LOCUS       NM_011640               1781 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus transformation related protein 53 (Trp53), transcript
            variant 1, mRNA.
ACCESSION   NM_011640
VERSION     NM_011640.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1781)
  AUTHORS   Zhou,X.N., Zhang,Q., Peng,H., Qin,Y.J., Liu,Y.H., Wang,L.,
            Cheng,M.L., Luo,X.H. and Li,H.
  TITLE     Silent information regulator sirtuin 1 ameliorates acute liver
            failure via the p53/glutathione peroxidase 4/gasdermin D axis
  JOURNAL   World J Gastroenterol 30 (11), 1588-1608 (2024)
   PUBMED   38617450
  REMARK    GeneRIF: Silent information regulator sirtuin 1 ameliorates acute
            liver failure via the p53/glutathione peroxidase 4/gasdermin D
            axis.
REFERENCE   2  (bases 1 to 1781)
  AUTHORS   Hill,R.J., Bona,N., Smink,J., Webb,H.K., Crisp,A.,
            Garaycoechea,J.I. and Crossan,G.P.
  TITLE     p53 regulates diverse tissue-specific outcomes to endogenous DNA
            damage in mice
  JOURNAL   Nat Commun 15 (1), 2518 (2024)
   PUBMED   38514641
  REMARK    GeneRIF: p53 regulates diverse tissue-specific outcomes to
            endogenous DNA damage in mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1781)
  AUTHORS   Francis,J.W., Hausmann,S., Ikram,S., Yin,K., Mealey-Farr,R.,
            Flores,N.M., Trinh,A.T., Chasan,T., Thompson,J., Mazur,P.K. and
            Gozani,O.
  TITLE     FAM86A methylation of eEF2 links mRNA translation elongation to
            tumorigenesis
  JOURNAL   Mol Cell (2024) In press
   PUBMED   38508183
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   4  (bases 1 to 1781)
  AUTHORS   Lu,J., Sun,W., Liu,B., Zhang,J., Wang,R., Goltzman,D. and Miao,D.
  TITLE     Chk2 Modulates Bmi1-Deficiency-Induced Renal Aging and Fibrosis via
            Oxidative Stress, DNA Damage, and p53/TGFbeta1-Induced
            Epithelial-Mesenchymal Transition
  JOURNAL   Int J Biol Sci 20 (6), 2008-2026 (2024)
   PUBMED   38617548
  REMARK    GeneRIF: Chk2 Modulates Bmi1-Deficiency-Induced Renal Aging and
            Fibrosis via Oxidative Stress, DNA Damage, and p53/TGFbeta1-Induced
            Epithelial-Mesenchymal Transition.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1781)
  AUTHORS   Flynn,P.A., Long,M.D., Kosaka,Y., Long,N., Mulkey,J.S., Coy,J.L.,
            Agarwal,A. and Lind,E.F.
  TITLE     Leukemic mutation FLT3-ITD is retained in dendritic cells and
            disrupts their homeostasis leading to expanded Th17 frequency
  JOURNAL   Front Immunol 15, 1297338 (2024)
   PUBMED   38495876
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1781)
  AUTHORS   Shaulian,E., Zauberman,A., Ginsberg,D. and Oren,M.
  TITLE     Identification of a minimal transforming domain of p53: negative
            dominance through abrogation of sequence-specific DNA binding
  JOURNAL   Mol Cell Biol 12 (12), 5581-5592 (1992)
   PUBMED   1448088
REFERENCE   7  (bases 1 to 1781)
  AUTHORS   Beier,D.R., Dushkin,H. and Sussman,D.J.
  TITLE     Mapping genes in the mouse using single-strand conformation
            polymorphism analysis of recombinant inbred strains and
            interspecific crosses
  JOURNAL   Proc Natl Acad Sci U S A 89 (19), 9102-9106 (1992)
   PUBMED   1409609
REFERENCE   8  (bases 1 to 1781)
  AUTHORS   Han,K.A. and Kulesz-Martin,M.F.
  TITLE     Altered expression of wild-type p53 tumor suppressor gene during
            murine epithelial cell transformation
  JOURNAL   Cancer Res 52 (3), 749-753 (1992)
   PUBMED   1370652
REFERENCE   9  (bases 1 to 1781)
  AUTHORS   Nadeau,J.H., Compton,J.G., Giguere,V., Rossant,J. and Varmuza,S.
  TITLE     Close linkage of retinoic acid receptor genes with homeobox- and
            keratin-encoding genes on paralogous segments of mouse chromosomes
            11 and 15
  JOURNAL   Mamm Genome 3 (4), 202-208 (1992)
   PUBMED   1377062
REFERENCE   10 (bases 1 to 1781)
  AUTHORS   Colombo,M.P., Martinotti,A., Howard,T.A., Schneider,C.,
            D'Eustachio,P. and Seldin,M.F.
  TITLE     Localization of growth arrest-specific genes on mouse chromosomes
            1, 7, 8, 11, 13, and 16
  JOURNAL   Mamm Genome 2 (2), 130-134 (1992)
   PUBMED   1347472
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X01237.1, AK147815.1,
            AB221571.1, AI323249.1 and AV450598.1.
            
            [WARNING] On May 2, 2024 this sequence was replaced by NM_011640.4.
            
            On May 13, 2008 this sequence version replaced NM_011640.2.
            
            Summary: This gene encodes tumor protein p53, which responds to
            diverse cellular stresses to regulate target genes that induce cell
            cycle arrest, apoptosis, senescence, DNA repair, or changes in
            metabolism. p53 protein is expressed at low level in normal cells
            and at a high level in a variety of transformed cell lines, where
            it's believed to contribute to transformation and malignancy. p53
            is a DNA-binding protein containing transcription activation,
            DNA-binding, and oligomerization domains. It is postulated to bind
            to a p53-binding site and activate expression of downstream genes
            that inhibit growth and/or invasion, and thus function as a tumor
            suppressor. Mice deficient for this gene are developmentally normal
            but are susceptible to spontaneous tumors. Evidence to date shows
            that this gene contains one promoter, in contrast to alternative
            promoters of the human gene, and transcribes a few of splice
            variants which encode different isoforms, although the biological
            validity or the full-length nature of some variants has not been
            determined. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X01237.1, AF151353.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                X01237.1           1-44
            45-735              AK147815.1         2-692
            736-1330            AB221571.1         579-1173
            1331-1751           AI323249.1         39-459
            1752-1781           AV450598.1         39-68
FEATURES             Location/Qualifiers
     source          1..1781
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.83 cM"
     gene            1..1781
                     /gene="Trp53"
                     /gene_synonym="bbl; bfy; bhy; p44; p53; Tp53"
                     /note="transformation related protein 53"
                     /db_xref="GeneID:22059"
                     /db_xref="MGI:MGI:98834"
     exon            1..157
                     /gene="Trp53"
                     /gene_synonym="bbl; bfy; bhy; p44; p53; Tp53"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..1330
                     /gene="Trp53"
                     /gene_synonym="bbl; bfy; bhy; p44; p53; Tp53"
                     /note="isoform a is encoded by transcript variant 1;
                     cellular tumor antigen p53; p53 cellular tumor antigen;
                     tumor supressor p53; tumor suppressor p53; mutant p53;
                     ME-delta123p53"
                     /codon_start=1
                     /product="cellular tumor antigen p53 isoform a"
                     /protein_id="NP_035770.2"
                     /db_xref="CCDS:CCDS36193.1"
                     /db_xref="GeneID:22059"
                     /db_xref="MGI:MGI:98834"
                     /translation="MTAMEESQSDISLELPLSQETFSGLWKLLPPEDILPSPHCMDDL
                     LLPQDVEEFFEGPSEALRVSGAPAAQDPVTETPGPVAPAPATPWPLSSFVPSQKTYQG
                     NYGFHLGFLQSGTAKSVMCTYSPPLNKLFCQLAKTCPVQLWVSATPPAGSRVRAMAIY
                     KKSQHMTEVVRRCPHHERCSDGDGLAPPQHLIRVEGNLYPEYLEDRQTFRHSVVVPYE
                     PPEAGSEYTTIHYKYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRDSFEVRVCACPG
                     RDRRTEEENFRKKEVLCPELPPGSAKRALPTCTSASPPQKKKPLDGEYFTLKIRGRKR
                     FEMFRELNEALELKDAHATEESGDSRAHSSYLKTKKGQSTSRHKKTMVKKVGPDSD"
     exon            158..240
                     /gene="Trp53"
                     /gene_synonym="bbl; bfy; bhy; p44; p53; Tp53"
                     /inference="alignment:Splign:2.1.0"
     exon            241..262
                     /gene="Trp53"
                     /gene_synonym="bbl; bfy; bhy; p44; p53; Tp53"
                     /inference="alignment:Splign:2.1.0"
     exon            263..523
                     /gene="Trp53"
                     /gene_synonym="bbl; bfy; bhy; p44; p53; Tp53"
                     /inference="alignment:Splign:2.1.0"
     exon            524..707
                     /gene="Trp53"
                     /gene_synonym="bbl; bfy; bhy; p44; p53; Tp53"
                     /inference="alignment:Splign:2.1.0"
     exon            708..820
                     /gene="Trp53"
                     /gene_synonym="bbl; bfy; bhy; p44; p53; Tp53"
                     /inference="alignment:Splign:2.1.0"
     exon            821..930
                     /gene="Trp53"
                     /gene_synonym="bbl; bfy; bhy; p44; p53; Tp53"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1067
                     /gene="Trp53"
                     /gene_synonym="bbl; bfy; bhy; p44; p53; Tp53"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1141
                     /gene="Trp53"
                     /gene_synonym="bbl; bfy; bhy; p44; p53; Tp53"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1248
                     /gene="Trp53"
                     /gene_synonym="bbl; bfy; bhy; p44; p53; Tp53"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1772
                     /gene="Trp53"
                     /gene_synonym="bbl; bfy; bhy; p44; p53; Tp53"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1751..1756
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trp53"
                     /gene_synonym="bbl; bfy; bhy; p44; p53; Tp53"
                     /note="hexamer: AATAAA"
     polyA_site      1772
                     /gene="Trp53"
                     /gene_synonym="bbl; bfy; bhy; p44; p53; Tp53"
                     /note="major polyA site"
ORIGIN      
        1 tttcccctcc cacgtgctca ccctggctaa agttctgtag cttcagttca ttgggaccat
       61 cctggctgta ggtagcgact acagttaggg ggcacctagc attcaggccc tcatcctcct
      121 ccttcccagc agggtgtcac gcttctccga agactggatg actgccatgg aggagtcaca
      181 gtcggatatc agcctcgagc tccctctgag ccaggagaca ttttcaggct tatggaaact
      241 acttcctcca gaagatatcc tgccatcacc tcactgcatg gacgatctgt tgctgcccca
      301 ggatgttgag gagttttttg aaggcccaag tgaagccctc cgagtgtcag gagctcctgc
      361 agcacaggac cctgtcaccg agacccctgg gccagtggcc cctgccccag ccactccatg
      421 gcccctgtca tcttttgtcc cttctcaaaa aacttaccag ggcaactatg gcttccacct
      481 gggcttcctg cagtctggga cagccaagtc tgttatgtgc acgtactctc ctcccctcaa
      541 taagctattc tgccagctgg cgaagacgtg ccctgtgcag ttgtgggtca gcgccacacc
      601 tccagctggg agccgtgtcc gcgccatggc catctacaag aagtcacagc acatgacgga
      661 ggtcgtgaga cgctgccccc accatgagcg ctgctccgat ggtgatggcc tggctcctcc
      721 ccagcatctt atccgggtgg aaggaaattt gtatcccgag tatctggaag acaggcagac
      781 ttttcgccac agcgtggtgg taccttatga gccacccgag gccggctctg agtataccac
      841 catccactac aagtacatgt gtaatagctc ctgcatgggg ggcatgaacc gccgacctat
      901 ccttaccatc atcacactgg aagactccag tgggaacctt ctgggacggg acagctttga
      961 ggttcgtgtt tgtgcctgcc ctgggagaga ccgccgtaca gaagaagaaa atttccgcaa
     1021 aaaggaagtc ctttgccctg aactgccccc agggagcgca aagagagcgc tgcccacctg
     1081 cacaagcgcc tctcccccgc aaaagaaaaa accacttgat ggagagtatt tcaccctcaa
     1141 gatccgcggg cgtaaacgct tcgagatgtt ccgggagctg aatgaggcct tagagttaaa
     1201 ggatgcccat gctacagagg agtctggaga cagcagggct cactccagct acctgaagac
     1261 caagaagggc cagtctactt cccgccataa aaaaacaatg gtcaagaaag tggggcctga
     1321 ctcagactga ctgcctctgc atcccgtccc catcaccagc ctccccctct ccttgctgtc
     1381 ttatgacttc agggctgaga cacaatcctc ccggtccctt ctgctgcctt ttttaccttg
     1441 tagctagggc tcagccccct ctctgagtag tggttcctgg cccaagttgg ggaataggtt
     1501 gatagttgtc aggtctctgc tggcccagcg aaattctatc cagccagttg ttggaccctg
     1561 gcacctacaa tgaaatctca ccctacccca caccctgtaa gattctatct tgggccctca
     1621 tagggtccat atcctccagg gcctactttc cttccattct gcaaagcctg tctgcattta
     1681 tccacccccc accctgtctc cctctttttt ttttttttac ccctttttat atatcaattt
     1741 cctattttac aataaaattt tgttatcact taaaaaaaaa a
//
