LOCUS       NM_001079932            2472 bp    mRNA    linear   ROD 08-DEC-2024
DEFINITION  Mus musculus tripartite motif-containing 72 (Trim72), mRNA.
ACCESSION   NM_001079932 XM_486011 XM_986291 XM_994564
VERSION     NM_001079932.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2472)
  AUTHORS   Jia,H., Zhou,L.C., Chen,Y.F., Zhang,W., Qi,W., Wang,P., Huang,X.,
            Guo,J.W., Hou,W.F., Zhang,R.R., Zhou,J.J. and Zhang,D.W.
  TITLE     Mitochondria-encoded peptide MOTS-c participates in plasma membrane
            repair by facilitating the translocation of TRIM72 to membrane
  JOURNAL   Theranostics 14 (13), 5001-5021 (2024)
   PUBMED   39267782
  REMARK    GeneRIF: Mitochondria-encoded peptide MOTS-c participates in plasma
            membrane repair by facilitating the translocation of TRIM72 to
            membrane.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2472)
  AUTHORS   Wu,J., Feng,Y., Wang,Y., He,X., Chen,Z., Lan,D., Wu,X., Wen,J.,
            Tsung,A., Wang,X., Ma,J. and Wu,Y.
  TITLE     MG53 binding to CAV3 facilitates activation of eNOS/NO signaling
            pathway to enhance the therapeutic benefits of bone marrow-derived
            mesenchymal stem cells in diabetic wound healing
  JOURNAL   Int Immunopharmacol 136, 112410 (2024)
   PUBMED   38843641
  REMARK    GeneRIF: MG53 binding to CAV3 facilitates activation of eNOS/NO
            signaling pathway to enhance the therapeutic benefits of bone
            marrow-derived mesenchymal stem cells in diabetic wound healing.
REFERENCE   3  (bases 1 to 2472)
  AUTHORS   Xue,Y., Song,T., Ke,J., Lin,S., Zhang,J., Chen,Y., Wang,J., Fan,Q.
            and Chen,F.
  TITLE     MG53 protects against Coxsackievirus B3-induced acute viral
            myocarditis in mice by inhibiting NLRP3 inflammasome-mediated
            pyroptosis via the NF-kappaB signaling pathway
  JOURNAL   Biochem Pharmacol 223, 116173 (2024)
   PUBMED   38552849
  REMARK    GeneRIF: MG53 protects against Coxsackievirus B3-induced acute
            viral myocarditis in mice by inhibiting NLRP3 inflammasome-mediated
            pyroptosis via the NF-kappaB signaling pathway.
REFERENCE   4  (bases 1 to 2472)
  AUTHORS   Sui,B., Zheng,J., Fu,Z., Zhao,L. and Zhou,M.
  TITLE     TRIM72 restricts lyssavirus infection by inducing K48-linked
            ubiquitination and proteasome degradation of the matrix protein
  JOURNAL   PLoS Pathog 20 (2), e1011718 (2024)
   PUBMED   38408103
  REMARK    GeneRIF: TRIM72 restricts lyssavirus infection by inducing
            K48-linked ubiquitination and proteasome degradation of the matrix
            protein.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2472)
  AUTHORS   Li,D., Li,L., Dong,S., Yu,Y., Zhang,L. and Jiang,S.
  TITLE     Alkylation Repair Homolog 5 Regulates N(6)-methyladenosine (m6A)
            Methylation of Mitsugumin 53 to Attenuate Myocardial Infarction by
            Inhibiting Apoptosis and Oxidative Stress
  JOURNAL   J Cardiovasc Pharmacol 83 (2), 183-192 (2024)
   PUBMED   37989146
  REMARK    GeneRIF: Alkylation Repair Homolog 5 Regulates N(6)-methyladenosine
            (m6A) Methylation of Mitsugumin 53 to Attenuate Myocardial
            Infarction by Inhibiting Apoptosis and Oxidative Stress.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2472)
  AUTHORS   Lee,C.S., Yi,J.S., Jung,S.Y., Kim,B.W., Lee,N.R., Choo,H.J.,
            Jang,S.Y., Han,J., Chi,S.G., Park,M., Lee,J.H. and Ko,Y.G.
  TITLE     TRIM72 negatively regulates myogenesis via targeting insulin
            receptor substrate-1
  JOURNAL   Cell Death Differ 17 (8), 1254-1265 (2010)
   PUBMED   20139895
  REMARK    GeneRIF: TRIM72 is a novel antagonist of IRS-1, and is essential as
            a negative regulator of IGF-induced muscle differentiation.
REFERENCE   7  (bases 1 to 2472)
  AUTHORS   Cai,C., Weisleder,N., Ko,J.K., Komazaki,S., Sunada,Y., Nishi,M.,
            Takeshima,H. and Ma,J.
  TITLE     Membrane repair defects in muscular dystrophy are linked to altered
            interaction between MG53, caveolin-3, and dysferlin
  JOURNAL   J Biol Chem 284 (23), 15894-15902 (2009)
   PUBMED   19380584
  REMARK    GeneRIF: Molecular complex formed by MG53, dysferlin, and Cav3 is
            essential for repair of muscle membrane damage in muscular
            dystrophy.
REFERENCE   8  (bases 1 to 2472)
  AUTHORS   Cai,C., Masumiya,H., Weisleder,N., Pan,Z., Nishi,M., Komazaki,S.,
            Takeshima,H. and Ma,J.
  TITLE     MG53 regulates membrane budding and exocytosis in muscle cells
  JOURNAL   J Biol Chem 284 (5), 3314-3322 (2009)
   PUBMED   19029292
  REMARK    GeneRIF: Co-expression studies indicated that MG53 activity is
            regulated by a functional interaction with caveolin-3
REFERENCE   9  (bases 1 to 2472)
  AUTHORS   Masumiya,H., Asaumi,Y., Nishi,M., Minamisawa,S., Adachi-Akahane,S.,
            Yoshida,M., Kangawa,K., Ito,K., Kagaya,Y., Yanagisawa,T.,
            Yamazaki,T., Ma,J. and Takeshima,H.
  TITLE     Mitsugumin 53-mediated maintenance of K+ currents in cardiac
            myocytes
  JOURNAL   Channels (Austin) 3 (1), 6-11 (2009)
   PUBMED   19202355
  REMARK    GeneRIF: Suggest MG53 is involved in a constitutive cycle of
            cell-surface proteins between the plasma membrane and endosome-like
            vesicles in striated muscle, and also that the vesicular dynamics
            are essential for the quality control of KV2.1 in cardiomyocytes.
REFERENCE   10 (bases 1 to 2472)
  AUTHORS   Cai,C., Masumiya,H., Weisleder,N., Matsuda,N., Nishi,M., Hwang,M.,
            Ko,J.K., Lin,P., Thornton,A., Zhao,X., Pan,Z., Komazaki,S.,
            Brotto,M., Takeshima,H. and Ma,J.
  TITLE     MG53 nucleates assembly of cell membrane repair machinery
  JOURNAL   Nat Cell Biol 11 (1), 56-64 (2009)
   PUBMED   19043407
  REMARK    GeneRIF: Intracellular vesicle translocation and Ca(2+)-dependent
            membrane fusion are distinct steps involved in the repair of
            membrane damage; MG53 may initiate the assembly of the membrane
            repair machinery in an oxidation-dependent manner.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124461.3 and AB231474.1.
            
            On Jul 30, 2009 this sequence version replaced NM_001079932.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067209.1, AB231474.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                AC124461.3         173523-173621
            100-2154            AB231474.1         4-2058
            2155-2472           AC124461.3         180221-180538
FEATURES             Location/Qualifiers
     source          1..2472
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.89 cM"
     gene            1..2472
                     /gene="Trim72"
                     /gene_synonym="MG53"
                     /note="tripartite motif-containing 72"
                     /db_xref="GeneID:434246"
                     /db_xref="MGI:MGI:3612190"
     exon            1..496
                     /gene="Trim72"
                     /gene_synonym="MG53"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..1540
                     /gene="Trim72"
                     /gene_synonym="MG53"
                     /EC_number="2.3.2.27"
                     /note="mitsugumin 53"
                     /codon_start=1
                     /product="tripartite motif-containing protein 72"
                     /protein_id="NP_001073401.1"
                     /db_xref="CCDS:CCDS40148.1"
                     /db_xref="GeneID:434246"
                     /db_xref="MGI:MGI:3612190"
                     /translation="MSAAPGLLRQELSCPLCLQLFDAPVTAECGHSFCRACLIRVAGE
                     PAADGTVACPCCQAPTRPQALSTNLQLSRLVEGLAQVPQGHCEEHLDPLSIYCEQDRT
                     LVCGVCASLGSHRGHRLLPAAEAQARLKTQLPQQKMQLQEACMRKEKTVAVLEHQLVE
                     VEETVRQFRGAVGEQLGKMRMFLAALESSLDREAERVRGDAGVALRRELSSLNSYLEQ
                     LRQMEKVLEEVADKPQTEFLMKFCLVTSRLQKILSESPPPARLDIQLPVISDDFKFQV
                     WKKMFRALMPALEELTFDPSSAHPSLVVSSSGRRVECSDQKAPPAGEDTRQFDKAVAV
                     VAQQLLSQGEHYWEVEVGDKPRWALGVMAADASRRGRLHAVPSQGLWLLGLRDGKILE
                     AHVEAKEPRALRTPERPPARIGLYLSFADGVLAFYDASNPDVLTPIFSFHERLPGPVY
                     PIFDVCWHDKGKNAQPLLLVGPEQEQA"
     exon            497..592
                     /gene="Trim72"
                     /gene_synonym="MG53"
                     /inference="alignment:Splign:2.1.0"
     exon            593..823
                     /gene="Trim72"
                     /gene_synonym="MG53"
                     /inference="alignment:Splign:2.1.0"
     exon            824..846
                     /gene="Trim72"
                     /gene_synonym="MG53"
                     /inference="alignment:Splign:2.1.0"
     exon            847..965
                     /gene="Trim72"
                     /gene_synonym="MG53"
                     /inference="alignment:Splign:2.1.0"
     exon            966..2472
                     /gene="Trim72"
                     /gene_synonym="MG53"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2446..2451
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim72"
                     /gene_synonym="MG53"
                     /note="hexamer: AATAAA"
     polyA_site      2472
                     /gene="Trim72"
                     /gene_synonym="MG53"
                     /note="major polyA site"
ORIGIN      
        1 tgggatgtga ggtagttaca ggatggggct ctgactgcgg ggccacagac ccagtgtagg
       61 attgagctgg aattcttgta atgggactcc tcttcccagg ctcaccatgt cggctgcacc
      121 cggccttctg cgtcaggaac tgtcctgccc actgtgcttg cagctgttcg atgcgccagt
      181 gacggctgag tgtggccaca gtttctgccg tgcctgcctg atccgggtgg caggggagcc
      241 tgctgcggac ggcacagttg cctgtccctg ttgtcaggca cctacacggc cgcaggctct
      301 aagcactaac ctccagttgt cacgccttgt ggagggtttg gcgcaagtgc cccaaggcca
      361 ctgcgaggaa cacctggatc cactgagcat ctactgcgag caggaccgca cacttgtgtg
      421 tggtgtgtgt gcctcgctcg gttctcaccg tggtcatcgt ctcctgcctg ccgctgaagc
      481 ccaagcacgc ctcaagacac agcttccaca gcagaagatg cagctgcagg aggcatgcat
      541 gcgcaaggag aagactgtag cggtgctgga gcatcagctg gtggaggtgg aggagacagt
      601 gcgccagttc cggggagctg tcggggagca gctggggaag atgcggatgt tcctggctgc
      661 cctagaaagt tctctggacc gtgaagcaga aagggttcgg ggtgatgctg gggttgcctt
      721 gcgtcgggag ctgtcaagcc tgaactctta cctagagcaa ctgaggcaga tggagaaggt
      781 gctggaggag gtggctgaca agccacagac agaattcctc atgaaattct gcctggtaac
      841 cagcaggctg cagaagatcc tgtcagagtc accaccaccg gcaaggctag atatccagct
      901 gcctgtcatc tcagatgact tcaaattcca ggtgtggaag aagatgttcc gggctctgat
      961 gccagcgctg gaggaactga cttttgaccc cagctctgcg cacccgagcc tggtggtgtc
     1021 ctcctctggt cgccgagtgg agtgctcaga ccagaaggcg ccgccagcgg gagaagacac
     1081 gcgtcagttc gacaaggcag tagcggtggt ggcgcagcag ctgctgtcac agggcgagca
     1141 ctattgggag gtggaggtgg gcgacaaacc acgctgggcc ctgggagtga tggcggctga
     1201 cgcttcccgc cgtggccggc tgcacgcggt gccctcacag gggctgtggc tgctgggtct
     1261 gcgcgatggc aagatcctgg aggcgcacgt ggaggccaag gagccgcggg cactgcgcac
     1321 cccagagagg cctccggcgc gcattggcct ctacctaagc ttcgcagatg gcgtcctggc
     1381 tttctatgat gcgagcaacc ccgacgtact tacgccaatc ttttctttcc acgagcgtct
     1441 gcccgggccg gtgtacccca tctttgacgt gtgctggcac gacaagggca agaatgccca
     1501 gcccctgctg cttgtggggc cggagcagga acaggcctga gctcctgccg actgggaggg
     1561 aggcctggtc ctgaaggcgg tgggatcact caggccacct ttgttaggtc tggatgggtt
     1621 gggtgggggt ggatttctag ggcctcaccc tctggctgag ggtggccagg aagtgggtgt
     1681 ttgtcttata gagttcaggg gagtacacag gttggggtgc acagggggac cgacgtgagg
     1741 gatagaggga agattactca ggtcagtgag gaaacctgag tttgggccaa gagttccagg
     1801 aggaagctga ggtttaggga ggctggggag aggataggat ttggaaagga tttagtggag
     1861 gatcttggga agtctgtgga acaatggtct cttcagccct gcgatccact cctgaaggcc
     1921 ccctcctttt caaggttgca gattcctcat acccgatggg ttttcaatta atgctcgtat
     1981 ctaactgtct tttcaaagcc cccagcagtc ctgagagggt gctgggtgca tggctataat
     2041 cccagcatcc aggaggctga ggcaagagga tgaaagttga aagccagcag gactctatca
     2101 aaaacaacag gggaaggggt cagagagggc tttttttttt tttttttttt ttttttggta
     2161 tttacttcat ttacatttca aatgctatcc tggaagtccc ctataccccc gcccccccct
     2221 gccccccact cccgcttctt ggccccggtg tttcatatca agtttgcagc agagagggct
     2281 tcttgaagct gtagagagct gtagagatgg ctcggtgtta tgggctgctc ttgcagagca
     2341 ttgaggatcc tccagtccca atgagtttga tggtctcttc cagcctctgt gagcatttgt
     2401 ggcacacaga tatatgtgcc ggcagaacac tgatacatgt taaaaaataa acagattccc
     2461 tctctatctc ta
//
