgtct tgctcagtaa gagcacatac tgctcttgct gaggacctta gttcccaatc
     3181 ccaccttgga taactcaaag ccacctgtga ccccaactcc agggcatcca acatccctcg
     3241 aacaccactg atgcctgcac tcacatttgt acacaccgat acacagacac acaaatatgc
     3301 attattttta aatctctcag ctgggcagtg gtgatgcatg tgtttaatcc cagcactcgg
     3361 gaggcagagg caggtggatc tctgtgagtt caagcccagc ctgatctaca gagggagttt
     3421 caggacagcc agggctacaa agagagaccc tgtccccaga aaacaaaaca aggcaccatt
     3481 tgaaggtgtg gggagagcag ctgagctgcc tcagggacac ccaggaaggc agccaggctg
     3541 ttgtccagca tggtgactgg agaataaggg gagtctgctg gggatgggga ggggagtggg
     3601 ggaggcatac acccaacacc agatctttgg gactggctgc cttgccacgg ggagacccta
     3661 ggggcaactc cactactgat cagcggcaga gggagagaaa caaactgaaa ggagctggac
     3721 tctgtctcct gaaggctgag atgtgcttct cagcatccat cgcctggctt tccaggaact
     3781 ccgatgaatc tttcaaccct aacacctact aacaaaagat atctgtttac ctgaaactta
     3841 tttacatgtt tagtcctttc cggaagagag agggacaaaa aaaatatttt cttgtcggtc
     3901 taacaataga aaggttcatt tgtctccggg atggagagga tgcaattcat agtggaaagg
     3961 agtaagttct ggaggcttcc gtagatggat gggagcagag agatggcatc tagtgctcag
     4021 ctagctctct cctttacata taatccaaat ggcaccagca acatttccat agatcttcct
     4081 tttcagtgaa gccttcctag aaatatcttc acagacactc aaaggtgcct ctctcaggag
     4141 atcccaaatc cagtcaactt ggcagtgaag tctgatgatc agggacaaag atggaacaag
     4201 gaagagatgg gcaaacaaca ccatgacggg ctggagagat ggctcagcag ttaagatcac
     4261 tgactgttct tccagaggtc ctgagttcaa ttcccagcaa ccgcatgatc tgtaatgcct
     4321 tttcctagta tgtctgaaga taactacagt ctactcaaca taaataaaaa taacaaatca
     4381 gaaaaacca
//
