LOCUS       NM_001081156            1671 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus TMF1-regulated nuclear protein 1 (Trnp1), mRNA.
ACCESSION   NM_001081156 XM_149530
VERSION     NM_001081156.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1671)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1671)
  AUTHORS   Kliesmete,Z., Wange,L.E., Vieth,B., Esgleas,M., Radmer,J.,
            Hulsmann,M., Geuder,J., Richter,D., Ohnuki,M., Gotz,M., Hellmann,I.
            and Enard,W.
  TITLE     Regulatory and coding sequences of TRNP1 co-evolve with brain size
            and cortical folding in mammals
  JOURNAL   Elife 12, e83593 (2023)
   PUBMED   36947129
  REMARK    GeneRIF: Regulatory and coding sequences of TRNP1 co-evolve with
            brain size and cortical folding in mammals.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1671)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1671)
  AUTHORS   Esgleas,M., Falk,S., Forne,I., Thiry,M., Najas,S., Zhang,S.,
            Mas-Sanchez,A., Geerlof,A., Niessing,D., Wang,Z., Imhof,A. and
            Gotz,M.
  TITLE     Trnp1 organizes diverse nuclear membrane-less compartments in
            neural stem cells
  JOURNAL   EMBO J 39 (16), e103373 (2020)
   PUBMED   32627867
  REMARK    GeneRIF: Trnp1 organizes diverse nuclear membrane-less compartments
            in neural stem cells.
REFERENCE   5  (bases 1 to 1671)
  AUTHORS   Matus-Ortega,M.E., Leff Gelman,P., Calva-Nieves,J.C.,
            Flores-Zamora,A., Salazar-Juarez,A., Torner-Aguilar,C.A., Gamba,G.,
            De Los Heros,P., Peng,B., Pintar,J.E., Gompf,H.S., Allen,C.N. and
            Anton-Palma,B.
  TITLE     Mexneurin is a novel precursor of peptides in the central nervous
            system of rodents
  JOURNAL   FEBS Lett 591 (12), 1627-1636 (2017)
   PUBMED   28504339
  REMARK    GeneRIF: Data suggest that neurons in mouse brain exhibit DNA
            sequence encoding protein precursor, proMexneurin, that contains
            three peptide sequences: Mexneurin-1 (an endomorphin1-like
            peptide), Mexneurin-2 (an endomorphin1-like peptide), and
            Mexneurin-3 (peptide which appears to be unrelated to
            endomorphins); neurons exhibit expression of proMexneurin mRNA
            throughout mouse brain.
REFERENCE   6  (bases 1 to 1671)
  AUTHORS   de Juan Romero,C., Bruder,C., Tomasello,U., Sanz-Anquela,J.M. and
            Borrell,V.
  TITLE     Discrete domains of gene expression in germinal layers distinguish
            the development of gyrencephaly
  JOURNAL   EMBO J 34 (14), 1859-1874 (2015)
   PUBMED   25916825
REFERENCE   7  (bases 1 to 1671)
  AUTHORS   Stahl,R., Walcher,T., De Juan Romero,C., Pilz,G.A., Cappello,S.,
            Irmler,M., Sanz-Aquela,J.M., Beckers,J., Blum,R., Borrell,V. and
            Gotz,M.
  TITLE     Trnp1 regulates expansion and folding of the mammalian cerebral
            cortex by control of radial glial fate
  JOURNAL   Cell 153 (3), 535-549 (2013)
   PUBMED   23622239
  REMARK    GeneRIF: Study identified Trnp1 as a regulator of mammalian brain
            development and as a key factor controlling neocortical expansion.
            Trnp1 levels have striking effects on tangential, radial, and
            lateral expansion of the cerebral cortex.
REFERENCE   8  (bases 1 to 1671)
  AUTHORS   Pereira,J.D., Sansom,S.N., Smith,J., Dobenecker,M.W.,
            Tarakhovsky,A. and Livesey,F.J.
  TITLE     Ezh2, the histone methyltransferase of PRC2, regulates the balance
            between self-renewal and differentiation in the cerebral cortex
  JOURNAL   Proc Natl Acad Sci U S A 107 (36), 15957-15962 (2010)
   PUBMED   20798045
REFERENCE   9  (bases 1 to 1671)
  AUTHORS   Volpe,M., Shpungin,S., Barbi,C., Abrham,G., Malovani,H., Wides,R.
            and Nir,U.
  TITLE     trnp: A conserved mammalian gene encoding a nuclear protein that
            accelerates cell-cycle progression
  JOURNAL   DNA Cell Biol 25 (6), 331-339 (2006)
   PUBMED   16792503
REFERENCE   10 (bases 1 to 1671)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB579578.1, BC049168.1 and AW120970.1.
            
            On Apr 11, 2007 this sequence version replaced NM_001081156.1.
            
            CCDS Note: This CCDS ID represents the protein described in PMID:
            16792503 and is supported by the mRNA BC049168.1. It should be
            noted that this transcript is predicted to undergo
            nonsense-mediated mRNA decay (NMD). However, the protein is
            represented because it was detected endogenously in PMID: 16792503.
            It is likely that the majority of transcripts representing this
            variant will undergo NMD, while some low level of NMD escape may
            allow for the expression of this protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049168.1, AY142705.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate          :: PMID: 16792503
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                BB579578.1         2-45
            45-1651             BC049168.1         1-1607
            1652-1671           AW120970.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..1671
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 66.25 cM"
     gene            1..1671
                     /gene="Trnp1"
                     /gene_synonym="2300002D11Rik; Trnp"
                     /note="TMF1-regulated nuclear protein 1"
                     /db_xref="GeneID:69539"
                     /db_xref="MGI:MGI:1916789"
     exon            1..923
                     /gene="Trnp1"
                     /gene_synonym="2300002D11Rik; Trnp"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..765
                     /gene="Trnp1"
                     /gene_synonym="2300002D11Rik; Trnp"
                     /note="mexneurin"
                     /codon_start=1
                     /product="TMF-regulated nuclear protein 1"
                     /protein_id="NP_001074625.1"
                     /db_xref="CCDS:CCDS38904.1"
                     /db_xref="GeneID:69539"
                     /db_xref="MGI:MGI:1916789"
                     /translation="MPGCRISACGPGAQEGTAEPGSPPPPPREPLPSLQPPSPSPTST
                     PTPTKSPPLPEAAETPVEGQELQRWRQGASGGSGGAGPAGIAGAAAGAGGRALELAEA
                     RRRLLEVEGRRRLVSELESRVLQLHRVFLAAELRLAHRAESLSRLSGGVAQAELYLAA
                     HGSRLKKGARRGRRGRPPALLASALGLGSCVPWGAGRLRRGQGPEPDSPFRRSPPRGP
                     ASPQR"
     exon            924..1654
                     /gene="Trnp1"
                     /gene_synonym="2300002D11Rik; Trnp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1632..1637
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trnp1"
                     /gene_synonym="2300002D11Rik; Trnp"
                     /note="hexamer: AATAAA"
     polyA_site      1651
                     /gene="Trnp1"
                     /gene_synonym="2300002D11Rik; Trnp"
                     /note="major polyA site"
ORIGIN      
        1 gggtgtgggc tctgcggccg cctctcacta gtctcgtgcc cagcatctct cctccccacg
       61 caccgacaac cctgggccgc cgcggggcgg gggatgccgg gctgccgaat cagcgcctgc
      121 ggcccagggg cccaggaagg gacggcagaa ccggggtcgc ccccgccgcc accccgggag
      181 cccctgccgt ccctccagcc cccttcccca tcgccgacct cgactccgac ccccactaag
      241 tcaccgccct tacccgaggc ggccgagaca cccgtggaag ggcaggagct gcagcgctgg
      301 cgccagggtg ctagtggggg gtctgggggc gcgggcccgg cggggatcgc gggcgcggcg
      361 gcgggggcag ggggccgtgc gctggagctg gccgaagcgc ggcggcgact gctagaagtg
      421 gagggccgcc ggcgcctggt gtcggagctg gagagccggg tgctgcagct gcaccgagtc
      481 ttcttggctg cggagctgcg cctggcgcat cgcgccgaga gcctgagccg cctgagcggc
      541 ggcgtggccc aggccgagct ctacctggct gcgcacgggt cccgtctcaa gaagggtgcg
      601 cgccgcggtc gccggggtcg tcccccggcg ctgctggcgt ccgcgctcgg cctggggagc
      661 tgcgtgccct ggggcgcagg gcggctacgg cgcggccagg gcccggagcc cgactcgccc
      721 ttccgccgca gcccgccccg cggccccgcc tccccccagc gctgacctca gtaccccgga
      781 cccctggctt cccgaggcag gcgagtctcc aggtgcggga ggacagacgg acggacggat
      841 ccaggtgctg gccagatgga cggcgtcatc tacgcggagg agtcagctgg gggtccatgg
      901 ggggccctga aagtgacact aagctcctca gaggctccac tctatgggtc tggactgact
      961 tctgcattcc gcaccttctc tggatacccc gccttcagga agacttccag gactgacggt
     1021 acccagtctc ggcgccctcc tcccaggagc ccttacagtg gcaagggtct gggtcctggg
     1081 aacttgctcc actctgcatt gcttcccata cactgtattt gcctttgctg atacagaggc
     1141 ccgagatgct ctcagattag ccgagaccgc agcaaacatt gccagtgtga ctgagagaag
     1201 aatttcttct taaagataga ctcctcattc tgacacgtca cggagtccct gtcatcacaa
     1261 gtcacagtgt agctggagtc cccatcgtcc cttctatgtc cagcagatcc aggaggcctc
     1321 ttggaggcag atcactgctg taggaaagcc ccattttcct ttccccacta tccttgtcct
     1381 cccccctgtg agtgaggaca tgcctgtagc cccttgcaga caatcagctg ctgcctccta
     1441 gggggacact tttctcagga agaggtggca gtaacctcca aagccaagtt acatgcagaa
     1501 aggcaagcca cttcttgatg tatcctgata gagggaagga ggcacattta ctcccacacc
     1561 gcccagaaca tataggcttc tctaaagtgg ctgtatagcg actcagttcc caactatata
     1621 cacgcaagaa gaataaatcg aaataacgag aggcaaaaaa aaaaaaaaaa a
//
