LOCUS       NM_021897               5394 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus transformation related protein 53 inducible nuclear
            protein 1 (Trp53inp1), transcript variant 1, mRNA.
ACCESSION   NM_021897
VERSION     NM_021897.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5394)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5394)
  AUTHORS   Beauchamp,M.C., Boucher,A., Dong,Y., Aber,R. and
            Jerome-Majewska,L.A.
  TITLE     Craniofacial Defects in Embryos with Homozygous Deletion of Eftud2
            in Their Neural Crest Cells Are Not Rescued by Trp53 Deletion
  JOURNAL   Int J Mol Sci 23 (16), 9033 (2022)
   PUBMED   36012294
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5394)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5394)
  AUTHORS   Beauchamp,M.C., Djedid,A., Bareke,E., Merkuri,F., Aber,R.,
            Tam,A.S., Lines,M.A., Boycott,K.M., Stirling,P.C., Fish,J.L.,
            Majewski,J. and Jerome-Majewska,L.A.
  TITLE     Mutation in Eftud2 causes craniofacial defects in mice via
            mis-splicing of Mdm2 and increased P53
  JOURNAL   Hum Mol Genet 30 (9), 739-757 (2021)
   PUBMED   33601405
REFERENCE   5  (bases 1 to 5394)
  AUTHORS   Warnez-Soulie,J., Macia,M., Lac,S., Pecchi,E., Bernard,M.,
            Bendahan,D., Bartoli,M., Carrier,A. and Giannesini,B.
  TITLE     Tumor protein 53-induced nuclear protein 1 deficiency alters mouse
            gastrocnemius muscle function and bioenergetics in vivo
  JOURNAL   Physiol Rep 7 (10), e14055 (2019)
   PUBMED   31124296
  REMARK    GeneRIF: TP53INP1 plays a role in regulating muscle function and
            bioenergetics through oxidative capacity impairment possibly as the
            consequence of abnormal mitochondrial respiration regulation and/or
            defective blood supply.
REFERENCE   6  (bases 1 to 5394)
  AUTHORS   Tomasini,R., Seux,M., Nowak,J., Bontemps,C., Carrier,A.,
            Dagorn,J.C., Pebusque,M.J., Iovanna,J.L. and Dusetti,N.J.
  TITLE     TP53INP1 is a novel p73 target gene that induces cell cycle arrest
            and cell death by modulating p73 transcriptional activity
  JOURNAL   Oncogene 24 (55), 8093-8104 (2005)
   PUBMED   16044147
  REMARK    GeneRIF: TP53INP1s are functionally associated with p73 to regulate
            cell cycle progression and apoptosis.
REFERENCE   7  (bases 1 to 5394)
  AUTHORS   Tomasini,R., Samir,A.A., Pebusque,M.J., Calvo,E.L., Totaro,S.,
            Dagorn,J.C., Dusetti,N.J. and Iovanna,J.L.
  TITLE     P53-dependent expression of the stress-induced protein (SIP)
  JOURNAL   Eur J Cell Biol 81 (5), 294-301 (2002)
   PUBMED   12067065
  REMARK    GeneRIF: Data show that induction of the stress-induced proteins
            (SIPs) SIP18 and SIP27, in human- and mouse-derived cell lines, is
            absent from cells with deleted, mutated or inactive p53, suggesting
            that regulation of SIP gene expression is dependent on p53.
REFERENCE   8  (bases 1 to 5394)
  AUTHORS   Tomasini,R., Samir,A.A., Vaccaro,M.I., Pebusque,M.J., Dagorn,J.C.,
            Iovanna,J.L. and Dusetti,N.J.
  TITLE     Molecular and functional characterization of the stress-induced
            protein (SIP) gene and its two transcripts generated by alternative
            splicing. SIP induced by stress and promotes cell death
  JOURNAL   J Biol Chem 276 (47), 44185-44192 (2001)
   PUBMED   11557757
REFERENCE   9  (bases 1 to 5394)
  AUTHORS   Carrier,A., Wurbel,M.A., Mattei,M.G., Kissenpfennig,A., Malissen,M.
            and Malissen,B.
  TITLE     Chromosomal localization of two mouse genes encoding
            thymus-specific serine peptidase and thymus-expressed acidic
            protein
  JOURNAL   Immunogenetics 51 (11), 984-986 (2000)
   PUBMED   11003393
REFERENCE   10 (bases 1 to 5394)
  AUTHORS   Carrier,A., Nguyen,C., Victorero,G., Granjeaud,S., Rocha,D.,
            Bernard,K., Miazek,A., Ferrier,P., Malissen,M., Naquet,P.,
            Malissen,B. and Jordan,B.R.
  TITLE     Differential gene expression in CD3epsilon- and RAG1-deficient
            thymuses: definition of a set of genes potentially involved in
            thymocyte maturation
  JOURNAL   Immunogenetics 50 (5-6), 255-270 (1999)
   PUBMED   10630289
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL840625.9.
            
            On Mar 19, 2018 this sequence version replaced NM_021897.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform (1;
            also known as SIP27).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY034612.1, AJ131776.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               AL840625.9         44723-44829
            108-366             AL840625.9         52593-52851
            367-724             AL840625.9         53372-53729
            725-5394            AL840625.9         57992-62661
FEATURES             Location/Qualifiers
     source          1..5394
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 5.03 cM"
     gene            1..5394
                     /gene="Trp53inp1"
                     /gene_synonym="2700057G22Rik; p53DINP1; SIP; SIP18; SIP27;
                     Stinp; Teap; Tp53inp1"
                     /note="transformation related protein 53 inducible nuclear
                     protein 1"
                     /db_xref="GeneID:60599"
                     /db_xref="MGI:MGI:1926609"
     exon            1..107
                     /gene="Trp53inp1"
                     /gene_synonym="2700057G22Rik; p53DINP1; SIP; SIP18; SIP27;
                     Stinp; Teap; Tp53inp1"
                     /inference="alignment:Splign:2.1.0"
     exon            108..366
                     /gene="Trp53inp1"
                     /gene_synonym="2700057G22Rik; p53DINP1; SIP; SIP18; SIP27;
                     Stinp; Teap; Tp53inp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..974
                     /gene="Trp53inp1"
                     /gene_synonym="2700057G22Rik; p53DINP1; SIP; SIP18; SIP27;
                     Stinp; Teap; Tp53inp1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     stress induced protein; tumor protein p53-inducible
                     nuclear protein 1; thymus-expressed acidic protein;
                     p53-dependent damage-inducible nuclear protein 1"
                     /codon_start=1
                     /product="tumor protein p53-inducible nuclear protein 1
                     isoform 1"
                     /protein_id="NP_068697.1"
                     /db_xref="CCDS:CCDS17964.1"
                     /db_xref="GeneID:60599"
                     /db_xref="MGI:MGI:1926609"
                     /translation="MFQRLNKMFVGEVTTSSSQEPEFSEKEDDEWILVDFIDTCPGFS
                     AEEEEEDEDIGEESSAEHTSVFSCLPASLECLTDTSDSCFLQFESCPMEESWFITPPP
                     CFTAGGLTTIKVETSPMENLLIEHPSMSVYAVHNSCPGLSEASCGNDEYNSSGPRMEA
                     QSEMGKHIHCCVAALAAQATFLEQPKSFRPSQWIKGHSERQSLNRNGLRRQNLTRDCH
                     TRQMKHSGWVVHQPCPRQYNY"
     exon            367..724
                     /gene="Trp53inp1"
                     /gene_synonym="2700057G22Rik; p53DINP1; SIP; SIP18; SIP27;
                     Stinp; Teap; Tp53inp1"
                     /inference="alignment:Splign:2.1.0"
     exon            725..5394
                     /gene="Trp53inp1"
                     /gene_synonym="2700057G22Rik; p53DINP1; SIP; SIP18; SIP27;
                     Stinp; Teap; Tp53inp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5373..5378
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trp53inp1"
                     /gene_synonym="2700057G22Rik; p53DINP1; SIP; SIP18; SIP27;
                     Stinp; Teap; Tp53inp1"
                     /note="hexamer: AATAAA"
     polyA_site      5394
                     /gene="Trp53inp1"
                     /gene_synonym="2700057G22Rik; p53DINP1; SIP; SIP18; SIP27;
                     Stinp; Teap; Tp53inp1"
                     /note="major polyA site"
ORIGIN      
        1 aacaacaaaa ggacccggac gggccggcgg cggccagggc agcgaccgca gcgcaggagc
       61 ccggcctgcc gcagctacct cagcacccgc agctctgctc ggctcacgga tgatgactct
      121 tcttgctctt catctaagtt gaagaaacac tgtgcacttt aatctctcgt ctgtgatatt
      181 gggccaactg aagacagggt tttgaaatct cagctataaa gatatctagc caaaatctca
      241 atcttgcctt aacaatgttt cagagactga ataaaatgtt tgtaggcgaa gtcactactt
      301 cttccagcca agaaccagaa ttcagtgaga aagaagatga tgaatggatt cttgttgact
      361 tcatagatac ctgccctggt ttctcagcag aggaagagga agaagatgaa gacattggtg
      421 aagagtcctc agcagagcac acttctgtct tctcctgttt acctgcatct ttggaatgct
      481 tgactgacac cagtgattcc tgcttccttc agtttgagtc ctgtccaatg gaggagagct
      541 ggttcatcac tcctccccca tgttttacag caggtggatt aaccactatc aaggtggaaa
      601 caagtcctat ggaaaacctt ctcattgaac atcccagcat gtctgtctat gctgtgcaca
      661 actcctgtcc tggtctcagt gaggcgagtt gtggaaatga tgaatataac tcaagtggtc
      721 ccagaatgga agcccagagt gaaatgggga agcacattca ctgctgtgtg gcagcacttg
      781 ctgctcaggc aacatttttg gaacaaccca agagttttcg cccttcccag tggataaaag
      841 gacacagtga aagacagtct ttgaacagaa atggtctccg tcgccagaac cttaccaggg
      901 attgccacac tcgacaaatg aagcacagtg gctgggtggt tcaccagccc tgcccacgcc
      961 agtacaatta ctgagaatgt tgagttatgt tggtttgttt ccttaggttt tgtgcatatg
     1021 tattggatgt gtgtgtgtac aatgaaagtg ctgtctcctt ccagccaagt gaagaccaat
     1081 cgcctagtgt atcagtgtgt ttagacacta tcacaaccag atttttgtgc tgtgtttcac
     1141 ataatgcctt gctcctgaca attacttttt aaaaaacctt ttagcatatt tttggaaaca
     1201 tatcaataca gtgacagtgt ttggggttgt ctttaagtac agtaaggtat atatatgagt
     1261 tagcatctta aggacatttc taaccccaag tctaagagta gacatctttt caatttcctt
     1321 tattttgtat tatttaatct tttgtgtaag caaaaatcta ttctcagggt cagccatata
     1381 ctttattgac cagtacttga tagccttttc tgtatataat gagtacattt ttacactaac
     1441 acaagcatta acaggtgatt ttttgccatg gatataatgg aattaatggt tgaacttact
     1501 tttgaaagaa aacttgacat atttctgtat atatgttttt ttttctccca gattagtcat
     1561 tgtagttcat tgtggaattc aggtacatta actttggtga acaatatatt cagtaattct
     1621 gatgtgactc cacgatatgg tacaaatact acagatgtcg tggccaaaag catttgtttc
     1681 atatgcagag ggaaaaatca gacccatgag atgatatctg gaatctattt gtagataacc
     1741 cacagagcag tcagtatttg gagatgtcta gattcctaac tgccagctca gctaaaaatg
     1801 cacaagccca ggcactcagt gacgtcatgc ttgtgtctgc cacaagaaag ggagagaaac
     1861 agtggtaact cctcagacat ggagcctgtc ttcccaaggg atttctggtg gcatctgttt
     1921 gcgcctaagt gaagattgat gggttggttt ccacaagctt tcgtttttaa acttcacaat
     1981 atccttagcc actttggcct ctctttcctc cacagcaggc gagtactaat acttaccaca
     2041 gcaggagagt actaatactt accacagcag gcgagtacta atacttacca cagcaggcgg
     2101 gtactaatac ttacctccct cacagagttg tgaggattgt atactgattg gaagtggggc
     2161 tgtcagaact gaactctgtg aactttcagg gtctttctcc tgaacctagt tgtgggaggc
     2221 tacggcagtt tactgccatg attattcttc agggttggtg ctaatgaggc tagagcacag
     2281 ggttccactc atatatacca gttaacgtgg tgtagaggaa agtccattct cttacctcta
     2341 tctggtcagc tcttaaagaa tagttttggt ggattttgat gagccatcca cacttgctgg
     2401 aagattaaac acatttacag cttgaagcac attctaatac cattgccgca tattcaaagt
     2461 gctcatttcc ctagcccctt tgcaaccata actaaacatt tgtttatgaa ataatttcaa
     2521 ggaaaaaaag aaacatactg ttatgtgaag tattattcct gaagcagctt gatgcaggga
     2581 accctgggaa actttcagga aggtacagtg cttttctctg atgaggctgg gcatttagag
     2641 ctgcagtcag atggggaaga gagttaacac tggctctgat taggtgccag gcaggatgtc
     2701 tcctaagaac aggaatctag acttaattct ttccttaagt cttttccata ttgacttccc
     2761 cttttattta tttgttttct aattaagggg ccaagtctgt agagtttgtt aaactgagaa
     2821 gttgttacta tttgttgtca tggaggtgtg catattttat accacagcta ttatagggtc
     2881 atatgttggt aacttgaaat agaccagtta agtgtcttct ggacaaaggt tctgaatcca
     2941 tgtagctttg cccctactcc cttacatcac acgaaagctg tcttacaagc tggaagttca
     3001 gccgtcagaa tttgtttggc cagcatgaat tggtttatgt attaaactat actttttttt
     3061 ttgttttttt aaaaaccttc ccaccacatt tatttatccc ttaagtacac ttacatctct
     3121 gtcacttacc gacttttcat ttgctttgtc tatgcttagt gttttgttcc tgtaaatcag
     3181 caaacaatca attattggga ttttttcttt ggggttaaga ttaccacacc acctatagta
     3241 agtgggtagc acactgtggt ttttgtgtga gaatctaaca tttatatcta aaattggcaa
     3301 gtttttaatc actaggtgtt ttgttaggca actataagtc taataacaca gaacaatttt
     3361 tttgaaacct ggccaaaaat acattttatg agttaattac tcattatcat catcaccatc
     3421 attttgctat tatacctact agtggtttac agtgttcttc aatgcactga aagtacaagt
     3481 aagaagaccc caagagttga ggatgtagct tagtggtaga ggatttgcct agcatgtgca
     3541 aggtcctgag ttccatcccc agcactgtag gatgaaaaca aaataagcaa gactccagaa
     3601 ttcagtagta ctgaccattt ctaaaccaat agcctagaat aatgcttgca aagtctggaa
     3661 tacatggtat gtatcagtca tacatctgga gtcttaattt tttagctttt atagtagacc
     3721 ccacattccc caaagtttgt attttatgtt cagcatttta gaatgtgtat tctgttaatt
     3781 actatatcct gggttatatt ctgtactgta catagctact taaagctcgc catacttatc
     3841 ttttgtgaca atttgtattt gtatggttgc ataggtgggg aattttttgc aagatgaaaa
     3901 aaggttggat tttacttgcc actgcagaaa gttcaaaaca aaacagaaca ttaactttct
     3961 gtatattttt ccaattccca tgcagactgt tcttgtttta ttaggtcttt ggttttagca
     4021 aaaagagtgt ttacttaaaa tgtgtgaggg ttcatatgtc tggttgtcgt ttttgtttct
     4081 caaatctgta caggtttaca gtcttcgctt ttgttaaagt ttgaattgct ttgctatttt
     4141 gctctgtcct cacagaggta ttcagtctct gtatactctt aaaagaagaa aaagcaaagg
     4201 agggtatctt tattctttat cgttttcttt gagttggaaa caaaagtatg tatgaaggac
     4261 tacaactaga agatagacat gcatttaaat aggctagtgg aaaaaagttt ttaccgtttt
     4321 ctttctgttt tagagacagt taaaagactg ctccttgtac tgggagatac cagtgtatgc
     4381 ttctattgtt gccttgaaat tatcttttta ttttttaagg cctatagata ctattacctt
     4441 taaagtcttt aaagttaggt ttcatgccag cagcctctaa tgtattataa atggcaaccc
     4501 tatcttctta ttctgttaaa attgtatatg aacacctgtc tattttacaa acttacatat
     4561 atgacagtgt tgtctacttt gtcataggcc agtttctctt gaaatgtgac accaattcaa
     4621 gtggcttagg tgcagggaga gaccaagaat agatgcagag aggcaggaag agaagttact
     4681 attcagagga aggcagctta aatggatgat gttctgtgta tcattgataa gtttccttgt
     4741 ggtattgaaa aatgtttcta attgtacttg cctgatgttt tagtattgtt ttctagatgg
     4801 acttgtaaaa accaaaccgt gatttgtgag gttagaagtg tgtatttggg ggcctcaggt
     4861 gtgtgtgtgg ttttattttc ctccagacgt tttgaacttt agtcaataat tgtgtgtgtt
     4921 atttttaaga agtaactttt attttttctc tagtaaaatt gtgaacacat tttccttctg
     4981 aaggcaggat atgagctatg gattctgaaa agtattgtag gttgtactat gtgccttctt
     5041 agtgtgttta tgggcacaat gttttctctc atcaacttga aacttaaaag ggacattttg
     5101 gttagattac tgtacaccaa tctatgcata aatggcagct tgttttcttg agccactatc
     5161 taattgttct ttttttatat ataaattttt ttatattgat tgggtcagag atggtcagtt
     5221 ttatacagaa tgaacagcac agcactttgc caaaaaaccc caaaaaacaa aaaacatgta
     5281 gcattgctta accattgtgt attaatacca gttctttgta atgggttcag tagtgcattt
     5341 tgcactgcac agagttttta aatctgtcag taaataaaat gtcctttaac ttaa
//
