LOCUS       NM_001418655            4493 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus transformation related protein 53 inducible nuclear
            protein 2 (Trp53inp2), transcript variant 2, mRNA.
ACCESSION   NM_001418655
VERSION     NM_001418655.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4493)
  AUTHORS   Huang,G., Li,Z., Liu,X., Guan,M., Zhou,S., Zhong,X., Zheng,T.,
            Xin,D., Gu,X., Mu,D., Guo,Y., Zhang,L., Zhang,L., Lu,Q.R. and He,X.
  TITLE     DOR activation in mature oligodendrocytes regulates
            alpha-ketoglutarate metabolism leading to enhanced remyelination in
            aged mice
  JOURNAL   Nat Neurosci 27 (11), 2073-2085 (2024)
   PUBMED   39266660
  REMARK    Erratum:[Nat Neurosci. 2024 Nov;27(11):2261. doi:
            10.1038/s41593-024-01785-2.. PMID: 39317798]
REFERENCE   2  (bases 1 to 4493)
  AUTHORS   Sebastian,D., Beltra,M., Irazoki,A., Sala,D., Aparicio,P., Aris,C.,
            Alibakhshi,E., Rubio-Valera,M., Palacin,M., Castellanos,J.,
            Lores,L. and Zorzano,A.
  TITLE     TP53INP2-dependent activation of muscle autophagy ameliorates
            sarcopenia and promotes healthy aging
  JOURNAL   Autophagy 20 (8), 1815-1824 (2024)
   PUBMED   38545813
  REMARK    GeneRIF: TP53INP2-dependent activation of muscle autophagy
            ameliorates sarcopenia and promotes healthy aging.
REFERENCE   3  (bases 1 to 4493)
  AUTHORS   Sun,P., Chen,J. and Qin,R.
  TITLE     TP53INP2 knockdown inhibits inflammatory response and apoptosis
            after spinal cord injury
  JOURNAL   Immun Inflamm Dis 12 (4), e1256 (2024)
   PUBMED   38652010
  REMARK    GeneRIF: TP53INP2 knockdown inhibits inflammatory response and
            apoptosis after spinal cord injury.
REFERENCE   4  (bases 1 to 4493)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 4493)
  AUTHORS   Liu,J., Liu,T., Ren,S.V., Zhu,C., Bouso,E., Mamlouk,S., Rau,C.D.,
            Wang,Y. and Gao,C.
  TITLE     Metabolic status differentiates Trp53inp2 function in
            pressure-overload induced heart failure
  JOURNAL   Front Cardiovasc Med 10, 1226586 (2023)
   PUBMED   38188257
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4493)
  AUTHORS   Romero,M., Sabate-Perez,A., Francis,V.A., Castrillon-Rodriguez,I.,
            Diaz-Ramos,A., Sanchez-Feutrie,M., Duran,X., Palacin,M.,
            Moreno-Navarrete,J.M., Gustafson,B., Hammarstedt,A.,
            Fernandez-Real,J.M., Vendrell,J., Smith,U. and Zorzano,A.
  TITLE     TP53INP2 regulates adiposity by activating beta-catenin through
            autophagy-dependent sequestration of GSK3beta
  JOURNAL   Nat Cell Biol 20 (4), 443-454 (2018)
   PUBMED   29593329
  REMARK    GeneRIF: TP53INP2 modulates adipogenesis through
            autophagy-dependent sequestration of GSK3beta into late endosomes
            and beta catenin activation, regulating adiposity.
REFERENCE   7  (bases 1 to 4493)
  AUTHORS   Sala,D., Ivanova,S., Plana,N., Ribas,V., Duran,J., Bach,D.,
            Turkseven,S., Laville,M., Vidal,H., Karczewska-Kupczewska,M.,
            Kowalska,I., Straczkowski,M., Testar,X., Palacin,M., Sandri,M.,
            Serrano,A.L. and Zorzano,A.
  TITLE     Autophagy-regulating TP53INP2 mediates muscle wasting and is
            repressed in diabetes
  JOURNAL   J Clin Invest 124 (5), 1914-1927 (2014)
   PUBMED   24713655
  REMARK    GeneRIF: TP53INP2 repression is part of an adaptive mechanism aimed
            at preserving muscle mass under conditions in which insulin action
            is deficient.
REFERENCE   8  (bases 1 to 4493)
  AUTHORS   Linares,G.R., Xing,W., Burghardt,H., Baumgartner,B., Chen,S.T.,
            Ricart,W., Fernandez-Real,J.M., Zorzano,A. and Mohan,S.
  TITLE     Role of diabetes- and obesity-related protein in the regulation of
            osteoblast differentiation
  JOURNAL   Am J Physiol Endocrinol Metab 301 (1), E40-E48 (2011)
   PUBMED   21467300
REFERENCE   9  (bases 1 to 4493)
  AUTHORS   Kawaguchi,A., Ikawa,T., Kasukawa,T., Ueda,H.R., Kurimoto,K.,
            Saitou,M. and Matsuzaki,F.
  TITLE     Single-cell gene profiling defines differential progenitor
            subclasses in mammalian neurogenesis
  JOURNAL   Development 135 (18), 3113-3124 (2008)
   PUBMED   18725516
REFERENCE   10 (bases 1 to 4493)
  AUTHORS   Bennetts,J.S., Rendtorff,N.D., Simpson,F., Tranebjaerg,L. and
            Wicking,C.
  TITLE     The coding region of TP53INP2, a gene expressed in the developing
            nervous system, is not altered in a family with autosomal recessive
            non-progressive infantile ataxia on chromosome 20q11-q13
  JOURNAL   Dev Dyn 236 (3), 843-852 (2007)
   PUBMED   17238154
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845325.10.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036958.1, SRR1660821.69964.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-898               AL845325.10        76143-77040
            899-1187            AL845325.10        77457-77745
            1188-4493           AL845325.10        78116-81421
FEATURES             Location/Qualifiers
     source          1..4493
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 77.26 cM"
     gene            1..4493
                     /gene="Trp53inp2"
                     /gene_synonym="1110029F20Rik; Tp53inp2"
                     /note="transformation related protein 53 inducible nuclear
                     protein 2"
                     /db_xref="GeneID:68728"
                     /db_xref="MGI:MGI:1915978"
     exon            1..898
                     /gene="Trp53inp2"
                     /gene_synonym="1110029F20Rik; Tp53inp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             775..1440
                     /gene="Trp53inp2"
                     /gene_synonym="1110029F20Rik; Tp53inp2"
                     /note="isoform a is encoded by transcript variant 2; tumor
                     protein p53-inducible nuclear protein 2; diabetes and
                     obesity-regulated protein"
                     /codon_start=1
                     /product="tumor protein p53-inducible nuclear protein 2
                     isoform a"
                     /protein_id="NP_001405584.1"
                     /db_xref="GeneID:68728"
                     /db_xref="MGI:MGI:1915978"
                     /translation="MFQRFTSLFFNTPAPPEDSNCPGAFVSEEDEVDGWLIIDLQDSY
                     TAPPDPGASPAPAGRPPPAPSLMDESWFVTPPACFTAEGPGLGPARLQSNPLEDLLIE
                     HPSMSVYVTGSTIVLESGPPSPHPEAALPDQDLSDGELAPALREPRALHHAAAPMPAR
                     AVLLEKAGQVRRLQRARQRAERHTLSAKVLQRQNRARESRSRRPKHQGSFIYQPCQRQ
                     FNY"
     exon            899..1187
                     /gene="Trp53inp2"
                     /gene_synonym="1110029F20Rik; Tp53inp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..4493
                     /gene="Trp53inp2"
                     /gene_synonym="1110029F20Rik; Tp53inp2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4473..4478
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trp53inp2"
                     /gene_synonym="1110029F20Rik; Tp53inp2"
                     /note="hexamer: AATAAA"
     polyA_site      4493
                     /gene="Trp53inp2"
                     /gene_synonym="1110029F20Rik; Tp53inp2"
                     /note="major polyA site"
ORIGIN      
        1 ggtagggccc catgtagttc agactggcct ttaactcact atgtagccta agcaggactt
       61 ggactctgat ccccctgcct ctaccttcta agtgctagga taatagacag gaggtcttca
      121 tgtctttgaa ctcttgtcct cttgcctcta gcccctaagt cctaagattc caggcttgcc
      181 ctttcacaca ctgtgaggat ataaggaaaa atggaccagg tttcttagta tagtgttgta
      241 tgttactgac acaggaatat taattatgat gatggtaata agaacaattt ttttccctta
      301 atggaaaatt cctatttact cctcaaagcc caggttggct gttatcttcc tctagagact
      361 taccctggca aagcttggtc atatatatca cttcttccat atccccaaag caccctgtca
      421 taacaccaag tttattagct tattgaatgt ttactgtgtg ctcaggcact gttctaaaca
      481 tgtcattaag tgtttcctca tttaagtctt attacgattg tcatttgaca gatgagaaaa
      541 caaagaccca gcacctttct aagtgcatac aggaacaccc actgaatgca gaaaagcaca
      601 cacaccaaga gcttctctgc tattactgct ctggcagcta ggggctatag ccttgtctcc
      661 agctaccaac tgaagggctg actttagttc gtgcttctac taatgtcttt ctatgcttct
      721 cagggcttta aactgccata gggcgccccc ttgaggttgc ttcacccgct gaccatgttc
      781 cagcgcttca ccagcctttt cttcaacacc cctgcgcctc ctgaagactc caactgtccg
      841 ggggcctttg tctctgagga ggatgaagtg gatggctggc tcatcatcga cctacaggac
      901 agctatacag ctcctcccga ccccggggcc tcgcctgctc ctgcaggccg ccctccaccc
      961 gcgccctcct tgatggatga gagctggttt gttacccctc ccgcctgttt tactgcagag
     1021 gggcccggcc ttgggcctgc ccgcctccag agcaatccgc tggaggacct cctcattgag
     1081 catcccagca tgtccgttta tgtcaccggc agcaccatag tgctggagtc tgggccacct
     1141 tcccctcacc ctgaagctgc cttgcctgat caggacctca gcgatggaga gctggcgcct
     1201 gccctccggg aacccagggc cttgcaccac gcagctgctc ctatgcccgc tcgagctgtg
     1261 ctgctggaga aggctggcca ggtgcggagg ctgcagagag cccgacagcg ggctgagcgc
     1321 cacacattga gtgctaaagt gttgcaacgg cagaatcgcg cccgggagag ccgttcgcgc
     1381 cggcccaagc accagggcag ctttatttac cagccgtgcc agcgccagtt caactactga
     1441 gcgcccctgc tgcaccgcga atccctcgcc gactcctggt cccatccgcc tcctctgcag
     1501 cagccagtgt gctgctcgag ggtgttgggg ggtccacccg cctccatctg gatactacaa
     1561 cctccctcct tcctaagttt tgaggtgggg tgatggccct ctacttccct gtttatagtc
     1621 taactcacct attaacctct ctcatcctgg gtcatcctcc ctcctttctc agtgtctgat
     1681 tctccaccct cacactcccc acacccactc tcccatgctt ctttttagga cctctattct
     1741 tgtctctcgc cccttcacct tttccctctt agcccacccg attcctaaga ccctgacttg
     1801 gcaccttctc cgcttcagct cctactttcc aagacttact cttctgtttg ggatcgctcc
     1861 cactcttgtt cccttttttt cattcctggc aattccctcc caatcctgca ggtgcaacct
     1921 gccaggcctg ggccattgtc ctcatcctgt agtcagggat caggcatggg ttttgatttc
     1981 agttttcccc ctttctctgc cctgggggct gggctcctta ttgctgctta ggcctagaaa
     2041 gtttaagtat gtggaagagg agagtgagtt gtaagttaga taaggtgaag ggaatggagg
     2101 gaaacaggca gcctagtggg ggccgcagat ggggacaggt gggttgagaa gtagcaggga
     2161 gcagggcatc ttgggagctg gtattgtgct tggtcagagt agctaagccc tggtcttagg
     2221 cctgagcctg gagtctgccc ccatttcctt ttcctataat cctgccttcc agggttcccc
     2281 cctccctgaa atttgtcctt caggagtaac ccctacccac ccctgtccct gtgagtctgg
     2341 agtccgaagg gcttgtacct tgtcacctta ccttgtcatg ccaccccagg agtagaagct
     2401 gggtaaggcc ccatcatcct gaccatctct gttcatatgc ccaaggtgct agaattagct
     2461 taggagagat gcaggccaga ggatttccag gcagggaaaa ggaaacacac cccaaggcaa
     2521 gaatgaggag gcatgatgct aaggaggaca actatgaggt aaagccatcc ccagactgac
     2581 agctctgcct ttatcttgcc tctggcctta tatttcatac tttgttcaat atggctggat
     2641 aataaacact cctgggtaga ggaggccagg agcctcactg tcccaattcc caaatttttc
     2701 ttacagagat tcagggcctt caagagtctt cttaatgttc tcccacaggg ctctttctga
     2761 gtgccctata atccctcccc cctttctaat tcaatatctg gagtaaggaa ttcttgggta
     2821 gggcacaggg atggggttgc cagcttcttc tttcttgtgg tggggctcag acaccagcaa
     2881 cagcctcttg ggatgcccca agttgtttcc ggttctttct agctgtcctt tttaaagtgt
     2941 gtgctcttcc ttccttaaaa cctttagatg tcctgttaca ctaacacagg tcttcccttc
     3001 cctccaaccc caggtttcag gtctcagagc caagccaggg ttggagaaaa ctgcattcct
     3061 acgagggtaa aagtagctgc cctctttgat cctttcttac taggcttcat gtgggatggg
     3121 agaggatgtc cccaggatgg ggacagagga agccctgcta gggtctccta gcccagtaag
     3181 ccaaatggga actataagca gatcaaaatt ttacactagc ttattagagc cctattagtt
     3241 cctgtcccaa gttcttcagt tacaacctag tagtatactt actcttccaa ctgtcctaag
     3301 gtcacttccc agccagctta ggatcttcag catttttaag agctgaagct ccctcttgcc
     3361 cttcttgtct actcctcact gccagttggg gcctaggctt agtcctgggc aaatgtccat
     3421 gatcttgctg ctgtaggaag cttgataggg catttggctc aaatttcaga aggcctcgct
     3481 cctgacctaa tttctcaaag ctccggtagt tctagacccc tccaatttct catctggttg
     3541 caaggcttat ttttcttttg tactttccta tagatgctat agcatttgag tgtggcaata
     3601 tttttgttgt gtatagatgt ctaagaacca acactactca gtctcctgct agtctgactc
     3661 ctgaagcatc agaccctgtc atactgtatt gactgtgtat gtgcctttca ccttgagcat
     3721 gcttcaggaa tttttttttt tcttaaacca cagaacttga atacacaagg gaaccagaat
     3781 tcacaaagtc ctatgcaacc ctagacagga ggaggttaga gagtctgtct tgatttgtgg
     3841 tttcagagac cctagagaaa tttgtaccag tttgtattaa agtcagtact accagcactt
     3901 tgccaaaact acggatgtca gagggacctg tttctagagt gagtcccaat tacatcaaag
     3961 ggcaacctgc gctttctcca ataagtctga gtggttctct tgagctggtg tcactttcta
     4021 acctttgcca gtctagcccc agcagggcac cgtgtgtgtg agtgtggttt ggtgctgttt
     4081 tggagtgtgc ctgcccccca gcctggaacc ctctgatcaa cttgctggga cctataacgt
     4141 cttaggtgca acaaggaccc taccagagct cctgggtggc tttgtgtgag gggactgaac
     4201 gcagacaaac cacagcctgc ttctaatacc ttctttccct accacctagt tccaaatgga
     4261 accaacaagt tgagtgcatc tctgttgggt gttttgtgtt gagactggct gaagtgaaga
     4321 atctttgact gaccatgttg tgatgtgtcg acagactcaa ggacacaacc acctcgacct
     4381 ggtcatgtgg catgcctgtg tatgtgtgta acaggattct gaatgttagg ttgtaatgct
     4441 attcctgtat gggagaaaaa ataatataaa caaataaaaa tctatttaaa gca
//
