LOCUS       NM_133975               9632 bp    mRNA    linear   ROD 31-JUL-2024
DEFINITION  Mus musculus thyroid hormone receptor interactor 12 (Trip12), mRNA.
ACCESSION   NM_133975 XM_619648
VERSION     NM_133975.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9632)
  AUTHORS   Brunet,M., Vargas,C., Fanjul,M., Varry,D., Hanoun,N., Larrieu,D.,
            Pieruccioni,L., Labrousse,G., Lulka,H., Capilla,F., Ricard,A.,
            Selves,J., Couvelard,A., Gigoux,V., Cordelier,P.,
            Guillermet-Guibert,J., Dufresne,M. and Torrisani,J.
  TITLE     The E3 ubiquitin ligase TRIP12 is required for pancreatic acinar
            cell plasticity and pancreatic carcinogenesis
  JOURNAL   J Pathol 263 (4-5), 466-481 (2024)
   PUBMED   38924548
REFERENCE   2  (bases 1 to 9632)
  AUTHORS   Keyan,K.S., Salim,S., Gowda,S., Abdelrahman,D., Amir,S.S.,
            Islam,Z., Vargas,C., Bengoechea-Alonso,M.T., Alwa,A., Dahal,S.,
            Kolatkar,P.R., Da'as,S., Torrisani,J., Ericsson,J., Mohammad,F. and
            Khan,O.M.
  TITLE     Control of TGFbeta signalling by ubiquitination independent
            function of E3 ubiquitin ligase TRIP12
  JOURNAL   Cell Death Dis 14 (10), 692 (2023)
   PUBMED   37863914
  REMARK    GeneRIF: Control of TGFbeta signalling by ubiquitination
            independent function of E3 ubiquitin ligase TRIP12.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9632)
  AUTHORS   Tang,Y., Wang,D., Niu,X., Wu,H., Yang,J., Zhang,Y., Song,S., Lv,D.,
            Chai,Y., Lu,H., Shen,H., Ling,C. and Li,M.
  TITLE     Mild iron overload induces TRIP12-mediated degradation of YY1 to
            trigger hepatic inflammation
  JOURNAL   Free Radic Biol Med 161, 187-197 (2020)
   PUBMED   33080340
  REMARK    GeneRIF: Mild iron overload induces TRIP12-mediated degradation of
            YY1 to trigger hepatic inflammation.
REFERENCE   4  (bases 1 to 9632)
  AUTHORS   Chen,D., Kon,N., Zhong,J., Zhang,P., Yu,L. and Gu,W.
  TITLE     Differential effects on ARF stability by normal versus oncogenic
            levels of c-Myc expression
  JOURNAL   Mol Cell 51 (1), 46-56 (2013)
   PUBMED   23747016
REFERENCE   5  (bases 1 to 9632)
  AUTHORS   Chio,I.I., Sasaki,M., Ghazarian,D., Moreno,J., Done,S., Ueda,T.,
            Inoue,S., Chang,Y.L., Chen,N.J. and Mak,T.W.
  TITLE     TRADD contributes to tumour suppression by regulating ULF-dependent
            p19Arf ubiquitylation
  JOURNAL   Nat Cell Biol 14 (6), 625-633 (2012)
   PUBMED   22561347
  REMARK    GeneRIF: data indicate that TRADD shuttles dynamically from the
            cytoplasm into the nucleus to modulate the interaction between
            p19(Arf) and its E3 ubiquitin ligase ULF, thereby promoting
            p19(Arf) protein stability and tumour suppression
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9632)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 9632)
  AUTHORS   Jensen,P., Magdaleno,S., Lehman,K.M., Rice,D.S., Lavallie,E.R.,
            Collins-Racie,L., McCoy,J.M. and Curran,T.
  TITLE     A neurogenomics approach to gene expression analysis in the
            developing brain
  JOURNAL   Brain Res Mol Brain Res 132 (2), 116-127 (2004)
   PUBMED   15582152
REFERENCE   8  (bases 1 to 9632)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 9632)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 9632)
  AUTHORS   Tate,P., Lee,M., Tweedie,S., Skarnes,W.C. and Bickmore,W.A.
  TITLE     Capturing novel mouse genes encoding chromosomal and other nuclear
            proteins
  JOURNAL   J Cell Sci 111 (Pt 17), 2575-2585 (1998)
   PUBMED   9701556
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK158807.1, AW543112.1, CF747879.1, CN536706.1, CA319321.1,
            DV647354.1, BG695625.1 and AC123882.6.
            
            On Apr 12, 2006 this sequence version replaced NM_133975.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223971.542.1, SRR10223969.516.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3073              AK158807.1         1-3073
            3074-3481           AW543112.1         3-410               c
            3482-3980           CF747879.1         192-690
            3981-4478           CN536706.1         178-675
            4479-4936           CA319321.1         165-622
            4937-5402           DV647354.1         240-705
            5403-6018           BG695625.1         50-665
            6019-9632           AC123882.6         54911-58524         c
FEATURES             Location/Qualifiers
     source          1..9632
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 43.42 cM"
     gene            1..9632
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /note="thyroid hormone receptor interactor 12"
                     /db_xref="GeneID:14897"
                     /db_xref="MGI:MGI:1309481"
     exon            1..76
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            77..223
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..6203
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /EC_number="2.3.2.26"
                     /note="gene trap locus 6; thyroid receptor interactor
                     TRIP12; TR-interacting protein 12; thyroid
                     receptor-interacting protein 12; HECT-type E3 ubiquitin
                     transferase TRIP12"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIP12"
                     /protein_id="NP_598736.4"
                     /db_xref="CCDS:CCDS35633.1"
                     /db_xref="GeneID:14897"
                     /db_xref="MGI:MGI:1309481"
                     /translation="MSNRPNNNPGGSLRRSQRNTAGAQPQDDSIGGRSCSSSSAVIVP
                     QPEDPDRANTSERQKTGQVPKKDNSRGVKRSASPDYNRTNSPSSAKKPRAFQHIESFS
                     ETNKPHSKSKKRHLDQEQQLKSAQLPSTSKAHTRKSVAAGSSRNQKRKRTESSCVKSG
                     SGSESTGAEERSAKPIKLASKSATSAKAGCSTITDSSSAASTSSSSSAIASASSTVPA
                     GARVKQGKDQNKARRSRSASSPSPRRSSREKEQSKTGGSSKFDWAARFSPKVSLPKTK
                     LSLPGSSKSETSKPGPSGLQAKLASLRKSTKKRSESPPAELPSLRRSTRQKTTGSCAS
                     TSRRGSGLGKRGAAEARRQEKMADPESNQETVNSSAARTDEAPQGAAASSSVAGAVGM
                     TTSGESESDDSEMGRLQALLEARGLPPHLFGPLGPRMSQLFHRTIGSGASSKAQQLLQ
                     GLQASDESQQLQAVIEMCQLLVMGNEETLGGFPVKSVVPALITLLQMEHNFDIMNHAC
                     RALTYMMEALPRSSAVVVDAIPVFLEKLQVIQCIDVAEQALTALEMLSRRHSKAILQA
                     GGLADCLLYLEFFSINAQRNALAIAANCCQSITPDEFHFVADSLPLLTQRLTHQDKKS
                     VESTCLCFARLVDNFQHEENLLQQVASKDLLTNVQQLLVVTPPILSSGMFIMVVRMFS
                     LMCSNCPTLAVQLMKQNIAETLHFLLCGASNGSCQEQIDLVPRSPQELYELTSLICEL
                     MPCLPKEGIFAVDTMLKKGNAQNTDGAIWQWRDDRGLWHPYNRIDSRIIEAAHQVGED
                     EISLSTLGRVYTIDFNSMQQINEDTGTARAIQRKPNPLANSNTSGYSELKKDDARAQL
                     MKEDPELAKSFIKTLFGVLYEVYSSSAGPAVRHKCLRAILRIIYFADAELLKDVLKNH
                     AVSSHIASMLSSQDLKIVVGALQMAEILMQKLPDIFSVYFRREGVMHQVKHLAESESL
                     LTSPPKACTNGSGSLGSTTPASSGTATAATNASADLGSPSLQHSRDDSLDLSPQGRLS
                     DVLKRKRLPKRGPRRPKYSPPRDDDKVDNQAKSPTTTQSPKSSFLASLNPKTWGRLSA
                     QSNSNNIEPARTAGVSGLARAASKDTISNNREKIKGWIKEQAHKFVERYFSSENMDGS
                     NPALNVLQRLCAATEQLNLQVDGGAECLVEIRSIVSESDVSSFEIQHSGFVKQLLLYL
                     TSKNEKDAVGREIRLKRFLHVFFSSPLPGEEPVGRVEPVGHAPLLALVHKMNNCLSQM
                     EQFPVKVHDFPSGNGAGGSFSLNRGSQALKFFNTHQLKCQLQRHPDCANVKQWKGGPV
                     KIDPLALVQAIERYLVVRGYGRVREDDEDSDDDGSDEEIDESLAAQFLNSGNVRHRLQ
                     FYIGEHLLPYNMTVYQAVRQFSVQAEDERESTDDESNPLGRAGIWTKTHTIWYKPVRE
                     DEESTKDCVGGKRGRAQTAPTKTSPRNAKKHDELWHDGVCPSVANPLEVYLIPTPPEN
                     ITFEDPSLDVILLLRVLHAISRYWYYLYDNAMCKEIIPTSEFINSKLTAKANRQLQDP
                     LVIMTGNIPTWLTELGKTCPFFFPFDTRQMLFYVTAFDRDRAMQRLLDTNPEINQSDS
                     QDSRVAPRLDRKKRTVNREELLKQAESVMQDLGSSRAMLEIQYENEVGTGLGPTLEFY
                     ALVSQELQRADLCLWRGEEVTLSNPKGSQEGTKYIQNLQGLFALPFGRTAKPAHIAKV
                     KMKFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFDIDPVVARSVYH
                     LEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLGLDFTLPGFPNIELKKGGK
                     DIPVTIHNLEEYLRLVIFWALNEGVCRQFDSFRDGFESVFPLCHLQYFYPEELDQLLC
                     GSKADTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLP
                     VGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPDYSSIDIMRDKLLIAAR
                     EGQQSFHLS"
     exon            224..1026
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1132
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1269
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1353
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1449
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1598
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1634
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1730
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1823
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..1985
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2054
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2220
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..2338
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2339..2495
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2496..2649
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2650..2878
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2879..2997
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2998..3205
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            3206..3306
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            3307..3481
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            3482..3623
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            3624..3815
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            3816..3967
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            3968..4140
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            4141..4214
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            4215..4414
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            4415..4542
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            4543..4694
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            4695..4837
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            4838..4994
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            4995..5093
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            5094..5208
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            5209..5363
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            5364..5528
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            5529..5693
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            5694..5807
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            5808..5902
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            5903..6006
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            6007..9632
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6494..6499
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /note="hexamer: AATAAA"
     polyA_site      6517
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /note="major polyA site"
     regulatory      7336..7341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /note="hexamer: AATAAA"
     polyA_site      7358
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
     regulatory      8038..8043
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /note="hexamer: ATTAAA"
     polyA_site      8064
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
     regulatory      9606..9611
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
                     /note="hexamer: AATAAA"
     polyA_site      9625
                     /gene="Trip12"
                     /gene_synonym="1110036I07Rik; 6720416K24Rik; Gtl6;
                     TRIP-12"
ORIGIN      
        1 ggggggggtg gggggagcca gtggaagttg ccgtcgcgcc acggagtccg gaccggagac
       61 tttggggcct aactagtgaa tggtagtgtc tagaaagggt atgtcccttc aagagagagg
      121 tgccaatgtc caaccggcct aataacaatc caggggggtc actgcgacgt tcacagagga
      181 acactgccgg ggcccaacca caagacgact caataggagg aagaagctgc agttcatcat
      241 ctgctgtcat agttccacaa ccagaggatc cagacagagc caatacttca gaaaggcaga
      301 aaacggggca ggtgcctaaa aaagacaatt ctcgaggagt gaaacgcagt gctagtccag
      361 actacaacag gaccaattct cctagctctg cgaaaaagcc cagagcattt cagcatattg
      421 agtctttctc agaaaccaat aagccacata gtaagtcaaa gaagagacat ttagaccagg
      481 agcaacaact gaaatctgca caattgccgt caacaagcaa ggctcacacc agaaagagtg
      541 tggctgctgg tagttcacgg aatcagaaaa gaaagaggac agagagttct tgtgttaaaa
      601 gtggttctgg gtccgaatca actggtgccg aagagagatc tgcaaaaccc atcaagctgg
      661 cttcaaaatc agccacctca gccaaagctg ggtgtagcac catcaccgat tcttcttctg
      721 ctgcctctac ttcctcatca tcttcagcta tagcctcggc ctcttctact gtaccagcag
      781 gtgccagggt gaaacaagga aaagaccaga acaaggccag gcgttcccgt tcagcatcca
      841 gccctagtcc cagaagaagt agcagggaaa aggaacagag taaaactggt ggctcttcaa
      901 aatttgattg ggctgctcgc ttcagcccca aagttagcct acctaaaaca aaactgtctc
      961 ttccagggtc ttctaagtca gagacatcaa aacctggacc ttctggatta caggccaaat
     1021 tagcaagttt aagaaagtcc accaagaaac gcagtgagtc cccacctgct gagctcccca
     1081 gtttgaggag gagcacacgc caaaagacca cgggctcctg tgctagtacc agtcggcgag
     1141 gctctggcct gggcaagaga ggagcagctg aggcccggcg gcaagagaaa atggcagacc
     1201 ctgaaagcaa ccaggagaca gtaaattcct cagctgcccg gacagatgaa gctccccaag
     1261 gagctgcagc ctctagttct gttgcagggg ctgttggcat gaccacctct ggggagagtg
     1321 aatcggatga ttctgagatg ggacgattac aagctctgtt agaggccagg ggtcttcctc
     1381 ctcacctatt tggtcctctc gggcctcgga tgtcacaact tttccataga acaattggaa
     1441 gcggagctag ttctaaggcc cagcagcttc ttcaaggact acaagccagt gatgaaagtc
     1501 aacagcttca ggccgtcatt gaaatgtgtc agttattggt catggggaat gaggagacac
     1561 taggagggtt tcctgtgaag agtgttgttc cagctttgat aacattactg cagatggaac
     1621 ataattttga cattatgaat catgcttgcc gagccttaac atatatgatg gaagctctcc
     1681 cccggtcatc tgctgttgta gtggatgcta tccctgtttt cttagaaaag ttgcaagtta
     1741 ttcagtgtat tgatgtggca gagcaggcct tgactgcctt ggagatgttg tcacggcgac
     1801 acagtaaagc cattttacaa gcgggtggtt tggcagattg cttgttgtat ctagaattct
     1861 tcagcatcaa tgcccaaaga aatgcactag caattgcagc caattgctgc cagagtatca
     1921 caccagatga gtttcatttt gtggcagatt ccctaccatt gcttacccaa aggctaactc
     1981 atcaggacaa aaagtcagta gaaagtactt gcctttgttt tgcacgttta gtggacaact
     2041 ttcaacatga ggagaactta ctgcaacagg ttgcttccaa agatctactt acaaatgttc
     2101 aacaattgtt ggtagtgact ccaccgattt taagttctgg gatgtttatt atggtggttc
     2161 gcatgttttc tctgatgtgt tccaactgtc caacattagc tgttcaactt atgaaacaaa
     2221 acattgcaga aacacttcac ttcctgctat gtggtgcctc caatggaagt tgtcaagagc
     2281 agattgacct tgttccacga agtcctcaag agctgtatga gctgacatct ttgatttgtg
     2341 aacttatgcc atgtttacca aaagaaggca tcttcgcagt tgataccatg ttgaaaaagg
     2401 gaaatgcaca gaacacagat ggtgcaatat ggcagtggcg ggatgaccga ggcctctggc
     2461 atccctataa caggattgac agccggatca ttgaggcagc ccatcaggtc ggtgaggatg
     2521 agataagctt gtccactctg ggacgagttt atactattga ttttaattct atgcagcaaa
     2581 tcaatgaaga cacgggaaca gcacgtgcca ttcagagaaa acctaatccc ttagccaatt
     2641 ctaacactag tggatattca gagttaaaga aggatgatgc tcgagcacag ctaatgaaag
     2701 aagatccgga actggctaag tctttcatta agaccttgtt tggtgttctc tatgaagtgt
     2761 acagctcctc agcaggccct gcggtcagac acaagtgcct tagagcaatt cttaggataa
     2821 tttattttgc tgatgctgaa cttctgaagg atgttctgaa aaatcatgct gtttcaagtc
     2881 acattgcttc aatgctatcc agccaagacc tgaagatagt agttggagct cttcagatgg
     2941 cagaaatcct aatgcaaaag ttacctgata tttttagtgt ttacttcagg agagaaggtg
     3001 tgatgcatca agtcaaacat ttagcagaat cagagtcttt gttgacaagt ccccccaagg
     3061 catgtacaaa tgggtcagga tccctgggat ctacaacacc agccagcagt gggactgcaa
     3121 cggcagcaac caacgcctct gctgatctgg ggtcacctag cttgcagcat agcagagatg
     3181 attctttgga tctgagccct caaggtcgat taagtgatgt tctcaagaga aaacgactgc
     3241 caaaacgagg gccaagaagg ccaaaatatt cccctccaag agatgatgac aaagtagaca
     3301 atcaagctaa aagccccacc actactcagt cacctaaatc ttccttcctg gcaagcttga
     3361 atccaaaaac atggggaagg ttaagcgcac agtccaacag caacaatatc gaaccagcac
     3421 gaactgcagg agttagtggt cttgccaggg cagcctcaaa agacaccata tccaataata
     3481 gagaaaaaat taaaggctgg attaaggagc aggcacataa atttgttgag cgttatttta
     3541 gttctgagaa tatggatgga agcaaccctg ccttgaatgt ccttcagaga ctttgtgctg
     3601 caactgaaca actcaacctc caggtggatg gtggagctga gtgccttgta gaaatccgta
     3661 gcatagtctc agagtcagat gtttcttcat ttgaaatcca acatagtggg tttgtgaaac
     3721 aactgttgct gtatttgaca tctaagaatg aaaaggatgc tgtcggcaga gagatccggt
     3781 taaaacgttt ccttcatgta tttttttctt ctccacttcc tggagaagag cctgttggaa
     3841 gagtagaacc agtgggccat gcacctttgc tggcattggt tcacaagatg aacaactgtc
     3901 tcagccaaat ggagcaattt ccagtcaaag tacatgattt ccctagtggg aacggagctg
     3961 gaggaagctt ttctctcaac agaggatcac aagctttaaa atttttcaac acacatcagt
     4021 taaaatgtca gttacaaaga cacccagact gtgcaaatgt gaagcagtgg aaaggcgggc
     4081 ctgtcaagat tgatcccctg gctctggtgc aagctattga gagatacctt gtggttagag
     4141 gatatggaag agtaagagaa gatgatgaag atagtgatga tgatgggtca gatgaagaaa
     4201 tagatgagtc tttggctgct caattcttaa attcgggaaa tgtaaggcac aggctacagt
     4261 tttatattgg agaacattta ctaccatata acatgaccgt gtatcaggca gtgcggcaat
     4321 tcagtgtaca ggctgaagat gaaagagaat ctactgatga tgagagcaat cctctgggaa
     4381 gagctggaat ttggacaaag actcatacaa tatggtacaa acctgtgagg gaggatgaag
     4441 aaagtactaa agattgtgtt ggtggcaaaa gggggagagc ccaaacagct ccaacaaaaa
     4501 cttcccccag aaatgcaaag aagcatgatg agttatggca tgatggagtg tgcccgtcag
     4561 tagcaaatcc tttagaagtt tacctcattc ccacaccacc tgaaaatatc acctttgaag
     4621 acccatcctt agatgtaata cttcttttaa gagttttaca tgccatcagt cgatattggt
     4681 attacttgta tgataatgcg atgtgcaagg agattattcc aactagtgaa tttattaaca
     4741 gtaaattaac agcaaaagca aataggcagc ttcaagaccc tctagtaatc atgacaggaa
     4801 acatcccaac atggctcact gagctaggaa aaacctgccc atttttcttt ccttttgata
     4861 cccgacaaat gcttttttat gtaactgcat ttgatcggga ccgggcaatg caaagattac
     4921 ttgataccaa cccagaaatc aaccagtctg attctcaaga cagcagagtt gcgcctagat
     4981 tggatagaaa aaaacgtact gtgaacagag aggagctact gaaacaagct gagtctgtga
     5041 tgcaggacct tggcagctct cgggccatgt tagaaatcca atatgaaaat gaggttggta
     5101 caggtctggg gccaacactg gagttttatg cacttgtttc tcaggaacta cagagagctg
     5161 acttgtgtct ctggaggggt gaagaagtaa ctcttagcaa tccaaaagga agccaagaag
     5221 ggaccaagta tattcaaaac ctccagggcc tgtttgcgct tccctttggt aggacagcta
     5281 agccagctca catcgcaaag gttaagatga agtttcgctt cttaggaaaa ttaatggcta
     5341 aggctatcat ggatttcaga ttggtggacc ttcctcttgg cctgcccttt tataagtgga
     5401 tgctgcggca ggaaacttca ttgacatctc atgatttatt tgacattgat cctgttgtag
     5461 ccagatcagt atatcaccta gaagacattg tcagacagaa gaaaagactg gagcaggata
     5521 aatcccagac caaagagagt ctacaatatg cattggaaac tcttacgatg aatggctgtt
     5581 cagtggaaga tctgggattg gattttacgc tgcctgggtt tcccaacatt gaattgaaga
     5641 aaggagggaa ggatattcca gttactatcc acaatttgga agagtacctg agattggtga
     5701 tattctgggc actaaatgaa ggtgtttgtc gacagtttga ctcattcaga gatggatttg
     5761 aatcggtctt cccgctctgc catcttcagt acttctaccc agaagagctg gaccagctcc
     5821 tgtgtggcag taaagcagac acttgggatg caaagacatt gatggaatgc tgcaggcctg
     5881 atcatggcta tactcatgac agtcgggctg tgaagttctt gtttgagatt ctcagtagtt
     5941 ttgataatga gcagcagagg ttgtttctcc agtttgtgac tggtagccca cgattgccag
     6001 ttggaggatt tcggagttta aatccacctc tgacaattgt gcggaagaca tttgaatcaa
     6061 cagaaaaccc agatgacttc ttaccatcag taatgacttg tgtgaactat cttaaattgc
     6121 cggactactc gagcattgac ataatgcggg acaaactctt gatagcagca agagaaggcc
     6181 aacagtcgtt ccatctttcc tgatcacaac aagaaatcag tgtctgcctg ttacagcaaa
     6241 agaaaaaaat catgatttct tttctgtgtc acctgagtca aggaaacatg ttcctccctc
     6301 ttgttgtagg aaaacggctt gcagattata attcgtaatg gccctgtgga cttaagtgat
     6361 caggccctaa agcattgttg tgatgaggtt tctttagcaa gttcttgttt aaattatcat
     6421 ttatttgatg agtgaagttt ttaacttgct ttgctgtgtg aaatttcaaa gggatgtttt
     6481 ttcaggctgg aacaataaat gtcgctgtgc agtttaattc tgggctgtgt gtatccatct
     6541 agctaagtct gcagtttgtt tcttccaaag acaactcttg tacataagta cagacattaa
     6601 attcatgtgt atttgacaac tctagtatag taaatgggtt ctgcgtgcct tccacctaat
     6661 tttcttttcc gagttcattg ctgcctctgc agttcataca ggtttggtgt ttggtttttg
     6721 tttgtttgtt ttacttttta aatacaacac gtacagtttc attagcccca ggccttgtca
     6781 tcctgtgttc attcaaattg agatacaatc taaaattcat tgaattgaaa tatactctca
     6841 atataataca gcctttgtat ctaggcaggt aggctttact tatagtttag tttaaaatag
     6901 ttacagagca cgcttggctt cttgccaggt gatacactag gtctgtttac atggtatttc
     6961 ccttgtcctc tggaaaggag gaaggaaagc tcactcattt ttctgtatag gttaaaaggt
     7021 ccacagtgtg ggctgcccag tatttattct atggccaaac cattttgaat tggtgtaaag
     7081 ttttaaatga attaggtccg cccccccacc cccttattgg agttacaaaa gatatttccc
     7141 ccactccttt gttcctgttt gtttctgttc tcagtcttta tttcattctc gtcttctccc
     7201 agcgtgaatt gcagacaagc tgttcagccc ttgtctacac atagatcaaa gcacctgtaa
     7261 gcaatgctgt ccatttgttt gtgtgctcat ttctcagatc tgcaataatc catcaggtta
     7321 atgtttttac ctaaaaataa aacagatttg cttcaccatt tttgtttata gttctgtgct
     7381 gtcacacaca cacacacaca cacctgtctt aatcacttac agtacaagta agtcgtcctg
     7441 tggtcagaag tcaagcaagg tcttgctgct gtttacagct tcttgaagaa cattaaatgt
     7501 ggaaaggaag tggaagcaga gctttcttcc tgaggctcaa atgaagacta ataaatttga
     7561 actctgactt catctccttc aatatgagat gcattattta aaaacaaaca aacaaacaaa
     7621 cctgaacttt gaagaaacta attgtactga catagagctg ccttctttat tccatcaccc
     7681 aaaaggaagg tagtgggtta gtttactcct gtaactgtca ttctacactg accttgcctt
     7741 atgtggaaac atcccttgct gacagaaatc tcttgacagt ttgcccagtc agtggggagg
     7801 agttggggcc aggaagtctc tgctcacaga ggcttgcaaa tgagcagtgt tatctggagg
     7861 gagttgggtt ctgcagcttc accttgatgg ctatgggatc tgggcccctt tgtctcctgt
     7921 tctcctgttt tacaaactga gcacaaagat ttttgtgtga aaatagcatt gtttcacctc
     7981 actttttaaa gatctgttaa aatgtagaca tctgtataaa acaaagtgat gtttcatatt
     8041 aaaataatat gtatttgcat tttacacctg tggtgctgac agatttgact tcattgattc
     8101 cttgtatcca atggttgtta tggttctgac tggaatattt cagagtccac ggtcatcagc
     8161 ttttgatcat caactaagtt tgctcaatac ctgggacctg tggttaattc ggggtcagga
     8221 agagcacact ttaagcactc tctgagcaga ggccttattg cacactaggg gtgtgtacac
     8281 ttggtttgct gtgttccagt ggtttgattc agggacctac caacaggcat ggttggtatg
     8341 ctttcaacac tcagttactc cagttgtcag gatgttaaca gaacctcttc ctggtcccag
     8401 aagagtaagt tacattctag gtctaggtgg ctgtggatgt ctcggctcag ttcagcaaaa
     8461 gcatttttca tatagccacc aacaatagga aagcagtaag gagttttgtg tctggttgtg
     8521 aaactgagca cacctcttga gtcatgtagc caacgggtgc cttctgcttc tagagtgact
     8581 tccttgggca tcttatgtat gaagggcaag gaccgagcac cagcttctgc atctcacaga
     8641 cagattgtct ccatcccttc ccctgcctag caggggccct ccatgccttt atcctccccc
     8701 tcctgccccg acactgtgca gccacaccta tatttgtgtg tgtggggggg gtggttgttt
     8761 gttttttgtt ttttcaaatg tggctggtga tgacccaata tgtcctcatg cttgtggctc
     8821 aagcatcaac cccactaagc catcttccca gccatcactt gggcagattt gagtttgtgg
     8881 tgttttctca agtttattgt gtcttgagat tcctttttca tttcttatca attagtacaa
     8941 ggttaggaaa taggaaggtt ggcattcttc caaaaacgat tgccaagaac aatttgttgg
     9001 aaggaaatac atcaaagtgc attgatatgc ctaccctttc ctttgcattc tgggtgttct
     9061 actaatagaa atgccttcca tttcttgtat gctttggttt tctgaccaat tttgttttct
     9121 ccattgtaat gagaatattg tctgatctgt tttgctttgt ttgattcttt tgaaaggtgt
     9181 tacatagggg ttaggtttga tgctgcagta gatccacaat aaagagtgac ctagtaacag
     9241 gccactggaa agtcgcggtt acccagacaa gtagtagctc tggcacaact cagctttcac
     9301 tgggtcaaaa agctggcata tgctaagaag ttcaaatgaa cagttattaa tgcaaagaag
     9361 acatttctta atgcttacag acttgttctg tatcaaggag acattcttca gtaatggaag
     9421 agggagtttt attttttaat acaagtggac tcatgaccaa actgataagc agctggtctc
     9481 tataaaatgt tttctttctc ttttgatctg aaacatttat ataaactgct ggaataatgg
     9541 aacttcagac taccaagtgt gtatgtaaaa ttgcatcgat gccctgactt cctgactata
     9601 tttttaataa acagcattat ccttcgtggt ta
//
