LOCUS       NM_027182               2240 bp    mRNA    linear   ROD 04-SEP-2024
DEFINITION  Mus musculus thyroid hormone receptor interactor 13 (Trip13),
            transcript variant 1, mRNA.
ACCESSION   NM_027182 XM_127444 XM_908766 XM_992798
VERSION     NM_027182.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2240)
  AUTHORS   Chotiner,J.Y., Leu,N.A., Yang,F., Cossu,I.G., Guan,Y., Lin,H. and
            Wang,P.J.
  TITLE     TRIP13 localizes to synapsed chromosomes and functions as a
            dosage-sensitive regulator of meiosis
  JOURNAL   Elife 12, 92195 (2024)
   PUBMED   39207914
  REMARK    GeneRIF: TRIP13 localizes to the central region of the synaptonemal
            complex and telomeres in spermatocytes.
            GeneRIF: Global loss of TRIP13 leads to meiotic arrest and TRIP13
            is a dosage sensitive regulator of meiosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2240)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2240)
  AUTHORS   Afaq,F., Agarwal,S., Bajpai,P., Diffalha,S.A., Kim,H.G., Peter,S.,
            Khushman,M., Chauhan,S.C., Mukherjee,P., Varambally,S. and Manne,U.
  TITLE     Targeting of oncogenic AAA-ATPase TRIP13 reduces progression of
            pancreatic ductal adenocarcinoma
  JOURNAL   Neoplasia 47, 100951 (2024)
   PUBMED   38039923
  REMARK    GeneRIF: Targeting of oncogenic AAA-ATPase TRIP13 reduces
            progression of pancreatic ductal adenocarcinoma.
REFERENCE   4  (bases 1 to 2240)
  AUTHORS   Li,C., Xia,J., Franqui-Machin,R., Chen,F., He,Y., Ashby,T.C.,
            Teng,F., Xu,H., Liu,D., Gai,D., Johnson,S.K., van Rhee,F., Janz,S.,
            Shaughnessy,J.D. Jr., Tricot,G., Frech,I. and Zhan,F.
  TITLE     TRIP13 modulates protein deubiquitination and accelerates tumor
            development and progression of B cell malignancies
  JOURNAL   J Clin Invest 131 (14) (2021)
   PUBMED   34061780
  REMARK    GeneRIF: TRIP13 modulates protein deubiquitination and accelerates
            tumor development and progression of B cell malignancies.
REFERENCE   5  (bases 1 to 2240)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2240)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   7  (bases 1 to 2240)
  AUTHORS   Wojtasz,L., Daniel,K., Roig,I., Bolcun-Filas,E., Xu,H.,
            Boonsanay,V., Eckmann,C.R., Cooke,H.J., Jasin,M., Keeney,S.,
            McKay,M.J. and Toth,A.
  TITLE     Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal
            proteins, are depleted from synapsed chromosome axes with the help
            of TRIP13 AAA-ATPase
  JOURNAL   PLoS Genet 5 (10), e1000702 (2009)
   PUBMED   19851446
  REMARK    GeneRIF: HORMAD1 and HORMAD2 are depleted from synapsed chromosome
            axes with the help of TRIP13.
REFERENCE   8  (bases 1 to 2240)
  AUTHORS   Li,X.C. and Schimenti,J.C.
  TITLE     Mouse pachytene checkpoint 2 (trip13) is required for completing
            meiotic recombination but not synapsis
  JOURNAL   PLoS Genet 3 (8), e130 (2007)
   PUBMED   17696610
  REMARK    GeneRIF: results demonstrate that in mice, the primary meiotic
            function of TRIP13 is in recombination itself
            Erratum:[PLoS Genet. 2007 Sep 7;3(9):e168. Li, Xin [corrected to
            Li, Xin Chenglin]]
REFERENCE   9  (bases 1 to 2240)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2240)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT010471.11.
            
            On Mar 22, 2023 this sequence version replaced NM_027182.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064315.1, AK146877.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-247               CT010471.11        130816-131062
            248-413             CT010471.11        132280-132445
            414-543             CT010471.11        135565-135694
            544-599             CT010471.11        138337-138392
            600-690             CT010471.11        138803-138893
            691-763             CT010471.11        140569-140641
            764-827             CT010471.11        147316-147379
            828-914             CT010471.11        148118-148204
            915-1021            CT010471.11        148451-148557
            1022-1175           CT010471.11        149988-150141
            1176-1288           CT010471.11        152982-153094
            1289-1358           CT010471.11        153995-154064
            1359-2240           CT010471.11        155213-156094
FEATURES             Location/Qualifiers
     source          1..2240
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 40.15 cM"
     gene            1..2240
                     /gene="Trip13"
                     /gene_synonym="2410002G23Rik; D13Ertd328e"
                     /note="thyroid hormone receptor interactor 13"
                     /db_xref="GeneID:69716"
                     /db_xref="MGI:MGI:1916966"
     exon            1..247
                     /gene="Trip13"
                     /gene_synonym="2410002G23Rik; D13Ertd328e"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1454
                     /gene="Trip13"
                     /gene_synonym="2410002G23Rik; D13Ertd328e"
                     /note="isoform 1 is encoded by transcript variant 1;
                     pachytene checkpoint protein 2 homolog; thyroid
                     receptor-interacting protein 13; TRIP-13; TR-interacting
                     protein 13"
                     /codon_start=1
                     /product="pachytene checkpoint protein 2 homolog isoform
                     1"
                     /protein_id="NP_081458.1"
                     /db_xref="CCDS:CCDS26637.1"
                     /db_xref="GeneID:69716"
                     /db_xref="MGI:MGI:1916966"
                     /translation="MDEAVGDLKQALPCVAESPAVHVEVLQRSGSTAKKEDIKSSVYR
                     LLNRHNIVFGDYVWTEFDDPFLSRNVQSVSIVDTELKAKDPQPIDLSACTIALHIFQL
                     NEEGPSSENLDEETENIIAASHWVLPAAEFHGLWDSLVYDVEVKSHLLDYVMTTVLFS
                     DKNVDSNLITWNRVVLLHGPPGTGKTSLCKALAQKLTIRLSSRYRYGQLIEINSHSLF
                     SKWFSESGKLVTKMFQKIQDLIDDKEALVFVLIDEVESLTAARNACRAGAEPSDAIRV
                     VNAVLTQIDQIKRHSNVVILTTSNITEKIDVAFVDRADIKQYIGPPSAAAIFKIYLSC
                     LEELMKCQIIYPRQQLLTLRELEMIGFIENNVSKLSLLLSEISRKSEGLSGRVLRKLP
                     FLAHALYIQAPSVTIEGFLQALSLAVDKQFEEKKKLSAYV"
     exon            248..413
                     /gene="Trip13"
                     /gene_synonym="2410002G23Rik; D13Ertd328e"
                     /inference="alignment:Splign:2.1.0"
     exon            414..543
                     /gene="Trip13"
                     /gene_synonym="2410002G23Rik; D13Ertd328e"
                     /inference="alignment:Splign:2.1.0"
     exon            544..599
                     /gene="Trip13"
                     /gene_synonym="2410002G23Rik; D13Ertd328e"
                     /inference="alignment:Splign:2.1.0"
     exon            600..690
                     /gene="Trip13"
                     /gene_synonym="2410002G23Rik; D13Ertd328e"
                     /inference="alignment:Splign:2.1.0"
     exon            691..763
                     /gene="Trip13"
                     /gene_synonym="2410002G23Rik; D13Ertd328e"
                     /inference="alignment:Splign:2.1.0"
     exon            764..827
                     /gene="Trip13"
                     /gene_synonym="2410002G23Rik; D13Ertd328e"
                     /inference="alignment:Splign:2.1.0"
     exon            828..914
                     /gene="Trip13"
                     /gene_synonym="2410002G23Rik; D13Ertd328e"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1021
                     /gene="Trip13"
                     /gene_synonym="2410002G23Rik; D13Ertd328e"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1175
                     /gene="Trip13"
                     /gene_synonym="2410002G23Rik; D13Ertd328e"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1288
                     /gene="Trip13"
                     /gene_synonym="2410002G23Rik; D13Ertd328e"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1358
                     /gene="Trip13"
                     /gene_synonym="2410002G23Rik; D13Ertd328e"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..2240
                     /gene="Trip13"
                     /gene_synonym="2410002G23Rik; D13Ertd328e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2222..2227
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trip13"
                     /gene_synonym="2410002G23Rik; D13Ertd328e"
                     /note="hexamer: ATTAAA"
     polyA_site      2237
                     /gene="Trip13"
                     /gene_synonym="2410002G23Rik; D13Ertd328e"
     polyA_site      2240
                     /gene="Trip13"
                     /gene_synonym="2410002G23Rik; D13Ertd328e"
                     /note="major polyA site"
ORIGIN      
        1 gcaaagcgcc gagcggctcg ggcggcggaa gtggatttgg ccggccctta gccaaggtgg
       61 atcctcctac atcggagaag gctgtcgcac agggcgcagg gaggcgaccg cggcctcact
      121 ccggcggcat tccctcggct cccggcggcg gcgccatgga cgaggcggtg ggcgacctga
      181 agcaagcgct tccctgtgtt gccgaatcgc ccgcggtcca tgtggaggtt ctgcagcgca
      241 gcggaagcac tgcaaaaaaa gaagatataa agtcgagtgt ttacaggctg ctcaaccggc
      301 ataatattgt gtttggagat tacgtctgga ctgagtttga tgatcctttt ctaagcagaa
      361 atgttcagtc agtgtctatt gttgacacag aactaaaggc taaagaccct cagcccattg
      421 atctgagtgc atgcaccatt gcacttcaca tcttccagct gaatgaagaa ggccccagca
      481 gtgagaattt ggatgaagaa acagaaaata taattgcagc aagtcactgg gttctgcctg
      541 cagctgaatt tcatggactt tgggatagcc tcgtgtatga tgtggaggtc aaatcacatc
      601 tccttgatta tgtgatgacc accgtactct tctcagacaa gaacgtggac agcaacctca
      661 tcacctggaa ccgggtggtg ctgctgcacg gtcctccggg tactggaaaa acatcccttt
      721 gtaaggcatt agcccaaaaa ctgaccatca gactgtcgag caggtaccgg tatggccagt
      781 tgattgaaat aaacagccac agcctatttt ctaagtggtt ttcagaaagt ggcaaattgg
      841 taactaagat gttccagaag attcaggact tgattgatga taaggaagct ttggtgtttg
      901 ttctgattga tgaggtggag agtctcacag ctgctcgaaa tgcttgcagg gcaggcgcag
      961 agccatcaga tgctatccga gtagtcaatg ctgtgttgac tcagattgac cagattaaaa
     1021 ggcattccaa tgtggtgatt ctgaccactt ccaacatcac tgagaagatt gatgtggctt
     1081 tcgtggatag agctgacatc aagcaataca ttggcccccc ctctgcagca gccatcttca
     1141 aaatctacct gtcttgttta gaagaactga tgaagtgcca gatcatatat cctcgtcagc
     1201 agctgttgac ccttcgggag ctggaaatga ttggcttcat tgaaaataat gtgtcaaagt
     1261 tgagcctcct tttgagtgaa atttcaagga agagtgaggg cctcagtggc cgggtcttga
     1321 ggaaacttcc tttcctggct catgctctct acatccaggc ccccagcgtc accatcgagg
     1381 gtttcctcca ggccctatct ctggcagtgg acaaacagtt tgaggagaaa aagaaacttt
     1441 cagcttatgt ttgatcccag acatccatat ctatggcttt caatggacaa gtaggaggtg
     1501 ataccgtcta cctcacagtg tgcatcagaa atgactctaa gccatgtaga tctgcaggcc
     1561 agacagatgg gtgtacaatc tttgtcaaaa ggactatgtg ttattttaca gtgcatatct
     1621 aaaggcaaaa aagactgctt gtctttttca ctgtttttaa aagataattc cagtctgttt
     1681 gcatctatgt aaagccccat cctgactcaa gcctgtcaga cacaagatgt tagaatttgt
     1741 ttaaaataaa gggagatcaa aacagctgtc atagaacaag ggggatgcta actaatgcag
     1801 ttacagcatt gaaagatgga ttctttgctc aggctagaag ggagcagttg ctttctggct
     1861 tgagtcggct ttggttagca caggatgcta tgtgatgggt gagaaagacg tgttgctgtg
     1921 atacggaaac tgagagggga ctgcaggtaa gaagatgaag agttctttgg tagtgcacag
     1981 gagcagtgtg tgctttctat ggtcacgtca atcaggcaat gtgttttgtt tctccagtca
     2041 ttttacttgt atttcaagtg aaaattcttg ttacgaaata taaaataagt caatatgtgt
     2101 tgcacctcac agaatatcat gttttatgtc atcttctgcc aaacgtagtt tggcactaat
     2161 actttataca tgaatacact tttaaatgga atgctgcctt tgtcacagaa cgttttgtaa
     2221 tattaaactt gttttcagaa
//
