LOCUS       NM_011639               1727 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus thyroid hormone receptor interactor 6 (Trip6),
            transcript variant 1, mRNA.
ACCESSION   NM_011639
VERSION     NM_011639.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1727)
  AUTHORS   Li,M.Y., Yang,X.L., Chung,C.C., Lai,Y.J., Tsai,J.C., Kuo,Y.L.,
            Yu,J.Y. and Wang,T.W.
  TITLE     TRIP6 promotes neural stem cell maintenance through YAP-mediated
            Sonic Hedgehog activation
  JOURNAL   FASEB J 38 (5), e23501 (2024)
   PUBMED   38411462
  REMARK    GeneRIF: TRIP6 promotes neural stem cell maintenance through
            YAP-mediated Sonic Hedgehog activation.
REFERENCE   2  (bases 1 to 1727)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1727)
  AUTHORS   Gou,H., Wong,C.C., Chen,H., Shang,H., Su,H., Zhai,J., Liu,W.,
            Liu,W., Sun,D., Wang,X. and Yu,J.
  TITLE     TRIP6 disrupts tight junctions to promote metastasis and drug
            resistance and is a therapeutic target in colorectal cancer
  JOURNAL   Cancer Lett 578, 216438 (2023)
   PUBMED   37827326
  REMARK    GeneRIF: TRIP6 disrupts tight junctions to promote metastasis and
            drug resistance and is a therapeutic target in colorectal cancer.
REFERENCE   4  (bases 1 to 1727)
  AUTHORS   Shukla,S., Haenold,R., Urbanek,P., Frappart,L., Monajembashi,S.,
            Grigaravicius,P., Nagel,S., Min,W.K., Tapias,A., Kassel,O.,
            Heuer,H., Wang,Z.Q., Ploubidou,A. and Herrlich,P.
  TITLE     TRIP6 functions in brain ciliogenesis
  JOURNAL   Nat Commun 12 (1), 5887 (2021)
   PUBMED   34620853
  REMARK    GeneRIF: TRIP6 functions in brain ciliogenesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1727)
  AUTHORS   Norizadeh Abbariki,T., Gonda,Z., Kemler,D., Urbanek,P., Wagner,T.,
            Litfin,M., Wang,Z.Q., Herrlich,P. and Kassel,O.
  TITLE     The LIM domain protein nTRIP6 modulates the dynamics of myogenic
            differentiation
  JOURNAL   Sci Rep 11 (1), 12904 (2021)
   PUBMED   34145356
  REMARK    GeneRIF: The LIM domain protein nTRIP6 modulates the dynamics of
            myogenic differentiation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1727)
  AUTHORS   Lai,Y.J., Chen,C.S., Lin,W.C. and Lin,F.T.
  TITLE     c-Src-mediated phosphorylation of TRIP6 regulates its function in
            lysophosphatidic acid-induced cell migration
  JOURNAL   Mol Cell Biol 25 (14), 5859-5868 (2005)
   PUBMED   15988003
  REMARK    GeneRIF: TRIP6 in lysophosphatidic acid signaling is regulated by
            c-Src-mediated phosphorylation of TRIP6 at the Tyr-55 residue.
REFERENCE   7  (bases 1 to 1727)
  AUTHORS   Xu,J., Lai,Y.J., Lin,W.C. and Lin,F.T.
  TITLE     TRIP6 enhances lysophosphatidic acid-induced cell migration by
            interacting with the lysophosphatidic acid 2 receptor
  JOURNAL   J Biol Chem 279 (11), 10459-10468 (2004)
   PUBMED   14688263
  REMARK    GeneRIF: TRIP6 functions at a point of convergence between the
            activated LPA(2) receptor and downstream signals involved in cell
            adhesion and migration
REFERENCE   8  (bases 1 to 1727)
  AUTHORS   Wilson,M.D., Riemer,C., Martindale,D.W., Schnupf,P., Boright,A.P.,
            Cheung,T.L., Hardy,D.M., Schwartz,S., Scherer,S.W., Tsui,L.C.,
            Miller,W. and Koop,B.F.
  TITLE     Comparative analysis of the gene-dense ACHE/TFR2 region on human
            chromosome 7q22 with the orthologous region on mouse chromosome 5
  JOURNAL   Nucleic Acids Res 29 (6), 1352-1365 (2001)
   PUBMED   11239002
REFERENCE   9  (bases 1 to 1727)
  AUTHORS   Cuppen,E., van Ham,M., Wansink,D.G., de Leeuw,A., Wieringa,B. and
            Hendriks,W.
  TITLE     The zyxin-related protein TRIP6 interacts with PDZ motifs in the
            adaptor protein RIL and the protein tyrosine phosphatase PTP-BL
  JOURNAL   Eur J Cell Biol 79 (4), 283-293 (2000)
   PUBMED   10826496
REFERENCE   10 (bases 1 to 1727)
  AUTHORS   Wang,Y., Dooher,J.E., Koedood Zhao,M. and Gilmore,T.D.
  TITLE     Characterization of mouse Trip6: a putative intracellular signaling
            protein
  JOURNAL   Gene 234 (2), 403-409 (1999)
   PUBMED   10395914
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC150682.2.
            
            On Mar 6, 2023 this sequence version replaced NM_011639.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF097511.1, AF116823.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-248               AC150682.2         41883-42130         c
            249-376             AC150682.2         41504-41631         c
            377-502             AC150682.2         41274-41399         c
            503-886             AC150682.2         40629-41012         c
            887-980             AC150682.2         40063-40156         c
            981-1150            AC150682.2         39797-39966         c
            1151-1329           AC150682.2         38576-38754         c
            1330-1450           AC150682.2         38208-38328         c
            1451-1727           AC150682.2         37821-38097         c
FEATURES             Location/Qualifiers
     source          1..1727
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 76.34 cM"
     gene            1..1727
                     /gene="Trip6"
                     /note="thyroid hormone receptor interactor 6"
                     /db_xref="GeneID:22051"
                     /db_xref="MGI:MGI:1343458"
     exon            1..248
                     /gene="Trip6"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..1582
                     /gene="Trip6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     thyroid receptor-interacting protein 6; ZRP-1; TRIP-6;
                     zyxin-related protein 1; TR-interacting protein 6"
                     /codon_start=1
                     /product="thyroid receptor-interacting protein 6 isoform
                     1"
                     /protein_id="NP_035769.1"
                     /db_xref="CCDS:CCDS19765.1"
                     /db_xref="GeneID:22051"
                     /db_xref="MGI:MGI:1343458"
                     /translation="MSGPTWLPPKQPEPSRLPQGRSLPRGALGPPTAHGATLQPHPRV
                     NFCPLPPEHCYQPPGVPEDRGPTWVGSHGTPQRLQGLPPDRGIIRPGSLDAEIDSLTS
                     MLADLDGGRSHAPRRPDRQAFEAPPPHAYRGGSLKPSGGAVPTPMLPASHYGGPTPAS
                     YATASTPAGPAFPVQVKVAQPVRGCGLPRRGASQASGPLPGPHFPLTGRGEVWGAGYR
                     SHREPGPGVPEGPSGVHIPAGGGRGGGHEPQGPLGQPPEEELERLTKKLVHDMSHPPS
                     GEYFGRCGGCGEDVVGDGAGVVALDRVFHIGCFVCSTCRAQLRGQHFYAVERRAYCES
                     CYVATLEKCSTCSEPILDRILRAMGKAYHPGCFTCVVCHRGLDGIPFTVDATSQIHCI
                     EDFHRKFAPRCSVCGGAIMPEPGQEETVRIVALDRSFHIGCYKCEECGLLLSSEGECQ
                     GCYPLDGHILCKACSAWRIQELSATVTTDC"
     exon            249..376
                     /gene="Trip6"
                     /inference="alignment:Splign:2.1.0"
     exon            377..502
                     /gene="Trip6"
                     /inference="alignment:Splign:2.1.0"
     exon            503..886
                     /gene="Trip6"
                     /inference="alignment:Splign:2.1.0"
     exon            887..980
                     /gene="Trip6"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1150
                     /gene="Trip6"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1329
                     /gene="Trip6"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1450
                     /gene="Trip6"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1727
                     /gene="Trip6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1702..1707
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trip6"
                     /note="hexamer: AATAAT"
     polyA_site      1727
                     /gene="Trip6"
                     /note="major polyA site"
ORIGIN      
        1 agaaaaagtt tctttgcggg agtcccaaac ggggcgtggg acagtaaggg agggaaaggg
       61 cccaaggctc cgagctccag gctctgagct tgtggggacc ctgacctctg tctggagtgg
      121 agtaacccta ttccagacca tgtccgggcc cacctggctt cccccgaagc agccagaacc
      181 ctccagactc cctcagggga gatcgctgcc cagaggcgcc ctgggcccgc caacggccca
      241 cggagcaaca ctccagcctc accccagggt caacttttgc cccctcccgc ctgaacactg
      301 ttatcagcct ccgggggtac cggaagatcg ggggcctact tgggtgggat cccatggaac
      361 accccagcgc ctgcaggggc tccctccaga cagggggatc atccgccctg gcagtctgga
      421 tgctgagata gattcgctca ccagcatgtt ggctgatctg gacgggggtc gcagtcatgc
      481 acctaggcgg ccagacagac aggcttttga ggctccccca ccccatgctt accgcggagg
      541 ctccctgaag cccagtggag gtgctgttcc aaccccgatg ctcccagcat cccactatgg
      601 tggacctacc ccagcctcct atgctaccgc gagcacgcca gctggccctg ctttccctgt
      661 acaagtgaag gtggctcaac ctgtgagagg ctgtggactg cccaggcgag gggcctctca
      721 ggcctctggg cctcttccag gcccccactt tcctctgaca ggtcgtggtg aagtctgggg
      781 ggctggctat aggagccacc gagagccagg accgggggtt ccggagggac cttctggagt
      841 acatatccct gcaggaggag ggagaggagg tgggcatgag cctcagggcc ccttaggcca
      901 acctcctgaa gaggaactgg agagactgac caagaaactg gtgcatgaca tgagccaccc
      961 tcccagtggg gagtactttg gtcggtgtgg tggctgtggc gaagatgtgg tgggcgatgg
     1021 agctggggtt gtggccctgg accgtgtctt ccatattggt tgctttgtgt gttctacctg
     1081 tcgggcccag ctccggggcc agcacttcta tgctgtggag aggcgggcat attgtgagag
     1141 ctgctatgtg gccaccctgg agaaatgttc cacatgctct gaacccatcc tggaccgaat
     1201 cctgagggct atggggaagg cgtaccaccc tggttgcttc acctgtgtgg tatgccaccg
     1261 tggtcttgat ggcatcccgt tcacagtgga cgccaccagc cagatccact gcattgaaga
     1321 tttccacagg aaatttgccc cacgatgctc agtgtgtggt ggggccatca tgccggaacc
     1381 aggtcaggag gagacggtga gaattgttgc tctggatcga agtttccaca tcggctgtta
     1441 caagtgtgag gagtgtgggc tgctgctgtc ctctgaggga gagtgtcaag gctgctaccc
     1501 gctggatggg cacatcttgt gcaaggcttg cagcgcctgg cgtatccaag agctctcagc
     1561 cactgtcacc actgattgtt gactgctctg agaagtacct gctgggatct cagcccccgt
     1621 ccgtccgtcc gtcacttccc ccaacatcta cccttagtgt ttgccatcaa atgctgtctt
     1681 ttcttcctct cttcatgaaa taataatccc tggagcattt aaaagca
//
