LOCUS       NM_001039048            1886 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus tripartite motif-containing 63 (Trim63), transcript
            variant 1, mRNA.
ACCESSION   NM_001039048 XM_485456 XM_900568
VERSION     NM_001039048.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1886)
  AUTHORS   da Mata,G.E., Bricola,R., Ribeiro,D.N., Simabuco,F.M., Pauli,J.R.,
            de Freitas,E.C., Ropelle,E.R., da Silva,A.S.R. and Pinto,A.P.
  TITLE     Acute exercise modulates Trim63 and Bmal1 in the skeletal muscle of
            IL-10 knockout mice
  JOURNAL   Cytokine 175, 156484 (2024)
   PUBMED   38159471
  REMARK    GeneRIF: Acute exercise modulates Trim63 and Bmal1 in the skeletal
            muscle of IL-10 knockout mice.
REFERENCE   2  (bases 1 to 1886)
  AUTHORS   Neyroud,D., Laitano,O., Dasgupta,A., Lopez,C., Schmitt,R.E.,
            Schneider,J.Z., Hammers,D.W., Sweeney,H.L., Walter,G.A., Doles,J.,
            Judge,S.M. and Judge,A.R.
  TITLE     Blocking muscle wasting via deletion of the muscle-specific E3
            ligase MuRF1 impedes pancreatic tumor growth
  JOURNAL   Commun Biol 6 (1), 519 (2023)
   PUBMED   37179425
  REMARK    GeneRIF: Blocking muscle wasting via deletion of the
            muscle-specific E3 ligase MuRF1 impedes pancreatic tumor growth.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1886)
  AUTHORS   Lindqvist,J., Kolb,J., de Winter,J., Tonino,P., Hourani,Z.,
            Labeit,S., Ottenheijm,C. and Granzier,H.
  TITLE     Removal of MuRF1 Increases Muscle Mass in Nemaline Myopathy Models,
            but Does Not Provide Functional Benefits
  JOURNAL   Int J Mol Sci 23 (15), 8113 (2022)
   PUBMED   35897687
  REMARK    GeneRIF: Removal of MuRF1 Increases Muscle Mass in Nemaline
            Myopathy Models, but Does Not Provide Functional Benefits.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1886)
  AUTHORS   Ghnaimawi,S., Zhang,S., Baum,J.I. and Huang,Y.
  TITLE     The Effects of Maternal Intake of EPA and DHA Enriched Diet During
            Pregnancy and Lactation on Offspring's Muscle Development and
            Energy Homeostasis
  JOURNAL   Front Physiol 13, 881624 (2022)
   PUBMED   35733999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1886)
  AUTHORS   Adams,V., Schauer,A., Augstein,A., Kirchhoff,V., Draskowski,R.,
            Jannasch,A., Goto,K., Lyall,G., Mannel,A., Barthel,P., Mangner,N.,
            Winzer,E.B., Linke,A. and Labeit,S.
  TITLE     Targeting MuRF1 by small molecules in a HFpEF rat model improves
            myocardial diastolic function and skeletal muscle contractility
  JOURNAL   J Cachexia Sarcopenia Muscle 13 (3), 1565-1581 (2022)
   PUBMED   35301823
  REMARK    GeneRIF: Targeting MuRF1 by small molecules in a HFpEF rat model
            improves myocardial diastolic function and skeletal muscle
            contractility.
REFERENCE   6  (bases 1 to 1886)
  AUTHORS   Witt,S.H., Granzier,H., Witt,C.C. and Labeit,S.
  TITLE     MURF-1 and MURF-2 target a specific subset of myofibrillar proteins
            redundantly: towards understanding MURF-dependent muscle
            ubiquitination
  JOURNAL   J Mol Biol 350 (4), 713-722 (2005)
   PUBMED   15967462
REFERENCE   7  (bases 1 to 1886)
  AUTHORS   Kedar,V., McDonough,H., Arya,R., Li,H.H., Rockman,H.A. and
            Patterson,C.
  TITLE     Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that
            degrades cardiac troponin I
  JOURNAL   Proc Natl Acad Sci U S A 101 (52), 18135-18140 (2004)
   PUBMED   15601779
REFERENCE   8  (bases 1 to 1886)
  AUTHORS   Arya,R., Kedar,V., Hwang,J.R., McDonough,H., Li,H.H., Taylor,J. and
            Patterson,C.
  TITLE     Muscle ring finger protein-1 inhibits PKC{epsilon} activation and
            prevents cardiomyocyte hypertrophy
  JOURNAL   J Cell Biol 167 (6), 1147-1159 (2004)
   PUBMED   15596539
REFERENCE   9  (bases 1 to 1886)
  AUTHORS   Valenzuela,D.M., Murphy,A.J., Frendewey,D., Gale,N.W.,
            Economides,A.N., Auerbach,W., Poueymirou,W.T., Adams,N.C.,
            Rojas,J., Yasenchak,J., Chernomorsky,R., Boucher,M., Elsasser,A.L.,
            Esau,L., Zheng,J., Griffiths,J.A., Wang,X., Su,H., Xue,Y.,
            Dominguez,M.G., Noguera,I., Torres,R., Macdonald,L.E.,
            Stewart,A.F., DeChiara,T.M. and Yancopoulos,G.D.
  TITLE     High-throughput engineering of the mouse genome coupled with
            high-resolution expression analysis
  JOURNAL   Nat Biotechnol 21 (6), 652-659 (2003)
   PUBMED   12730667
REFERENCE   10 (bases 1 to 1886)
  AUTHORS   Bodine,S.C., Latres,E., Baumhueter,S., Lai,V.K., Nunez,L.,
            Clarke,B.A., Poueymirou,W.T., Panaro,F.J., Na,E., Dharmarajan,K.,
            Pan,Z.Q., Valenzuela,D.M., DeChiara,T.M., Stitt,T.N.,
            Yancopoulos,G.D. and Glass,D.J.
  TITLE     Identification of ubiquitin ligases required for skeletal muscle
            atrophy
  JOURNAL   Science 294 (5547), 1704-1708 (2001)
   PUBMED   11679633
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ131880.1, AL627314.6, CK128385.1, AJ278734.1 and AL627253.9.
            
            On Jan 26, 2007 this sequence version replaced NM_001039048.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849375,
                              SAMN00849385 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-490               CJ131880.1         2-491
            491-605             AL627314.6         191548-191662
            606-1153            CK128385.1         149-696
            1154-1174           AJ278734.1         26-46
            1175-1886           AL627253.9         6319-7030
FEATURES             Location/Qualifiers
     source          1..1886
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 66.58 cM"
     gene            1..1886
                     /gene="Trim63"
                     /gene_synonym="MuRF1; RF1; Rnf28"
                     /note="tripartite motif-containing 63"
                     /db_xref="GeneID:433766"
                     /db_xref="MGI:MGI:2447992"
     exon            1..263
                     /gene="Trim63"
                     /gene_synonym="MuRF1; RF1; Rnf28"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..1172
                     /gene="Trim63"
                     /gene_synonym="MuRF1; RF1; Rnf28"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     ubiquitin-protein ligase TRIM63; MURF-1; muscle-specific
                     RING finger protein 1; tripartite motif-containing protein
                     63; ring finger protein 28; muscle ring finger protein 1;
                     RING-type E3 ubiquitin transferase TRIM63"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM63 isoform 1"
                     /protein_id="NP_001034137.2"
                     /db_xref="CCDS:CCDS38914.1"
                     /db_xref="GeneID:433766"
                     /db_xref="MGI:MGI:2447992"
                     /translation="MDYKSSLIPDGNAMENLEKQLICPICLEMFTKPVVILPCQHNLC
                     RKCANDIFQAANPYWTNRGGSVSMSGGRFRCPSCRHEVIMDRHGVYGLQRNLLVENII
                     DIYKQECSSRPLQKGSHPMCKEHEDEKINIYCLTCEVPTCSLCKVFGAHQACEVAPLQ
                     SIFQGQKTELSNCISMLVAGNDRVQTIISQLEDSCRVTKENSHQVKEELSQKFDTLYA
                     ILDEKKSELLQRITQEQEEKLGFIEALILQYREQLEKSTKLVETAIQSLDEPGGATFL
                     SSAKQLIKSIVEASKGCQLGKTEQGFENMDYFTLDLEHIAEALRAIDFGTDEEEEEEE
                     FTEEEADEEEGVTTEGKEEHQ"
     exon            264..436
                     /gene="Trim63"
                     /gene_synonym="MuRF1; RF1; Rnf28"
                     /inference="alignment:Splign:2.1.0"
     exon            437..605
                     /gene="Trim63"
                     /gene_synonym="MuRF1; RF1; Rnf28"
                     /inference="alignment:Splign:2.1.0"
     exon            606..701
                     /gene="Trim63"
                     /gene_synonym="MuRF1; RF1; Rnf28"
                     /inference="alignment:Splign:2.1.0"
     exon            702..935
                     /gene="Trim63"
                     /gene_synonym="MuRF1; RF1; Rnf28"
                     /inference="alignment:Splign:2.1.0"
     exon            936..958
                     /gene="Trim63"
                     /gene_synonym="MuRF1; RF1; Rnf28"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1083
                     /gene="Trim63"
                     /gene_synonym="MuRF1; RF1; Rnf28"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1161
                     /gene="Trim63"
                     /gene_synonym="MuRF1; RF1; Rnf28"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1886
                     /gene="Trim63"
                     /gene_synonym="MuRF1; RF1; Rnf28"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaagtcggg ggtcagggga cgaagacaaa gaggatccga gtgggtttgg agacaaagac
       61 ttggtgtgac gcaggtgggc gagacagtcg catttcaaag caatatggat tataaatcta
      121 gcctgattcc tgatggaaac gctatggaga acctggagaa gcagctgatc tgccccatct
      181 gcctggagat gtttaccaag cctgtggtca tcctgccctg ccaacacaac ctctgccgga
      241 agtgtgccaa cgacatcttc caggctgcga atccctactg gaccaaccgc ggtggctcag
      301 tgtccatgtc tggaggtcgt ttccgttgcc cctcgtgccg ccatgaagtg atcatggacc
      361 ggcacggggt gtacggcctg cagaggaacc tgctggtgga aaacatcatt gacatctaca
      421 agcaggagtg ctccagtcgg cccctgcaga aaggcagcca cccgatgtgc aaggaacacg
      481 aagacgagaa aatcaacatc tactgtctca cgtgtgaggt gcctacttgc tccttgtgca
      541 aggtgtttgg ggctcaccag gcctgtgagg ttgccccttt gcaaagcatc ttccaaggac
      601 agaagactga gctgagtaac tgcatctcca tgctggtggc gggcaacgac cgagtgcaga
      661 cgatcatctc tcagctggag gactcctgca gagtgaccaa ggagaatagc caccaggtga
      721 aggaggagct gagtcagaag tttgacaccc tctacgccat cctggacgag aagaagagcg
      781 agctgctgca gcggatcacg caggagcagg aggagaagct gggcttcatc gaggctctga
      841 tcctccagta cagggagcag ctggaaaagt ccaccaaact tgtggagacc gccatccagt
      901 ccctggatga gcccggaggg gctaccttcc tctcaagtgc caagcagctc atcaagagca
      961 ttgtagaagc ctccaagggc tgccagctgg ggaagacaga gcaaggcttt gagaacatgg
     1021 actactttac tctggactta gaacacatag cagaggcctt gagggccatt gactttggga
     1081 cagatgagga ggaggaggag gaggagttta cagaagagga ggctgatgag gaagagggcg
     1141 tgaccacaga gggtaaagaa gaacaccaat gaagaaggag atgagtgaga cacgctctgg
     1201 acgcagagac gggggaggtg ggggcaggcc catctcggga gggggttagg gctccttggg
     1261 gggtacaata gggaagtgtg tcttctctct gctcagagag cagggactag catagggctc
     1321 cccaccactg tgtccagcag ctgctgaaac acaattggaa atgtatccaa aacgtcacag
     1381 gacacttttc tacgttggtg cgaaatgaaa tattttgtat gtttttaaaa tgtgattttt
     1441 gtatatactt gtatatgtat gccaatttgg tgctttttgt acgagaactt ttgtatgatc
     1501 acgcctggtc attgtgtgac tggcgattgt cacaaagtgg gaaggaagcc aagacaatag
     1561 agatgcctac ttcctttcct tggtgggagg gctgggtctc actcggtggc ctagagaggg
     1621 gcaatgtact gtacagtgcc catccccaaa catggggata ggactgaatt tgtgttatat
     1681 gttgttttgc acaaggggct gggccttggg gcacacaccc tttgatccca gcactctgga
     1741 ggcagaggca gttggatctc tatgagttca aggccagcct ggtctacatg gagagttaca
     1801 ggccagccag agctacatag agagactctg cctcaaaaat aaaaatgaaa aagaataaaa
     1861 aataaactca caatgctctt ttcctg
//
