LOCUS       NM_198012               2391 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus tripartite motif-containing 68 (Trim68), transcript
            variant 1, mRNA.
ACCESSION   NM_198012 XM_145747
VERSION     NM_198012.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2391)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2391)
  AUTHORS   Wynne,C., Lazzari,E., Smith,S., McCarthy,E.M., Ni Gabhann,J.,
            Kallal,L.E., Higgs,R., Greco,A., Cryan,S.A., Biron,C.A. and
            Jefferies,C.A.
  TITLE     TRIM68 negatively regulates IFN-beta production by degrading TRK
            fused gene, a novel driver of IFN-beta downstream of anti-viral
            detection systems
  JOURNAL   PLoS One 9 (7), e101503 (2014)
   PUBMED   24999993
  REMARK    Erratum:[PLoS One. 2015 Feb 09;10(2):e0117957. doi:
            10.1371/journal.pone.0117957.. Greco, Angela [added]. PMID:
            25664835]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2391)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2391)
  AUTHORS   Hatakeyama,S.
  TITLE     TRIM proteins and cancer
  JOURNAL   Nat Rev Cancer 11 (11), 792-804 (2011)
   PUBMED   21979307
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161431.4, AK089546.1, BY014556.1, AK164544.1 and CO424835.1.
            
            On Feb 14, 2018 this sequence version replaced NM_198012.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034249.1, SRR7345562.3583214.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AC161431.4         102642-102661       c
            21-36               AK089546.1         20-35
            37-57               BY014556.1         2-22
            58-1008             AK164544.1         2-952
            1009-1031           CO424835.1         415-437
            1032-2381           AK164544.1         953-2302
            2382-2391           AC161431.4         92913-92922         c
FEATURES             Location/Qualifiers
     source          1..2391
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.8 cM"
     gene            1..2391
                     /gene="Trim68"
                     /gene_synonym="F730114J12Rik; Rnf137; SS-56"
                     /note="tripartite motif-containing 68"
                     /db_xref="GeneID:101700"
                     /db_xref="MGI:MGI:2142077"
     exon            1..187
                     /gene="Trim68"
                     /gene_synonym="F730114J12Rik; Rnf137; SS-56"
                     /inference="alignment:Splign:2.1.0"
     exon            188..651
                     /gene="Trim68"
                     /gene_synonym="F730114J12Rik; Rnf137; SS-56"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..1683
                     /gene="Trim68"
                     /gene_synonym="F730114J12Rik; Rnf137; SS-56"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; ring
                     finger protein 137; E3 ubiquitin-protein ligase TRIM68;
                     tripartite motif-containing protein 68; RING-type E3
                     ubiquitin transferase TRIM68"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM68 isoform 1"
                     /protein_id="NP_932129.2"
                     /db_xref="CCDS:CCDS40052.1"
                     /db_xref="GeneID:101700"
                     /db_xref="MGI:MGI:2142077"
                     /translation="MDPAVLMEAIVEEVNCPICMTFLREPVSISCGHTFCHSCLSGLW
                     KLPGESQNLSYTCPLCRAPVKPRKLRPNWQLASVVDKVRLLGFCMEMGLKTDVCDLHK
                     EQLTMFCKEDDMVTCEACKQSPEHEAHSVVPIKDVAWEYKWKLQQALEHLRKEQEEAW
                     KLEVSEKEQAAIWKTQMERRKQSIRWEFEKYRQLLKEKELPCQQAEEEAAAAQASLEQ
                     EKGETASKLELRREAIIRQSQVLWSMIVELEERSQRPVRWMLQGIQEALNRSESWTLQ
                     QLEPISLELKTDCRVLGLRETLKTFAVDVRLDPDTAYSRLVVSKDRKSVHYGVTQQNL
                     PDNPERFYRYNIVLGSQCISSGRHYWEVEVGDRSEWGLGVCVENVDRKEVVYLSPRYG
                     FWVIRLRKGTEYRAGTDEYPLLPLTVPPHRVGIFLDYEAHDISFYNVTDGASHIFTFP
                     RYPFPGRLLPYFSPCYSIDTNNTTPLTICTLGGEG"
     exon            652..747
                     /gene="Trim68"
                     /gene_synonym="F730114J12Rik; Rnf137; SS-56"
                     /inference="alignment:Splign:2.1.0"
     exon            748..1008
                     /gene="Trim68"
                     /gene_synonym="F730114J12Rik; Rnf137; SS-56"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1031
                     /gene="Trim68"
                     /gene_synonym="F730114J12Rik; Rnf137; SS-56"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1132
                     /gene="Trim68"
                     /gene_synonym="F730114J12Rik; Rnf137; SS-56"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..2391
                     /gene="Trim68"
                     /gene_synonym="F730114J12Rik; Rnf137; SS-56"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2366..2371
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim68"
                     /gene_synonym="F730114J12Rik; Rnf137; SS-56"
                     /note="hexamer: AACAAA"
     polyA_site      2391
                     /gene="Trim68"
                     /gene_synonym="F730114J12Rik; Rnf137; SS-56"
                     /note="major polyA site"
ORIGIN      
        1 gggtgggtcc tgcagctccg ggcgcggctc ttgccttggg tccctcgccc ccgctgctat
       61 cgcggcttcc ggcggcgggc gagcgccccg ctgcttccta cgctgcggat tggaccgctg
      121 gagccccgcg cctccacagc tgcttagaga aggaggcgac agcagacctc tttggaggac
      181 aacacagcct tcattcatgt tctgagacga ctgtcacttg caaccatgga tcctgcagtg
      241 ttaatggaag ccattgtgga agaagtgaac tgtcctatct gtatgacctt cctcagggaa
      301 cctgtgagca tcagctgtgg ccacactttc tgccacagct gcctctctgg actctggaag
      361 ctcccaggag agtcccagaa cttgagctac acctgtcccc tttgtcgagc tcccgtgaag
      421 ccaaggaaac tccgtcccaa ttggcagctg gccagtgttg tagacaaggt ccgtctgcta
      481 ggcttctgta tggaaatggg actaaagacc gatgtgtgtg atctccacaa ggaacagcta
      541 accatgttct gcaaggagga tgatatggta acctgcgagg cctgtaagca gtccccagag
      601 catgaagccc acagtgttgt acccataaag gatgttgcct gggaatataa gtggaaactc
      661 cagcaggctc tggagcatct gaggaaagaa caggaagaag cctggaaact ggaagtcagt
      721 gagaaggaac aggctgccat ctggaagaca cagatggaaa gacgaaagca gagcatccga
      781 tgggagtttg aaaaatatcg gcagttatta aaggaaaagg agctgccctg ccagcaggca
      841 gaagaggagg cagctgcagc tcaggctagc ctcgagcagg agaagggaga gacagcaagc
      901 aaactggagt tgaggcgcga ggcgatcatc cggcagagcc aggtcctgtg gagcatgatt
      961 gtggagctgg aagagagatc ccagagacct gtgcgctgga tgctgcaggg tattcaggaa
     1021 gccttgaaca ggagcgagtc ttggaccctg cagcagctag agccaatctc cttggagctg
     1081 aagacagatt gccgtgtgct aggactaaga gagaccctga agacatttgc agtggatgtg
     1141 cgtctagatc cagacacagc ttactcccgc cttgtcgttt ccaaggacag aaaaagtgtg
     1201 cactatggag tcacccagca gaacctgcct gacaatcctg agagatttta ccgctataac
     1261 attgttttgg gcagccaatg catctcctcc ggccggcact actgggaggt agaggttgga
     1321 gacagatctg aatggggtct gggagtgtgt gtggaaaatg ttgaccggaa ggaggtggtg
     1381 tacttatccc ctcgctatgg cttctgggtg ataaggttga ggaaaggaac agagtaccgt
     1441 gcaggcacag atgaatatcc gctcctgccc ttgacagttc ctccgcaccg ggtaggaatc
     1501 ttcctagact atgaggccca tgacatctcc ttctataatg tgactgatgg tgcctcccac
     1561 attttcacct tcccccgcta tcccttccca ggccgtctct tgccctattt cagtccttgc
     1621 tacagcattg acactaacaa taccactcca ctcaccattt gtaccctggg tggggaaggc
     1681 taggagagcc atcctaactt aatagatcat tgttggagga tgcttccact gataagcata
     1741 tccctgaaca cagcttaaag cccaagagcc cctctatctg acctcatgat atgatgctgt
     1801 taaaaaaaaa ctgtcagtgc ctctcataga aaaacagtcc cagtgagata agcattgtga
     1861 tccatgatgg aaacatgaca gtggtgatag gctttgtcca ttcaggagat ctcagccctc
     1921 ctccctggtt ccataattaa gtgggtgcca gtgattaaat aaatgcagac tccagaaaag
     1981 cttttaaata tggttttcca ttaagagaag taataatgta catgcccaga actgattgcc
     2041 atggtgaaac caggtagagg gtccttcaag tgagatttgc tgctaccaaa caaaccctaa
     2101 cctccaggct agagaaacac aatttgtgct tttccagcac agaatgcaga actcacccag
     2161 ggtacttcct gtatctcctt cctgagcatg agggtgggtc tgtgccctgg gcctgtcttt
     2221 tctctaaggg gcaggatcag aaaccttagg ggccttagtt tttattttta ctgtatgtat
     2281 aaagaaattg aaacagcctt gtttcctaca gagcttcggg aagtaagatt ttaaagattg
     2341 taaaatgatt ttcacattaa aatgaaacaa agttgtcaaa ctcaatccac a
//
