LOCUS       NM_001410293            2486 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus thyroid hormone receptor interactor 10 (Trip10),
            transcript variant 5, mRNA.
ACCESSION   NM_001410293
VERSION     NM_001410293.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2486)
  AUTHORS   Li,X., Li,J., Martinez,E.C., Froese,A., Passariello,C.L.,
            Henshaw,K., Rusconi,F., Li,Y., Yu,Q., Thakur,H., Nikolaev,V.O. and
            Kapiloff,M.S.
  TITLE     Calcineurin Abeta-Specific Anchoring Confers Isoform-Specific
            Compartmentation and Function in Pathological Cardiac Myocyte
            Hypertrophy
  JOURNAL   Circulation 142 (10), 948-962 (2020)
   PUBMED   32611257
  REMARK    Erratum:[Circulation. 2020 Sep 8;142(10):e153. doi:
            10.1161/CIR.0000000000000917. PMID: 32897744]
REFERENCE   2  (bases 1 to 2486)
  AUTHORS   Zhang,X., Liu,Y., Shao,R. and Li,W.
  TITLE     Cdc42-interacting protein 4 silencing relieves pulmonary fibrosis
            in STZ-induced diabetic mice via the Wnt/GSK-3beta/beta-catenin
            pathway
  JOURNAL   Exp Cell Res 359 (1), 284-290 (2017)
   PUBMED   28720386
  REMARK    GeneRIF: CIP4 silencing can efficiently alleviate
            Streptozotocin-induced pulmonary fibrosis in mice, perhaps through
            suppressing Wnt/GSK-3beta/beta-catenin signaling.
REFERENCE   3  (bases 1 to 2486)
  AUTHORS   Chen,Y., Aardema,J., Kale,S., Whichard,Z.L., Awomolo,A.,
            Blanchard,E., Chang,B., Myers,D.R., Ju,L., Tran,R., Reece,D.,
            Christensen,H., Boukour,S., Debili,N., Strom,T.S., Rawlings,D.,
            Vazquez,F.X., Voth,G.A., Zhu,C., Kahr,W.H., Lam,W.A. and Corey,S.J.
  TITLE     Loss of the F-BAR protein CIP4 reduces platelet production by
            impairing membrane-cytoskeleton remodeling
  JOURNAL   Blood 122 (10), 1695-1706 (2013)
   PUBMED   23881916
  REMARK    GeneRIF: CIP4 is a new component in the highly coordinated system
            of megakaryocytic membrane and cytoskeletal remodeling affecting
            platelet production.
REFERENCE   4  (bases 1 to 2486)
  AUTHORS   Saengsawang,W., Taylor,K.L., Lumbard,D.C., Mitok,K., Price,A.,
            Pietila,L., Gomez,T.M. and Dent,E.W.
  TITLE     CIP4 coordinates with phospholipids and actin-associated proteins
            to localize to the protruding edge and produce actin ribs and veils
  JOURNAL   J Cell Sci 126 (Pt 11), 2411-2423 (2013)
   PUBMED   23572514
  REMARK    GeneRIF: CIP4 coordinates with phospholipids and actin-associated
            proteins to localize to the protruding edge and produce actin ribs
            and veils.
REFERENCE   5  (bases 1 to 2486)
  AUTHORS   Koshkina,N.V., Yang,G. and Kleinerman,E.S.
  TITLE     Inhibition of Cdc42-interacting protein 4 (CIP4) impairs
            osteosarcoma tumor progression
  JOURNAL   Curr Cancer Drug Targets 13 (1), 48-56 (2013)
   PUBMED   22920438
  REMARK    GeneRIF: Data suggest that down-regulation of CIP4 in osteosarcoma
            changes cell morphology (reduces actin; alters cytoskeleton),
            inhibits primary tumor growth, impairs invasiveness and migration
            of tumor cells, delays metastasis, and prolongs survival time.
REFERENCE   6  (bases 1 to 2486)
  AUTHORS   Archila,S., King,M.A., Carlson,G.M. and Rice,N.A.
  TITLE     The cytoskeletal organizing protein Cdc42-interacting protein 4
            associates with phosphorylase kinase in skeletal muscle
  JOURNAL   Biochem Biophys Res Commun 345 (4), 1592-1599 (2006)
   PUBMED   16735024
REFERENCE   7  (bases 1 to 2486)
  AUTHORS   Tsujita,K., Suetsugu,S., Sasaki,N., Furutani,M., Oikawa,T. and
            Takenawa,T.
  TITLE     Coordination between the actin cytoskeleton and membrane
            deformation by a novel membrane tubulation domain of PCH proteins
            is involved in endocytosis
  JOURNAL   J Cell Biol 172 (2), 269-279 (2006)
   PUBMED   16418535
REFERENCE   8  (bases 1 to 2486)
  AUTHORS   Yin,X., Warner,D.R., Roberts,E.A., Pisano,M.M. and Greene,R.M.
  TITLE     Identification of novel CBP interacting proteins in embryonic
            orofacial tissue
  JOURNAL   Biochem Biophys Res Commun 329 (3), 1010-1017 (2005)
   PUBMED   15752756
REFERENCE   9  (bases 1 to 2486)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2486)
  AUTHORS   Wang,L., Rudert,W.A., Grishin,A., Dombrosky-Ferlan,P., Sullivan,K.,
            Deng,X., Whitcomb,D. and Corey,S.
  TITLE     Identification and genetic analysis of human and mouse activated
            Cdc42 interacting protein-4 isoforms
  JOURNAL   Biochem Biophys Res Commun 293 (5), 1426-1430 (2002)
   PUBMED   12054674
  REMARK    GeneRIF: Identification and genetic analysis of human and mouse
            activated Cdc42 interacting protein-4 isoforms (CIP4)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT025692.15.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784647.612091.1,
                                           SRR12282455.3094179.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               CT025692.15        132670-132776
            108-223             CT025692.15        133947-134062
            224-280             CT025692.15        134160-134216
            281-428             CT025692.15        136467-136614
            429-491             CT025692.15        136702-136764
            492-596             CT025692.15        137262-137366
            597-725             CT025692.15        137465-137593
            726-872             CT025692.15        138223-138369
            873-1067            CT025692.15        138478-138672
            1068-1235           CT025692.15        140065-140232
            1236-1345           CT025692.15        140440-140549
            1346-1372           CT025692.15        143421-143447
            1373-1505           CT025692.15        144495-144627
            1506-1654           CT025692.15        144845-144993
            1655-1773           CT025692.15        145559-145677
            1774-2486           CT025692.15        146205-146917
FEATURES             Location/Qualifiers
     source          1..2486
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.74 cM"
     gene            1..2486
                     /gene="Trip10"
                     /gene_synonym="Cip4"
                     /note="thyroid hormone receptor interactor 10"
                     /db_xref="GeneID:106628"
                     /db_xref="MGI:MGI:2146901"
     exon            1..107
                     /gene="Trip10"
                     /gene_synonym="Cip4"
                     /inference="alignment:Splign:2.1.0"
     exon            108..223
                     /gene="Trip10"
                     /gene_synonym="Cip4"
                     /inference="alignment:Splign:2.1.0"
     exon            224..280
                     /gene="Trip10"
                     /gene_synonym="Cip4"
                     /inference="alignment:Splign:2.1.0"
     exon            281..428
                     /gene="Trip10"
                     /gene_synonym="Cip4"
                     /inference="alignment:Splign:2.1.0"
     exon            429..491
                     /gene="Trip10"
                     /gene_synonym="Cip4"
                     /inference="alignment:Splign:2.1.0"
     exon            492..596
                     /gene="Trip10"
                     /gene_synonym="Cip4"
                     /inference="alignment:Splign:2.1.0"
     exon            597..725
                     /gene="Trip10"
                     /gene_synonym="Cip4"
                     /inference="alignment:Splign:2.1.0"
     exon            726..872
                     /gene="Trip10"
                     /gene_synonym="Cip4"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1067
                     /gene="Trip10"
                     /gene_synonym="Cip4"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1235
                     /gene="Trip10"
                     /gene_synonym="Cip4"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1345
                     /gene="Trip10"
                     /gene_synonym="Cip4"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1372
                     /gene="Trip10"
                     /gene_synonym="Cip4"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1505
                     /gene="Trip10"
                     /gene_synonym="Cip4"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1654
                     /gene="Trip10"
                     /gene_synonym="Cip4"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1773
                     /gene="Trip10"
                     /gene_synonym="Cip4"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..2486
                     /gene="Trip10"
                     /gene_synonym="Cip4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2174..2179
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trip10"
                     /gene_synonym="Cip4"
                     /note="hexamer: ATTAAA"
     regulatory      2196..2201
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trip10"
                     /gene_synonym="Cip4"
                     /note="hexamer: TATAAA"
     polyA_site      2197
                     /gene="Trip10"
                     /gene_synonym="Cip4"
                     /note="major polyA site"
     polyA_site      2217
                     /gene="Trip10"
                     /gene_synonym="Cip4"
                     /note="major polyA site"
     regulatory      2422..2427
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trip10"
                     /gene_synonym="Cip4"
                     /note="hexamer: GATAAA"
     polyA_site      2440
                     /gene="Trip10"
                     /gene_synonym="Cip4"
     regulatory      2452..2457
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trip10"
                     /gene_synonym="Cip4"
                     /note="hexamer: AATAAA"
     polyA_site      2486
                     /gene="Trip10"
                     /gene_synonym="Cip4"
ORIGIN      
        1 acactgccct ggggctgagt ctccggtgga gggcggcgga gacccgggca ggaggcggtg
       61 gcgtcctggg cggcaagagc agcatggatt ggggtaccga gttgtgggat cagtttgagg
      121 tgctggaacg ccacacgcag tgggggctgg atttgttgga caaatacgtg aagttcgtga
      181 aagaacgcgc ggaggtggag caggcttatg ctaagcaact ccggagcctg gtgaaaaagt
      241 atcttcccaa gagacctacc aaagatgacc ctgaagtcaa gttcagccag cagcagtcat
      301 ttgtccagct tctccaggag gtcaatgact tcgcaggcca gagagagctg gtggctgaga
      361 gcctcggtat ccgagtgtgt ctggagctgg ctaagtattc acaggagatg aagcaggaga
      421 ggaagatgca cttccaggaa ggtcgtcggg cccagcagca gctggagaat ggcttcaaac
      481 agctggagaa tagtaagcgg aagtttgaac gagattgccg ggaggctgag aaagcggctc
      541 acactgctga gcgcctagat caggacatta atgccaccaa ggcggatgtg gagaaggcca
      601 agcagcaagc tcaccttcgg aaccacatgg cagaagagag caagaatgaa tatgcggccc
      661 agctgcagcg cttcaaccga gaccaggctc acttctactt ctcacagatg ccccagatat
      721 tcgataagct gcaggacatg gacgaacgcc gggccacccg cctgggggcc gggtatgggc
      781 tcttatcaga ggctgaactg caggtggttc ccattattgg caaatgcttg gagggcatga
      841 aggtggccgc cgagtctgtg gatgctaaga acgactcaca ggtcctcatc gaattacaca
      901 agtccgggtt tgcccgccca ggggacttgg aatttgaaga ctttagccaa gttatcaacc
      961 gagtgccttc ggacagcagc ctgggcaccc cggatggcag gcctgagctc cgagcagcct
     1021 ccagccgtag ccgcgccaag cgttggcctt tcgggaaaaa gaacaagcca cgtcccccat
     1081 ccctgtccct cctggggggt cacctaccct ccacactgtc tgatggaccc tcatcccccc
     1141 gttctggccg cgaccccttg gccatactga gcgagatcag taagtcggtc aaaccgcggc
     1201 tagcatcctt ccgcagcttc cgaggtggcc gtgggaccgt ggctaccgaa gatttcagtc
     1261 acttgccccc ggagcagcag agaaagcgac ttcagcaaca gctggaagag cggaaccgag
     1321 agttgcagaa ggaggaggac cagagaagtc ggaggacagc tcgctggagt cgggaggccc
     1381 tgaagaagat gaaagatgta tatgagaaaa caccacaaat gggggaccct gccagcttag
     1441 agccccgcat tgcagagacc ctgggcaaca ttgagaggct gaagttggaa gtgcagaagt
     1501 atgaggcttg gttggcagaa gctgaaagcc gggtcctcag taaccgaggg gacagcctaa
     1561 gccgtcacgc taggccccct gatcccccaa ctactgcccc acctgatagc agcagtagca
     1621 gcaccaacag tggatcccag gacaataagg agagcagctc agaagagccc ccttcagaag
     1681 gccaggacac ccccatctat actgagttcg atgaggactt tgaggagcct gcatccccta
     1741 tcggccagtg tgtggctatc taccattttg aaggatccag cgagggaacc gtctccatgt
     1801 ccgaggggga agacctcagc ctgatggagg aagacaaggg tgatggatgg acgcgggtca
     1861 ggaggaaaca gggagctgag ggctacgtgc ccacctctta cctccgagtc acactcaact
     1921 gaaccccacc agagggggac gaggggcagg gctgtcagct gctgcttctg ggccacaggg
     1981 ggggccccca ggaccttgca ctttattcct gcccacgtgg cttttggctg agacctgtgt
     2041 aacctgctgt ccctcactca cctgtcacct gtcaccctac ggggacccac ttgtggcttc
     2101 ccacgtggtt gtacatattt gtcatttaag atctttcttc ccgccgcttg gcttgagcca
     2161 agttttgttt tatattaaaa aagtatatat aattatataa agttcttgga gtctgcaccg
     2221 ccagtgtcgg gaatggacct tcaaaaggca tctctgtgga gaggtggttt gggagtcggg
     2281 ttttggatgc tcttgcagag gaccaggagt tggttttcaa aagcagctcc caaagctcac
     2341 agacatccaa gcctaggccc cctctggccg actctggcag tcgcactcat acctgcatgt
     2401 atcctgccca agttaaaatg agataaaagc tttcttatga gccccgtgtg gaataaatgg
     2461 aggtgaacct cggtgcgctc tggcaa
//
