LOCUS       NM_001404369            4418 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus tRNA methyltransferase 10A (Trmt10a), transcript
            variant 6, mRNA.
ACCESSION   NM_001404369 XM_030252349
VERSION     NM_001404369.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4418)
  AUTHORS   Tresky,R., Miyamoto,Y., Nagayoshi,Y., Yabuki,Y., Araki,K.,
            Takahashi,Y., Komohara,Y., Ge,H., Nishiguchi,K., Fukuda,T.,
            Kaneko,H., Maeda,N., Matsuura,J., Iwasaki,S., Sakakida,K.,
            Shioda,N., Wei,F.Y., Tomizawa,K. and Chujo,T.
  TITLE     TRMT10A dysfunction perturbs codon translation of initiator
            methionine and glutamine and impairs brain functions in mice
  JOURNAL   Nucleic Acids Res 52 (15), 9230-9246 (2024)
   PUBMED   38950903
REFERENCE   2  (bases 1 to 4418)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4418)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4418)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4418)
  AUTHORS   White,J.K., Gerdin,A.K., Karp,N.A., Ryder,E., Buljan,M.,
            Bussell,J.N., Salisbury,J., Clare,S., Ingham,N.J., Podrini,C.,
            Houghton,R., Estabel,J., Bottomley,J.R., Melvin,D.G., Sunter,D.,
            Adams,N.C., Tannahill,D., Logan,D.W., Macarthur,D.G., Flint,J.,
            Mahajan,V.B., Tsang,S.H., Smyth,I., Watt,F.M., Skarnes,W.C.,
            Dougan,G., Adams,D.J., Ramirez-Solis,R., Bradley,A. and Steel,K.P.
  CONSRTM   Sanger Institute Mouse Genetics Project
  TITLE     Genome-wide generation and systematic phenotyping of knockout mice
            reveals new roles for many genes
  JOURNAL   Cell 154 (2), 452-464 (2013)
   PUBMED   23870131
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131122.4.
            
            On Apr 9, 2022 this sequence version replaced XM_030252349.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.4079037.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-435               AC131122.4         47853-48287         c
            436-542             AC131122.4         45761-45867         c
            543-738             AC131122.4         44584-44779         c
            739-898             AC131122.4         43641-43800         c
            899-970             AC131122.4         42629-42700         c
            971-1045            AC131122.4         41677-41751         c
            1046-1195           AC131122.4         39813-39962         c
            1196-1301           AC131122.4         37356-37461         c
            1302-4418           AC131122.4         32333-35449         c
FEATURES             Location/Qualifiers
     source          1..4418
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 64.09 cM"
     gene            1..4418
                     /gene="Trmt10a"
                     /gene_synonym="3110023L08Rik; Rg9mtd2; Rnmtd2"
                     /note="tRNA methyltransferase 10A"
                     /db_xref="GeneID:108943"
                     /db_xref="MGI:MGI:1920421"
     exon            1..435
                     /gene="Trmt10a"
                     /gene_synonym="3110023L08Rik; Rg9mtd2; Rnmtd2"
                     /inference="alignment:Splign:2.1.0"
     exon            436..542
                     /gene="Trmt10a"
                     /gene_synonym="3110023L08Rik; Rg9mtd2; Rnmtd2"
                     /inference="alignment:Splign:2.1.0"
     exon            543..738
                     /gene="Trmt10a"
                     /gene_synonym="3110023L08Rik; Rg9mtd2; Rnmtd2"
                     /inference="alignment:Splign:2.1.0"
     exon            739..898
                     /gene="Trmt10a"
                     /gene_synonym="3110023L08Rik; Rg9mtd2; Rnmtd2"
                     /inference="alignment:Splign:2.1.0"
     exon            899..970
                     /gene="Trmt10a"
                     /gene_synonym="3110023L08Rik; Rg9mtd2; Rnmtd2"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1045
                     /gene="Trmt10a"
                     /gene_synonym="3110023L08Rik; Rg9mtd2; Rnmtd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1195
                     /gene="Trmt10a"
                     /gene_synonym="3110023L08Rik; Rg9mtd2; Rnmtd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1301
                     /gene="Trmt10a"
                     /gene_synonym="3110023L08Rik; Rg9mtd2; Rnmtd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..4418
                     /gene="Trmt10a"
                     /gene_synonym="3110023L08Rik; Rg9mtd2; Rnmtd2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2851..2856
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trmt10a"
                     /gene_synonym="3110023L08Rik; Rg9mtd2; Rnmtd2"
                     /note="hexamer: AATAAA"
     polyA_site      2874
                     /gene="Trmt10a"
                     /gene_synonym="3110023L08Rik; Rg9mtd2; Rnmtd2"
                     /note="major polyA site"
     regulatory      4392..4397
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trmt10a"
                     /gene_synonym="3110023L08Rik; Rg9mtd2; Rnmtd2"
                     /note="hexamer: AATAAA"
     polyA_site      4418
                     /gene="Trmt10a"
                     /gene_synonym="3110023L08Rik; Rg9mtd2; Rnmtd2"
ORIGIN      
        1 ggttgtcgcc gcggtgtgcg ctccgggttt ctgttgttta ggagagtccc taccggaagt
       61 gtggcagaaa ggagccatgt ggagtctcag ggtagcttgt cgcaacgctg cgttgcgcct
      121 agagggcagg cgagccgttt tcccttcttt tcctcttttt ccttccctgg gtcaggccgt
      181 cgcatgtaag ggcgccgagg ggcagttgct gcccaggcgg ctcggcctcg tggtcagctg
      241 aggatgaggt taagatggac gcgttaccgg ttgccactga aatattttgt gtttaaaatg
      301 tggttgcgtg tccggagatg taaaattact catttaaaaa aaaaaaaaaa aaaaagctct
      361 cctgagattc cctcccaagc cagaactcaa gccaaaggga ctttgacaac tgaacaaagg
      421 gctattgcta ctgcgccata gctaaagcat ttacagatat atagtgacat ttattagaga
      481 gagaaagaaa acttgtatca ttcaagttag aaaatccaga tacccatgaa cagaagtgga
      541 agagacaatg aatatgtcat ctgaaatgct gccagcatcc atcgagtcta ctaatgtgga
      601 ggaaaagctg ggtacgagtg acggtgaaga ggagagacag gagcctagag tggatgcagg
      661 ggctgagcca atatctaaac ggcaactgaa gaagctgatg aaacaaaaac agtgggaaga
      721 gcaacgtgaa cagcgcaagg agaaacgaaa agaaaaacgg aagagaaaga aattagaacg
      781 acgccagctg gagtccaact cagatggcaa cgacaggaag cgcgttcgga gagatgttgc
      841 tcgcagcagc ctccgcctgg tcatcgactg tagctttgat gacttgatgg tgttaaagga
      901 tattaagaaa cttcataaac agattcaacg atgttatgca gaaaaccgcc gagcctctca
      961 tccagtgcag ttttacttga caagccatgg aggtcaactg aagaagaaca tggatgagaa
     1021 cgaccaagga tgggtcaact ggaaggatat tcacatcaag tcagagcact atagtgaact
     1081 cataaaaaaa gaagacctgg tttatctgac gtcagactca cctaatgtac tgaaggactt
     1141 agatgagtca aaggcctacg tgattggagg gctagtggac cacaaccatc acaagggact
     1201 cacatttaaa caagcaacca gttacggaat cgaacatgca cagctccctc ttgcagattt
     1261 tgtgaagatg aacagtcgaa aagtcctggc cgttaaccat gtgtttgaaa ttatcctgga
     1321 gttcttggaa acaagagact ggcaagaggc attctttaca atcttacccc aacggaaagg
     1381 ggccgttcct gctcacaagg cctgcgaaag ctctcctcag gaccaccagt ccctgccaga
     1441 aggatgggac agtgccagcg agggagagag ttgcagggat aatcctgtct caccacagaa
     1501 agacgagcag ggccagcaga gcagcccggt tctgcagtga gccccgtccc acagtaacct
     1561 tcccctgtcc tcctctcgct taagagaaac caggcagtgc ggtgctttac agaatgctca
     1621 gactgcaaga aaactttctc tagtctatgt tgtggaattt taaatctgtt ttaagagtta
     1681 aataataatg aaaaaaaccc tttaaacact aagaaaggat cgtttggttt tgtgtaagaa
     1741 gacttaaaga tatgatttca aaattgcttt aagcctcaaa tcagtcatgg aggacgtgga
     1801 atacgagtct gcctcggttc gtcactcact ggagcatatc cttcaggacg tgtcttctga
     1861 cccttgagct tggttcttta agttcctacc tgtatctttt tagtccgatg tctatttggt
     1921 ggagcagata ttcataactg acctgtgtgt cttctagaat gttgaacttt ggaagctatg
     1981 cttttttctg tagctttggt gttttgtcta agaaatacat taattctagg agaactacca
     2041 gttgtttgct gggctctaca attcattcct tttggacaat ggagtctatt cctgtgcctc
     2101 ccttgtgata ccttgttatg cttctgaaat agtcacaaga ataatcttaa atcctgtaat
     2161 gacaataact tattcaatta cacagctaag ttttgctggc tagattatta tataagcttt
     2221 ttttgaagga tcaatttgtc tttacctcag tttaaaacaa aacaaaaaag ttatccttct
     2281 catatatttt ccatatatat atataccata tatttccata atgttatctt ttaatgtgaa
     2341 tattatacat ctgcctccaa ctaatataaa tgtttctgta aatagcatat gcatgtagga
     2401 aaatgagcat gtaataatgt ttacatctgt ccatatcaca tttagccttc atgccttaat
     2461 ccacaatgac aggactgatg cattctttgc ggaatgggtg tgttgaattc actagtttga
     2521 attcgttaaa tggaattgaa cagtggtttg gaaaccgatg gagacagagc agagggcact
     2581 gcactgttgg gcttctgcag agagtttgca gagtagtatt caggtcacaa gcccttcgca
     2641 cgagtgcagt ggagctccag gggctctcat tggtcttttc tctttatgat acaatgtgtg
     2701 cgctgtgtta gcatctcact tacacagacg ctcatgacat ttggtgttgg tggtcagtgc
     2761 ctattgcttt attcttagtt acctattgta gctagctctt tcaaagtcta taaatgaagt
     2821 atgtaaacag tcacagtata gttctaaatg aataaagttc atgttgttac tgtacttttc
     2881 taaaattcag gttttgtgag gtacacccca tgggcccgtg tgtttggaca cttggtctcc
     2941 agctgatggt gccgttttcg aggttgtggg gcctttcaaa ggggaagctt tgctggaggg
     3001 agcatgtcac ttagggtggg cttttctttc ttccttcttt ctttctttct ttctttcttt
     3061 ctttctttct ctttctttct ttctctttct ttcttttctt tccttccttc cttccttcct
     3121 tccttccttc tttccttctt tctttctttc tttctttctt tctttttttt tttttttttt
     3181 tggttttctg agacagggtt tctctgtgta tctctggctg tcctggaact cactctgtag
     3241 accaggctgg cctcgaactc agagatccgc ctgcctctgc ctcccaagtg ctgggatcaa
     3301 aggtgtgagc caccactgcc tggtgggctt ttcaactcta tagccagtcc tgttttttgt
     3361 gtcttctttc ctttatacag gcaaatgtga tcaccacgtc ctgacatcca aaccaacctg
     3421 acaatcccac tgccaggcct cccctgcagt gagggtctgt atacctcctc agagctctag
     3481 accaaaataa ccctcccttc cttattggcc ttttgtcagg gtgttttgtc atgaagtaac
     3541 ataaaagtat ctaacaaaaa catatcattt tatatgggag aggaccctat aaaagtgaag
     3601 gaaatcattt caagtgccac atggtttcag ctcactcatt gcaaaagctc tgttgatttc
     3661 ctgggcatgc tataagaaaa caccacagac ctagtgggct aaaataacca caacttattt
     3721 tctacagtgt cagaggctgc aagttcagaa tcaagcctgg tagggtcatg ctccctctgg
     3781 ctcacaagac gttcttttta accttaatgt atttttttct gtcaactttt tgttttccag
     3841 tacagcagca gatgaaaagg agaaaatagg taacaatgat ttgaattaat ggcagcagag
     3901 accatgagct cagtgagtga gctagctcat ggaggtcttt ctccctcttt ctagctcatt
     3961 tcgagggcat gcgccgtgag cttaatatgt gtgaagaaga cagtgatggt cgcctcaaga
     4021 gtcgggattg ttgctgggga gatcagggga ttggatgagg cgtaagcctt gtactcttat
     4081 gcttgtattg tgacactggg tatgttagaa ctcagtgtcc ctattttaaa tgtgactgtt
     4141 acatattggt cctgtcagca gcgtgtgagg taggcaatgg ggacttggtg actttcttcc
     4201 tctccttgtt tctcttctct cttgaccttg ccagctctaa aatatcagta aacctgcttc
     4261 agactttttg ttcttttggg gtacaagtct tgacaagatt ttaaaaatct gctttctgcc
     4321 agaacagggg caaagaacta aatgcatagc atttcataaa ggctttatta caacagtaaa
     4381 aacaatgcta aaataaaaca caaccatgaa agaccaaa
//
