LOCUS       NM_001381929            1544 bp    mRNA    linear   ROD 06-AUG-2023
DEFINITION  Mus musculus tripartite motif family-like 2 (Triml2), transcript
            variant 1, mRNA.
ACCESSION   NM_001381929 XM_006509471
VERSION     NM_001381929.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1544)
  AUTHORS   Ringel AR, Szabo Q, Chiariello AM, Chudzik K, Schopflin R, Rothe P,
            Mattei AL, Zehnder T, Harnett D, Laupert V, Bianco S, Hetzel S,
            Glaser J, Phan MHQ, Schindler M, Ibrahim DM, Paliou C, Esposito A,
            Prada-Medina CA, Haas SA, Giere P, Vingron M, Wittler L, Meissner
            A, Nicodemi M, Cavalli G, Bantignies F, Mundlos S and Robson MI.
  TITLE     Repression and 3D-restructuring resolves regulatory conflicts in
            evolutionarily rearranged genomes
  JOURNAL   Cell 185 (20), 3689-3704 (2022)
   PUBMED   36179666
REFERENCE   2  (bases 1 to 1544)
  AUTHORS   Kung CP, Khaku S, Jennis M, Zhou Y and Murphy ME.
  TITLE     Identification of TRIML2, a novel p53 target, that enhances p53
            SUMOylation and regulates the transactivation of proapoptotic genes
  JOURNAL   Mol Cancer Res 13 (2), 250-262 (2015)
   PUBMED   25256710
  REMARK    GeneRIF: Data indicate that TRIML2 is part of a feed-forward loop
            that activates p53 in cells expressing the R72 variant,
            particularly after prolonged stress.
REFERENCE   3  (bases 1 to 1544)
  AUTHORS   Kunarso G, Wong KY, Stanton LW and Lipovich L.
  TITLE     Detailed characterization of the mouse embryonic stem cell
            transcriptome reveals novel genes and intergenic splicing
            associated with pluripotency
  JOURNAL   BMC Genomics 9, 155 (2008)
   PUBMED   18400104
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC142104.4.
            
            On Apr 20, 2020 this sequence version replaced XM_006509471.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU599039.1, SRR15390195.548261.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                AC142104.4         37174-37250         c
            78-321              AC142104.4         34421-34664         c
            322-417             AC142104.4         33988-34083         c
            418-597             AC142104.4         32328-32507         c
            598-738             AC142104.4         30075-30215         c
            739-761             AC142104.4         27695-27717         c
            762-862             AC142104.4         27417-27517         c
            863-1544            AC142104.4         23902-24583         c
FEATURES             Location/Qualifiers
     source          1..1544
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 23.89 cM"
     gene            1..1544
                     /gene="Triml2"
                     /gene_synonym="EG622117; Tu4"
                     /note="tripartite motif family-like 2"
                     /db_xref="GeneID:622117"
                     /db_xref="MGI:MGI:3642989"
     exon            1..77
                     /gene="Triml2"
                     /gene_synonym="EG622117; Tu4"
                     /inference="alignment:Splign:2.1.0"
     exon            78..321
                     /gene="Triml2"
                     /gene_synonym="EG622117; Tu4"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..1410
                     /gene="Triml2"
                     /gene_synonym="EG622117; Tu4"
                     /EC_number="2.3.2.27"
                     /codon_start=1
                     /product="probable E3 ubiquitin-protein ligase TRIML2"
                     /protein_id="NP_001368858.1"
                     /db_xref="GeneID:622117"
                     /db_xref="MGI:MGI:3642989"
                     /translation="MSQAPKPQLPGNTEDPNCGTHPEPSQFFSDDDQVIVCSKCFQSP
                     EHKQHGAYGIQEAAEYYRTLLQETLVTLREKRDAATSLLAEERERMVTIQEEEQRFKE
                     MIEAEYKMRFQLLTEEEELAAYKVDLNLNGPNPDQLMKCGTELMQKSQEMLQRLSHLG
                     RENMEKLKASEVRLGEHLRSLQTMITDLEKNCGESAVALLQNAKCYLKRNESILLQSL
                     EPAQITDLSFCLIIETSRVLLRLQRHITLDPGTAHPSLVLSEDLRSVGFRETPKTGPG
                     TTRRLDFSASVLGAESFTTGRHYWEVAVGQATQWQVGICDCTERKDNIPGASGDKVLL
                     MGSMMGTDCTLWVFPPLRKVCLRNQMYKVGVFLDCECGQVSFYNVTEQSLIYSFSDLT
                     FRGAIKPIFSLCIPNGDMSSDSLTVCLPQTHP"
     exon            322..417
                     /gene="Triml2"
                     /gene_synonym="EG622117; Tu4"
                     /inference="alignment:Splign:2.1.0"
     exon            418..597
                     /gene="Triml2"
                     /gene_synonym="EG622117; Tu4"
                     /inference="alignment:Splign:2.1.0"
     exon            598..738
                     /gene="Triml2"
                     /gene_synonym="EG622117; Tu4"
                     /inference="alignment:Splign:2.1.0"
     exon            739..761
                     /gene="Triml2"
                     /gene_synonym="EG622117; Tu4"
                     /inference="alignment:Splign:2.1.0"
     exon            762..862
                     /gene="Triml2"
                     /gene_synonym="EG622117; Tu4"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1544
                     /gene="Triml2"
                     /gene_synonym="EG622117; Tu4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccttcgtact gaagtctctg gtctccactg gctgtggctt tccctgaagg aaatccttaa
       61 gatttctgga aaggaaggga agaagtccac atcggaaaca agcagtcgag tgttcatctg
      121 gtgccactga ctagaatgtc ccaagcgccc aagccccagt tacctggcaa cacagaggat
      181 ccaaactgcg ggacacaccc ggagccatcg cagttcttca gtgatgatga ccaagtcata
      241 gtttgcagca aatgtttcca gtctccagag cacaagcagc atggggcata cggtatccaa
      301 gaagctgctg agtattacag gacgttactc caggaaaccc tggttacatt gagggagaag
      361 cgtgatgcag ctacgagctt actggccgaa gagcgagaga gaatggtgac aattcaggaa
      421 gaagagcaga ggtttaaaga gatgatcgag gctgagtata agatgcgatt ccagttactg
      481 actgaagagg aggaactggc agcctacaaa gttgacctga acttaaatgg acctaatcca
      541 gaccagctga tgaagtgtgg cactgagctc atgcagaagt cccaagaaat gctacagaga
      601 cttagtcacc tggggagaga gaacatggaa aaactgaagg cgagtgaagt ccggcttggt
      661 gagcacctgc gcagcctcca gacgatgatc acggacctcg agaagaactg tggggaatct
      721 gccgttgcac tgctccagaa tgcaaagtgc tatttaaaaa ggaatgagtc tatactgctt
      781 cagagcctag agccagctca gataacagac ctgagtttct gcctgataat cgaaacgagc
      841 cgtgttctac tgaggctcca aagacatatt actttggacc caggcacagc tcacccctcc
      901 ctagtcttat ccgaagacct gagaagtgtg ggattccgag agacaccaaa gactgggcct
      961 ggcactacaa ggagattgga tttcagcgct tctgtgttgg gtgcagagag cttcaccacg
     1021 gggaggcatt attgggaggt ggctgtggga caggcaaccc aatggcaggt gggcatatgt
     1081 gactgtacag agagaaagga caacattccc ggggcttctg gagataaagt cttgctcatg
     1141 gggtccatga tggggaccga ttgtaccctc tgggtctttc cccctttaag aaaggtctgt
     1201 ctgagaaacc aaatgtacaa agttggagtc ttcctagact gtgaatgtgg gcaagtatcc
     1261 ttctacaatg tgacagagca gtccctcatt tacagtttct ctgaccttac cttccgagga
     1321 gcgattaaac caatattttc tctttgtatt ccaaatggag acatgagttc agactctctc
     1381 actgtctgtc ttcctcagac tcatccctga aatgctgctg atagctcttc atcttcctgt
     1441 gtgtggaacc caagatcaaa agagacacaa aaataagatc cagactttgt gaacaccact
     1501 tatgtaatta atctaatata atccaataaa gccattagac ttaa
//
