LOCUS       NM_153097               3633 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus tripartite motif-containing 60 (Trim60), mRNA.
ACCESSION   NM_153097
VERSION     NM_153097.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3633)
  AUTHORS   Gu,Z., Chen,X., Yang,W., Qi,Y., Yu,H., Wang,X., Gong,Y., Chen,Q.,
            Zhong,B., Dai,L., Qi,S., Zhang,Z., Zhang,H. and Hu,H.
  TITLE     The SUMOylation of TAB2 mediated by TRIM60 inhibits MAPK/NF-kappaB
            activation and the innate immune response
  JOURNAL   Cell Mol Immunol 18 (8), 1981-1994 (2021)
   PUBMED   33184450
  REMARK    GeneRIF: The SUMOylation of TAB2 mediated by TRIM60 inhibits
            MAPK/NF-kappaB activation and the innate immune response.
REFERENCE   2  (bases 1 to 3633)
  AUTHORS   Huang,C.J., Huang,C.C. and Chang,C.C.
  TITLE     Association of the testis-specific TRIM/RBCC protein RNF33/TRIM60
            with the cytoplasmic motor proteins KIF3A and KIF3B
  JOURNAL   Mol Cell Biochem 360 (1-2), 121-131 (2012)
   PUBMED   21909995
  REMARK    GeneRIF: the first demonstration of a TRIM protein, RNF33,
            interacting with kinesin molecular motors, possibly contributing to
            kinesin-dependent mobilization along the microtubule in the testis
            of the mouse
REFERENCE   3  (bases 1 to 3633)
  AUTHORS   Choo,K.B., Chen,H.H., Liu,T.Y. and Chang,C.P.
  TITLE     Different modes of regulation of transcription and pre-mRNA
            processing of the structurally juxtaposed homologs, Rnf33 and
            Rnf35, in eggs and in pre-implantation embryos
  JOURNAL   Nucleic Acids Res 30 (22), 4836-4844 (2002)
   PUBMED   12433986
  REMARK    GeneRIF: Regulation of transcription and pre-mRNA processing of
            Rnf33 in eggs and in pre-implantation embryos
REFERENCE   4  (bases 1 to 3633)
  AUTHORS   Chen,H.H., Liu,T.Y., Li,H. and Choo,K.B.
  TITLE     Use of a common promoter by two juxtaposed and intronless mouse
            early embryonic genes, Rnf33 and Rnf35: implications in zygotic
            gene expression
  JOURNAL   Genomics 80 (2), 140-143 (2002)
   PUBMED   12160726
  REMARK    GeneRIF: Rnf33 and Rnf35 mRNAs are apparently transcribed from the
            same putative promoter and may be products of alternative splicing.
REFERENCE   5  (bases 1 to 3633)
  AUTHORS   Choo,K.B., Chen,H.H., Cheng,W.T., Chang,H.S. and Wang,M.
  TITLE     In silico mining of EST databases for novel pre-implantation
            embryo-specific zinc finger protein genes
  JOURNAL   Mol Reprod Dev 59 (3), 249-255 (2001)
   PUBMED   11424210
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA561473.1, AK135841.1 and AC164589.6.
            
            On Feb 5, 2010 this sequence version replaced NM_153097.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK135841.1, BC139469.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               CA561473.1         1-104
            105-1160            AK135841.1         2-1057
            1161-3633           AC164589.6         12314-14786
FEATURES             Location/Qualifiers
     source          1..3633
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 32.51 cM"
     gene            1..3633
                     /gene="Trim60"
                     /gene_synonym="2czf45; Rnf33"
                     /note="tripartite motif-containing 60"
                     /db_xref="GeneID:234329"
                     /db_xref="MGI:MGI:2387430"
     exon            1..231
                     /gene="Trim60"
                     /gene_synonym="2czf45; Rnf33"
                     /inference="alignment:Splign:2.1.0"
     exon            232..3633
                     /gene="Trim60"
                     /gene_synonym="2czf45; Rnf33"
                     /inference="alignment:Splign:2.1.0"
     CDS             486..1886
                     /gene="Trim60"
                     /gene_synonym="2czf45; Rnf33"
                     /note="ring finger protein 33; tripartite motif-containing
                     protein 60"
                     /codon_start=1
                     /product="E3 SUMO-protein ligase TRIM60"
                     /protein_id="NP_694737.1"
                     /db_xref="CCDS:CCDS22331.1"
                     /db_xref="GeneID:234329"
                     /db_xref="MGI:MGI:2387430"
                     /translation="MDSTALKILQDKCICYICSDFMEDPVTSRCGHNFCFACLRLLWD
                     DLQGNIFCPVCQTPFPPKSFSRNYQFRNMTETIRLLQKRQSKRKRQEEHTVCPKHDQP
                     LVLFCVRDRDVLCTQCSLSVEHQGHYTCPIKKASSYHRKVLESAIATLKFGVKQVEEK
                     LAVQHRRVLGLREEAQYQKIEIRYEIGQIKLFLQSEYEAHLNESHMEELRSFSELNGY
                     LETLLDHVSTAKDLLKEVEAIHERSDVTLLRAYHKLQNLKSPKPWLFRTKQYGLSLPA
                     QYSGLSRIIKQFQADVTFDRDTAHPQLVISEDRKSVFYKEAWPCVCASPQKFHLWPAL
                     LGCKGFDSGRQYWEVKVGDKPRWTLGVCQAHFSGDWSNQSSGFWAIGRYAENSYVTYG
                     PLRTEFLPVVRPSKVGIFLDYELGELSFYNMNDRSLLYTFRNSFTSTLWPYFYIGTDS
                     ESLEILTHPTPDTGSY"
ORIGIN      
        1 ccagaagcaa ttcagtgatt ggccaattag ggaagccacc tgatgctctt caggaacaaa
       61 gcaagcagag aaagtaagag ggggtattgg gcatgcgcag ttccaagcct cgctcaattt
      121 cccaaggagc tgcccacaac tgagcaggca ggaccagcca cagcaggaat ggcccacgta
      181 ggcatggatg cagtgtctgg tgtaagctgc accacccgct ttctctaaca ggaaccctag
      241 gtccattaca gccatgtctg ctttctaaac caagctcgtg atctaacctg tgagacaagc
      301 agagaattct gctcaccgtc tgagctaagt taaagcattt tgattggacg tcagtgaata
      361 ccatccgagt actagaccag tgacacctac gaggacttgg aaggacacaa cggctcacag
      421 ttccttgagc tcctggaagg caggccctgc caaggaattt ctccatttag tttcctctca
      481 gaccaatgga ctccacagcc ctaaaaatct tgcaggacaa atgtatctgt tacatttgtt
      541 cggatttcat ggaagaccca gtgaccagta ggtgtgggca caacttctgt tttgcctgcc
      601 tccgtttgct ctgggatgat ctacaaggca acatcttctg tcccgtctgt caaaccccct
      661 ttccaccgaa aagcttcagc aggaactacc agttccgtaa catgactgaa accattaggc
      721 tcctgcaaaa gagacagagc aagaggaaga ggcaggaaga acacacagta tgtccgaagc
      781 atgatcagcc tctggtcttg ttctgtgtga gggatcggga tgtcttatgt acccagtgta
      841 gcctctctgt cgaacaccag ggccattaca cctgccccat taagaaagcc agctcttatc
      901 acaggaaagt cctagagagc gccattgcaa cgttaaagtt cggagtgaaa caagttgaag
      961 aaaagctagc tgtgcagcac agaagggttc ttggactgag ggaggaggct caatatcaaa
     1021 aaatagagat acgttatgaa attgggcaaa tcaaactgtt cctacaaagt gagtacgaag
     1081 cgcatctaaa tgagagccac atggaggagc tgcggagttt ctcagaactg aatggatatc
     1141 ttgagaccct gttagaccat gtttccacag caaaagatct gttgaaggaa gtggaggcca
     1201 tacatgaaag gtcagatgtc acactcctga gagcctacca caagttgcaa aaccttaaat
     1261 cccccaaacc gtggttattt aggacaaagc aatatggcct cagtctccca gcgcagtatt
     1321 ctggcttgag cagaatcatc aagcaatttc aagcagatgt gacttttgat cgtgacacag
     1381 cacaccctca gctggttatt tctgaggata gaaaatctgt gttttataaa gaagcatggc
     1441 catgtgtgtg tgctagccct cagaaatttc acctctggcc cgctctcctg ggatgtaaag
     1501 gattcgattc tggtcgacag tactgggaag tcaaagtggg agacaagccc agatggacac
     1561 tgggtgtgtg tcaagcccac ttttctgggg actggagcaa tcagtcctca ggtttctggg
     1621 caattgggcg gtatgctgag aatagttatg tcacctatgg acctctaaga acggagtttc
     1681 tgccagtggt gcgacccagc aaggtcggca tatttttgga ttatgaattg ggtgagctct
     1741 ccttttataa tatgaatgac aggtctcttc tctacacttt caggaattct tttaccagca
     1801 ccctttggcc ttatttctat ataggaacag attctgaatc tcttgaaatc ttaacccacc
     1861 ccaccccaga cacagggtct tactaagttc taggctaatt tagccagcac atttaagcta
     1921 gtaattcagc aagcaaacaa acaacaaaat ccaccaccca caagaccccc caagtcttct
     1981 aaatttaacc actgaaaacc agactgtgtt tttaactatc attcccagta actctaagaa
     2041 catgatggct gccacaagtg tgacacatgc ctgccccatc ctagcacccc cagagattta
     2101 ggtaccaaga gtaaggcagc ccaagccaat atgtgaccct gggatggcag ctgaggttgt
     2161 cctcagcctc tgcctgcaca cacacttccc ctcatgccat acacaataaa aaaaatgcat
     2221 gtcagaaaat agaatattgg ggaagaggca ccgaattggc agtgatttaa ggaagagctg
     2281 ctgctgccct atttaggaga caaactgaag atgaaccggc ttgacctgtg tgagtggaca
     2341 tttcattcat tgaagtaacc actgtatgtt aagataggag acctcatgca ctatgtgaag
     2401 gattagtgac tgagaagatg ggttagaaca gccaatagga ggtagggtgt agtcacaggt
     2461 agaatgtatg actgccttat gcccagggtc caatcctcag tactgggttg ggaaatcgaa
     2521 cacaaggttg cattttgttg ggctaggtgg catcccagcc ctcaggacgc tatgtctaac
     2581 aacagaccct acctcacaca ggaagaaagc gaggaccaat cctcaaggct gtcctctacc
     2641 ctgagcatgt accctatagc ttgtcatgtc catcctcacg cacaagaaca cacacatatc
     2701 atataagcac accaacaatt taaaaatgag gaaagtgggg tctccagtca tctacttcag
     2761 atggtcctat cttgaaaaaa aagaagcaaa aacatcagac aactaactca tttcataact
     2821 tctgtgaggc tgacaggccc ttgtctggtc tcatattggc ctggagctgt atagttcgac
     2881 tagagcagct agctaatgag tcccagatat tctggctcct gcttcccagc attgggaaga
     2941 cagatgcatg ctataatact tgggattttt atgtgtgttt tgggattgag ttctggtttg
     3001 tatgtttcaa ggcaagctct ttcacaactg ggccagctct taaacatctg atcccttagc
     3061 tcatgcagtg gtgtcggcct taatcccagt gcttccaaag ctgaggtagg gggattgtgg
     3121 gttacagagc agtcagggct ctatagcaac atcctataaa atacaataca tacagtaaaa
     3181 taaaagcctg tgttcccagc actcatggag gtagatccaa tgttgaagac tctcctcaac
     3241 acacagatag ttccaggcca gccgaggcta cgagagaccc agcttcaaca aaccaaacgg
     3301 aacaaacgaa taaacaacaa agctcacttg tagttgttgg gatgaatatt ttgatcctgt
     3361 agttggtgac tgaagtatgg cagaaaggtg gccttccatg gtaaattagc tgtactcaca
     3421 tgaatccttc atgtttctgt atatatgtat gactttggtg ggagtagcaa acttattaaa
     3481 aaggatcaac atgctgggtg tggtggtgca caccttcaat cccagtacca gggaggcaga
     3541 ggcaggtgaa tctctgtgtc aaaggccagc ctggtctaca gagaactttc caggcttgcc
     3601 agagacaccg tgagaccctg tctcaaaaac taa
//
