LOCUS       NM_028604               2310 bp    mRNA    linear   ROD 15-DEC-2024
DEFINITION  Mus musculus tRNA methyltransferase 11 (Trmt11), transcript variant
            1, mRNA.
ACCESSION   NM_028604
VERSION     NM_028604.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2310)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 2310)
  AUTHORS   Diez-Roux,G., Banfi,S., Sultan,M., Geffers,L., Anand,S., Rozado,D.,
            Magen,A., Canidio,E., Pagani,M., Peluso,I., Lin-Marq,N., Koch,M.,
            Bilio,M., Cantiello,I., Verde,R., De Masi,C., Bianchi,S.A.,
            Cicchini,J., Perroud,E., Mehmeti,S., Dagand,E., Schrinner,S.,
            Nurnberger,A., Schmidt,K., Metz,K., Zwingmann,C., Brieske,N.,
            Springer,C., Hernandez,A.M., Herzog,S., Grabbe,F., Sieverding,C.,
            Fischer,B., Schrader,K., Brockmeyer,M., Dettmer,S., Helbig,C.,
            Alunni,V., Battaini,M.A., Mura,C., Henrichsen,C.N.,
            Garcia-Lopez,R., Echevarria,D., Puelles,E., Garcia-Calero,E.,
            Kruse,S., Uhr,M., Kauck,C., Feng,G., Milyaev,N., Ong,C.K.,
            Kumar,L., Lam,M., Semple,C.A., Gyenesei,A., Mundlos,S., Radelof,U.,
            Lehrach,H., Sarmientos,P., Reymond,A., Davidson,D.R., Dolle,P.,
            Antonarakis,S.E., Yaspo,M.L., Martinez,S., Baldock,R.A., Eichele,G.
            and Ballabio,A.
  TITLE     A high-resolution anatomical atlas of the transcriptome in the
            mouse embryo
  JOURNAL   PLoS Biol 9 (1), e1000582 (2011)
   PUBMED   21267068
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153899.3, AK032943.1, BY259542.1, AK010722.1 and BG083636.1.
            
            On Dec 9, 2017 this sequence version replaced NM_028604.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK010722.1, AF532979.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AC153899.3         80947-80951
            6-111               AK032943.1         2-107
            112-177             BY259542.1         109-174
            178-1649            AK010722.1         169-1640
            1650-1650           BG083636.1         201-201             c
            1651-2310           AK010722.1         1642-2301
FEATURES             Location/Qualifiers
     source          1..2310
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 17.07 cM"
     gene            1..2310
                     /gene="Trmt11"
                     /gene_synonym="2410075D05Rik; 3110045I18Rik"
                     /note="tRNA methyltransferase 11"
                     /db_xref="GeneID:73681"
                     /db_xref="MGI:MGI:1920931"
     exon            1..111
                     /gene="Trmt11"
                     /gene_synonym="2410075D05Rik; 3110045I18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..1422
                     /gene="Trmt11"
                     /gene_synonym="2410075D05Rik; 3110045I18Rik"
                     /note="isoform 1 is encoded by transcript variant 1; tRNA
                     guanosine-2'-O-methyltransferase TRM11 homolog; tRNA
                     (guanine(10)-N2)-methyltransferase homolog; tRNA
                     methyltransferase 11 homolog; tRNA
                     (guanine(10)-N(2))-methyltransferase homolog"
                     /codon_start=1
                     /product="tRNA (guanine(10)-N(2))-methyltransferase
                     homolog isoform 1"
                     /protein_id="NP_082880.2"
                     /db_xref="CCDS:CCDS23763.1"
                     /db_xref="GeneID:73681"
                     /db_xref="MGI:MGI:1920931"
                     /translation="MALPGSLNRYLLLMAQEHLEFRLPEIKSLLSVFGGQFTNSQETY
                     GKSPFWILNIPSEDIARNLMKRTVCAKSIFELWGHGKSPEELYTSLKSYPVEKMVPYL
                     HSDSTYKIKIHTFNKTLTQEEKVKRIDALEFLPFQGKVNLKKPQHVFSILEDYGLDPN
                     SIPKDPHNIYFGRWIADGQRELIESYSVKKRHFIGNTSMDAGLSFIMTNHAKVKENDL
                     VFDPFVGTGGLLIASAHFGAYVCGTDIDYNTVHGLGKASRKNQKWRGPDENIRANLRQ
                     YGLEKFYLDVLVSDASKPSWRKGTYFDAIITDPPYGIRESTRRSGSQKDIPKGIEKCP
                     ESHVPVSLSYHLSDMFFDLLNFAAETLVLGGRLVYWLPVYTPEYTEEMVPWHPCLRLI
                     SNCEQKLSSHTARRLITMEKVKEFENRDKYSHLLSDHFLPYQGHNSFREKYFSGVTKR
                     IAKEEKCSHE"
     exon            112..177
                     /gene="Trmt11"
                     /gene_synonym="2410075D05Rik; 3110045I18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            178..251
                     /gene="Trmt11"
                     /gene_synonym="2410075D05Rik; 3110045I18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            252..333
                     /gene="Trmt11"
                     /gene_synonym="2410075D05Rik; 3110045I18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            334..426
                     /gene="Trmt11"
                     /gene_synonym="2410075D05Rik; 3110045I18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            427..561
                     /gene="Trmt11"
                     /gene_synonym="2410075D05Rik; 3110045I18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            562..718
                     /gene="Trmt11"
                     /gene_synonym="2410075D05Rik; 3110045I18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            719..799
                     /gene="Trmt11"
                     /gene_synonym="2410075D05Rik; 3110045I18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            800..964
                     /gene="Trmt11"
                     /gene_synonym="2410075D05Rik; 3110045I18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1037
                     /gene="Trmt11"
                     /gene_synonym="2410075D05Rik; 3110045I18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1169
                     /gene="Trmt11"
                     /gene_synonym="2410075D05Rik; 3110045I18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1290
                     /gene="Trmt11"
                     /gene_synonym="2410075D05Rik; 3110045I18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..2310
                     /gene="Trmt11"
                     /gene_synonym="2410075D05Rik; 3110045I18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1793..1798
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trmt11"
                     /gene_synonym="2410075D05Rik; 3110045I18Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1820
                     /gene="Trmt11"
                     /gene_synonym="2410075D05Rik; 3110045I18Rik"
                     /note="major polyA site"
     regulatory      2285..2290
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trmt11"
                     /gene_synonym="2410075D05Rik; 3110045I18Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      2308
                     /gene="Trmt11"
                     /gene_synonym="2410075D05Rik; 3110045I18Rik"
ORIGIN      
        1 ggcccgtgga ggccgcgcag gcgcacggta gtagctgcaa tggcgctgcc gggctccttg
       61 aatcgctatc tcttgctcat ggcacaggag catctggagt tccgcttacc ggaaataaag
      121 tctttactat cggtgtttgg agggcagttc actaacagtc aggaaactta tggaaagtct
      181 ccattttgga ttcttaacat tccctctgaa gatattgcaa gaaacttaat gaaacggact
      241 gtgtgtgcca agtctatatt tgaactatgg ggtcatggaa aatctcccga ggagctgtat
      301 acttctctta aaagttaccc cgtggagaag atggttccat atctgcattc agattcgaca
      361 tataaaataa agattcacac atttaataaa acattaactc aagaagaaaa agtgaaacga
      421 attgatgcac ttgaatttct gccgtttcaa ggaaaagtga acttaaagaa accacagcat
      481 gtattctcca ttttggagga ctatggtttg gacccaaact ctatccccaa ggatccacat
      541 aatatttatt ttggcagatg gattgcagat ggacaaagag agctaattga gtcatacagt
      601 gtcaaaaaga gacattttat tggaaataca agtatggatg ctggtttatc attcatcatg
      661 accaaccatg caaaagtgaa agaaaatgat cttgtctttg acccctttgt tggaacaggt
      721 ggcctcctta tagcatctgc tcactttggt gcatatgtgt gtgggacaga catagactac
      781 aatacagttc atggcttggg aaaggctagt agaaaaaacc agaaatggcg tggaccagat
      841 gaaaacatca gggcaaatct tcgtcagtat ggcttagaga agttttacct tgatgtcttg
      901 gtttcagatg cgtctaagcc ttcctggagg aagggaacat attttgatgc aatcatcaca
      961 gatcctccat atggtatcag agaatctaca agaagatcag gttcacagaa ggacatacca
     1021 aagggaatag aaaaatgtcc agaaagccac gttcctgttt ccttgagtta tcacctgagt
     1081 gacatgtttt ttgacctgtt aaattttgca gctgagaccc ttgtactggg tggaagacta
     1141 gtctattggc taccagtata tacaccagag tacactgagg agatggtgcc gtggcaccct
     1201 tgcctgagac tcattagcaa ctgtgaacag aagctttcca gtcacacagc aaggcgcctg
     1261 atcaccatgg aaaaggtgaa ggaatttgag aaccgggaca agtattcaca cctgctgagt
     1321 gatcattttc tgccgtacca aggacataat tctttccgtg agaaatattt tagtggtgta
     1381 acaaaaagaa ttgccaagga agaaaaatgc agccacgagt gaaaactctg atgctgacaa
     1441 tcaggaaaga aggagcgttt tataaaaagg ctttggatgg gaatttgtgc atatgattaa
     1501 aaaacctgtg ctgatttaca atttttatat aaataactgc tattaatcaa aattggataa
     1561 tttcaaaatg gtctttgttt tagagactat tttgatgtat atgtcttttg agccttgtta
     1621 agtgtcaggg actggtatat atatatatag agagagaaag tgtttatatt tttacaaaga
     1681 caatattgta tctgccacat acatggtagg taattaatag tgatttagaa cttactcatt
     1741 ttgtaaagtt gcttggtttg acttttagtt gtgactgttt ttcattgaca ccaataaact
     1801 ttactgggaa tttctaaaaa ttatgtgata ctcagtattt ctcatggaat gtttaaccat
     1861 aaatcccata ttagtcataa cagtggccat gcagaggcaa ggaaacctaa gggctgagaa
     1921 ctgtggagaa tccaacccca agacctccac gagggccctt gtgcttctga aggtgtctgc
     1981 tccttggatt tgctcttgca ttcctaaaac ttgactgttg gtcacgttaa ctaactacct
     2041 tcaatgtttg gttgagaaag ttacatttaa aagcaggcac agcagctcaa gtccttgacg
     2101 gccacgcaaa ggcattgggt ttcatcagta ctcactgaga cagaagctgt agttttcttg
     2161 aaggaaaaac tttgctgagt ctacgtaatg tccatcatgg aaataccttt tttgcaaacc
     2221 acttttccca ttaattctag ctgctaatag ctttctgctt ttggtggtac ctcagtgagg
     2281 tggcagtaaa tggatacttt ctttctaacc
//
