LOCUS       NM_027925               1146 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus tRNA selenocysteine 1 associated protein 1 (Trnau1ap),
            mRNA.
ACCESSION   NM_027925 XM_284024
VERSION     NM_027925.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1146)
  AUTHORS   Hu,X., Luo,J., Lai,H., Li,M., Zheng,X., Nie,T., Li,F. and Li,H.
  TITLE     Knockdown of Trnau1ap inhibits the proliferation and migration of
            NIH3T3, JEG-3 and Bewo cells via the PI3K/Akt signaling pathway
  JOURNAL   Biochem Biophys Res Commun 503 (2), 521-527 (2018)
   PUBMED   29758194
  REMARK    GeneRIF: Knockdown of Trnau1ap reduced cell migration and
            proliferation. Knockdown of Trnau1ap blocked the PI3K/Akt signaling
            pathway.
REFERENCE   2  (bases 1 to 1146)
  AUTHORS   Mahdi,Y., Xu,X.M., Carlson,B.A., Fradejas,N., Gunter,P., Braun,D.,
            Southon,E., Tessarollo,L., Hatfield,D.L. and Schweizer,U.
  TITLE     Expression of Selenoproteins Is Maintained in Mice Carrying
            Mutations in SECp43, the tRNA Selenocysteine 1 Associated Protein
            (Trnau1ap)
  JOURNAL   PLoS One 10 (6), e0127349 (2015)
   PUBMED   26043259
  REMARK    GeneRIF: These findings suggest that the targeted domains in the
            SECp43 protein are not essential for selenoprotein biosynthesis in
            hepatocytes and neurons.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1146)
  AUTHORS   Xu,X.M., Mix,H., Carlson,B.A., Grabowski,P.J., Gladyshev,V.N.,
            Berry,M.J. and Hatfield,D.L.
  TITLE     Evidence for direct roles of two additional factors, SECp43 and
            soluble liver antigen, in the selenoprotein synthesis machinery
  JOURNAL   J Biol Chem 280 (50), 41568-41575 (2005)
   PUBMED   16230358
  REMARK    GeneRIF: SECp43 and SLA have roles in selenoprotein synthesis
REFERENCE   4  (bases 1 to 1146)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY283216.1, CJ166630.1, AK152986.1 and BC099594.1.
            
            On Jul 29, 2006 this sequence version replaced NM_027925.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC055454.1, AK152986.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                BY283216.1         2-45
            45-52               CJ166630.1         8-15
            53-1128             AK152986.1         2-1077
            1129-1146           BC099594.1         814-831
FEATURES             Location/Qualifiers
     source          1..1146
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 65.16 cM"
     gene            1..1146
                     /gene="Trnau1ap"
                     /gene_synonym="1110007F05Rik; Secp43; Trspap1;
                     WI1-2643G14.2"
                     /note="tRNA selenocysteine 1 associated protein 1"
                     /db_xref="GeneID:71787"
                     /db_xref="MGI:MGI:1919037"
     exon            1..186
                     /gene="Trnau1ap"
                     /gene_synonym="1110007F05Rik; Secp43; Trspap1;
                     WI1-2643G14.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..1023
                     /gene="Trnau1ap"
                     /gene_synonym="1110007F05Rik; Secp43; Trspap1;
                     WI1-2643G14.2"
                     /note="tRNA selenocysteine-associated protein 1"
                     /codon_start=1
                     /product="tRNA selenocysteine 1-associated protein 1"
                     /protein_id="NP_082201.2"
                     /db_xref="CCDS:CCDS18722.1"
                     /db_xref="GeneID:71787"
                     /db_xref="MGI:MGI:1919037"
                     /translation="MAASLWMGDLEPYMDENFISRAFATMGETVMSVKIIRNRLTGIP
                     AGYCFVEFADLATAEKCLHKINGKPLPGATPAKRFKLNYATYGKQPDNSPEYSLFVGD
                     LTPDVDDGMLYEFFVKVYPSCRGGKVVLDPTGVSKGYGFVKFTDELEQKRALTECQGA
                     VGLGCKPVRLSVAIPKASRVKPVEYSQMYSYSYNQYYQQYQNYYAQWGYDQNTGSYSY
                     SYPQYGYTQSTMQTYEEVGDDALEDPAPQLDVTEANKEFMEQSEELYDALMDCHWQPL
                     DTVSSEIPAMM"
     exon            187..284
                     /gene="Trnau1ap"
                     /gene_synonym="1110007F05Rik; Secp43; Trspap1;
                     WI1-2643G14.2"
                     /inference="alignment:Splign:2.1.0"
     exon            285..384
                     /gene="Trnau1ap"
                     /gene_synonym="1110007F05Rik; Secp43; Trspap1;
                     WI1-2643G14.2"
                     /inference="alignment:Splign:2.1.0"
     exon            385..437
                     /gene="Trnau1ap"
                     /gene_synonym="1110007F05Rik; Secp43; Trspap1;
                     WI1-2643G14.2"
                     /inference="alignment:Splign:2.1.0"
     exon            438..569
                     /gene="Trnau1ap"
                     /gene_synonym="1110007F05Rik; Secp43; Trspap1;
                     WI1-2643G14.2"
                     /inference="alignment:Splign:2.1.0"
     exon            570..689
                     /gene="Trnau1ap"
                     /gene_synonym="1110007F05Rik; Secp43; Trspap1;
                     WI1-2643G14.2"
                     /inference="alignment:Splign:2.1.0"
     exon            690..852
                     /gene="Trnau1ap"
                     /gene_synonym="1110007F05Rik; Secp43; Trspap1;
                     WI1-2643G14.2"
                     /inference="alignment:Splign:2.1.0"
     exon            853..886
                     /gene="Trnau1ap"
                     /gene_synonym="1110007F05Rik; Secp43; Trspap1;
                     WI1-2643G14.2"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1130
                     /gene="Trnau1ap"
                     /gene_synonym="1110007F05Rik; Secp43; Trspap1;
                     WI1-2643G14.2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1109..1114
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trnau1ap"
                     /gene_synonym="1110007F05Rik; Secp43; Trspap1;
                     WI1-2643G14.2"
                     /note="hexamer: AATAAA"
     polyA_site      1130
                     /gene="Trnau1ap"
                     /gene_synonym="1110007F05Rik; Secp43; Trspap1;
                     WI1-2643G14.2"
                     /note="major polyA site"
ORIGIN      
        1 ggaagcggcg gacaggtcgg aggaaaaccc ggatcgctct ggccgccgag gcagcgtgtg
       61 cgcaggaggt gctgcaggct taggctccgg gcgggccggg tcgcgcagac tggcgcggtt
      121 gcgcgccaca ggccctcagg gtccccgccc gggtgcggga tggcggccag cctatggatg
      181 ggagacctgg aaccctacat ggatgagaac ttcatctcta gagcctttgc caccatgggg
      241 gagaccgtga tgagcgtcaa aattatccga aaccgcctca ctggaatccc agctggctac
      301 tgctttgtgg aattcgcaga tttggccaca gccgagaagt gtttgcataa aattaatggg
      361 aaaccccttc cgggagccac tcctgcaaaa cgttttaaac tgaattatgc cacttatggg
      421 aaacagccag acaatagccc tgagtactcc ctgtttgtgg gggacctgac ccccgacgtg
      481 gacgatggca tgctgtatga gttctttgtc aaagtctacc cgtcctgccg gggaggcaag
      541 gtggttttgg acccaacagg cgtgtctaag ggctatggtt ttgtgaaatt cacagatgag
      601 ttggaacaga agcgagcctt gacggagtgc cagggagcag tgggactggg gtgtaaaccc
      661 gtgcggctga gtgtggccat ccctaaagcg agccgggtaa agccagtgga gtacagccag
      721 atgtacagtt acagctacaa ccagtattac cagcagtacc agaactacta tgcccagtgg
      781 ggctatgacc agaacacagg cagctacagc tacagctacc cccagtatgg ctacacccag
      841 agcaccatgc agacatatga agaggttggg gatgatgctc tggaagaccc agccccacag
      901 ctggatgtga ctgaagccaa caaagagttc atggagcaga gcgaggaact gtacgatgct
      961 ctgatggact gtcactggca gcccctggac actgtatcct cagagatccc agctatgatg
     1021 tagccaggac gtgaaggcag aggcctagaa taatgacctt tttctattgt gaagcttcta
     1081 tctttttgaa tgtgatttat aatgttttaa taaattactg tttccttgaa aaaaaaaaaa
     1141 aaaaaa
//
