LOCUS       NP_083856                501 aa            linear   ROD 01-MAY-2025
DEFINITION  tRNA (guanine(37)-N(1))-methyltransferase isoform 1 [Mus musculus].
ACCESSION   NP_083856
VERSION     NP_083856.1
DBSOURCE    REFSEQ: accession NM_029580.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 501)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 501)
  AUTHORS   Perniss,A., Liu,S., Boonen,B., Keshavarz,M., Ruppert,A.L., Timm,T.,
            Pfeil,U., Soultanova,A., Kusumakshi,S., Delventhal,L., Aydin,O.,
            Pyrski,M., Deckmann,K., Hain,T., Schmidt,N., Ewers,C., Gunther,A.,
            Lochnit,G., Chubanov,V., Gudermann,T., Oberwinkler,J., Klein,J.,
            Mikoshiba,K., Leinders-Zufall,T., Offermanns,S., Schutz,B.,
            Boehm,U., Zufall,F., Bufe,B. and Kummer,W.
  TITLE     Chemosensory Cell-Derived Acetylcholine Drives Tracheal Mucociliary
            Clearance in Response to Virulence-Associated Formyl Peptides
  JOURNAL   Immunity 52 (4), 683-699 (2020)
   PUBMED   32294408
  REMARK    GeneRIF: Chemosensory Cell-Derived Acetylcholine Drives Tracheal
            Mucociliary Clearance in Response to Virulence-Associated Formyl
            Peptides.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159813.2 and AC122025.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012521.1, AK049127.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 30.42 cM"
     Protein         1..501
                     /product="tRNA (guanine(37)-N(1))-methyltransferase
                     isoform 1"
                     /EC_number="2.1.1.228"
                     /note="tRNA (guanine-N(1)-)-methyltransferase; TRM5 tRNA
                     methyltransferase 5 homolog; M1G-methyltransferase; tRNA
                     [GM37] methyltransferase; tRNA
                     (guanine(37)-N1)-methyltransferase; tRNA
                     (guanine(37)-N(1))-methyltransferase"
                     /calculated_mol_wt=56663
     Region          192..412
                     /region_name="Met_10"
                     /note="Met-10+ like-protein; pfam02475"
                     /db_xref="CDD:396850"
     Region          474..501
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D0C4.1)"
     CDS             1..501
                     /gene="Trmt5"
                     /gene_synonym="2610027O18Rik; mKIAA1393"
                     /coded_by="NM_029580.4:55..1560"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS36474.1"
                     /db_xref="GeneID:76357"
                     /db_xref="MGI:MGI:1923607"
ORIGIN      
        1 mrivwklfgf srrllqvewc hpsesillft lvprlrkaps vfllgqrqgl stmpeieasv
       61 rdselfspps dvrgmreldr tafkktvsip vlkarkevvn rlmralrrva lqrpgikrvi
      121 edpkdedsrl imldpyrmlt adsfdkaelg vlkeldvspq lsqynlelty enfkseeilk
      181 avlpegqdvt sgfsrvghia hlnlrdhqlp fkhligqvmv dknpgitsav nktsnidnty
      241 rnfqmevlcg eenmltkvre nnytyefdfs kvywnprlst ehgritelln pgdvlfdvfa
      301 gvgpfaipaa rknctvfand lnpeshkwll hncklnkvdq kvkvfnmdgk dfiqgpvree
      361 lmlrlglsae akpsvhivmn lpakaiefls vfrslldgqp cstellptvh cycfskdsdp
      421 akdvrqqaea vlgvsletss svhlvrnvap nkemlcitfq iptatlyrnq slslqndqep
      481 plkrqktgdp fsgepqiasd s
//
