LOCUS       NM_026876               2787 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus tRNA methyltransferase 1 like (Trmt1l), transcript
            variant 1, mRNA.
ACCESSION   NM_026876 XM_355244
VERSION     NM_026876.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2787)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2787)
  AUTHORS   Vauti,F., Goller,T., Beine,R., Becker,L., Klopstock,T.,
            Holter,S.M., Wurst,W., Fuchs,H., Gailus-Durner,V., de Angelis,M.H.
            and Arnold,H.H.
  TITLE     The mouse Trm1-like gene is expressed in neural tissues and plays a
            role in motor coordination and exploratory behaviour
  JOURNAL   Gene 389 (2), 174-185 (2007)
   PUBMED   17198746
  REMARK    GeneRIF: Trm1-like deficient mice are viable and show no anatomical
            defects; behavioural tests, however, revealed significantly altered
            motor coordination and aberrant exploratory behaviour thus, Trm1
            plays a role in modulating postnatal neuronal functions.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK148524.1, BC110425.1 and AI853808.1.
            
            On Oct 31, 2017 this sequence version replaced NM_026876.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146088.1, BC110425.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               AK148524.1         2-124
            124-2749            BC110425.1         1-2626
            2750-2787           AI853808.1         1-38                c
FEATURES             Location/Qualifiers
     source          1..2787
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 64.12 cM"
     gene            1..2787
                     /gene="Trmt1l"
                     /gene_synonym="1190005F20Rik; C1orf25; Trm1-like; Trm1l"
                     /note="tRNA methyltransferase 1 like"
                     /db_xref="GeneID:98685"
                     /db_xref="MGI:MGI:1916185"
     exon            1..561
                     /gene="Trmt1l"
                     /gene_synonym="1190005F20Rik; C1orf25; Trm1-like; Trm1l"
                     /inference="alignment:Splign:2.1.0"
     CDS             336..2522
                     /gene="Trmt1l"
                     /gene_synonym="1190005F20Rik; C1orf25; Trm1-like; Trm1l"
                     /note="isoform 1 is encoded by transcript variant 1;
                     TRMT1-like protein"
                     /codon_start=1
                     /product="TRMT1-like protein isoform 1"
                     /protein_id="NP_081152.2"
                     /db_xref="CCDS:CCDS15361.1"
                     /db_xref="GeneID:98685"
                     /db_xref="MGI:MGI:1916185"
                     /translation="MENMAEEELLPQEKEEAQVRVPTRAPDSAPVPAPAADTALDSAP
                     TPDSDPAPALAPAPAPALSPSLASVPEEAESKRHISIQRRLADLEKLAFGTEGDVDSA
                     SSLNSDNPGTENSQTCPLCPKEKFRAYSSHKLRRHLQNLHWKISVEFEGYRMCICHLA
                     CRPVKPTIVGEQISSKLGAHYHCIICSATITRRTDMLGHVKRHVNKGETKSRYIAAST
                     AKSSNEILKETDTDIQVFPNYSIPQKTDSYFNPKMKLNRQIIFCTLAALAKERKPLEC
                     LDAFGATGIMGLQWAKHLGNAVKVTINDLNENSVTLIQKNCHLNKLKVVVDSEEKEEG
                     DALEDDGTLGDIQVTRMDANVLMHLRSFDFIHLDPFGTSVNYLDSAFRNVRNLGIVSV
                     TSTDISSLYAKAQHVARRHYGCNIVRTEYYKELAARIVVAAVARAAARCNKGIEVLFA
                     VALEHFVLVVVRVLRGPTSADETAKKIQYLIHCQWCEERIFQKDGNMVEENPYRQLPC
                     NCHGSMPGKTAIELGPLWSSSLFNTGFLKRMLFESIHHGLDDIQPLIKTLIFESECTP
                     QSQCSTHAPSNTNKQEENGVFVKTTDDTTIDIYSAQGKRKSNEMAINLAKKQKTDAST
                     AHPPFYYNIHRHSIKGMNMPKLKKFLCCLSQAGFRVSRTHFDPMGIRTDAPLMQFKSI
                     LLKYSTPTYTGAQSEGQMPPAAEDTVTDRVEMSVSDKAEASGCRRW"
     exon            562..672
                     /gene="Trmt1l"
                     /gene_synonym="1190005F20Rik; C1orf25; Trm1-like; Trm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            673..786
                     /gene="Trmt1l"
                     /gene_synonym="1190005F20Rik; C1orf25; Trm1-like; Trm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            787..851
                     /gene="Trmt1l"
                     /gene_synonym="1190005F20Rik; C1orf25; Trm1-like; Trm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            852..981
                     /gene="Trmt1l"
                     /gene_synonym="1190005F20Rik; C1orf25; Trm1-like; Trm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1105
                     /gene="Trmt1l"
                     /gene_synonym="1190005F20Rik; C1orf25; Trm1-like; Trm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1185
                     /gene="Trmt1l"
                     /gene_synonym="1190005F20Rik; C1orf25; Trm1-like; Trm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1429
                     /gene="Trmt1l"
                     /gene_synonym="1190005F20Rik; C1orf25; Trm1-like; Trm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1642
                     /gene="Trmt1l"
                     /gene_synonym="1190005F20Rik; C1orf25; Trm1-like; Trm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1833
                     /gene="Trmt1l"
                     /gene_synonym="1190005F20Rik; C1orf25; Trm1-like; Trm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1912
                     /gene="Trmt1l"
                     /gene_synonym="1190005F20Rik; C1orf25; Trm1-like; Trm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2079
                     /gene="Trmt1l"
                     /gene_synonym="1190005F20Rik; C1orf25; Trm1-like; Trm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2142
                     /gene="Trmt1l"
                     /gene_synonym="1190005F20Rik; C1orf25; Trm1-like; Trm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2269
                     /gene="Trmt1l"
                     /gene_synonym="1190005F20Rik; C1orf25; Trm1-like; Trm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..2771
                     /gene="Trmt1l"
                     /gene_synonym="1190005F20Rik; C1orf25; Trm1-like; Trm1l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2729..2734
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trmt1l"
                     /gene_synonym="1190005F20Rik; C1orf25; Trm1-like; Trm1l"
                     /note="hexamer: AATAAA"
     polyA_site      2749
                     /gene="Trmt1l"
                     /gene_synonym="1190005F20Rik; C1orf25; Trm1-like; Trm1l"
                     /note="major polyA site"
ORIGIN      
        1 ggttcggtgg cggccagtga tgcagaggac gtaccgagga aacggaactc tttttcctca
       61 ttggacactg tccgccacac gcttctgcgc agtctgtggt ggcgtcgtaa cgcctcgggg
      121 aaggggaagc cggcgaaggg tcgaaccgct gcctctggct ttcagttttt ctgctgacag
      181 ggttgggtca ctggagctcc gccgtttgtc tgtggcacgc gtacagcctt cccaattgct
      241 tccccgccct tggatccagc cctgtgtgca ttaacgtcta ttaacccact ccgccgcgag
      301 tcccctccgc gtcccctggc tcggaggccg taactatgga gaatatggcg gaggaggagc
      361 tgctacccca ggagaaggag gaggcccagg tcagggtccc gacccgggcc ccggattcgg
      421 ctccggtccc agctccggcc gcagatacgg ctctggactc ggctccgacg ccggactcgg
      481 atccagcccc agcccttgcc ccggccccgg ctccggccct gtccccgtcc ctagcctctg
      541 tccccgagga ggctgaaagc aagagacaca tctcaattca aaggcggctt gctgacctgg
      601 agaagttagc ttttgggact gaaggagatg ttgactctgc cagttcattg aactcagata
      661 atccaggcac agaaaacagt caaacttgcc cgctgtgtcc taaggaaaag ttcagagctt
      721 atagtagtca caagcttcgt cgacaccttc agaatttaca ctggaaaatc tcagttgaat
      781 ttgaaggcta cagaatgtgc atctgtcact tagcctgccg cccggtgaag ccaaccatcg
      841 ttggagaaca gatatccagt aaactgggcg cccattatca ctgcatcatt tgttcagcaa
      901 caatcaccag gaggactgac atgctagggc atgttaagcg ccatgtcaac aaaggggaaa
      961 ctaaatccag gtacattgct gcttctactg ccaaatcatc taatgagatt ttgaaggaga
     1021 cagacacaga catacaagtt tttcctaact actctatacc tcagaaaaca gattcatatt
     1081 ttaatcccaa aatgaagcta aatcgtcaga taatattctg tacattggct gctttggcta
     1141 aggaacgaaa acctttggag tgtttagatg cctttggagc cactggaata atgggattac
     1201 agtgggcaaa gcaccttgga aatgcagtca aagttacaat taatgacttg aatgaaaact
     1261 ctgtgacttt gattcagaaa aactgccact taaacaagtt aaaagtggta gtggacagcg
     1321 aggaaaagga agagggtgat gccctcgaag acgacggcac tctgggggat atccaggtga
     1381 ccaggatgga cgccaatgtt ctgatgcacc tcagatcttt tgactttata catctggatc
     1441 cctttggaac gtcagtgaac tacctcgact ctgcgttcag aaatgtaagg aaccttggca
     1501 tagtgtcagt gacttctaca gacatcagct ccttgtatgc caaggcacag catgttgccc
     1561 ggcgtcacta cggatgtaac attgtccgaa cagagtatta caaggagctg gcggccagaa
     1621 ttgtcgtagc tgcagtggca agagctgcag cacggtgcaa caaaggtata gaagtgctgt
     1681 ttgcggtggc cctggaacac ttcgtgttgg tagttgtgag ggtcttaaga ggccctactt
     1741 cagcggacga gactgccaag aaaatccagt acctgatcca ctgccagtgg tgtgaagaga
     1801 ggatttttca gaaggatgga aacatggtgg aagaaaaccc atacagacag ctgccctgta
     1861 attgtcatgg gagcatgcct ggcaagacag cgatagaact cgggcctctg tggtcaagtt
     1921 cccttttcaa tactggattc ctcaaaagga tgctatttga atctattcac catggtttgg
     1981 atgacattca acccctaata aagacattaa tctttgaatc agagtgtacc ccccaaagcc
     2041 agtgttcaac tcatgcacct tcaaatacca acaagcaaga agaaaatggc gtatttgtta
     2101 aaaccaccga tgataccaca atagatattt acagtgcaca gggcaagaga aaaagtaatg
     2161 agatggccat taacctagcc aaaaagcaga agaccgacgc cagcacggct cacccgccct
     2221 tttactacaa catccacagg cacagcatca aagggatgaa catgccgaag ttaaaaaaat
     2281 ttttgtgctg tctttcgcaa gcaggctttc gagtaagccg aactcacttt gacccaatgg
     2341 gcatccgtac cgatgcccct ctgatgcagt ttaaatccat cttgctaaag tacagcaccc
     2401 ccacttacac tggagcacaa tcagaaggcc agatgccgcc agcagctgag gacacggtca
     2461 ccgacagggt tgagatgtcc gtgagtgaca aagcggaagc gagtggctgc aggagatggt
     2521 gactgtgagg gggttcttct cagggttctg tatgatggcc caagtctctg taccgctgca
     2581 atcctttttt attcttgcaa tttagtgata tgagatttaa aaaaaaattt aaaaagcact
     2641 gttttcattc agaaaattgg ctgtttctga cttggctggt gtgagagcgt tgctttttaa
     2701 gtttttatta ttttaaagaa aaaaatttaa taaaaacatt tgaagccaag tttctgactg
     2761 ggctcgcgtg aaaaaaaaaa aaaaaaa
//
