LOCUS       NM_198632               8832 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus tripartite motif-containing 67 (Trim67), mRNA.
ACCESSION   NM_198632 XM_284448
VERSION     NM_198632.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8832)
  AUTHORS   Cai,C., Luo,Q., Jia,L., Xia,Y., Lan,X., Wei,X., Shi,S., Liu,Y.,
            Wang,Y., Xiong,Z., Shi,R., Huang,C. and Chen,Z.
  TITLE     TRIM67 Implicates in Regulating the Homeostasis and Synaptic
            Development of Mitral Cells in the Olfactory Bulb
  JOURNAL   Int J Mol Sci 24 (17), 13439 (2023)
   PUBMED   37686246
  REMARK    GeneRIF: TRIM67 Implicates in Regulating the Homeostasis and
            Synaptic Development of Mitral Cells in the Olfactory Bulb.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8832)
  AUTHORS   Jia,L., Chen,Z., Pan,T., Xia,Y., He,J., Jahangir,A., Wei,X.,
            Liu,W., Shi,R., Huang,C. and Luo,Q.
  TITLE     TRIM67 Deficiency Exacerbates Hypothalamic Inflammation and Fat
            Accumulation in Obese Mice
  JOURNAL   Int J Mol Sci 23 (16), 9438 (2022)
   PUBMED   36012700
  REMARK    GeneRIF: TRIM67 Deficiency Exacerbates Hypothalamic Inflammation
            and Fat Accumulation in Obese Mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8832)
  AUTHORS   Huang,C., Wei,X., Luo,Q., Xia,Y., Pan,T., He,J., Jahangir,A.,
            Jia,L., Liu,W., Zou,Y., Li,L., Guo,H., Geng,Y. and Chen,Z.
  TITLE     Loss of TRIM67 Attenuates the Progress of Obesity-Induced
            Non-Alcoholic Fatty Liver Disease
  JOURNAL   Int J Mol Sci 23 (13), 7475 (2022)
   PUBMED   35806477
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8832)
  AUTHORS   Fan,W., Liu,X., Zhang,J., Qin,L., Du,J., Li,X., Qian,S., Chen,H.
            and Qian,P.
  TITLE     TRIM67 Suppresses TNFalpha-Triggered NF-kB Activation by
            Competitively Binding Beta-TrCP to IkBa
  JOURNAL   Front Immunol 13, 793147 (2022)
   PUBMED   35273593
  REMARK    GeneRIF: TRIM67 Suppresses TNFalpha-Triggered NF-kB Activation by
            Competitively Binding Beta-TrCP to IkBa.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8832)
  AUTHORS   Urbina,F.L., Menon,S., Goldfarb,D., Edwards,R., Ben Major,M.,
            Brennwald,P. and Gupton,S.L.
  TITLE     TRIM67 regulates exocytic mode and neuronal morphogenesis via
            SNAP47
  JOURNAL   Cell Rep 34 (6), 108743 (2021)
   PUBMED   33567284
  REMARK    GeneRIF: TRIM67 regulates exocytic mode and neuronal morphogenesis
            via SNAP47.
REFERENCE   6  (bases 1 to 8832)
  AUTHORS   Boyer,N.P., McCormick,L.E., Menon,S., Urbina,F.L. and Gupton,S.L.
  TITLE     A pair of E3 ubiquitin ligases compete to regulate filopodial
            dynamics and axon guidance
  JOURNAL   J Cell Biol 219 (1) (2020)
   PUBMED   31820781
REFERENCE   7  (bases 1 to 8832)
  AUTHORS   Wang,S., Zhang,Y., Huang,J., Wong,C.C., Zhai,J., Li,C., Wei,G.,
            Zhao,L., Wang,G., Wei,H., Zhao,Z. and Yu,J.
  TITLE     TRIM67 Activates p53 to Suppress Colorectal Cancer Initiation and
            Progression
  JOURNAL   Cancer Res 79 (16), 4086-4098 (2019)
   PUBMED   31239268
REFERENCE   8  (bases 1 to 8832)
  AUTHORS   Boyer,N.P., Monkiewicz,C., Menon,S., Moy,S.S. and Gupton,S.L.
  TITLE     Mammalian TRIM67 Functions in Brain Development and Behavior
  JOURNAL   eNeuro 5 (3) (2018)
   PUBMED   29911180
  REMARK    GeneRIF: Study shows that mice lacking Trim67 exhibit abnormal
            anatomy of specific brain regions, including hypotrophy of the
            hippocampus, striatum, amygdala, and thalamus, and thinning of
            forebrain commissures. Additionally, Trim67-/- mice display
            impairments in spatial memory, cognitive flexibility, social
            novelty preference, muscle function, and sensorimotor gating,
            whereas several other behaviors remain intact.
            Erratum:[eNeuro. 2019 Aug 16;6(4):ENEURO.0281-19.2019. doi:
            10.1523/ENEURO.0281-19.2019.. PMID: 31420404]
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 8832)
  AUTHORS   Monaghan,C.E., Nechiporuk,T., Jeng,S., McWeeney,S.K., Wang,J.,
            Rosenfeld,M.G. and Mandel,G.
  TITLE     REST corepressors RCOR1 and RCOR2 and the repressor INSM1 regulate
            the proliferation-differentiation balance in the developing brain
  JOURNAL   Proc Natl Acad Sci U S A 114 (3), E406-E415 (2017)
   PUBMED   28049845
REFERENCE   10 (bases 1 to 8832)
  AUTHORS   Yaguchi,H., Okumura,F., Takahashi,H., Kano,T., Kameda,H.,
            Uchigashima,M., Tanaka,S., Watanabe,M., Sasaki,H. and Hatakeyama,S.
  TITLE     TRIM67 protein negatively regulates Ras activity through
            degradation of 80K-H and induces neuritogenesis
  JOURNAL   J Biol Chem 287 (15), 12050-12059 (2012)
   PUBMED   22337885
  REMARK    GeneRIF: TRIM67 regulates Ras signaling via degradation of 80K-H,
            leading to neural differentiation including neuritogenesis.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK051455.1, BC094596.1 and AC151736.6.
            
            On Jul 31, 2009 this sequence version replaced NM_198632.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3464789.1,
                                           SRR7652917.682592.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AK051455.1         2-74
            74-3837             BC094596.1         1-3764
            3838-4886           BC094596.1         3767-4815
            4887-7925           AC151736.6         60241-63279         c
            7926-8832           BC094596.1         4816-5722
FEATURES             Location/Qualifiers
     source          1..8832
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 72.81 cM"
     gene            1..8832
                     /gene="Trim67"
                     /gene_synonym="D130049O21Rik; TNL"
                     /note="tripartite motif-containing 67"
                     /db_xref="GeneID:330863"
                     /db_xref="MGI:MGI:3045323"
     exon            1..1887
                     /gene="Trim67"
                     /gene_synonym="D130049O21Rik; TNL"
                     /inference="alignment:Splign:2.1.0"
     CDS             883..3189
                     /gene="Trim67"
                     /gene_synonym="D130049O21Rik; TNL"
                     /note="TRIM9-like protein TNL"
                     /codon_start=1
                     /product="tripartite motif-containing protein 67"
                     /protein_id="NP_941034.2"
                     /db_xref="CCDS:CCDS52704.1"
                     /db_xref="GeneID:330863"
                     /db_xref="MGI:MGI:3045323"
                     /translation="MEEELKCPVCGSLFREPIILPCSHNVCLPCARTIAVQTPDGEQH
                     LPPPLLLSRGAAAAATPPDQDAAAGATSGGAGANTAGGLGGGATGGGDHADKLSLYSE
                     TDSGYGSYTPSLKSPNGVRVLPMVPAPPGSSAAAARGAACSSLCSSSSSITCPQCHRS
                     ASLDHRGLRGFQRNRLLEGIVQRYQQGRGVVPGAAAAPAVAICQLCDRTPPEPAATLC
                     EQCDVLYCATCQLKCHPSRGPFAKHRLVQPPPPPTPPEATPAVTGTSTASSAGGCRSP
                     GGAGASAPRKFPTCPEHEMENYSMYCVSCRSPVCYMCLEEGRHSKHEVKPLGATWKQH
                     KAQLSQALNGVSDKAKEAKEFLVQLKNILQQIQENGLDYEACLVAQCDALVDALTRQK
                     AKLLTKVTKEREHKLKMVWDQINHCTLKLRQSTGLMEYCLEVIKEDDPSGFLQISDAL
                     IKRVQTSQEQWVKGALEPKVSAEFDLTLDSEPLLQAIHQLDFVQMKLPPVPLLQLEKC
                     CTRNNSVTLAWRTPPFTHSPAEGYILELDDGDGGQFREVYVGKETLCTIDGLHFNSTY
                     NARVKAFNSSGVGPYSKTVVLQTSDVAWFTFDPNSGHRDIILSNDNQTATCSSYDDRV
                     VLGTAAFSKGVHYWELHVDRYDNHPDPAFGVARASVVKDMMLGKDDKAWAMYVDNNRS
                     WFMHCNSHTNRTEGGVCKGATVGVLLDLNKHTLTFFINGQQQGPTAFSHVDGVFMPAL
                     SLNRNVQVTLHTGLEVPTNLGRPKLSGN"
     exon            1888..1983
                     /gene="Trim67"
                     /gene_synonym="D130049O21Rik; TNL"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2106
                     /gene="Trim67"
                     /gene_synonym="D130049O21Rik; TNL"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2217
                     /gene="Trim67"
                     /gene_synonym="D130049O21Rik; TNL"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2371
                     /gene="Trim67"
                     /gene_synonym="D130049O21Rik; TNL"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..2517
                     /gene="Trim67"
                     /gene_synonym="D130049O21Rik; TNL"
                     /inference="alignment:Splign:2.1.0"
     exon            2518..2656
                     /gene="Trim67"
                     /gene_synonym="D130049O21Rik; TNL"
                     /inference="alignment:Splign:2.1.0"
     exon            2657..2960
                     /gene="Trim67"
                     /gene_synonym="D130049O21Rik; TNL"
                     /inference="alignment:Splign:2.1.0"
     exon            2961..3123
                     /gene="Trim67"
                     /gene_synonym="D130049O21Rik; TNL"
                     /inference="alignment:Splign:2.1.0"
     exon            3124..8808
                     /gene="Trim67"
                     /gene_synonym="D130049O21Rik; TNL"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3485
                     /gene="Trim67"
                     /gene_synonym="D130049O21Rik; TNL"
                     /note="major polyA site"
     regulatory      8785..8790
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim67"
                     /gene_synonym="D130049O21Rik; TNL"
                     /note="hexamer: AATAAA"
     polyA_site      8808
                     /gene="Trim67"
                     /gene_synonym="D130049O21Rik; TNL"
                     /note="major polyA site"
ORIGIN      
        1 actctcgctc tggaaattac aactcctggg cgcgcggcac ggcgggcggg cgggcgcggg
       61 aggcggtggg gccgggaggg ggattcccga gccagcgggt gctcgccccc cacccgccgc
      121 tgcagcgtgg cgcggccaag gtcaggggcg ctgcaggaac cggagccggc gaggccagcc
      181 tgggacgctg ctcaataccg gcctacgagg aggcagctca gagagcagcg gcccgagcag
      241 cggtacggcg acggtctccg ggccggggga tgccgaggtg gccgcggctg cacagcagcc
      301 tggcggagga tgcgcgcggg aggggggacg ggcgcggact ccgggcccat cctctcgcgg
      361 gcgctgtccg ccgtctggtg gtgctgaacc agccctggcc ccgccactcg ggcactggcc
      421 aagagctggg taggggcggg gcgctcgcag aaagaagact cggggcagcg gcgctgcgga
      481 gtcgggctca gtagccttgc tggctcacag cagcgggtca ctggtccttc gtggagtgga
      541 ggcacgaggt accccggacg gcgctactgc tgcctattca acacctggac aacctcggag
      601 gccaccgcga gggctccccg ccaccttcag acggctgcct ccggtgaggg agcctcgcct
      661 tcaggaggtg aggacccctc ctttctctgg cggccaagcg tcttagggcg gtggcctgag
      721 gacagagagg gggcgtgcca ccctcgggtg aagacagcat gcccgtgaaa tacccccgcc
      781 tcctgactca agagcgctga catcgccagc ccagctgcgc ttgtcttcgg agccttgacc
      841 attcttggct ggtcccgagc ggctctggcc gcgggcgcgg cgatggagga ggagctgaag
      901 tgcccagtgt gcggatccct gttccgggaa cccatcatcc tgccctgctc tcacaatgtc
      961 tgcttgccgt gcgcccgcac tatcgcggtt cagaccccgg acggcgagca gcacctgccc
     1021 ccgccgctcc ttctttcgcg aggtgccgcc gccgccgcaa cccctccgga tcaggacgca
     1081 gccgccggcg cgaccagcgg aggcgcggga gctaacacag ccggaggcct aggcggcggg
     1141 gcgaccggtg gcggagacca cgcggacaag ctgagcttgt acagcgagac tgacagcggc
     1201 tatggctcct acacccccag cctcaagtcc cccaatggag tccgcgtgct gcccatggtg
     1261 cctgcgcccc cgggctcttc ggccgccgcg gcccgaggcg ccgcctgctc ctcgctctgc
     1321 tcgtcctcca gctccatcac ctgcccgcag tgccaccgca gcgcctcctt ggatcaccgc
     1381 ggcctgcgag gcttccagcg caaccggcta ctggagggca ttgtgcagcg gtaccagcag
     1441 ggccgtgggg ttgttccggg ggcggctgca gccccggcgg tggccatctg ccagctgtgc
     1501 gaccgcaccc caccggagcc ggcagccact ctctgcgagc aatgcgacgt gctctattgc
     1561 gccacctgcc agctcaagtg ccacccgtcc cggggcccct tcgctaagca tcggctagtt
     1621 cagccaccgc cgccgcccac acccccagag gctacccctg ctgttacagg cacttccact
     1681 gcctccagcg caggaggatg caggagccca gggggtgccg gggccagcgc gccgcgaaag
     1741 ttccccacat gtcccgagca cgagatggag aactacagca tgtactgcgt gagctgtcgg
     1801 agccctgtgt gctacatgtg cctggaggaa ggcaggcaca gcaagcacga ggtgaagccg
     1861 ctgggggcaa cgtggaagca gcacaaggcc cagctgtctc aggccttaaa tggggtttca
     1921 gataaggcca aagaggcgaa ggagtttctg gttcagctca agaacatatt gcagcagatc
     1981 caggaaaatg gactggacta tgaagcttgc ctggtggctc agtgtgacgc cctggtggat
     2041 gccctgactc ggcagaaagc caagctgctc accaaggtga ccaaagagag ggagcacaag
     2101 ctgaagatgg tttgggacca gatcaatcac tgcaccctga agctacgcca gtccacgggc
     2161 ctgatggagt actgcctgga ggtgatcaag gaggacgacc cctccgggtt cctgcagatc
     2221 tcagacgcct tgatcaagcg cgtgcaaacc tcgcaagagc agtgggtcaa aggtgccctg
     2281 gagcccaaag tatctgcgga atttgacctg actctggaca gcgagccact gctgcaagcc
     2341 atccaccagc tggatttcgt ccagatgaaa ttgccacctg tacccctgct gcagctggag
     2401 aagtgctgca cccgcaacaa cagcgtcacc ctggcctgga ggactccgcc attcacccac
     2461 agccctgccg aaggctacat cctggagctg gatgatggcg atggagggca gttccgggag
     2521 gtgtatgttg gcaaggagac cctgtgcacc attgacgggc tgcactttaa tagcacctac
     2581 aatgccagag tcaaagcctt caactcctct ggtgttgggc cctacagcaa gactgtggtc
     2641 ctgcagacct ccgacgtggc ctggttcacc tttgacccca actctggcca tcgggacatc
     2701 atcttatcca atgacaacca gacggctact tgcagcagct atgatgaccg ggtggtgcta
     2761 ggcacagctg ccttctccaa aggcgtgcac tactgggagc tgcacgtgga ccgctatgac
     2821 aaccacccgg acccagcctt cggagtggcc agggccagcg tggtcaaaga tatgatgcta
     2881 ggcaaggatg acaaggcctg ggccatgtac gtggacaaca accgcagctg gttcatgcac
     2941 tgtaactccc ataccaacag gactgaaggc ggtgtgtgca agggggccac tgtgggtgtg
     3001 ctgctggacc taaacaaaca cactctgacc ttcttcatca atgggcaaca gcagggcccc
     3061 acagccttca gccacgtgga tggggtcttc atgcctgccc tcagcctcaa ccgaaacgtg
     3121 caggtcaccc tgcacacagg actggaggtg ccaacaaacc tgggacggcc aaagctgtca
     3181 ggcaactagc ctggtggctc ccgctgccta gctggccgtg atggagggct tcacggagga
     3241 ccagggcata acagaaagtc ctgggtgcca gcagccagcg gacatctgaa gacgcttttc
     3301 tgggggaact gagaatgaat cacatgcgag ccccacgacc atactgtggc cgcctatatc
     3361 aggagtggcc tttcacctca atgccacagg gctatggtcc cccccagggt gccctcaaga
     3421 tggacacctt ttgtttccgg cttatatttt ctgacatctg tttaaaaact ttgatttcct
     3481 cttaagtttt tgttttttgt tttcctggag ggagaggaga aggcagactc tgagactggt
     3541 atcccaggat ggatcagccc cgtgatgtta ctccatgcct gcctgtaacc cattgctagg
     3601 actctgttcc tttatggagt cccaggctga cagtttgtca cctctgcggg aagaaacgga
     3661 ccttgagcct ctgggatatg cagttttcaa tacactgcaa actaatttga aagggacatt
     3721 agtcattaat gaactgctag gacccttcag aaaggcttcc ttagggtctg tatcattacc
     3781 catgtgctgt tgacctctct ctctctctct ctctctcaca cacacacaca cacacactct
     3841 cacacacatg tgtgtgtatg tgtaacaatc tgttatattt tattcactca gttcttagtt
     3901 atgagtagaa acactggaat ccaagacagt gacacgtctt tgcacagtgg tggctttttc
     3961 tagaacctgc ttccacagaa attgctggac atatatctgc accgccttcc tgggctgggc
     4021 cttgatcaca gaggcggcag accctgggaa gacagactgt gcatctcagt aagctcttac
     4081 ggcttcaccc ggtgccctct ttgaagcatc atgaacacaa ggagcgaccc tggtggcgac
     4141 aggggtggct ctgtcacgat gagacagatg agaccccaga gaaaggctga aactagatgg
     4201 cgacacccta caacttctct tttcacatga gccagggttc cctgggatgc agccgagtct
     4261 tccttcttcc gaggagcact acccttgctg gggagttcca cacggagtca tcctgccttc
     4321 cggccctgtg tgctcacttc ctgtctctct cctgcagcca ccagctctgc ctggtagcaa
     4381 ccttgctcaa tcccttgcaa agaaatcatc tcatcatctc atcgggcgtt acgttctaca
     4441 cagagaaatg acttgcctgt cagcggggct gtttttatca gacatacctg cacgccgacc
     4501 ccaactgtgc ttccttgccg attctgtgct caggccctgc accagttccc aagtacccac
     4561 tactgggctg cacagacccg ccagtcctac ctcagaattc tttctcttgg tccttgtttc
     4621 ctcaaacact ccaacatcac caggagccct tcagcactgt ccagcctccg cactgggccc
     4681 tggggccata ttcattgcat aggcatagcc ttggcctctc tggactctct tcctgctaag
     4741 tggctcacag ctccatctcg agccctcggg gcagccgcag gaccccggcc gctgccgctg
     4801 ccatcctcag ttgctctgca gcttccgttg tccctttcct acagtctagc cacagccaca
     4861 gccacagctc tgaaaaggag gcacaggtac ttcaaaggga agaacatgga ggaacctctg
     4921 ccttcctggc ccaggaagtt gtggtcaggg gtggtccagg gatttgggtg tcttgtggaa
     4981 gagaaaccag aaaccctgga gtaagaacag ggcagaaagg ctggccacag agaatcttta
     5041 cagtctcaaa gcctgggcca atcaccttcc tgggaagcag gagtcacttg agccaatctg
     5101 cacctgtggg tggctttggg gagatgagaa agtgaccaca atcccaggtg actttttctt
     5161 cttccttcct tccttccttc cttccttcct tccttccttc cttccttcct tccttccttc
     5221 ctttcttttc tttttttttt ttcttttttg gtgctggaga acccaagcct tggccttgca
     5281 ctgagcctcc aactcttcag gaggccactt tcctcctcct ccccctcctc ctcttgttcc
     5341 tctttcacct cctcttcctc ctcctcttcc tcttcttcct cctcctcccc tcttctctcc
     5401 tcctttcttt gtcttccttc tcctcttccc cctcctcttc tcttcctctt cctcctcttt
     5461 cccctcctct tctcttcttc ctcctcctct cctcctcttc tacctcttcc tcttctttct
     5521 ccttctcctt ctcttcctct tcttcctcct cctcctcttt tttcttcttg ttttgtttga
     5581 gacatggtct cacactgtag cccaggctgg cctggaattc actatacagc tcaggctagc
     5641 cttgaactca cagcaatcct cctgcctcag cctcctgagt actgggatta cagaggtgag
     5701 caccacatcc aactcagatg acctctttaa ggaggttccc tggggttgaa cacagcagag
     5761 ccagctcccc gccccccaca ggagtatgag tgggcggggc tagctgtctc cctttgctca
     5821 ctggagccca gaagcaatat gctggtgcca gggacagccc aggcagccct gcacagccac
     5881 ctctcccctg ccttctgcac agggcgcctt tcagggacaa gaacgcatgg aggagagtag
     5941 ggtaagacgg ggtctcatga ttcgggtttg aggcaactgg aaaagtggca aggccctggg
     6001 atcatggggt tctatcccat ggagtcctta gcagctggca ctgaggttcc gctgctgtat
     6061 atgagtgata ccagcataag gccttccttt gtgagccact gagaaggacc tcggggtaag
     6121 tctgtcaaat gtccgcgaga aggaaattca gctcctgagc ctgttctctg ggtgagtcaa
     6181 tgaacgtcaa ttccttttga atgagtgtcc ttgataagta cccactggca cccactctac
     6241 acacagcacc tcttccctct cagcaggaca gcagtgccca cagagcaggt ttttccttct
     6301 ctgtcctgtc tgggaacaca gccccagttt taggagacag gcaccaacct tggcagtctc
     6361 acaccgtgtg tggtccaggc tgtaccttca gatctttatg tggttccaaa atgtccttag
     6421 ctgccctgtg gcctgaagga atccagagcc agggagcaat atgctgatag cagggtgggc
     6481 cctgaaacat ggacaagctc tgtgagagaa ggggtagggg tgaccacttt actgagccct
     6541 gtcttctgtg aaaggtaccc taacccctct caggtcagtg accatgggca cgtaccttcc
     6601 caggggcatc atgtcagcct tcattctttg agtgaaaggc ttgccccttg agtctgagac
     6661 atgattcagt gctgctgccc gggtttgcct ttcatcctgt ggcctgttgc agaggtgaag
     6721 ggggtggata aaaccatttg ggggtcctaa gaacacatca caggactgtg ggggtgaacc
     6781 cagggctctg tttctctccc aattttgggg gtgggacctg ggtgctggag agcattaagc
     6841 acccctggtc tctactctcc agatgccaat agcaccccca gttagtgtga cacccccaat
     6901 acctaagggc acccagatgc cccctggggc tggcctggat ctggattcgt tggatgttga
     6961 cattcatagc gttggtgggt acctcttcct gtgtcacata ggtctgtccc aaagccattg
     7021 gcctagtgtt aacccaacct aagaattctt cacaggtctt cagtaaggaa caaagggctc
     7081 acattttccc caactcccat ctccattctt gcaaaggaaa acttcccttt tcttggccac
     7141 agtttactgg taggagcagg gacatcttaa tggatctagg gccctcaagg ggttaaagaa
     7201 ttcttaccta tattgttaaa agactttcaa aacccacact agtcctggga actctggtac
     7261 cccaggaaaa gccagttgtc actgacagtc tagtatgaac tcctggctga aggggttcct
     7321 gacagctgag gggaagaggt gggtgaagga aaaggcaagc tgaggtaaac aggaggcttg
     7381 aggcacgacc aaaggccaga gtgcagagta tccctcacca cttacctctt aagctggctt
     7441 tggtgttgcc tcatggcatg tgtgggatga atctcctaac tgttctgtgc ctcagtatcc
     7501 ctccctgcaa caggactggt cataccaacc tacctccgct gtgtggatca tggaacagtc
     7561 tcaaaaataa ggtttgggct aaatggctca tttagtggat gtaacctggg tgggtgttat
     7621 tatgtcctct aaccacaata tcttcccgta agctccccgt gaccagggca gcacttgtca
     7681 cactgctgcc tggcatttca gacagctcac atgaccacag caagcacatt cctttagtgg
     7741 agagcctggg ttagtgaaat gttccagggc cttgaccagg ccaaaccctg agtgctaaag
     7801 acatctgcat gtgctatccc cgaagccaag aacatatatt agccagactt ttgcttcccg
     7861 ttccttcagt tctggtttct aggactcccc caaccccatg gcatttggct tttgttttcc
     7921 aacagtgggg atggctttgg aagtcacctg agagtgttat gacatacagc tgaactagga
     7981 cctcgagggg atggctggtc tcaagtgaat tttagacaac tgactgctgc caggatttcc
     8041 tggcataaac taagaagggt gggagcctga cctcttccac gaacgagcag ggctgaactc
     8101 ggtgggagga gctgggaccc gactctaggt gaaatgtctc cctctagtag tgatgctcac
     8161 tgagaacccc gttgtcaact cggctctggg aaagttccca gagttggagg gctagaagtg
     8221 gggccctggg caccattaag gctacacagc tgctggagat ttgggagtgg cccgcggtgg
     8281 ccgttccaag ccccaggaga ctggacttcc ctaagcaccc cgccgtctca gcaccagcgg
     8341 agagtggggt gtagacacaa ctgaaaacgt gaatgcatga tatagaaccg ccgcctttgc
     8401 actgcgcggc gcactgagca tgaacggtgt ttgtataatg ttggcgaagg aatttaacag
     8461 aaacagaaag ctgtgtaccg ttgtttggcc ccgttttccc gcctttcctt gccttctctt
     8521 cccccactct ccctactgat tctgttccca gtggttggta tttggtgaca gctcttggtt
     8581 ctgtggctgt ttatgtctca ctgaaaacac ggaggggtgg gcagtggtaa ggaaagtact
     8641 ttttttctaa ttttgtatag ctatccacaa gcgtttgtat tttttgaatt gcaaacactg
     8701 ttttctggtc cttgggggtt ggttaaactt cctgtattac tttttggaaa acttgagttt
     8761 taccacattc ttaaacagat ttgaaataaa ttcttttgac actgccaaaa aaaaaaaaaa
     8821 aaaaaaaaaa aa
//
