LOCUS       NM_173378               4377 bp    mRNA    linear   ROD 14-DEC-2022
DEFINITION  Mus musculus transformation related protein 53 binding protein 2
            (Trp53bp2), mRNA.
ACCESSION   NM_173378
VERSION     NM_173378.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4377)
  AUTHORS   Xie F, Xu HF, Zhang J, Liu XN, Kou BX, Cai MY, Wu J, Dong JL, Meng
            QH, Wang Y, Chen D and Zhang Y.
  TITLE     Dysregulated hepatic lipid metabolism and gut microbiota associated
            with early-stage NAFLD in ASPP2-deficiency mice
  JOURNAL   Front Immunol 13, 974872 (2022)
   PUBMED   36466835
  REMARK    GeneRIF: Dysregulated hepatic lipid metabolism and gut microbiota
            associated with early-stage NAFLD in ASPP2-deficiency mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4377)
  AUTHORS   Yang T, Zhu C, Shi Y, Shen Y, Gao Y, Zhang B, Jin R, Liu D, Ouyang
            Y, Liu X, Wang W, Yang P, Xu Q, Cai J and Chen D.
  TITLE     RDIVpSGP motif of ASPP2 binds to 14-3-3 and enhances
            ASPP2/k18/14-3-3 ternary complex formulation to promote
            BRAF/MEK/ERK signal inhibited cell proliferation in hepatocellular
            carcinoma
  JOURNAL   Cancer Gene Ther 29 (11), 1616-1627 (2022)
   PUBMED   35504951
  REMARK    GeneRIF: RDIVpSGP motif of ASPP2 binds to 14-3-3 and enhances
            ASPP2/k18/14-3-3 ternary complex formulation to promote
            BRAF/MEK/ERK signal inhibited cell proliferation in hepatocellular
            carcinoma.
REFERENCE   3  (bases 1 to 4377)
  AUTHORS   Wang Y, Che Y, Wang S, Wang J, Liu X, Kou B, Guan Y, Chen D and Shi
            Y.
  TITLE     ASPP2 reduction attenuates HBV induced chronic liver damage: A
            hybrid mouse model study
  JOURNAL   Biochem Biophys Res Commun 610, 61-69 (2022)
   PUBMED   35436632
  REMARK    GeneRIF: ASPP2 reduction attenuates HBV induced chronic liver
            damage: A hybrid mouse model study.
REFERENCE   4  (bases 1 to 4377)
  AUTHORS   Royer C, Sandham E, Slee E, Schneider F, Lagerholm CB, Godwin J,
            Veits N, Hathrell H, Zhou F, Leonavicius K, Garratt J, Narendra T,
            Vincent A, Jones C, Child T, Coward K, Graham C, Fritzsche M, Lu X
            and Srinivas S.
  TITLE     ASPP2 maintains the integrity of mechanically stressed
            pseudostratified epithelia during morphogenesis
  JOURNAL   Nat Commun 13 (1), 941 (2022)
   PUBMED   35177595
  REMARK    GeneRIF: ASPP2 maintains the integrity of mechanically stressed
            pseudostratified epithelia during morphogenesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4377)
  AUTHORS   Wang S, Kou B, Chai M, Gao Y, Lin X, Yin L, Chen D and Liu X.
  TITLE     Knockout of ASPP2 promotes DEN-induced hepatocarcinogenesis via the
            NF-kappaB pathway in mice
  JOURNAL   Cancer Gene Ther 29 (2), 202-214 (2022)
   PUBMED   33558702
  REMARK    GeneRIF: Knockout of ASPP2 promotes DEN-induced
            hepatocarcinogenesis via the NF-kappaB pathway in mice.
REFERENCE   6  (bases 1 to 4377)
  AUTHORS   Kampa KM, Acoba JD, Chen D, Gay J, Lee H, Beemer K, Padiernos E,
            Boonmark N, Zhu Z, Fan AC, Bailey AS, Fleming WH, Corless C,
            Felsher DW, Naumovski L and Lopez CD.
  TITLE     Apoptosis-stimulating protein of p53 (ASPP2) heterozygous mice are
            tumor-prone and have attenuated cellular damage-response thresholds
  JOURNAL   Proc Natl Acad Sci U S A 106 (11), 4390-4395 (2009)
   PUBMED   19251665
  REMARK    GeneRIF: ASPP2(+/-) mice appeared developmentally normal, they
            displayed an increased incidence of a variety of spontaneous tumors
            as they aged
REFERENCE   7  (bases 1 to 4377)
  AUTHORS   Sun WT, Hsieh PC, Chiang ML, Wang MC and Wang FF.
  TITLE     p53 target DDA3 binds ASPP2 and inhibits its stimulation on
            p53-mediated BAX activation
  JOURNAL   Biochem Biophys Res Commun 376 (2), 395-398 (2008)
   PUBMED   18793611
REFERENCE   8  (bases 1 to 4377)
  AUTHORS   Hakuno F, Kurihara S, Watson RT, Pessin JE and Takahashi S.
  TITLE     53BP2S, interacting with insulin receptor substrates, modulates
            insulin signaling
  JOURNAL   J Biol Chem 282 (52), 37747-37758 (2007)
   PUBMED   17965023
  REMARK    GeneRIF: 53BP2S interacts and modulates the insulin signals
            mediated by insulin receptor substrates.
REFERENCE   9  (bases 1 to 4377)
  AUTHORS   Sullivan A and Lu X.
  TITLE     ASPP: a new family of oncogenes and tumour suppressor genes
  JOURNAL   Br J Cancer 96 (2), 196-200 (2007)
   PUBMED   17211478
  REMARK    Review article
REFERENCE   10 (bases 1 to 4377)
  AUTHORS   Vives V, Su J, Zhong S, Ratnayaka I, Slee E, Goldin R and Lu X.
  TITLE     ASPP2 is a haploinsufficient tumor suppressor that cooperates with
            p53 to suppress tumor growth
  JOURNAL   Genes Dev 20 (10), 1262-1267 (2006)
   PUBMED   16702401
  REMARK    GeneRIF: ASPP2 is a haploinsufficient tumor suppressor that shares
            overlapping function(s) with p53 in mouse development and tumor
            suppression.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY020445.1, BQ180182.1, CN529251.1, AK134556.1, AC131742.2 and
            AW990556.1.
            
            [WARNING] On Jan 22, 2024 this sequence was replaced by
            NM_173378.3.
            
            On Aug 18, 2006 this sequence version replaced NM_173378.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                BY020445.1         1-15
            16-715              BQ180182.1         1-700
            716-1425            CN529251.1         4-713
            1426-3713           AK134556.1         396-2683
            3714-3869           AC131742.2         128635-128790
            3870-4377           AW990556.1         1-508               c
FEATURES             Location/Qualifiers
     source          1..4377
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 84.93 cM"
     gene            1..4377
                     /gene="Trp53bp2"
                     /gene_synonym="53BP2; ASPP2; PPP1R13A; Tp53bp2"
                     /note="transformation related protein 53 binding protein
                     2"
                     /db_xref="GeneID:209456"
                     /db_xref="MGI:MGI:2138319"
     exon            1..284
                     /gene="Trp53bp2"
                     /gene_synonym="53BP2; ASPP2; PPP1R13A; Tp53bp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..3662
                     /gene="Trp53bp2"
                     /gene_synonym="53BP2; ASPP2; PPP1R13A; Tp53bp2"
                     /note="tumor protein p53 binding protein, 2; p53BP2;
                     p53-binding protein 2; tumor suppressor p53-binding
                     protein 2"
                     /codon_start=1
                     /product="apoptosis-stimulating of p53 protein 2"
                     /protein_id="NP_775554.2"
                     /db_xref="CCDS:CCDS48476.1"
                     /db_xref="GeneID:209456"
                     /db_xref="MGI:MGI:2138319"
                     /translation="MRFGSKMMPMFLTVYLSNSEQHFTEVPVTPETICRDVVDLCKEP
                     GENDCHLAEVWCGSERPVADNERMFDVLQRFGSQRNEVRFFLRHERPPNRDIVSGPRS
                     QDPSVKRNGVKVPGEHRRKENGVNSPRLDLTLAELQEMASRQQQQIEAQQQMLATKEQ
                     RLKFLKQQDQRQQQQAAEQEKLKRLREIAESQEAKLKKVRALKGHVEQKRLSNGKLVE
                     EIEQMNSLFQQKQRELVLAVSKVEELTRQLEMLKNGRIDGHHDNQSAVAELDRLYKEL
                     QLRNKLNQEQNAKLQQQRECLNKRNSEVAVMDKRVSELRDRLWKKKAALQQKENLPVS
                     PDGNLPQQAVSAPSRVAAVGPYIQSSTMPRMPSRPELLVKPALPDGSLLMQSAEGPMK
                     IQTLPNMRSGAASQSKGSKAHPASPDWNPSNADLLPSQGSSVPQSAGTALDQVDDGEI
                     AVREKEKKVRPFSMFDTVDQCAAPPSFGTLRKNQSSEDILRDAQAVNKNVAKVPPPVP
                     TKPKQIHLPYFGQTAQSPSDMKPDGNAQQLPIAATSVGAKLKPAGPQARMLLSPGAPS
                     GGQDQVLSPASKQESPPAAAVRPFTPQPSKDTFPPAFRKPQTVAASSIYSMYTQQQAP
                     GKNFQQAVQSALTKTQPRGPHFSSVYGKPVIAAAQNPQQHPENIYSCSQGKPGSPEPE
                     TETVSSVHESHENERIPRPLSPTKLLPFLSNPYRNQSDADLEALRKKLSNAPRPLKKR
                     SSITEPEGPNGPNIQKLLYQRTTIAAMETISVPSHPSKSPGSVTVNPESSVEIPNPYL
                     HVEPEKEVGSLVPEPLSPEDMGSASTENSDVPAPSAGLEYVSEGVTDSSTNLQNNVEE
                     TNPEAPHLLEVYLEEYPPYPPPPYPSGEPEVSEEDSARMRPPEITGQVSLPPGKRTNL
                     RKTGSERIAHGMRVKFNPLALLLDSSLEGEFDLVQRIIYEVDDPSLPNDEGITALHNA
                     VCAGHTEIVKFLVQFGVNVNAADSDGWTPLHCAASCNNVQVCKFLVESGAAVFAMTYS
                     DMQTAADKCEEMEEGYTQCSQFLYGVQEKMGIMNKGVIYALWDYEPQHDDELLMKEGD
                     CMTVIRREDEEEIEWWWARLNDKEGYVPRNLLGLYPRIKPRQRSLA"
     exon            285..432
                     /gene="Trp53bp2"
                     /gene_synonym="53BP2; ASPP2; PPP1R13A; Tp53bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            433..546
                     /gene="Trp53bp2"
                     /gene_synonym="53BP2; ASPP2; PPP1R13A; Tp53bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            547..629
                     /gene="Trp53bp2"
                     /gene_synonym="53BP2; ASPP2; PPP1R13A; Tp53bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            630..731
                     /gene="Trp53bp2"
                     /gene_synonym="53BP2; ASPP2; PPP1R13A; Tp53bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            732..906
                     /gene="Trp53bp2"
                     /gene_synonym="53BP2; ASPP2; PPP1R13A; Tp53bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1088
                     /gene="Trp53bp2"
                     /gene_synonym="53BP2; ASPP2; PPP1R13A; Tp53bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1253
                     /gene="Trp53bp2"
                     /gene_synonym="53BP2; ASPP2; PPP1R13A; Tp53bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1482
                     /gene="Trp53bp2"
                     /gene_synonym="53BP2; ASPP2; PPP1R13A; Tp53bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1590
                     /gene="Trp53bp2"
                     /gene_synonym="53BP2; ASPP2; PPP1R13A; Tp53bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1739
                     /gene="Trp53bp2"
                     /gene_synonym="53BP2; ASPP2; PPP1R13A; Tp53bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..2202
                     /gene="Trp53bp2"
                     /gene_synonym="53BP2; ASPP2; PPP1R13A; Tp53bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2981
                     /gene="Trp53bp2"
                     /gene_synonym="53BP2; ASPP2; PPP1R13A; Tp53bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2982..3119
                     /gene="Trp53bp2"
                     /gene_synonym="53BP2; ASPP2; PPP1R13A; Tp53bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3120..3253
                     /gene="Trp53bp2"
                     /gene_synonym="53BP2; ASPP2; PPP1R13A; Tp53bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3254..3420
                     /gene="Trp53bp2"
                     /gene_synonym="53BP2; ASPP2; PPP1R13A; Tp53bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3421..3620
                     /gene="Trp53bp2"
                     /gene_synonym="53BP2; ASPP2; PPP1R13A; Tp53bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3621..4370
                     /gene="Trp53bp2"
                     /gene_synonym="53BP2; ASPP2; PPP1R13A; Tp53bp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggattagttg gtttcggcga gaaggaggag gaggaggtgg gagtcgcgag cgccgagaca
       61 aagccgcgtc ccggagacgg gcgaggggat tgggccccgg actcggtggc gtcccggtcc
      121 gctgagggga ctccagcgcc gctgcctcgc aacaggtcgg ccgccgggcg cgcggcctcg
      181 ttctcgcttg gcttccccgg gcccgcgacc ctcgggtcac ttctgctcgg ccaggccgcc
      241 gccagacccc cgcttccatg cggttcgggt ccaaaatgat gccgatgttc ctgacagttt
      301 acctcagtaa cagtgagcag cacttcacag aagttcctgt taccccagag acaatatgca
      361 gagatgtggt ggatctgtgc aaggagcctg gagagaacga ctgccattta gccgaagtgt
      421 ggtgtggctc tgaacgccca gttgctgata acgaacggat gtttgatgtt cttcagcggt
      481 ttggaagtca aaggaatgaa gttcgcttct ttcttcgtca tgaacgcccc cctaacaggg
      541 acattgtgag tggaccgaga tcccaagatc caagtgtaaa aagaaatggt gtcaaagttc
      601 ccggcgagca tcggaggaag gagaatgggg ttaacagtcc taggctggac ctgacgcttg
      661 ctgagctcca ggagatggca tctcgccagc agcagcagat cgaggcccag caacaaatgc
      721 tggctactaa ggagcaacgc ttaaagtttt taaaacagca agatcaacgt caacagcaac
      781 aagctgctga acaggagaaa cttaagaggc ttagagaaat agctgaaagt caggaagcta
      841 agcttaagaa agtgagagcg ctaaagggcc atgtggagca aaagaggctg agcaacggaa
      901 aactcgtgga ggagatcgag cagatgaata gcttgttcca gcagaagcag agggagctgg
      961 tgctggctgt gtcgaaagtg gaggagctga cgaggcagct ggagatgctg aagaacggca
     1021 ggatcgatgg ccaccacgac aaccagtcgg ccgtggctga gctggaccgc ctttacaagg
     1081 agctgcagtt aagaaacaaa ctgaaccaag agcagaatgc caagctgcaa caacagaggg
     1141 agtgtttgaa taagcgcaat tcagaggtgg ccgtcatgga taaacgcgtc agtgagctga
     1201 gggaccggct gtggaagaag aaggcagcac tgcagcagaa agagaatctc ccggtttcac
     1261 ctgatggaaa tcttccccaa caagcagtgt cagccccaag tcgtgtggct gctgtaggcc
     1321 cttacatcca gtcatccact atgccacgga tgccctccag acctgagctg ctcgtgaagc
     1381 cagccctgcc tgatggttcc ttgctcatgc agtcagcaga ggggccaatg aagatacaga
     1441 cactgcccaa tatgaggtct ggggctgctt cacaaagtaa aggctctaaa gctcacccag
     1501 ctagccccga ttggaaccct tccaatgccg acctcttacc cagccaaggc tcttctgtac
     1561 cccagagtgc tggaactgct ctggaccaag ttgacgatgg ggagattgct gtgagggaga
     1621 aagagaagaa agtgcgtccc ttttccatgt ttgacacagt ggaccagtgt gctgccccac
     1681 cctcctttgg taccctgagg aaaaaccaga gcagcgagga catcttgcgg gatgctcagg
     1741 ctgtaaataa aaatgtagct aaagtaccac ctcccgttcc tacaaagcca aaacagattc
     1801 atttgcctta ctttggacaa acggctcagt cgccttctga catgaagcca gatggaaatg
     1861 ctcagcaatt gccaatagct gctacatccg tgggggctaa gctcaagcca gcagggccac
     1921 aggcaaggat gctgctgtct cctggtgccc cttcaggtgg tcaggaccaa gtcctgtctc
     1981 cagcatctaa gcaagaaagt cctcctgctg ctgcagtccg gcccttcacg ccccagccgt
     2041 ccaaggacac cttccctcca gcctttcgaa aaccccagac tgtggcagca agctccatct
     2101 attccatgta cacccagcaa caggcaccag gaaaaaactt ccagcaggct gtgcagagtg
     2161 ccttgaccaa gacgcaaccc agaggccccc acttttcaag tgtgtatggc aagcctgtga
     2221 tagctgctgc ccagaatcca caacagcacc cagagaacat ttactcctgt agccagggga
     2281 agcctggcag tccggagccc gagacagaga ccgtttcttc agttcatgag agccatgaaa
     2341 acgaaaggat tcctcgacca ctcagcccaa caaaattact gcctttcttg tctaaccctt
     2401 atcgaaacca gagcgatgct gacttagaag ccctgaggaa aaaattgtcg aatgcaccac
     2461 ggccactaaa gaaacgtagc tccattacag aaccagaagg ccctaatggg ccaaatattc
     2521 agaaactttt gtatcagagg accaccatag ctgccatgga gaccatctca gtcccctcac
     2581 acccatctaa gtcaccaggc tcagtgactg tcaatccaga gagctccgtt gaaatcccaa
     2641 atccatattt acatgtggag ccagagaagg aggtgggctc tttagtccct gaaccactgt
     2701 ccccagagga tatggggagt gccagtacgg agaacagtga cgtgccagct ccttctgcag
     2761 gccttgagta tgtgtctgag ggagtcacag acagcagtac caatctgcag aataacgtag
     2821 aagaaacaaa cccagaggct ccccacttac ttgaagtgta cctagaagaa taccccccat
     2881 acccaccccc tccataccca tctggggagc cagaggtgtc cgaagaagac tccgcacgta
     2941 tgcgcccacc tgaaatcacc gggcaggtgt ctctgcctcc tggcaaaagg acaaacttgc
     3001 ggaaaactgg ctccgagcgg attgctcacg ggatgagggt gaaattcaac ccccttgctt
     3061 tgctgctaga ttcatctctg gagggagagt ttgatcttgt acagagaatt atctatgagg
     3121 ttgatgaccc aagcctacca aatgatgagg gcatcacagc tcttcataat gctgtgtgtg
     3181 caggccacac agaaattgtg aagttcctgg tacagttcgg tgtgaatgta aatgcagcag
     3241 atagtgatgg atggacgcca ttgcattgtg ctgcctcctg caacaatgtc caagtgtgta
     3301 agttcctggt ggagtctgga gcagctgtgt ttgctatgac ctacagtgac atgcagactg
     3361 ctgcagacaa gtgcgaggaa atggaggaag gctacacgca gtgctcccag tttctctatg
     3421 gcgttcagga gaagatgggc ataatgaaca aaggcgtcat ttatgcactg tgggattacg
     3481 agccgcagca tgacgatgag ctgctcatga aagaaggaga ttgcatgacc gtcatccgca
     3541 gagaagatga agaggagatc gagtggtggt gggcgcgcct taacgataag gaaggatatg
     3601 ttccacgcaa cttgctagga ctatacccaa gaattaaacc aagacaaagg agcttggcct
     3661 gaaacttgag ttaatgaaga attaatgagc tagaagaaat actatgatta tccaggaaaa
     3721 aaaaatcaga aggcttactt taatgacagt atagctcaga agcaatgaag aatgtgccgt
     3781 ggaagaaaat gaaggaccga aggactcggc gtgagcagag gcattgctgc tgagcccgca
     3841 ccaccctggc tggcagaatg ctcatggcgg cgcagcatag gaggcagcca tctggctttg
     3901 tcaagaaatg ggaccatttg ctggactgtg ggaaaatcag tttcttgtcc tgtgtagggt
     3961 gattttggca ctgttcccat tccgctgacc tgccagaaag gacctgtgcc atctggcacc
     4021 atctccaact gcccctgagc accagcaggc tttgggatcc ccggcgggtg ctgtacactt
     4081 gtgtgttatc agtgaagaac tgttagctgc ttgtcagtga gcagtaacta ttgtatgagt
     4141 tattgtagca tttaagaatt atgcgtatat ttgaaatact gaaattaaac tacactacct
     4201 aatctaaagt agatttagaa tcttgttttt agattgaatt tgaatctata tttattgtct
     4261 ttttgtatct tggaaattag agatttgtta tagatttacc tgtatttgtc aagatcatag
     4321 ctggttttaa aaatgattgt aataaaatta aactttatga ctccaagcta aaaaaaa
//
