LOCUS       NM_001166370            1047 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus tRNA methyltransferase 11-2 (Trmt112), transcript
            variant 1, mRNA.
ACCESSION   NM_001166370
VERSION     NM_001166370.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1047)
  AUTHORS   Kusevic,D., Kudithipudi,S. and Jeltsch,A.
  TITLE     Substrate Specificity of the HEMK2 Protein Glutamine
            Methyltransferase and Identification of Novel Substrates
  JOURNAL   J Biol Chem 291 (12), 6124-6133 (2016)
   PUBMED   26797129
REFERENCE   2  (bases 1 to 1047)
  AUTHORS   Gu,T., He,H., Zhang,Y., Han,Z., Hou,G., Zeng,T., Liu,Q. and Wu,Q.
  TITLE     Trmt112 gene expression in mouse embryonic development
  JOURNAL   Acta Histochem Cytochem 45 (2), 113-119 (2012)
   PUBMED   22685353
REFERENCE   3  (bases 1 to 1047)
  AUTHORS   Figaro,S., Scrima,N., Buckingham,R.H. and Heurgue-Hamard,V.
  TITLE     HemK2 protein, encoded on human chromosome 21, methylates
            translation termination factor eRF1
  JOURNAL   FEBS Lett 582 (16), 2352-2356 (2008)
   PUBMED   18539146
REFERENCE   4  (bases 1 to 1047)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   5  (bases 1 to 1047)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC087959.1, DV654053.1 and BE951374.1.
            
            Transcript Variant: This variant (1) represents the longer and more
            frequently occurring transcript. Both variants encode the same
            protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016191.1, CO046056.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               BC087959.1         1-110
            111-806             DV654053.1         1-696
            807-1047            BE951374.1         1-241               c
FEATURES             Location/Qualifiers
     source          1..1047
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 5.08 cM"
     gene            1..1047
                     /gene="Trmt112"
                     /gene_synonym="0610038D11Rik; Trm112p"
                     /note="tRNA methyltransferase 11-2"
                     /db_xref="GeneID:67674"
                     /db_xref="MGI:MGI:1914924"
     exon            1..565
                     /gene="Trmt112"
                     /gene_synonym="0610038D11Rik; Trm112p"
                     /inference="alignment:Splign:2.1.0"
     CDS             488..865
                     /gene="Trmt112"
                     /gene_synonym="0610038D11Rik; Trm112p"
                     /note="tRNA methyltransferase 112 homolog; TRM112-like
                     protein; tRNA methyltransferase 11-2 homolog"
                     /codon_start=1
                     /product="multifunctional methyltransferase subunit
                     TRM112-like protein"
                     /protein_id="NP_001159842.1"
                     /db_xref="CCDS:CCDS29508.1"
                     /db_xref="GeneID:67674"
                     /db_xref="MGI:MGI:1914924"
                     /translation="MKLLTHNLLSSHVRGVGTRGFPLRLQATEVRINPVEFNPEFVAR
                     MIPKVEWAALVQAADTLNLAEVPKEPTEGYEHDETFLRKMHHVLLEVDVLEGTLQCPE
                     SGRLFPISRGIPNMLLNDEETET"
     exon            566..667
                     /gene="Trmt112"
                     /gene_synonym="0610038D11Rik; Trm112p"
                     /inference="alignment:Splign:2.1.0"
     exon            668..757
                     /gene="Trmt112"
                     /gene_synonym="0610038D11Rik; Trm112p"
                     /inference="alignment:Splign:2.1.0"
     exon            758..1034
                     /gene="Trmt112"
                     /gene_synonym="0610038D11Rik; Trm112p"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1014..1019
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trmt112"
                     /gene_synonym="0610038D11Rik; Trm112p"
                     /note="hexamer: ATTAAA"
     polyA_site      1034
                     /gene="Trmt112"
                     /gene_synonym="0610038D11Rik; Trm112p"
                     /note="major polyA site"
ORIGIN      
        1 acgtcccacg tcgcagccac agcgccggct tagaggggca gggccgtgac gcactacgac
       61 gcggcggggc tctcagggct cgcacacctt cttcaatcgc agaaagaggt gcctggttta
      121 ccgacgtgac agttcgtgac ccatagccgc aaacagaggt cggggatgat ctggctgagc
      181 ctcaaatgtg ttcgttttac ctgcgccgta acgcagccgg tttacacgtg acttgcatag
      241 tgtgtactct cttcagcgag cgggattcgg cgtaagcctt tgcagtctcc ccgagaaacg
      301 cttccggtac caggacgtga cccaacacag tccttccgat ctcggctgcc gccaagcccc
      361 ccaaaaggtc ccctaagtcg gccacttccg gtccggcgaa gagttcaacg gcttcaaagc
      421 ggaagtggta gaaaggagaa gtgtggactc cttccggttc cggcctcacg cgctccgctg
      481 tgacaacatg aaactgctca cccacaatct cctaagctcc catgtgcggg gcgtgggcac
      541 gcgtggcttc ccgctgcgcc tgcaggccac tgaggtccgc atcaaccccg tggagttcaa
      601 cccggagttc gtggcgcgga tgatccccaa agtggagtgg gcggcgcttg tgcaggcagc
      661 ggacacctta aacttggccg aggtacccaa agagccgact gaaggctatg agcacgacga
      721 gacatttttg aggaagatgc accacgtgtt gcttgaggtt gatgtactgg agggcaccct
      781 gcaatgccca gaatctggtc gtcttttccc catcagccgc gggatcccca atatgctgtt
      841 gaatgatgag gagactgaga cgtaaccttg ctagccgcca ctttggtatt ttgttgactg
      901 tgtgtttctg ttgtacggtc tgttaaatag acgtgtcatg tgtgaccccc aaactccccc
      961 cagtgactca ccgaccaccg tgtacttgag ctccatagta tatttttttt ctcattaaag
     1021 gttcaaaacc aaaaaaaaaa aaaaaaa
//
