LOCUS       NM_013735               9652 bp    mRNA    linear   ROD 25-APR-2023
DEFINITION  Mus musculus transformation related protein 53 binding protein 1
            (Trp53bp1), transcript variant 1, mRNA.
ACCESSION   NM_013735 XR_104711 XR_107397
VERSION     NM_013735.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9652)
  AUTHORS   Zhao S, Huang C, Yang Y, Xu W, Yu Y, Wen C, Cao L, Gao F, Qin Y,
            Chen ZJ, Guo T and Zhao S.
  TITLE     DNA repair protein FANCD2 has both ubiquitination-dependent and
            ubiquitination-independent functions during germ cell development
  JOURNAL   J Biol Chem 299 (3), 102905 (2023)
   PUBMED   36642183
REFERENCE   2  (bases 1 to 9652)
  AUTHORS   Tominaga K, Sakashita E, Kasashima K, Kuroiwa K, Nagao Y, Iwamori N
            and Endo H.
  TITLE     Tip60/KAT5 Histone Acetyltransferase Is Required for Maintenance
            and Neurogenesis of Embryonic Neural Stem Cells
  JOURNAL   Int J Mol Sci 24 (3), 2113 (2023)
   PUBMED   36768434
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9652)
  AUTHORS   Rodriguez A, Epperly M, Filiatrault J, Velazquez M, Yang C, McQueen
            K, Sambel LA, Nguyen H, Iyer DR, Juarez U, Ayala-Zambrano C,
            Martignetti DB, Frias S, Fisher R, Parmar K, Greenberger JS and
            D'Andrea AD.
  TITLE     TGFbeta pathway is required for viable gestation of Fanconi anemia
            embryos
  JOURNAL   PLoS Genet 18 (11), e1010459 (2022)
   PUBMED   36441774
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9652)
  AUTHORS   Yang Y, Xu W, Gao F, Wen C, Zhao S, Yu Y, Jiao W, Mi X, Qin Y, Chen
            ZJ and Zhao S.
  TITLE     Transcription-replication conflicts in primordial germ cells
            necessitate the Fanconi anemia pathway to safeguard genome
            stability
  JOURNAL   Proc Natl Acad Sci U S A 119 (34), e2203208119 (2022)
   PUBMED   35969748
REFERENCE   5  (bases 1 to 9652)
  AUTHORS   Vincendeau E, Wei W, Zhang X, Planchais C, Yu W, Lenden-Hasse H,
            Cokelaer T, Pipoli da Fonseca J, Mouquet H, Adams DJ, Alt FW,
            Jackson SP, Balmus G, Lescale C and Deriano L.
  TITLE     SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but
            critical for productive class switch recombination
  JOURNAL   Nat Commun 13 (1), 3707 (2022)
   PUBMED   35764636
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9652)
  AUTHORS   Morales JC, Xia Z, Lu T, Aldrich MB, Wang B, Rosales C, Kellems RE,
            Hittelman WN, Elledge SJ and Carpenter PB.
  TITLE     Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in
            maintaining genomic stability
  JOURNAL   J Biol Chem 278 (17), 14971-14977 (2003)
   PUBMED   12578828
  REMARK    GeneRIF: m53BP1(tr/tr) mice are sensitive to ionizing radiation and
            cells from these animals exhibit chromosomal abnormalities
            consistent with defects in DNA repair, indicating that 53BP1 is a
            critical element in the DNA damage response.
REFERENCE   7  (bases 1 to 9652)
  AUTHORS   Ward IM, Minn K, van Deursen J and Chen J.
  TITLE     p53 Binding protein 53BP1 is required for DNA damage responses and
            tumor suppression in mice
  JOURNAL   Mol Cell Biol 23 (7), 2556-2563 (2003)
   PUBMED   12640136
  REMARK    GeneRIF: 53BP1 acts downstream of ATM and upstream of Chk2 in the
            DNA damage response pathway and is involved in tumor suppression
REFERENCE   8  (bases 1 to 9652)
  AUTHORS   Celeste A, Petersen S, Romanienko PJ, Fernandez-Capetillo O, Chen
            HT, Sedelnikova OA, Reina-San-Martin B, Coppola V, Meffre E,
            Difilippantonio MJ, Redon C, Pilch DR, Olaru A, Eckhaus M,
            Camerini-Otero RD, Tessarollo L, Livak F, Manova K, Bonner WM,
            Nussenzweig MC and Nussenzweig A.
  TITLE     Genomic instability in mice lacking histone H2AX
  JOURNAL   Science 296 (5569), 922-927 (2002)
   PUBMED   11934988
REFERENCE   9  (bases 1 to 9652)
  AUTHORS   Jullien D, Vagnarelli P, Earnshaw WC and Adachi Y.
  TITLE     Kinetochore localisation of the DNA damage response component 53BP1
            during mitosis
  JOURNAL   J Cell Sci 115 (Pt 1), 71-79 (2002)
   PUBMED   11801725
REFERENCE   10 (bases 1 to 9652)
  AUTHORS   Datta B, Li B, Choubey D, Nallur G and Lengyel P.
  TITLE     p202, an interferon-inducible modulator of transcription, inhibits
            transcriptional activation by the p53 tumor suppressor protein, and
            a segment from the p53-binding protein 1 that binds to p202
            overcomes this inhibition
  JOURNAL   J Biol Chem 271 (44), 27544-27555 (1996)
   PUBMED   8910340
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY777325.1, BC079906.1, CA316961.1, AK132323.1, AK036324.1,
            AK045416.1, CA752558.1 and CF744583.1.
            
            [WARNING] On May 18, 2023 this sequence was replaced by
            NM_013735.5.
            
            On Mar 20, 2014 this sequence version replaced NM_013735.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a). This variant is
            supported by the 5'-partial mRNA AJ414734.1, with inference of the
            first exon from other transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164138,
                              SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-354               BY777325.1         2-355
            355-3337            BC079906.1         289-3271
            3338-3946           CA316961.1         13-621
            3947-3967           BC079906.1         3881-3901
            3968-6203           AK132323.1         1-2236
            6204-7724           AK036324.1         2009-3529
            7725-8139           AK045416.1         1776-2190
            8140-8361           CA752558.1         364-585
            8362-9620           AK045416.1         2413-3671
            9621-9652           CF744583.1         1-32                c
FEATURES             Location/Qualifiers
     source          1..9652
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2"
     gene            1..9652
                     /gene="Trp53bp1"
                     /gene_synonym="53BP1; m53BP1; p53BP1; Tp53bp1"
                     /note="transformation related protein 53 binding protein
                     1"
                     /db_xref="GeneID:27223"
                     /db_xref="MGI:MGI:1351320"
     exon            1..136
                     /gene="Trp53bp1"
                     /gene_synonym="53BP1; m53BP1; p53BP1; Tp53bp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..6039
                     /gene="Trp53bp1"
                     /gene_synonym="53BP1; m53BP1; p53BP1; Tp53bp1"
                     /note="isoform a is encoded by transcript variant 1; tumor
                     suppressor p53-binding protein 1; murine p53-binding
                     protein; TP53-binding protein 1"
                     /codon_start=1
                     /product="TP53-binding protein 1 isoform a"
                     /protein_id="NP_038763.3"
                     /db_xref="CCDS:CCDS50684.1"
                     /db_xref="GeneID:27223"
                     /db_xref="MGI:MGI:1351320"
                     /translation="MPGEQMDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEEDAGSH
                     FSVLSRHLPNLQMHKENPVLDIVSNPEQSAVEQGDSNSSFNEHLKEKKASDPVESSHL
                     GTSGSISQVIERLPQPNRTSSALAVTVEAASLPEEEKEEEELEEEKEGVGANAPGADS
                     LAAEDSASSQLGFGVLELSQSQDVEEHTVPYDVNQEHLQLVTTNSGSSPLSDVDASTA
                     IKCEEQPTEDIAMIEQPSKDIPVTVQPGKGIHVVEEQNLPLVRSEDRPSSPQVSVAAV
                     ETKEQVPARELLEEGPQVQPSSEPEVSSTQEDLFDQSSKTASDGCSTPSREEGGCSPV
                     STPATTLQLLQLSGQKPLVQESLSTNSSDLVAPSPDAFRSTPFIVPSSPTEQGGRKDE
                     PMDMSVIPVGGEPFQKLHDDEAMETEKPLLPSQPAVSPQASTPVSRSTPVFTPGSLPI
                     PSQPEFSHDIFIPSPSLEEPSDDVKKGGGLHSSSLTVECSKTSESEPKNFTDDLGLSM
                     TGDSCKLMLSTSEYSQSSKMESLGSPRTEEDRENTQIDDTEPLSPVSNSKLPADSENV
                     LVTPSQDDQVEMSQNVDKAKEDETEDRGDCKGREDAVAEDVCIDLTCDSGSQAVPSPA
                     TRSEALSSVLDQEEAMDTKEHHPEEGFSGSEVEEVPETPCGSHREEPKEEPMESIPLH
                     LSLTETQSEALCLQKEAPKEECPEAMEVETSVISIDSPQKLQVLDQELEHKDPDTWEE
                     ATSEDSSVVIVDVKEPSPRADVSCEPLEEVEKCSDSQSWEGVAPEEEPCAENRLDTPE
                     EKRIECDGDSKAETTEKDAVTEDSPQPPLPSVRDEPVRPDQETQQPQVQEKESPVTVD
                     AEVADDKQLGPEGACQQLEKAPACASQSFCESSSETPFHFTLPKEGDIIPPLTGATPP
                     LIGHLKLEPKRHSTPIGISNYPESTIATSDVTSESMVEINDPLLGNEKGDSESAPEMD
                     GKLSLKMKLVSPETEASEESLQFSLEKPTTAERKNGSTAIAEPVASLQKPVPVFGCIY
                     EAQQEKEAQSEAPPSAPDRANLLHFPSAQEEDKERPDVTPKLRQSEQPVKPVGPVMDD
                     AAPEDSASPVSQQRASQEQRASQEPFSPAEDVMETDLLEGLAANQDRPSKMLMDRPTQ
                     SNIGIQTVDHSLCAPETVSAATQTVKSVCEQGTSTAEQNSGKQDATVQTERGSGEKPA
                     SAPVDDTESLHSQGEEEFEMPQPPHGHVLHRHMRTIREVRTLVTRVITDVYYVDGTEV
                     ERKVTEETEEPIVECQECETEVSPSQTGGSSGDLGDISSFSSKASSSHHTSSGTSLSA
                     IHSSGSSGRGAGPLKGKASGTEAADFALPSSRGGPGKLSPRKGISQTGAPVCEEDGDA
                     GLGIRQGGKAPVTPRGRGRRGRPPSRTTGTRETVVSGPLGVEDISPSMSPDDKSFTRI
                     MPRVPDSTKRTDASSSTLRRSDSPEIPFQAATGSSDGLDSSSSGNSFVGLRVVAKWSS
                     NGYFYSGKITRDVGAGKYKLLFDDGYECDVLGKDILLCDPIPLDTEVTALSEDEYFSA
                     GVVKGHRKESGELYYSIEKEGQRKWYKRMAVILSLEQGNRLREQYGLGPYEAVTPLTK
                     AADISLDNLVEGKRKRRSNISSPVTPTAASSSSTTPTRKATESPRASTGVPSGKRKLP
                     TSEEERSPAKRGRKSATVKPGTVGAAEFVSPCETGDNIGEPSVLEEPRGPLPLNKTLF
                     LGYAFLLTMATTSDKLASRSKLLDGPTGSSEEEEEFLEIPPFNKQYTECQLRAGAGYI
                     LEDFNEAQCNTAYQCLLIADQHCRTRKYFLCLASGIPCVSHVWVHDSCHANQLQNYRN
                     YLLPAGYSLEEQRILDWQPRENPFQNLKVLLVSDQQQNFLELWSEILMTGGAASVKQH
                     HSSAHNKDIALGVFDVVVTDPSCPASVLKCAEALQLPVVSQEWVIQCLIVGERIGFKQ
                     HPKYKHDYVSH"
     exon            137..321
                     /gene="Trp53bp1"
                     /gene_synonym="53BP1; m53BP1; p53BP1; Tp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            322..412
                     /gene="Trp53bp1"
                     /gene_synonym="53BP1; m53BP1; p53BP1; Tp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            413..497
                     /gene="Trp53bp1"
                     /gene_synonym="53BP1; m53BP1; p53BP1; Tp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            498..622
                     /gene="Trp53bp1"
                     /gene_synonym="53BP1; m53BP1; p53BP1; Tp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            623..781
                     /gene="Trp53bp1"
                     /gene_synonym="53BP1; m53BP1; p53BP1; Tp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            782..911
                     /gene="Trp53bp1"
                     /gene_synonym="53BP1; m53BP1; p53BP1; Tp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1078
                     /gene="Trp53bp1"
                     /gene_synonym="53BP1; m53BP1; p53BP1; Tp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1205
                     /gene="Trp53bp1"
                     /gene_synonym="53BP1; m53BP1; p53BP1; Tp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1300
                     /gene="Trp53bp1"
                     /gene_synonym="53BP1; m53BP1; p53BP1; Tp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1503
                     /gene="Trp53bp1"
                     /gene_synonym="53BP1; m53BP1; p53BP1; Tp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..2800
                     /gene="Trp53bp1"
                     /gene_synonym="53BP1; m53BP1; p53BP1; Tp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2801..2920
                     /gene="Trp53bp1"
                     /gene_synonym="53BP1; m53BP1; p53BP1; Tp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2921..3124
                     /gene="Trp53bp1"
                     /gene_synonym="53BP1; m53BP1; p53BP1; Tp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3125..3182
                     /gene="Trp53bp1"
                     /gene_synonym="53BP1; m53BP1; p53BP1; Tp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3183..3275
                     /gene="Trp53bp1"
                     /gene_synonym="53BP1; m53BP1; p53BP1; Tp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3276..3780
                     /gene="Trp53bp1"
                     /gene_synonym="53BP1; m53BP1; p53BP1; Tp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3781..3933
                     /gene="Trp53bp1"
                     /gene_synonym="53BP1; m53BP1; p53BP1; Tp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3934..4205
                     /gene="Trp53bp1"
                     /gene_synonym="53BP1; m53BP1; p53BP1; Tp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            4206..4355
                     /gene="Trp53bp1"
                     /gene_synonym="53BP1; m53BP1; p53BP1; Tp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            4356..4786
                     /gene="Trp53bp1"
                     /gene_synonym="53BP1; m53BP1; p53BP1; Tp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            4787..4978
                     /gene="Trp53bp1"
                     /gene_synonym="53BP1; m53BP1; p53BP1; Tp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            4979..5194
                     /gene="Trp53bp1"
                     /gene_synonym="53BP1; m53BP1; p53BP1; Tp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            5195..5410
                     /gene="Trp53bp1"
                     /gene_synonym="53BP1; m53BP1; p53BP1; Tp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            5411..5505
                     /gene="Trp53bp1"
                     /gene_synonym="53BP1; m53BP1; p53BP1; Tp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            5506..5705
                     /gene="Trp53bp1"
                     /gene_synonym="53BP1; m53BP1; p53BP1; Tp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            5706..5851
                     /gene="Trp53bp1"
                     /gene_synonym="53BP1; m53BP1; p53BP1; Tp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            5852..9624
                     /gene="Trp53bp1"
                     /gene_synonym="53BP1; m53BP1; p53BP1; Tp53bp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgacgggaa aagggggagc tcgcggccag tggcggcggt ggcgacagtg gcgacctggg
       61 gatcgacctg gaggggcctg ggcagcgtgc agaaacctct agatccagcg cgaggcacct
      121 ctcgccggga tgccagggga gcagatggac cctactggaa gtcaattgga ttcagatttc
      181 tctcagcaag acactccttg cctgataata gaagattctc agcctgaaag ccaggttctg
      241 gaagaagatg caggctctca cttcagcgtg ctatctcgac accttcctaa tctgcagatg
      301 cacaaagaga accccgtgtt ggatattgta tcaaatccgg aacaatctgc tgtagaacaa
      361 ggagacagta atagctcatt caatgaacat ctgaaagaaa agaaagcttc agatcctgtg
      421 gagtcttctc atttgggtac cagtggttcc atcagtcagg tcattgaacg gttacctcag
      481 ccaaacagga caagcagtgc tctggcagtg acagtagaag ctgcttctct cccagaggag
      541 gagaaggaag aagaggagtt agaggaggag aaggaagggg tgggagcaaa cgctcccggt
      601 gctgactccc ttgctgctga agattctgct tcatcacagt tgggctttgg agttctggaa
      661 ctgtcccaga gccaggatgt tgaagaacat acagtgccat atgatgtcaa ccaagagcat
      721 ctgcagttgg tgaccactaa ctcgggttct agcccgctat ctgatgtgga tgcgagcact
      781 gcaattaaat gtgaagaaca gcccactgaa gatattgcca tgatagaaca gcccagcaaa
      841 gacatccctg ttacagtaca gcccggtaaa ggtatccatg tggtagaaga acaaaatcta
      901 ccacttgtaa ggtccgaaga ccggccgtcc agtcctcaag tttctgttgc tgctgtggaa
      961 acaaaggaac aggtacctgc ccgggagctg ctggaagagg ggccgcaggt tcagccgtca
     1021 tcagagcctg aggtttcctc aacccaggag gacttgtttg accagagtag taaaacagct
     1081 tctgatggtt gttctactcc ttcaagggag gaaggtgggt gctctccggt ttccacacct
     1141 gctaccaccc tgcagctcct gcagctctct ggtcagaagc cccttgttca ggagagtctt
     1201 tccacgaatt cctcagatct tgttgctcct tcccctgatg ctttccgatc tacccctttt
     1261 atcgttccta gcagtcccac agagcaagga gggagaaaag atgagcccat ggatatgtca
     1321 gtgatacctg taggagggga gcctttccag aagcttcatg atgacgaagc aatggagaca
     1381 gaaaaacccc ttctcccgtc tcagcctgct gtgtcaccgc aagcatcaac accagtgtct
     1441 cggagcacgc cagttttcac tcctggctct cttcccatcc cgtcccagcc cgagttctct
     1501 catgacattt tcattccatc accaagtctg gaagaaccat cagatgatgt gaagaaaggt
     1561 ggaggtttac atagctcatc tcttactgtt gagtgttcca agacttcaga gagtgaacca
     1621 aagaatttca ctgatgacct tgggctctcc atgacagggg attcttgcaa actgatgctt
     1681 tctacaagtg agtatagtca gtcctcaaag atggagagct tgggttctcc caggactgag
     1741 gaagacagag agaacacaca gattgacgat actgaacctt tgtctccagt tagcaattct
     1801 aaacttcctg ctgacagtga gaatgtcctg gtgactccat cgcaggacga ccaggtagaa
     1861 atgagtcaga atgtagataa agcaaaagag gatgaaacgg aggacagagg tgactgtaaa
     1921 ggcagagaag acgcggttgc tgaagatgtt tgcatcgacc tcacttgtga ttctgggagt
     1981 caggcagttc cttctccagc tacccgttcg gaggcacttt ccagtgtctt agatcaggag
     2041 gaagctatgg acactaaaga acaccatcca gaggaagggt tttcgggatc tgaagtagaa
     2101 gaagtccctg agactccctg tggaagtcac agagaggagc ccaaagaaga accgatggaa
     2161 agtatcccac tgcacctttc tctgactgaa acccagtctg aggcattgtg tctgcagaag
     2221 gaagccccca aagaggaatg cccagaagct atggaagttg aaaccagtgt gattagtatt
     2281 gactcccccc agaaactgca agtacttgac caggaattag agcataagga cccagacacc
     2341 tgggaagaag ctacttctga ggactccagt gttgttatcg ttgatgtgaa ggagccctct
     2401 cctcgagctg atgtttcctg tgaacctttg gaggaggtgg agaaatgctc tgactcccag
     2461 tcctgggagg gtgtggctcc agaggaagaa ccatgtgctg agaatagatt agatactcca
     2521 gaagaaaagc gtatagaatg tgatggagat tcaaaagcag agaccacaga aaaggacgct
     2581 gtaacagaag actctccaca acctcctttg ccttcagtga gagacgaacc tgtcagaccc
     2641 gatcaggaga cacagcagcc ccaagttcaa gagaaagaga gcccagtgac tgtagatgca
     2701 gaagtggctg atgacaagca gctgggacca gagggcgcat gccagcagct tgagaaggcc
     2761 cctgcctgtg cctcacagag tttctgtgaa agttctagtg aaactccatt tcatttcact
     2821 ttgcctaaag aaggtgatat tatcccacca ttgactggcg caaccccacc tcttattggg
     2881 cacctaaaat tggagcccaa gagacatagt actcctattg ggattagcaa ctatccagaa
     2941 agcaccatag caaccagtga tgtcacatct gaaagcatgg tggagatcaa tgatcctcta
     3001 cttgggaatg aaaaagggga ttctgagtct gccccagaaa tggatggaaa actgtctctg
     3061 aaaatgaaac tggttagtcc tgagacagag gccagtgaag aatctttgca atttagcctg
     3121 gaaaagccta caactgctga gagaaaaaat ggatctactg ccattgcaga gcctgttgcc
     3181 agtctccaga agccggtgcc tgtgtttggc tgcatctatg aagcccagca agagaaggag
     3241 gctcaaagtg aggctcctcc ctctgcaccc gacagggcga atttgctcca ttttccaagt
     3301 gctcaagaag aagacaaaga aagaccagat gttaccccaa aactcaggca gagtgaacag
     3361 cctgtgaagc ctgttgggcc tgtcatggac gatgctgctc ctgaggactc agcttctcct
     3421 gtttcgcagc agagggcctc acaggagcag agggcctcac aggagccctt cagtcctgca
     3481 gaggacgtga tggaaacaga cctgctggaa ggactggctg ctaaccagga cagacctagt
     3541 aagatgttga tggacaggcc cacccagagt aacatcggga tccagaccgt ggaccattcc
     3601 ctgtgcgccc cagaaactgt ctcggcagca actcagactg tgaagagtgt gtgtgagcag
     3661 gggaccagta cagcggagca gaactctggg aaacaagatg ccactgtgca gactgagagg
     3721 gggagtggag agaaacctgc cagtgctccc gtggacgaca cagagtccct ccacagccag
     3781 ggggaagagg aatttgaaat gccccagcct ccgcatggcc atgtcttgca tcgccacatg
     3841 agaaccattc gagaagtccg tacactcgtc acccgcgtca tcacagatgt ttattatgtg
     3901 gatgggacag aagtggaaag gaaagtaacg gaggagactg aagaaccaat cgtagagtgt
     3961 caggaatgtg aaacagaagt ttccccttca cagactggag gttcctctgg ggacctgggg
     4021 gacatcagct ccttctcctc caaagcttcc agctcacacc acacatccag tggaacaagt
     4081 ctctcagcca tacacagcag tggcagctca gggcgaggag ctgggccact caaaggaaaa
     4141 gccagtggga cagaagctgc agattttgcc ttacccagtt cccgaggagg cccaggaaaa
     4201 ctgagtccta gaaaagggat cagtcagaca ggggcaccgg tgtgtgagga agatggtgat
     4261 gcaggccttg gcatcagaca gggagggaag gctccagtta cacctcgtgg gcgtgggcga
     4321 aggggccgcc caccttctcg gaccactgga accagagaaa cagttgtctc tggtccgttg
     4381 ggcgtagaag atatttcacc tagcatgtca ccagatgaca agtccttcac ccgcattatg
     4441 cctcgtgtgc cagattctac caaacggacg gatgccagtt ctagtacttt gcggcggagt
     4501 gattctccag agattccttt tcaggctgct actggttcct ctgatggctt ggattcctca
     4561 tcttcaggaa acagctttgt gggtctccgt gttgtagcta agtggtcatc caatggctac
     4621 ttttactctg ggaagatcac ccgagatgtg ggggctggga agtacaagct gctctttgat
     4681 gatgggtacg aatgtgacgt gctgggcaaa gacattctcc tgtgtgaccc catccccctg
     4741 gacactgaag tgacagccct ctcagaagat gaatatttca gtgcaggagt ggtgaaagga
     4801 cataggaagg agtctgggga gctgtattac agcattgaaa aagaaggcca aaggaagtgg
     4861 tataaacgaa tggcagtcat tctgtccttg gagcaaggaa acagactgag agagcaatat
     4921 gggcttggcc catatgaagc tgtcacaccg ctcacgaagg cagcagatat cagcttagac
     4981 aatttggtgg aaggaaagcg gaaacggcgc agtaacatca gctccccagt cacccccact
     5041 gccgccagta gcagcagcac aacgcccaca cgtaaagcca cggagagtcc ccgtgcttcc
     5101 acgggagtcc catcaggcaa aaggaaactt ccgacttctg aagaggaacg ctctcctgct
     5161 aagcgaggtc gaaagtctgc caccgtgaaa cctggaacag tgggggcagc agagtttgtg
     5221 agtccctgtg agactggaga caacataggt gagccttctg tcctagaaga gccaagaggg
     5281 cctttgcccc tcaacaagac cttgtttctg ggctatgcct ttctcctcac catggctaca
     5341 actagtgaca agctggccag tcgctctaag ctgctagatg gtcctacagg aagcagtgaa
     5401 gaagaggagg aatttttaga aattcctcct ttcaacaagc agtatacaga atgccagctt
     5461 cgagcaggag ctgggtatat ccttgaagac ttcaatgaag cccagtgtaa cacagcctac
     5521 cagtgtctcc taattgcgga ccagcactgt cgaacccgga agtacttcct gtgccttgcc
     5581 agtggcattc cttgtgtgtc tcatgtctgg gtccatgaca gttgccatgc caaccaactt
     5641 caaaactatc gtaattatct gctgcctgct gggtatagcc ttgaagagca acgaattctg
     5701 gattggcaac cccgtgaaaa ccctttccag aatctgaagg tcctcttggt gtcagatcaa
     5761 caacagaact tcttggagct ctggtctgag atccttatga ctggaggggc agcctctgtg
     5821 aagcagcacc attcaagtgc ccacaacaaa gacattgctt taggggtatt tgatgtggtg
     5881 gtgacagacc cctcatgccc agcctcggtg ctcaagtgtg ctgaagcctt gcaactgcct
     5941 gtggtatcac aagaatgggt gatccagtgc ctcattgttg gggagagaat tggattcaag
     6001 cagcatccaa aatataaaca tgattatgtt tctcactaaa gatacttggt cttactggtt
     6061 ttattccctg ctattgtgga gattgtgttt taatcaggtt ttaagtgtgt cttgtgtgta
     6121 attgtattct ttgcatggac cttgtacata gttttatttg ctggactttt atgataaaat
     6181 aaatgttgaa tctctttggt tgtagtaact gggatgtctt catctgtttc tttgagctta
     6241 atctcagaac atgataaaca taggatcttc tctgaagttg tcagcaggct tgtcacttta
     6301 gcagtacagc aaacaaaggg agataaaaat agaggagtga gctttatttt gtggcatcac
     6361 tgtcaaggtt atcccaggct acctaaaatg ttatacttcc aaaaacagtt taaagtaggt
     6421 gagggcctgg gtaaacagta gtgctaaagt tgagtgggac tgggaacagc tctgggtatc
     6481 aggagtttat tgacagatga cctgctactg ggaacatgaa catgaccagt tgttaatgaa
     6541 tggacagtga ctataaattt gctgggacgg ttttctataa aataagctgt cacaactgtt
     6601 ggaagttatt ccttcctcac actcatcatc atcatccctg ttagcgaacg gcttctcatt
     6661 ctctaaataa agccagcggt ctcatttttt ctatagtgcc aaatagtaaa tacttttagg
     6721 ctttgtgacc acacttgtct gtctcaacaa cttgtcttgt ctgtgagcaa tcaccgacaa
     6781 tagctaaatt gagtatgtgt ggctgtttga atagtacttt atttacaaaa acaagcagca
     6841 ggctgttatc tgcttttaga ggtgaggtaa caaggtggga taatcctcct gggtagttga
     6901 caagtacggg ctcaggcttt catagtggtt ggtagacagt gtagatgaag agaggactca
     6961 gtgactacag actgaggccc ggatgtttca ttcttgtcca gcttggaggg aaagatgtca
     7021 gtgaagtgtt ttgtttatgc tgatgagaac attagtatgt tctcagcccg tggtggctag
     7081 gctatctgac cataaaacct taactcatgt ggcaggtcta aggtgggaaa actgggttgc
     7141 agtgaaaact aaattgtttc taaatctaaa caatttgacc tctatcctct ttagccagaa
     7201 ttgccctttt actagtctga aagaattaga actcactggc tcaattcttc agataaagga
     7261 tactcaaatc ttaaatttta gggaaggata aagatagtct gtgtagttac aaggtacaga
     7321 aagagggaaa gctcacaggc tctctgaagg gttttctcat ttggtggtga cacagaagct
     7381 gacctgttca ggagcgtgat tccgttctta catgagccaa cccactgttt actgtggtta
     7441 tcttccatag gaatatagta agtgttcaat aaaccccggt tacacaaatg aacccaccca
     7501 acagatgtct tcaaaatcct tcgtgtggtc agcagaggga tatcagaccc cagttcccct
     7561 acaggaatgg cagggaggat ttttatacct ctgcatttct tctagaagac cctttcagca
     7621 gtctgcaggc atttgatgaa tgatttgaga gatttgttac agacatcaga atgtggcagg
     7681 gctgtttcat tttttgaacc agagttttct tttacatccc aaaactataa aagaaaaaaa
     7741 aagtttcatt aaatgccatg ccttccaaag aaacatggca atctgagata gagctaacac
     7801 catggcaaca acacagctct cttaagaagc cgacgatgac cactggatat cagtattaga
     7861 tttaaggaag tttagaagag agcatggcac cacagccaca ctgctgctag tacatgtcag
     7921 agcaggcagt ggaagccaga ctgcccccag aacatagcag tacatagcct aacacagacc
     7981 ttaccctcag ctttagtatt ttaatatgct gatgaacttc actagaaaat aaattccagt
     8041 aaaattgtag aacatgatca ccctactccc atacccccaa ccccttcctg catctctgag
     8101 ccttgtttat aaaatgaggg taatctggag gtgatggcca gagttgcatt ttggtcttct
     8161 attgttcatt aaccccctcc tccaaatcta gtaagtgccc catgaattgt tcctacctgc
     8221 ccagagtccc accagcctgg gtatagtatt tattatagtc tagccggagc agtaactgag
     8281 ccaaatctga gttgatctgg tgattccgaa cactggaaag aatcttgaac aggagtgaag
     8341 actggcgact aaagccctgt tgagagaccc gagctgtcag tgaccaggct agggtactgg
     8401 gaaccaaggg ggtctttgga aaagctttgc ttaaatgttt gcaggaccac ctggccttcc
     8461 catattccca tttctatcag ctcctaacat gacttcttag tacatgtccg tgagatgcat
     8521 gactcccatg aaagtgcttt ctcgttagta ggaatttaac agctcattta agattaatat
     8581 attccatcac atactgggat tgcagtgatc ctgctttgtt acaaggagat aaatatagtc
     8641 tgagattata attataagtg agataggagg ctggttcagg gaaggaagtg ggatgtgaga
     8701 aaatgagcac aaagccagtg catacttggt gggctgaaga aactattcag ggctgaacta
     8761 tttctgaaca ctgtgaggca gcacattata tattcaccga taccagcgct tttatctttt
     8821 tatctcgtca tttctatgtc tgttctggaa aacgctttat tgacccggag cagactgcct
     8881 gctccacagc tggggggaga ggtatgtatt ttcagtggct aggcagactc accttcacga
     8941 gaatgctcag ctgggccgct ccgcgctcat ccagtggacc taggttctga ctgaccagtg
     9001 aacaaaaact gtgacagaga tctaggattt cattcaggca gtgaaacacc tatccaaaaa
     9061 tatagctggc gttaagaaat gaagaaatcg ctgagaaatg caaggtttgg gaaaatagtt
     9121 tttaacagcc tactacctcc catgtctgat ctcagcagag acaccgcaac cttcaaagct
     9181 gtttggccct cccaagtaac acacagaatg aacatccctt cttgggacag ctggcttctc
     9241 tgactccctg cacaaaacct ctgctctagt caccattaac tcctccttcc ttagacccac
     9301 tgagaatgct cttgcctttg agctctgagt gttgttccct gagattctct tctctttact
     9361 aacagttcaa gcctcattct ctgtgaacta ctccttcccc actgcagcct ttagcggtct
     9421 ccacccttct tctgttgtag tacctgtgtt gttcactggt gattgtcggg ccacccgtgc
     9481 tgttgctgac ttttgtatgt acatgtcttg ttgttttcca actagattgt gagctcctta
     9541 agggcagagc catgacttat acctctttgt atccccagtg ccttgcatac agtaagcact
     9601 caataaagac ttcaattatg atgaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
