LOCUS       NM_053100               3262 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus tripartite motif-containing 8 (Trim8), transcript
            variant 1, mRNA.
ACCESSION   NM_053100
VERSION     NM_053100.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3262)
  AUTHORS   Xiao,M.C., Jiang,N., Chen,L.L., Liu,F., Liu,S.Q., Ding,C.H.,
            Wu,S.H., Wang,K.Q., Luo,Y.Y., Peng,Y., Yan,F.Z., Zhang,X., Qian,H.
            and Xie,W.F.
  TITLE     TRIB3-TRIM8 complex drives NAFLD progression by regulating
            HNF4alpha stability
  JOURNAL   J Hepatol 80 (5), 778-791 (2024)
   PUBMED   38237865
  REMARK    GeneRIF: TRIB3-TRIM8 complex drives NAFLD progression by regulating
            HNF4alpha stability.
REFERENCE   2  (bases 1 to 3262)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3262)
  AUTHORS   Qiu,T., Lv,Y., Niu,L. and Zhang,Y.
  TITLE     Knockdown of TRIM8 alleviates dextran sulfate sodium-induced
            colitis in mice by inhibiting the NF-kappaB signaling pathway
  JOURNAL   Allergol Immunopathol (Madr) 51 (1), 92-97 (2023)
   PUBMED   36617827
  REMARK    GeneRIF: Knockdown of TRIM8 alleviates dextran sulfate
            sodium-induced colitis in mice by inhibiting the NF-kappaB
            signaling pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3262)
  AUTHORS   Venuto,S., Monteonofrio,L., Cozzolino,F., Monti,M., Appolloni,I.,
            Mazza,T., Canetti,D., Giambra,V., Panelli,P., Fusco,C., Squeo,G.M.,
            Croce,A.I., Pucci,P., Malatesta,P., Soddu,S., Merla,G. and
            Micale,L.
  TITLE     TRIM8 interacts with KIF11 and KIFC1 and controls bipolar spindle
            formation and chromosomal stability
  JOURNAL   Cancer Lett 473, 98-106 (2020)
   PUBMED   31904480
  REMARK    GeneRIF: TRIM8 interacts with KIF11 and KIFC1 and controls bipolar
            spindle formation and chromosomal stability.
REFERENCE   5  (bases 1 to 3262)
  AUTHORS   Tao,Q., Tianyu,W., Jiangqiao,Z., Zhongbao,C., Xiaoxiong,M., Long,Z.
            and Jilin,Z.
  TITLE     Tripartite Motif 8 Deficiency Relieves Hepatic
            Ischaemia/reperfusion Injury via TAK1-dependent Signalling Pathways
  JOURNAL   Int J Biol Sci 15 (8), 1618-1629 (2019)
   PUBMED   31360105
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3262)
  AUTHORS   Toniato,E., Flati,V., Laglia,E., Mincione,G. and Martinotti,S.
  TITLE     Genomic organization and cytokine-mediated inducibility of the
            human TRIM-8/Gerp gene
  JOURNAL   Int J Immunopathol Pharmacol 17 (2 Suppl), 71-76 (2004)
   PUBMED   15345195
  REMARK    GeneRIF: Gerp transcribes interferon-gamma in epithelial and
            lymphoid cells and is expressed almost ubiquitously in tissues.
REFERENCE   7  (bases 1 to 3262)
  AUTHORS   Toniato,E., Chen,X.P., Losman,J., Flati,V., Donahue,L. and
            Rothman,P.
  TITLE     TRIM8/GERP RING finger protein interacts with SOCS-1
  JOURNAL   J Biol Chem 277 (40), 37315-37322 (2002)
   PUBMED   12163497
REFERENCE   8  (bases 1 to 3262)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
REFERENCE   9  (bases 1 to 3262)
  AUTHORS   Vincent,S.R., Kwasnicka,D.A. and Fretier,P.
  TITLE     A novel RING finger-B box-coiled-coil protein, GERP
  JOURNAL   Biochem Biophys Res Commun 279 (2), 482-486 (2000)
   PUBMED   11118312
REFERENCE   10 (bases 1 to 3262)
  AUTHORS   Villalba,M., Lopez-Otin,C., Martin-Orozco,E., Monsalve,R.I.,
            Palomino,P., Lahoz,C. and Rodriguez,R.
  TITLE     Isolation of three allergenic fractions of the major allergen from
            Olea europea pollen and N-terminal amino acid sequence
  JOURNAL   Biochem Biophys Res Commun 172 (2), 523-528 (1990)
   PUBMED   2241952
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM944255.1 and BC082298.1.
            
            On Jul 31, 2007 this sequence version replaced NM_053100.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082298.1, AK155303.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               BM944255.1         7-131
            126-3147            BC082298.1         1-3022
            3148-3262           BC082298.1         3024-3138
FEATURES             Location/Qualifiers
     source          1..3262
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 38.92 cM"
     gene            1..3262
                     /gene="Trim8"
                     /gene_synonym="GERP; Rnf27"
                     /note="tripartite motif-containing 8"
                     /db_xref="GeneID:93679"
                     /db_xref="MGI:MGI:1933302"
     exon            1..1366
                     /gene="Trim8"
                     /gene_synonym="GERP; Rnf27"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1462
                     /gene="Trim8"
                     /gene_synonym="GERP; Rnf27"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1696
                     /gene="Trim8"
                     /gene_synonym="GERP; Rnf27"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1728
                     /gene="Trim8"
                     /gene_synonym="GERP; Rnf27"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1844
                     /gene="Trim8"
                     /gene_synonym="GERP; Rnf27"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..3241
                     /gene="Trim8"
                     /gene_synonym="GERP; Rnf27"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3220..3225
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim8"
                     /gene_synonym="GERP; Rnf27"
                     /note="hexamer: AAGAAA"
     regulatory      3231..3236
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim8"
                     /gene_synonym="GERP; Rnf27"
                     /note="hexamer: AATAAA"
     polyA_site      3238
                     /gene="Trim8"
                     /gene_synonym="GERP; Rnf27"
                     /note="major polyA site"
     polyA_site      3241
                     /gene="Trim8"
                     /gene_synonym="GERP; Rnf27"
ORIGIN      
        1 tttttttttt tttttttttt tccacttctc tccctccccc ttccgtttct atttgtgaag
       61 ggaggaggaa ggcagaggcg ggctggtgtc tctggccggg gactggaatt tcatctgaat
      121 gactgcccca gcgcgcacgc agcgccccgg agtcggcccg cccgcgccct gccacccgca
      181 gccggccggc cagctggggg acgcctgcgc cacggcccgg ggaccgctgg cgcgccttgc
      241 tcgccggctc cggctctagc cagcctcggc gcggccgaac tagcttcccg tgccccctcg
      301 gacctcggcc gggatccagg cgaggaaggc gcggctcgca ccagccagaa ggtagccact
      361 gtcgccgcca aaggaagagt gcggctcccc cgctcggtgc gccgcggggc gcgccccgat
      421 gtcagccgcg gggccgagcg caggccgtgg gccgccgctg ccctagccgc gctgccccgg
      481 aggcggcctg ttatatggaa tttggaccac agcgctctcc tccagggctg gtgcccgggc
      541 cgcggccctg gcgcagcccg ccgcctcccg ctagccactc gccaggagga ggagacgcag
      601 ccggcggcgc gcgcggcgcg aggacccagg ctccctcctc tggggggcgg gcacgcggaa
      661 ggcgctggtg actgagcgac tggcgcggcc ggcggggacc ggagctccgg gctcggtggg
      721 tccccagctg taccagacgg atccccaggg ttggggactt agagaggtct acccgggccc
      781 cctgcccgca gccgccatgg cggagaattg gaagaactgc tttgaggagg agctcatctg
      841 ccccatctgc ctgcacgttt tcgtggaacc ggtgcagctg ccatgcaaac ataacttctg
      901 ccggggctgc atcggcgagg cttgggccaa ggacagtggc cttgtgcgct gcccggagtg
      961 caaccaggcc tacaatcaga agccgggcct ggagaagaac ctgaagctca ccaacatcgt
     1021 ggagaagttc aacgccctgc acgtggagaa gccgccgacg gcactgcact gcgtgttctg
     1081 tcgccgcggc cccccgctgc cggcacagaa ggtctgcctg cgctgcgagg ctccctgctg
     1141 ccagtctcac gtgcagacgc acctgcagca gccctccacc gcccgcgggc acctcctggt
     1201 ggaggcggac gacgtgcggg cctggagctg cccgcagcac aacgcctacc gcctgtacca
     1261 ctgcgaggcc gagcaggtgg ctgtgtgcca gtactgctgc tactacagcg gcgcgcatca
     1321 gggacactcg gtgtgtgacg tggagatacg gaggaatgag atacggaaga tgctcatgaa
     1381 gcagcaggag cggctggagg agagagagca ggacattgag gaccagctgt acaagctcga
     1441 gtcagacaag cgcctggtgg aggagaaagt gagccagctg aaggaggagg tgcggctgca
     1501 gtacgaaaag ctgcaccagc tgctggatga agacttgcgg cagacagtgg aggtcctgga
     1561 caaggcgcaa gccaagttct gcagcgagaa cgcggcgcag gcgctgcacc ttggggagcg
     1621 catgcaggag gccaagaagc tgctgggctc cctgcagcgt ctcttcgaca agacagagga
     1681 cgtcggcttc atgaagaaca ccaagtctgt gaaaatccta atggacagga cccagacctg
     1741 cacgggcagc agcctttctc cccctaagat cggccacctg aactccaagc tgttcctgaa
     1801 cgaggtggcc aagaaggaga agcagttgcg gaagatgcta gaaggtccct tcagcacacc
     1861 ggtgcccttc ctacagagcg tacccctgta cccttgtggt gtgaacagct ctggggccga
     1921 aaagcgcaag cactcgacag ccttccctga ggctagcttc ctggagactt cgtcaggccc
     1981 agtgggcggc cagtacgggg cagcgggcac agccagcagc gaggggcagt ctgggcagcc
     2041 cctgggtccc tgcagctcca cgcagcactt ggtggctctg ccaggcggta cccagccagt
     2101 acactcgagt cccgtgttcc ccccttcgca gtaccccaac ggctccacca cccagcaacc
     2161 catgctcccc cagtatggcg gccgcaagat tctcgtctgt tctgtggaca actgttactg
     2221 ctcttccgtg gccaaccacg gtggccacca gccgtacccc cgatccggcc acttcccctg
     2281 gacagtgccc tcacaggagt attcacaccc acttccaccc acaccctccg tccctcagtc
     2341 acttcctggc ctggcggtca gagactggct cgacgcttct cagcagcctg gccaccagga
     2401 tttctacagg gtgtatgggc agccgtccac caaacactat gtgacaagct aacgccaagc
     2461 aggcaatgga cgctggggac ccttctcccc agccccggtg gctcgggaat tatgcattca
     2521 gagaccggcc ctttccaccc tcctctctcc tttcttctcc attcctccac gtcatttctt
     2581 tttttggatt atgttttatt tagggtcttg ttttgatttt tttttttttt aattatgcat
     2641 ctcctggatg aggaggtgac ggtgggaagt agccttggcc cttggcaggg gctgcaggta
     2701 gccctggagt tgggacagta tcttaactca aggcactggg ctctctttcc ttttcttttt
     2761 aaaaaaaaac aaatcctacc cccttccctt cacaccccca tggctggaag aagccctgga
     2821 tggcagctct ttgctcgccc tgggaggcag cccagcaccc actgcccgtt tctcctccct
     2881 tcactggttc ctctgggcag tgtgatcact ggtggagaaa agagtgacct agagattgtg
     2941 gagggttttc tttgttttag ttttcaattt ttttttttta aaccaagagt gatttctata
     3001 gaccctcttt ctagccggaa gttcaaggcc acatctcaag cagcctttgg catcttcaaa
     3061 cccaagtgga atctttcaaa gccaggagcc ccgtgtccaa gaaaagctga gaaaaaaaaa
     3121 aaaaaaaaaa aggagaaaaa aaaaaaagga actttgccaa tgatagtgac cacagcgaaa
     3181 gcaaataata ataatattaa taataataaa gagaaataaa agaaataatg aataaaaaca
     3241 aaaaaaaaaa aaaaaaaaaa aa
//
