LOCUS       NM_028446               6448 bp    mRNA    linear   ROD 06-AUG-2023
DEFINITION  Mus musculus thyroid hormone receptor interactor 11 (Trip11), mRNA.
ACCESSION   NM_028446 XM_001001171 XM_912718
VERSION     NM_028446.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6448)
  AUTHORS   Yamaguchi H, Meyer MD, He L and Komatsu Y.
  TITLE     Disruption of Trip11 in cranial neural crest cells is associated
            with increased ER and Golgi stress contributing to skull defects in
            mice
  JOURNAL   Dev Dyn 251 (7), 1209-1222 (2022)
   PUBMED   35147267
  REMARK    GeneRIF: Disruption of Trip11 in cranial neural crest cells is
            associated with increased ER and Golgi stress contributing to skull
            defects in mice.
REFERENCE   2  (bases 1 to 6448)
  AUTHORS   Yamaguchi H, Meyer MD, He L, Senavirathna L, Pan S and Komatsu Y.
  TITLE     The molecular complex of ciliary and golgin protein is crucial for
            skull development
  JOURNAL   Development 148 (13) (2021)
   PUBMED   34128978
REFERENCE   3  (bases 1 to 6448)
  AUTHORS   Wang Z, Shi Y, Ma S, Huang Q, Yap YT, Shi L, Zhang S, Zhou T, Li W,
            Hu B, Zhang L, Krawetz SA, Pazour GJ, Hess RA and Zhang Z.
  TITLE     Abnormal fertility, acrosome formation, IFT20 expression and
            localization in conditional Gmap210 knockout mice
  JOURNAL   Am J Physiol Cell Physiol 318 (1), C174-C190 (2020)
   PUBMED   31577511
  REMARK    GeneRIF: GMAP210 is essential for acrosome biogenesis, normal
            mitochondrial sheath formation, and male fertility, and it
            determines expression levels and acrosomal localization of IFT20
            and other acrosomal proteins.
REFERENCE   4  (bases 1 to 6448)
  AUTHORS   Bird IM, Kim SH, Schweppe DK, Caetano-Lopes J, Robling AG, Charles
            JF, Gygi SP, Warman ML and Smits PJ.
  TITLE     The skeletal phenotype of achondrogenesis type 1A is caused
            exclusively by cartilage defects
  JOURNAL   Development 145 (1) (2018)
   PUBMED   29180569
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6448)
  AUTHORS   Monis WJ, Faundez V and Pazour GJ.
  TITLE     BLOC-1 is required for selective membrane protein trafficking from
            endosomes to primary cilia
  JOURNAL   J Cell Biol 216 (7), 2131-2150 (2017)
   PUBMED   28576874
REFERENCE   6  (bases 1 to 6448)
  AUTHORS   Keady BT, Le YZ and Pazour GJ.
  TITLE     IFT20 is required for opsin trafficking and photoreceptor outer
            segment development
  JOURNAL   Mol Biol Cell 22 (7), 921-930 (2011)
   PUBMED   21307337
REFERENCE   7  (bases 1 to 6448)
  AUTHORS   Dwyer ND, Manning DK, Moran JL, Mudbhary R, Fleming MS, Favero CB,
            Vock VM, O'Leary DD, Walsh CA and Beier DR.
  TITLE     A forward genetic screen with a thalamocortical axon reporter mouse
            yields novel neurodevelopment mutants and a distinct emx2 mutant
            phenotype
  JOURNAL   Neural Dev 6, 3 (2011)
   PUBMED   21214893
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 6448)
  AUTHORS   Smits P, Bolton AD, Funari V, Hong M, Boyden ED, Lu L, Manning DK,
            Dwyer ND, Moran JL, Prysak M, Merriman B, Nelson SF, Bonafe L,
            Superti-Furga A, Ikegawa S, Krakow D, Cohn DH, Kirchhausen T,
            Warman ML and Beier DR.
  TITLE     Lethal skeletal dysplasia in mice and humans lacking the golgin
            GMAP-210
  JOURNAL   N Engl J Med 362 (3), 206-216 (2010)
   PUBMED   20089971
  REMARK    GeneRIF: mice with lethal skeletal dysplasia had a nonsense
            mutation in the thyroid hormone receptor interactor 11 gene
            (Trip11), which encodes the Golgi microtubule-associated protein
            210 (GMAP-210)
REFERENCE   9  (bases 1 to 6448)
  AUTHORS   Follit JA, San Agustin JT, Xu F, Jonassen JA, Samtani R, Lo CW and
            Pazour GJ.
  TITLE     The Golgin GMAP210/TRIP11 anchors IFT20 to the Golgi complex
  JOURNAL   PLoS Genet 4 (12), e1000315 (2008)
   PUBMED   19112494
  REMARK    GeneRIF: GMAP210 and IFT20 function together at the Golgi in the
            sorting of proteins destined for the ciliary membrane.
REFERENCE   10 (bases 1 to 6448)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121965.3.
            
            On or before Apr 14, 2009 this sequence version replaced
            XM_912718.3, XM_001001171.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158098.1, SRR10223971.13005.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-482               AC121965.3         79037-79518
            483-544             AC121965.3         86392-86453
            545-655             AC121965.3         89866-89976
            656-934             AC121965.3         93105-93383
            935-1000            AC121965.3         96492-96557
            1001-1166           AC121965.3         97781-97946
            1167-1529           AC121965.3         98415-98777
            1530-1570           AC121965.3         101590-101630
            1571-1657           AC121965.3         102417-102503
            1658-1870           AC121965.3         105188-105400
            1871-4891           AC121965.3         105932-108952
            4892-5032           AC121965.3         113279-113419
            5033-5226           AC121965.3         114060-114253
            5227-5390           AC121965.3         118722-118885
            5391-5494           AC121965.3         120281-120384
            5495-5594           AC121965.3         129516-129615
            5595-5676           AC121965.3         145531-145612
            5677-5791           AC121965.3         146362-146476
            5792-5908           AC121965.3         147034-147150
            5909-6053           AC121965.3         147284-147428
            6054-6448           AC121965.3         154442-154836
FEATURES             Location/Qualifiers
     source          1..6448
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 51.3 cM"
     gene            1..6448
                     /gene="Trip11"
                     /gene_synonym="2610511G22Rik; 3110031G15Rik;
                     6030460N08Rik; GMAP-210; TRIP230"
                     /note="thyroid hormone receptor interactor 11"
                     /db_xref="GeneID:109181"
                     /db_xref="MGI:MGI:1924393"
     exon            1..482
                     /gene="Trip11"
                     /gene_synonym="2610511G22Rik; 3110031G15Rik;
                     6030460N08Rik; GMAP-210; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     CDS             344..6274
                     /gene="Trip11"
                     /gene_synonym="2610511G22Rik; 3110031G15Rik;
                     6030460N08Rik; GMAP-210; TRIP230"
                     /codon_start=1
                     /product="thyroid receptor-interacting protein 11"
                     /protein_id="NP_082722.1"
                     /db_xref="CCDS:CCDS49143.1"
                     /db_xref="GeneID:109181"
                     /db_xref="MGI:MGI:1924393"
                     /translation="MSSWLGGLGSGLGQSLGQVGGSLASLTGQISNFTKDMLLEGTED
                     VPADFPNSGREENEATHSVLRSENERLKKLYTDLEEKHEASELQIKQQSSSYRSQLQQ
                     KEEEINHLKARQLALQDELLRLQSAAQSAHLGSGSAPAASASSSFSYGVSHRVSAFHE
                     DDMDFGDVISSQQEINRLSNEVSRLESELGHWRHIAQTKVQGAQSSDQTEICKLQNII
                     KELKQNRSQDLDDHQHELSALQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGG
                     SGVTVTDHSKVYEMQNTIQILQMEKVESTKQIEDLENKIKEIHKRLSSAEHDQEVWKK
                     EQERLEVEKREMTEQCERLKLELSEAQQSALRQSDAAVEEETILPHSSSVAEVLRLQQ
                     ALTDAENEIMRLRSLNQDISLAEDNQKLQMCVQTLEKEKSLLSQEKEELQISLSKLSS
                     EYEVIKSTATRDLDLFSQVHDLKHNLEAKEQELNQSIHENEILMAELEELDKQNQEAT
                     KHVILIKDQLSKQQSEGDSVIKKLKEELAGEKQRTHQLEDDKMNIIKELTVQKEKLTH
                     SEQALSDLQLTKQKLEDKVEDLVDQLSKSEKNNFDIQKENHELREHIRQNEEELSTVR
                     SELTQSQTQGSSRNVKDDLLKERETQVQNLKQNLSEVEQLNEHLEQVAFDLRTENEEL
                     LEAYEEVRNQLEESVAGNKQISLEKTAMLEWEKAPLETELCRAEKRVLEEERKYEQTV
                     QELSSACSPDTSALQLEQERLIQLNQEKDFEIAELKKSIEQMDTDHKRTKETLSSSLE
                     EQKQLTQLINEKEICIVKLKEKSSELQKELDKCAQTLRKNETLRQTIEEKDRSLGSMK
                     EENNHLQEELERLREQQSRVVPAPEPRTLDSTTELESELSQLHRIKGHLEEEIKHHQK
                     MIEDQNQSKLQLLQSLQEQKKELDEFKYQHEQMSISHTRLFLEKDEEIKNLQKTIEQI
                     KAQLHEERQDSQTENSDIFQETKVQSLSIEHGSEKHDLSKAETERLVKGIKERELEIK
                     LLNEKNTSLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSASYSQDVVYLQQQL
                     HAYAMEREKVMVILNEKTRENSQLKTEYHKVIDIISAKEAALIKLQDENKKMSTRFES
                     SGQDMFKETIQNLSRIIREKDIEIDALSQKCQTLLTVLQTSGTGSEAGGVNSNQFEEL
                     LQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVSVDSDNNSKLQV
                     DYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIMSPQLSSGSSLT
                     SQAAEPLRASQSSEPHESSQLLQQEVDDLRKSLQEKDATIRTLQENNHRLSDSVAASS
                     EVERKEHEQADSEIKQLKEKQEVLQNLLKEKDLLIKAKSDQLHSSNENLANKVNENEL
                     LRQAVTNLKERILILEMDISKLKGENEKIVDASKGKETEYQALQETNMKFSMMLREKE
                     FECHSMREKALAFEQLLKEKEQGKAGELNQLLNAVKSMQEKTVTFQQERDQVMLALKQ
                     KQMETSTLQNEVQRLRDKESRLNQELQRLRDHLLESEDSHTREALAAEDREAKLRKKV
                     SVLEEKLVSSSNAMENASHQASVQVESLQEQLNMVSKQRDETALQLSVSQEQVKQYAL
                     SLANLQMVLEHFQQEEKAMYSAELEKQNHLLAEWKKKAESLEGKVLSLQERLDEANAA
                     LDSASRLTEQLDLKEEQIEELKKQNELHQEMLDDAQKKLMSLVNSTEGKVDKVLMRNL
                     FIGHFHTPKHQRHEVLRLMGSILGVKREEMEQLFAEDQGGVTRWMAGWLGGGSKSVPN
                     TPLRPNQQSVFNSSFSELFVKFLETESHPSVPPPKLSVHGLKPLDSPGRRKADTGIPE
                     SFRDTAESRAGRRTDVNPFLAPRSAAVPLINPAGHGPGGPGHLLLKPISDVLPTFTPL
                     PVSPDNSAGVVLKDLLKQ"
     exon            483..544
                     /gene="Trip11"
                     /gene_synonym="2610511G22Rik; 3110031G15Rik;
                     6030460N08Rik; GMAP-210; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     exon            545..655
                     /gene="Trip11"
                     /gene_synonym="2610511G22Rik; 3110031G15Rik;
                     6030460N08Rik; GMAP-210; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     exon            656..934
                     /gene="Trip11"
                     /gene_synonym="2610511G22Rik; 3110031G15Rik;
                     6030460N08Rik; GMAP-210; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1000
                     /gene="Trip11"
                     /gene_synonym="2610511G22Rik; 3110031G15Rik;
                     6030460N08Rik; GMAP-210; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1166
                     /gene="Trip11"
                     /gene_synonym="2610511G22Rik; 3110031G15Rik;
                     6030460N08Rik; GMAP-210; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1529
                     /gene="Trip11"
                     /gene_synonym="2610511G22Rik; 3110031G15Rik;
                     6030460N08Rik; GMAP-210; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1570
                     /gene="Trip11"
                     /gene_synonym="2610511G22Rik; 3110031G15Rik;
                     6030460N08Rik; GMAP-210; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1657
                     /gene="Trip11"
                     /gene_synonym="2610511G22Rik; 3110031G15Rik;
                     6030460N08Rik; GMAP-210; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1870
                     /gene="Trip11"
                     /gene_synonym="2610511G22Rik; 3110031G15Rik;
                     6030460N08Rik; GMAP-210; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..4891
                     /gene="Trip11"
                     /gene_synonym="2610511G22Rik; 3110031G15Rik;
                     6030460N08Rik; GMAP-210; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     exon            4892..5032
                     /gene="Trip11"
                     /gene_synonym="2610511G22Rik; 3110031G15Rik;
                     6030460N08Rik; GMAP-210; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     exon            5033..5226
                     /gene="Trip11"
                     /gene_synonym="2610511G22Rik; 3110031G15Rik;
                     6030460N08Rik; GMAP-210; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     exon            5227..5390
                     /gene="Trip11"
                     /gene_synonym="2610511G22Rik; 3110031G15Rik;
                     6030460N08Rik; GMAP-210; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     exon            5391..5494
                     /gene="Trip11"
                     /gene_synonym="2610511G22Rik; 3110031G15Rik;
                     6030460N08Rik; GMAP-210; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     exon            5495..5594
                     /gene="Trip11"
                     /gene_synonym="2610511G22Rik; 3110031G15Rik;
                     6030460N08Rik; GMAP-210; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     exon            5595..5676
                     /gene="Trip11"
                     /gene_synonym="2610511G22Rik; 3110031G15Rik;
                     6030460N08Rik; GMAP-210; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     exon            5677..5791
                     /gene="Trip11"
                     /gene_synonym="2610511G22Rik; 3110031G15Rik;
                     6030460N08Rik; GMAP-210; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     exon            5792..5908
                     /gene="Trip11"
                     /gene_synonym="2610511G22Rik; 3110031G15Rik;
                     6030460N08Rik; GMAP-210; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     exon            5909..6053
                     /gene="Trip11"
                     /gene_synonym="2610511G22Rik; 3110031G15Rik;
                     6030460N08Rik; GMAP-210; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     exon            6054..6448
                     /gene="Trip11"
                     /gene_synonym="2610511G22Rik; 3110031G15Rik;
                     6030460N08Rik; GMAP-210; TRIP230"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttctacgcta tcgcgaagct tctctatggt cactgccgct ttcccggcag tgtcatggcg
       61 gccggcgttg agttggcagg actggcccac gaaactgagg aaagtcagta aagctgagaa
      121 agaagtagtg cagccgcacg gcgggaagcc gtgggaatga gcagaggcct cgcggggccc
      181 acggtgtcca caacggcgaa cccttggtga agcgtcaggc cgggcctcgg ctttctgacg
      241 cggccgttgg tgggagtgcc gtgtcctgcg agtcctcagc gtctggatcc gcaccagctt
      301 cggcgtccag ggacatttgg agaggacgtg tccacccgca gcgatgtcgt cctggctcgg
      361 gggcctcggc tccggcttgg gccagtctct cggtcaagta gggggcagcc tggcttccct
      421 cactggccag atttcgaact tcacgaagga tatgctgttg gagggcacgg aggatgtgcc
      481 agcagatttc cctaattccg ggagagagga gaatgaagcc actcattcag tcttaagatc
      541 agagaatgaa aggcttaaaa agctttacac tgatctagag gaaaagcatg aagcatccga
      601 acttcaaatt aagcagcaat cttccagtta ccgaagtcag ttacagcaga aagaggaaga
      661 aatcaaccac cttaaagcaa ggcagctcgc actacaggat gaactgctca gactgcagtc
      721 agctgctcag tcagcccact taggatctgg cagcgcacca gcagccagtg catcatcttc
      781 attcagctat ggggtcagtc atcgtgtgtc agccttccat gaagacgaca tggactttgg
      841 tgatgtgatc tcatcacaac aagaaataaa cagattatca aatgaagttt caagacttga
      901 gtctgaactt ggacattgga gacatattgc tcagactaag gtacagggag cacaaagctc
      961 tgatcaaact gaaatctgca aactacaaaa tattattaag gaacttaaac agaacagaag
     1021 tcaggacctc gatgaccatc agcatgagct gtcagccctg cagaacgctc atcagcagaa
     1081 gctgacagag ataagtcggc ggcatcgaga ggagttaagt gactatgaag agcgtattga
     1141 agaactggaa aatctgttac agcaaggtgg ctcaggagtt acggtaactg atcactctaa
     1201 agtgtatgag atgcaaaaca ctattcagat cttacagatg gaaaaagtag aatctaccaa
     1261 acaaatcgaa gaccttgaga ataaaataaa agagatacat aaaagattgt cttctgcaga
     1321 acatgaccag gaagtctgga aaaaagaaca agagcggctg gaagtggaaa agagagagat
     1381 gactgagcag tgtgagcgct tgaagctgga actcagtgaa gcccagcaga gtgctctgcg
     1441 gcagagtgat gctgcggtgg aggaggagac gatcctccca cacagctcct cagtcgcaga
     1501 ggtcctgaga ttgcagcaag ctttgactga tgctgaaaat gaaataatga gactaaggag
     1561 tttaaaccag gatatcagtc ttgctgaaga caatcagaaa cttcaaatgt gtgtccaaac
     1621 tttagaaaaa gagaagtctt tattgagtca agaaaaggaa gaacttcaga tatcactttc
     1681 caaactgagc agtgaatatg aagtcattaa aagtacagct acaagggact tagatttgtt
     1741 ttctcaagta catgacttaa aacataacct ggaggcgaag gagcaagaac tgaaccagag
     1801 tattcatgaa aatgaaatcc ttatggctga attagaagaa ctggacaagc agaaccaaga
     1861 ggctactaag catgtgattt tgataaaaga tcagctatca aaacaacaaa gtgaaggaga
     1921 tagtgtcatc aagaaactga aagaagagct agctggtgag aagcagagaa cccatcagct
     1981 tgaggatgat aaaatgaata ttattaaaga gttaaccgta cagaaagaaa agctaactca
     2041 cagtgaacag gccctaagtg atttacagtt aaccaaacag aagcttgaag ataaagtaga
     2101 agatttagta gatcagctaa gtaaatcaga gaaaaacaat tttgacattc agaaggagaa
     2161 ccatgaactg agggaacaca tcagacaaaa tgaagaggag ctgtccacag tcaggagtga
     2221 gttaactcag tcccaaaccc agggctccag caggaacgtg aaggatgact tacttaaaga
     2281 aagggaaact caagttcaaa acttaaagca aaatctttca gaagtagaac agctcaatga
     2341 acatttagag caagttgctt ttgatctcag aacagaaaat gaagagttgc ttgaagcata
     2401 tgaagaggta agaaatcagt tggaagaatc tgttgctggc aacaagcaga tttctctgga
     2461 aaaaactgct atgctggaat gggaaaaggc accactagaa acagagctgt gtcgagctga
     2521 aaagcgggtg ttggaagaag agcggaagta cgagcaaact gtccaggaac tgtccagcgc
     2581 gtgcagcccc gatacctccg ccttacagct ggaacaggag cgcttaattc aactcaatca
     2641 agaaaaagac tttgaaatag cagaactcaa aaaaagtatt gagcaaatgg atactgatca
     2701 taaacgaacc aaggagactt tgtcatctag tttagaagag cagaaacaat tgacacaact
     2761 tataaatgag aaagagattt gtattgtgaa acttaaagaa aaaagttcag aactgcagaa
     2821 ggaattagac aaatgtgctc agaccttaag gaaaaatgag actttaaggc agaccataga
     2881 agaaaaggat agaagtcttg gatccatgaa agaagagaac aatcacttgc aagaggagct
     2941 ggagcggctc cgggagcagc agagtcgggt agtgcccgcg cctgagccca gaacccttga
     3001 cagcaccacc gagctggagt ctgagctgtc tcagctgcac agaatcaagg gtcatctgga
     3061 agaagagatt aaacatcacc agaagatgat tgaagatcaa aaccagagca agctgcagct
     3121 actccagtct ctacaggagc agaagaaaga actggatgag tttaaatacc agcatgaaca
     3181 aatgagtatc tcacacacac gactcttttt agaaaaagat gaggaaatta agaacttgca
     3241 aaaaacaatt gaacaaataa aagcccagtt gcatgaagaa aggcaggata gtcaaacaga
     3301 gaattccgat atttttcaag aaacaaaagt tcagagcctt agtatagaac atggaagtga
     3361 aaaacatgac ctctctaaag cggagacgga aaggttagtg aaggggataa aggagaggga
     3421 gctggagatc aagcttctga atgagaagaa cacctcgcta actaaacaga tcgatcagct
     3481 gtccaaagac gaggtcggca agctcacgca gatcatccag cagaaggact tggagataca
     3541 ggctcttcat gccaggatct cctccgcgtc ctactcacag gatgttgtgt accttcagca
     3601 gcagctgcat gcatacgcta tggaaagaga gaaagtgatg gttattttga atgagaagac
     3661 aagggaaaat agccagctaa aaacagaata tcataaggtg atcgatatta ttagtgccaa
     3721 agaagcagcc cttattaagt tgcaagatga gaataagaaa atgtccacta gatttgaaag
     3781 tagtggtcaa gatatgttta aagaaactat tcagaattta tcccggatca ttcgagaaaa
     3841 ggacattgag atcgatgcac tgagtcagaa gtgccagacc ctgctgacag tcttgcagac
     3901 ttctggcacg gggagtgagg ctggaggggt taacagtaac cagtttgagg agctcttaca
     3961 ggagcgggat aaactgaagc agcaggtgaa gaaaatggag gagtggaaac aacaagtgat
     4021 gaccaccgtc cagaacatgc agcacgagtc tgcccagctc caggaagagc ttcaccaact
     4081 tcaggcacaa gtttcggttg acagtgataa caattctaaa ctgcaagtgg actacacagg
     4141 cctgatccaa agttatgagc agaatgaaac caaacttaag aactttgggc aggaattggc
     4201 acaagttcag catagcatag ggcagctttg taataccaag gaccttcttt taggaaaact
     4261 tgatattatg tctcctcagc tctcctctgg ctcatcactt acctctcagg cagcagagcc
     4321 tcttagagca agccagtctt ctgagccaca tgagtcttct cagttgcttc aacaagaagt
     4381 agatgatctg agaaaatcac tgcaggagaa agatgccaca attcgaacgc tccaggaaaa
     4441 caatcataga ctgtctgact ctgttgctgc ttcctcagag gtagaaagaa aagaacacga
     4501 gcaagctgat tcagaaatta agcagctgaa ggaaaaacaa gaggttttac aaaacttgct
     4561 taaggaaaaa gacctcttaa tcaaagccaa aagtgaccaa ttacattctt caaatgaaaa
     4621 ccttgctaac aaagtgaatg aaaacgagct tttgaggcag gcagtgacaa atttgaagga
     4681 gagaatattg attttagaaa tggacatttc taaattaaaa ggggaaaatg aaaaaatagt
     4741 agacgcatcc aaggggaagg aaacagaata ccaggcgtta caagagacca acatgaagtt
     4801 ttccatgatg ttacgagaaa aggagtttga atgccattca atgagagaga aggcacttgc
     4861 ttttgagcaa ctactgaaag aaaaagaaca gggcaaggct ggggagctaa atcaactttt
     4921 aaatgcagtt aaatcaatgc aggagaagac agttacgttt cagcaggaaa gagaccaagt
     4981 tatgttggcc ctgaaacaga agcaaatgga aaccagtacc ctgcagaatg aggtccagcg
     5041 cttacgggac aaagaatccc ggctgaacca ggagctacag agactgcgtg accacctctt
     5101 agagtcagaa gactctcata cgcgggaagc tttggctgca gaagacagag aggccaaact
     5161 gaggaagaag gtctcggtgt tggaggaaaa gctggtgtca tcctctaatg caatggaaaa
     5221 cgcaagtcat caagccagtg tgcaagtaga gtctttacaa gaacaactga acatggtctc
     5281 caagcaaaga gatgagactg ccctgcaact ctctgtctct caggaacaag tgaagcagta
     5341 tgctttgtca ctagccaatc tgcagatggt tcttgaacac ttccaacaag aggaaaaagc
     5401 tatgtattct gctgaattag aaaagcaaaa ccacctctta gctgaatgga agaaaaaggc
     5461 agagagtctg gaaggaaaag tgttatcgct gcaggaacgt ttggatgaag caaatgctgc
     5521 actggattca gcatcaagac ttacagaaca gttagattta aaagaagagc aaattgaaga
     5581 acttaaaaag caaaatgagc tccaccaaga gatgctggac gacgcgcaga agaaactgat
     5641 gagcttggtc aacagcacag aagggaaagt ggacaaagtc ctcatgagaa acctctttat
     5701 cggtcatttc cacacaccta aacaccagcg tcacgaagtc cttcggctca tggggagcat
     5761 cctgggtgtt aaaagggaag agatggagca gctgtttgca gaagatcaag gaggtgttac
     5821 tcggtggatg gctggatggc tgggaggagg atcgaaaagt gtgcccaata cacctttgag
     5881 accaaatcag cagtctgtgt tcaatagttc tttttcagaa ctctttgtta aatttctgga
     5941 aacagaatct catccatctg tcccgcctcc aaagctgtca gtccatggcc tgaagcctct
     6001 agattctcca ggaagaagga aagctgacac aggcataccc gaaagtttta gagatacagc
     6061 agaatccagg gcaggaagaa gaacagatgt gaatccattc ttggctcccc gctcagcagc
     6121 tgtgcccctt attaacccag ctggacatgg acctggtggg cctgggcatc ttcttttgaa
     6181 acccatctca gatgttctac ccacgtttac acctttgcca gtgtcacctg acaacagtgc
     6241 aggtgttgta ttgaaagacc ttctaaagca ataggtagct ttcaaggctg agacttagta
     6301 gcactttaaa gaaaccatga acactgtatg tgtgtgaact ttatcacaaa gtggccttct
     6361 agaaagagtc atttatttgt ttgtagttat aatttctctg ttaataaaaa tattcttaat
     6421 gcttttagaa attgcaggtg tcagaaga
//
