LOCUS       NM_178110               3294 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus tripartite motif-containing 62 (Trim62), transcript
            variant 2, mRNA.
ACCESSION   NM_178110
VERSION     NM_178110.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3294)
  AUTHORS   Liu,X. and Lei,Q.
  TITLE     TRIM62 knockout protects against cerebral ischemic injury in mice
            by suppressing NLRP3-regulated neuroinflammation
  JOURNAL   Biochem Biophys Res Commun 529 (2), 140-147 (2020)
   PUBMED   32703402
  REMARK    GeneRIF: TRIM62 knockout protects against cerebral ischemic injury
            in mice by suppressing NLRP3-regulated neuroinflammation.
REFERENCE   2  (bases 1 to 3294)
  AUTHORS   Chowdhury,R., Laboissonniere,L.A., Wester,A.K., Muller,M. and
            Trimarchi,J.M.
  TITLE     The Trim family of genes and the retina: Expression and functional
            characterization
  JOURNAL   PLoS One 13 (9), e0202867 (2018)
   PUBMED   30208054
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3294)
  AUTHORS   Cao,Z., Conway,K.L., Heath,R.J., Rush,J.S., Leshchiner,E.S.,
            Ramirez-Ortiz,Z.G., Nedelsky,N.B., Huang,H., Ng,A., Gardet,A.,
            Cheng,S.C., Shamji,A.F., Rioux,J.D., Wijmenga,C., Netea,M.G.,
            Means,T.K., Daly,M.J. and Xavier,R.J.
  TITLE     Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal
            Immunity and Intestinal Inflammation
  JOURNAL   Immunity 43 (4), 715-726 (2015)
   PUBMED   26488816
  REMARK    GeneRIF: Ubiquitination of CARD9 by TRIM62 regulates CARD9-mediated
            anti-fungal immunity. Trim62-deficient mice had increased
            susceptibility to fungal infection.
REFERENCE   4  (bases 1 to 3294)
  AUTHORS   Lewandowski,J.P., Du,F., Zhang,S., Powell,M.B., Falkenstein,K.N.,
            Ji,H. and Vokes,S.A.
  TITLE     Spatiotemporal regulation of GLI target genes in the mammalian limb
            bud
  JOURNAL   Dev Biol 406 (1), 92-103 (2015)
   PUBMED   26238476
REFERENCE   5  (bases 1 to 3294)
  AUTHORS   Quintas-Cardama,A., Post,S.M., Solis,L.M., Xiong,S., Yang,P.,
            Chen,N., Wistuba,I.I., Killary,A.M. and Lozano,G.
  TITLE     Loss of the novel tumour suppressor and polarity gene Trim62
            (Dear1) synergizes with oncogenic Ras in invasive lung cancer
  JOURNAL   J Pathol 234 (1), 108-119 (2014)
   PUBMED   24890125
  REMARK    GeneRIF: Trim62 loss cooperates with K-Ras mutation in
            tumourigenesis and metastasis in vivo, indicating that decreased
            levels of TRIM62 may play an important role in the evolution of
            lung cancer.
REFERENCE   6  (bases 1 to 3294)
  AUTHORS   Chen,N., Balasenthil,S., Reuther,J., Frayna,A., Wang,Y.,
            Chandler,D.S., Abruzzo,L.V., Rashid,A., Rodriguez,J., Lozano,G.,
            Cao,Y., Lokken,E., Chen,J., Frazier,M.L., Sahin,A.A., Wistuba,I.I.,
            Sen,S., Lott,S.T. and Killary,A.M.
  TITLE     DEAR1 is a chromosome 1p35 tumor suppressor and master regulator of
            TGF-beta-driven epithelial-mesenchymal transition
  JOURNAL   Cancer Discov 3 (10), 1172-1189 (2013)
   PUBMED   23838884
REFERENCE   7  (bases 1 to 3294)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL607086.19.
            
            On May 28, 2019 this sequence version replaced NM_178110.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049095.1, SRR11927936.2397870.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-534               AL607086.19        22288-22821
            535-630             AL607086.19        35064-35159
            631-887             AL607086.19        38790-39046
            888-1003            AL607086.19        40717-40832
            1004-3294           AL607086.19        47280-49570
FEATURES             Location/Qualifiers
     source          1..3294
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 62.38 cM"
     gene            1..3294
                     /gene="Trim62"
                     /gene_synonym="6330414G21Rik; Dear1"
                     /note="tripartite motif-containing 62"
                     /db_xref="GeneID:67525"
                     /db_xref="MGI:MGI:1914775"
     exon            1..534
                     /gene="Trim62"
                     /gene_synonym="6330414G21Rik; Dear1"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..1554
                     /gene="Trim62"
                     /gene_synonym="6330414G21Rik; Dear1"
                     /EC_number="2.3.2.27"
                     /note="isoform 2 is encoded by transcript variant 2;
                     tripartite motif-containing protein 62; E3
                     ubiquitin-protein ligase TRIM62; RING-type E3 ubiquitin
                     transferase TRIM62"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM62 isoform 2"
                     /protein_id="NP_835211.1"
                     /db_xref="CCDS:CCDS18677.1"
                     /db_xref="GeneID:67525"
                     /db_xref="MGI:MGI:1914775"
                     /translation="MACSLKDELLCSICLSIYQDPVSLGCEHYFCRRCITEHWVRQEA
                     QGARDCPECRRTFAEPALAPSLKLANIVERYSAFPLDAILNARRAARPCQAHDKVKLF
                     CLTDRALLCFFCDEPALHEQHQVTGIDDAFEELQRELKEQLQALQDSEREHTEALQLL
                     KRQLAETKSSTKSLRTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRY
                     SQQLRKVQEGAQILQERLAETDRHTFLAGVASLSERLKGKIHETNLTYEDFPTSKYTG
                     PLQYTIWKSLFQDIHPVPAALTMDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRF
                     DVEVSVLGSEAFSSGVHYWEVVVAEKTQWVIGLAHEAASRKGSIQIQPSRGFYCIVMH
                     DGNQYSACTEPWTRLNVRDKLDKVGVFLDYDQGLLIFYNADDMSWLYTFREKFPGKLC
                     SYFSPGQSHANGKNVQPLRINTVRI"
     exon            535..630
                     /gene="Trim62"
                     /gene_synonym="6330414G21Rik; Dear1"
                     /inference="alignment:Splign:2.1.0"
     exon            631..887
                     /gene="Trim62"
                     /gene_synonym="6330414G21Rik; Dear1"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1003
                     /gene="Trim62"
                     /gene_synonym="6330414G21Rik; Dear1"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..3294
                     /gene="Trim62"
                     /gene_synonym="6330414G21Rik; Dear1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3280..3285
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim62"
                     /gene_synonym="6330414G21Rik; Dear1"
                     /note="hexamer: ATTAAA"
     polyA_site      3294
                     /gene="Trim62"
                     /gene_synonym="6330414G21Rik; Dear1"
                     /note="major polyA site"
ORIGIN      
        1 gctccccccg cgctccccgg cgcctgtcgc ccgtgccccc gtgggcctgg cccccgggta
       61 ccgcccccaa tcgcgccgcg ccggccgccg gcctcccggg ctccgcttcg cgccgcccct
      121 ggcgccatgg cgtgcagcct caaggacgag ctgctgtgct ccatctgcct gagcatctac
      181 caggacccgg tgagcctggg ctgcgagcac tacttctgcc gccgctgcat caccgagcac
      241 tgggtgcggc aggaggctca gggcgcccgc gactgcccgg agtgccggcg cacgttcgcc
      301 gagcccgcgc tcgcgcccag cctcaagctg gccaacatcg tggagcgcta cagcgccttc
      361 ccgctggacg ccatcctcaa cgcgcgccga gccgcgcgac cctgccaggc tcacgacaag
      421 gtcaagctct tctgcctcac ggaccgcgca ctgctctgct tcttctgtga tgagcccgcg
      481 ctgcacgagc aacaccaggt cactggcatc gacgatgcct tcgaggagtt gcagagagaa
      541 ctgaaggagc agcttcaggc ccttcaggac agcgagcggg aacacacgga ggcgctgcag
      601 ctcctcaagc gacagttggc agagaccaag tcctctacca agagcctgcg gaccaccatc
      661 ggggaagcct ttgagcggct gcaccggcta cttcgagagc gacagaaggc catgctggag
      721 gaactggagg ccgacacagc ccgcacactg acggacattg agcagaaggt ccagcgttac
      781 agccagcaac tacgaaaggt gcaagagggg gcccagatcc tgcaggagcg gctggcagag
      841 actgaccgcc acaccttcct tgcaggagtg gcctccctgt ctgagaggct caaggggaag
      901 attcatgaga ccaacctaac gtacgaagac ttcccgacct ccaagtacac aggccccctg
      961 cagtacacca tctggaaatc gcttttccag gacatccatc cagtgccagc tgccctgacc
     1021 atggacccag gcactgccca ccagcgcctg atcctgtccg atgactgcac catcgtggcc
     1081 tacgggaacc tacacccaca accactgcag gactcaccaa agcgctttga cgtagaggtg
     1141 tcggtgctgg gctctgaagc cttcagtagc ggtgtccact actgggaggt ggtggtggcg
     1201 gagaagaccc agtgggtgat tgggctggcc catgaggctg ccagtcgcaa aggcagcatc
     1261 cagattcagc ctagccgcgg cttctactgc atcgttatgc atgacggtaa ccagtacagc
     1321 gcctgcacag agccctggac taggctcaac gtccgtgaca agcttgacaa ggtgggcgtc
     1381 ttcctggact atgaccaggg cctcctcatc ttctacaacg ccgatgacat gtcctggctc
     1441 tacaccttcc gagagaagtt tcctggcaag ctctgctcct acttcagccc cggccagagc
     1501 cacgccaatg gcaagaacgt ccaaccactg cggatcaaca ccgtccgcat ctaatctggg
     1561 cagagggaga ccaaagcctc ctggggctgt gaccaccagc aagagccttg cctgacagat
     1621 ggaggacctg gactgctcag gcccactgtg gccaccctga gacctcaggc caactgtttg
     1681 tcccctcctc ctccccttct gcgagctgga gattgcactc cgtggttgat gccctgtggc
     1741 tctgatctta atgggatgtg acatggcttc tccccagggc agcccttgcc caacccctca
     1801 tccccattct ctcaggaaca gggaagctct ctgttcccct cctcctgccc agctaaccta
     1861 gcatcgtgac aggtcagatg tgatcagtag ctagcagccc aaaaggtata caaaatcctc
     1921 ttatgcctaa gaattgactc acccttgacc aggagagcta tgggccattt tactttggat
     1981 ccaattcctt aggggagctt ggcagaagct ggattatttg agagtcaccc tctcttgcta
     2041 cccgtgctcc aagccgagaa ctgtgggttt cctcctctct cactgatctg caagtcacac
     2101 aagacaggta gctcacaaca taccattacc ttctagccca tggattctgg ggcagagtga
     2161 ggtataagga ccctagaaac ccatatagaa gaacaccatc aggacaaagc accaatggat
     2221 gatccaagtc cccaacagcc cctggggaca gaggtcctac aatcctcatc acacaggtct
     2281 ctgacctact gcatggacgg agagggtgct ggcagcagct ttttttccgt caggacctga
     2341 agcccaggag attgttatcg ggtaccaccc tggacttgac atctggctcc cttaggatcc
     2401 tgaggcacaa acaatagccg ccttagttga cttcatcaga caagaatttg cagtcagctc
     2461 cctggtgact tgcaagatca ctgaaaggga tggaagagga cagcctttgc cagagtttcc
     2521 aggaacagct cccaccatct agagggtttg tgtcttgtga ccagaatggt gcttccattt
     2581 gcagctgccc cacaagctgc tggctgccac catccacgcc agaaagttat tgtccgtgtc
     2641 tgtcccacca caccacaccc cccaactcgg gtcccagttc tacatctttc agagggattc
     2701 tttttgtgga aacttgagtc cagaacctag actttgactg caaagcactc tgagaaatgt
     2761 agtttttcct cttccagcct cagccacaaa gttatcatgg aggtggaata gatccatcca
     2821 caatttcctt gccaatgaat ccaactgtga agaactcagg agaatccatg aatccacctg
     2881 aaggccttgg ctttgaaaca gaactgctaa aaatgtcctg ctccgtgact ctgtccctgc
     2941 ctgtccctgc ctgtccctgc ctgtccctgc ccagaggcaa caacttaggg aatcagtagc
     3001 atcagaaata gagacaaaat gacttcccag cctgggcctt cctttgttgc cccaggtcct
     3061 caattctgta cttgggattc agtgagcatg tccatctccg gtgagccaga atatgaactt
     3121 gaggggttct cactcacaac tgccatgtgc tagccccccc tgagcaagaa gaatcctgag
     3181 tcctgctctt cctctcaact cccagacacc aggccacgcc tggcagtatt tttatttaaa
     3241 acatggcccc ttttgtgcat tctgatcagt ttgtattaaa ttaaagttac aggg
//
