LOCUS       NM_001347446            2787 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus tripartite motif-containing 7 (Trim7), transcript
            variant 2, mRNA.
ACCESSION   NM_001347446 XM_006534570
VERSION     NM_001347446.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2787)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2787)
  AUTHORS   Wang,J., Qin,X., Huang,Y., Zhang,Q., Pei,J., Wang,Y., Goren,I.,
            Ma,S., Song,Z., Liu,Y., Xing,H., Wang,H. and Yang,B.
  TITLE     TRIM7/RNF90 promotes autophagy via regulation of ATG7
            ubiquitination during L. monocytogenes infection
  JOURNAL   Autophagy 19 (6), 1844-1862 (2023)
   PUBMED   36576150
  REMARK    GeneRIF: TRIM7/RNF90 promotes autophagy via regulation of ATG7
            ubiquitination during L. monocytogenes infection.
REFERENCE   3  (bases 1 to 2787)
  AUTHORS   Yang,B., Zhang,G., Qin,X., Huang,Y., Ren,X., Sun,J., Ma,S., Liu,Y.,
            Song,D., Liu,Y., Cui,Y., Wang,H. and Wang,J.
  TITLE     Negative Regulation of RNF90 on RNA Virus-Triggered Antiviral
            Immune Responses Targeting MAVS
  JOURNAL   Front Immunol 12, 730483 (2021)
   PUBMED   34512666
  REMARK    GeneRIF: Negative Regulation of RNF90 on RNA Virus-Triggered
            Antiviral Immune Responses Targeting MAVS.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2787)
  AUTHORS   Giraldo,M.I., Xia,H., Aguilera-Aguirre,L., Hage,A., van Tol,S.,
            Shan,C., Xie,X., Sturdevant,G.L., Robertson,S.J., McNally,K.L.,
            Meade-White,K., Azar,S.R., Rossi,S.L., Maury,W., Woodson,M.,
            Ramage,H., Johnson,J.R., Krogan,N.J., Morais,M.C., Best,S.M.,
            Shi,P.Y. and Rajsbaum,R.
  TITLE     Envelope protein ubiquitination drives entry and pathogenesis of
            Zika virus
  JOURNAL   Nature 585 (7825), 414-419 (2020)
   PUBMED   32641828
REFERENCE   5  (bases 1 to 2787)
  AUTHORS   Yang,B., Liu,Y., Cui,Y., Song,D., Zhang,G., Ma,S., Liu,Y., Chen,M.,
            Chen,F., Wang,H. and Wang,J.
  TITLE     RNF90 negatively regulates cellular antiviral responses by
            targeting MITA for degradation
  JOURNAL   PLoS Pathog 16 (3), e1008387 (2020)
   PUBMED   32126128
  REMARK    GeneRIF: findings suggested a novel function of RNF90 in innate
            immunity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2787)
  AUTHORS   Lu,M., Zhu,X., Yang,Z., Zhang,W., Sun,Z., Ji,Q., Chen,X., Zhu,J.,
            Wang,C. and Nie,S.
  TITLE     E3 ubiquitin ligase tripartite motif 7 positively regulates the
            TLR4-mediated immune response via its E3 ligase domain in
            macrophages
  JOURNAL   Mol Immunol 109, 126-133 (2019)
   PUBMED   30928727
  REMARK    GeneRIF: TRIM7 may facilitate the TLR4-mediated innate response via
            its E3 ligase domain in macrophages.
REFERENCE   7  (bases 1 to 2787)
  AUTHORS   Montori-Grau,M., Pedreira-Casahuga,R., Boyer-Diaz,Z., Lassot,I.,
            Garcia-Martinez,C., Orozco,A., Cebria,J., Osorio-Conles,O.,
            Chacon,M.R., Vendrell,J., Vazquez-Carrera,M., Desagher,S.,
            Jimenez-Chillaron,J.C. and Gomez-Foix,A.M.
  TITLE     GNIP1 E3 ubiquitin ligase is a novel player in regulating glycogen
            metabolism in skeletal muscle
  JOURNAL   Metabolism 83, 177-187 (2018)
   PUBMED   29466708
  REMARK    GeneRIF: GNIP1 is an ubiquitin ligase with a markedly glycogenic
            effect in skeletal muscle.
REFERENCE   8  (bases 1 to 2787)
  AUTHORS   Skurat,A.V., Dietrich,A.D., Zhai,L. and Roach,P.J.
  TITLE     GNIP, a novel protein that binds and activates glycogenin, the
            self-glucosylating initiator of glycogen biosynthesis
  JOURNAL   J Biol Chem 277 (22), 19331-19338 (2002)
   PUBMED   11916970
REFERENCE   9  (bases 1 to 2787)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645849.17.
            
            On Nov 29, 2016 this sequence version replaced XM_006534570.2.
            
            Transcript Variant: This variant (2) encodes the longer isoform
            (2).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2315106.1,
                                           SRR1660815.350820.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-575               AL645849.17        97194-97768
            576-671             AL645849.17        98560-98655
            672-902             AL645849.17        105159-105389
            903-925             AL645849.17        107238-107260
            926-1041            AL645849.17        107748-107863
            1042-1077           AL645849.17        108296-108331
            1078-2787           AL645849.17        109201-110910
FEATURES             Location/Qualifiers
     source          1..2787
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 28.8 cM"
     gene            1..2787
                     /gene="Trim7"
                     /note="tripartite motif-containing 7"
                     /db_xref="GeneID:94089"
                     /db_xref="MGI:MGI:2137353"
     exon            1..575
                     /gene="Trim7"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1589
                     /gene="Trim7"
                     /EC_number="2.3.2.27"
                     /note="isoform 2 is encoded by transcript variant 2;
                     tripartite motif-containing protein 7;
                     glycogenin-interacting protein; tripartite motif protein
                     7; E3 ubiquitin-protein ligase TRIM7"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM7 isoform 2"
                     /protein_id="NP_001334375.1"
                     /db_xref="CCDS:CCDS83797.1"
                     /db_xref="GeneID:94089"
                     /db_xref="MGI:MGI:2137353"
                     /translation="MATVGPRTGPNAGAEALALAAELQGEATCSICLEFFREPVSVEC
                     GHSFCRACIMRCWERPGAGTGTATRTLPCPLPCPQCREPARPSQLRPNRQLAAVASLL
                     RRFSLPPTAPGERGTPAVPARAAAARCSQHGEQLKLYCQDDGRAICVVCDRAREHRSH
                     AVLPLEEAVQEAKELLDSRLRALKKVLEDYEAFRSTEERESKELLKQMAAEKEKVGAE
                     FQALRAFLVEQEGRLLSRLEVLSREVTQKQNENLAQLEGEITQLSKLSGQIQETAQKP
                     DLDFLQEFKSTLSKCSSVPSSKPTTVSSEMKNKVWNVSLKSFVLKGLLKKFKEDLQGE
                     LEKEEKVELTLDPDTANPRLILSLDLKSVRLGQRAQDLPNHPRRFDTNTRVLASCGFS
                     SGRHHWEVEVGSKDGWAFGVARESVRRKGLTPFTPEEGVWAMQLNNGQYWAVTSPERT
                     QLNCGHLSRVRVALDLEVGAVSFYAVEDMRHLYTFRVNFQERVFPLFSVCSTGTYLRI
                     WP"
     exon            576..671
                     /gene="Trim7"
                     /inference="alignment:Splign:2.1.0"
     exon            672..902
                     /gene="Trim7"
                     /inference="alignment:Splign:2.1.0"
     exon            903..925
                     /gene="Trim7"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1041
                     /gene="Trim7"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1077
                     /gene="Trim7"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..2787
                     /gene="Trim7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtagcatcc agggacctcc ccaaagccac aagactcgaa tgtactaagg acacggatgg
       61 cgactgtggg gccgcggacc gggccgaacg caggagccga ggcgctggcc ctagcggcag
      121 agctccaagg cgaggcgacg tgctccatct gcctagagtt tttccgggag ccggtgtcag
      181 tcgaatgcgg ccacagcttc tgccgagcct gtattatgcg ctgctgggag cgtcccggag
      241 ctgggaccgg cacggcgacc cgcacgctgc cctgcccact gccctgtcct cagtgccgcg
      301 agcccgcgcg ccccagccag ctgcgaccca atcgacagct ggccgcggtg gcctcgctcc
      361 ttcggcgctt cagcctgccc cccaccgccc ccggggagcg cgggactcca gcggtgcctg
      421 cccgggcggc ggctgcgcgg tgctcccaac acggagagca acttaagctc tactgccaag
      481 acgacggccg cgccatttgc gtggtgtgcg accgcgcccg cgagcaccgt tcgcacgccg
      541 tgctgccgct ggaggaggcg gtgcaggagg ccaaggagtt gctggattcc aggctgaggg
      601 ccttgaagaa ggtactggaa gactatgaag cgttccggtc aacagaggag agggagagca
      661 aggagcttct aaagcagatg gcagcagaga aagagaaggt aggggcggag ttccaagcgc
      721 tgcgggcctt cctggtggag caggagggtc ggcttctaag ccgactggag gtgctgtccc
      781 gggaagtgac acagaaacag aatgagaacc tggcccagct ggagggtgag atcactcagc
      841 tgtccaaact cagcggccag atccaggaga cagctcagaa gccggaccta gacttcctcc
      901 aggagttcaa aagcacactg agcaagtgca gcagcgtgcc cagctccaag ccaaccacag
      961 tctcatctga gatgaagaat aaagtgtgga atgtttccct caagagtttc gtcttaaaag
     1021 gattgctgaa gaagttcaaa gaggatctcc agggagagct ggagaaagaa gagaaagtgg
     1081 aactcacttt ggatccagac acagccaacc cccgtctcat cttgtccctg gatctaaaga
     1141 gcgtacgtct aggacagcgc gcccaggact tgcctaacca tcctcgccgc tttgatacca
     1201 acacccgcgt tctggcatcc tgtggtttct cctctgggcg acatcactgg gaggtggaag
     1261 tgggctccaa ggacggctgg gctttcggtg tggcccggga gagcgtgcgt cgcaagggcc
     1321 tcacgccttt tacccccgag gagggcgtct gggcaatgca actcaacaat gggcaatact
     1381 gggcggtgac cagccccgag aggacacagc tcaactgtgg gcacttgtcg cgggtgaggg
     1441 tggcgctgga ccttgaggtg ggagcagtgt ccttctatgc agtggaggac atgcgccacc
     1501 tctacacctt ccgcgtcaac ttccaggagc gagtgttccc ccttttctct gtttgttcta
     1561 ccggcacata cttgagaatc tggccttgaa gagctgtcag gcttactagg aggggacagg
     1621 gcagcggtgt atctcggtga gaccgaggta ctttatcttg gaccttcctt cacaccccta
     1681 cttctgctgc ccaagaaggc tgccagagag cacaacacag gcgctgaaga ctgattgagc
     1741 aaagaggccc tgtgggtaac ttcgcgattg cacagcgaag agatgccttg gacccttggt
     1801 gcctgctggc tcctgtaatg ttcctgcaaa ttgtgtctga actatggaga ggcatggctc
     1861 actggcataa aaacccagct ttaagcaagg ctgcttctta ccacaagggc ttactgcctt
     1921 gatttagaag ggtccctgtt tacacagaac aatgtcaaag actagtcccc ttgcaaaggg
     1981 tgtggtttga ccctgggccc atcatgtatt actttacatt ttgtgacagc tgcaggctct
     2041 gcctggagag gtcgttgagt cccttggatc cagctggcct tcctggattg tttattctgg
     2101 gaggagcatt gtgctcccca attagaagcc agtctggctg gatctgaaag gagactcatg
     2161 acttatacaa gaggccagaa ctatagtata tacatataag cacattgccg ttctccagca
     2221 actccccccc ccccccccca tggcttctct gtgtagccct ggctgtcctg gaactctgca
     2281 gagcaggctg gccttgaact cagaaatcca cctgcctctg cctcccaagt gctggaatta
     2341 aaggcgtgcc tggctctctc cagcactctt tggggcatcc tttaccacat tgactgccag
     2401 tgtggtcaca gatgccttaa gcctcacatt ttcctttggc taaggagatc agaggttctg
     2461 gaactgtgaa acacatgttg atacttagga gtttacagat gcagctagca cccgtgtaga
     2521 gatgcacaca gctcaagcac agtcttaaca aaccctttct ggaacgttct aaatctatgc
     2581 aaacaccaga acatgctggt gacaaggatt cctgagcatc tgccctggag ggggttgggc
     2641 aggccagcct ccttagcctc tcctctcaac tggcttttgt tccatagtgt ccacaaagcg
     2701 aggcaaagaa gggcaggagt gggctgttcc ctgcttagtg ctctgcttgg aagtgggaga
     2761 ggagatcgaa atacagattg tgagcac
//
