LOCUS       NM_001013616            3827 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus tripartite motif-containing 6 (Trim6), mRNA.
ACCESSION   NM_001013616 XM_133616
VERSION     NM_001013616.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3827)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3827)
  AUTHORS   Liu,X., Zhao,J., Dong,P., Du,X., Lu,W., Feng,Y. and Wang,L.
  TITLE     TRIM6 silencing for inhibiting growth and angiogenesis of gliomas
            by regulating VEGFA
  JOURNAL   J Chem Neuroanat 132, 102291 (2023)
   PUBMED   37236551
  REMARK    GeneRIF: TRIM6 silencing for inhibiting growth and angiogenesis of
            gliomas by regulating VEGFA.
REFERENCE   3  (bases 1 to 3827)
  AUTHORS   Zhang,Y., Dong,P., Liu,N., Yang,J.Y., Wang,H.M. and Geng,Q.
  TITLE     TRIM6 Reduces Ferroptosis and Chemosensitivity by Targeting SLC1A5
            in Lung Cancer
  JOURNAL   Oxid Med Cell Longev 2023, 9808100 (2023)
   PUBMED   36654781
  REMARK    GeneRIF: TRIM6 Reduces Ferroptosis and Chemosensitivity by
            Targeting SLC1A5 in Lung Cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3827)
  AUTHORS   van Tol,S., Kalveram,B., Ilinykh,P.A., Ronk,A., Huang,K.,
            Aguilera-Aguirre,L., Bharaj,P., Hage,A., Atkins,C., Giraldo,M.I.,
            Wakamiya,M., Gonzalez-Orozco,M., Warren,A.N., Bukreyev,A.,
            Freiberg,A.N. and Rajsbaum,R.
  TITLE     Ubiquitination of Ebola virus VP35 at lysine 309 regulates viral
            transcription and assembly
  JOURNAL   PLoS Pathog 18 (5), e1010532 (2022)
   PUBMED   35533195
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3827)
  AUTHORS   Zeng,G., Lian,C., Yang,P., Zheng,M., Ren,H. and Wang,H.
  TITLE     E3-ubiquitin ligase TRIM6 aggravates myocardial
            ischemia/reperfusion injury via promoting STAT1-dependent
            cardiomyocyte apoptosis
  JOURNAL   Aging (Albany NY) 11 (11), 3536-3550 (2019)
   PUBMED   31171760
  REMARK    GeneRIF: these results suggest that TRIM6 aggravates MI/R injury
            through promoting IKKepsilon/STAT1 activation-dependent
            cardiomyocyte apoptosis
REFERENCE   6  (bases 1 to 3827)
  AUTHORS   Rajsbaum,R., Versteeg,G.A., Schmid,S., Maestre,A.M.,
            Belicha-Villanueva,A., Martinez-Romero,C., Patel,J.R., Morrison,J.,
            Pisanelli,G., Miorin,L., Laurent-Rolle,M., Moulton,H.M.,
            Stein,D.A., Fernandez-Sesma,A., tenOever,B.R. and Garcia-Sastre,A.
  TITLE     Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin
            ligase TRIM6 stimulates the interferon-IKKepsilon kinase-mediated
            antiviral response
  JOURNAL   Immunity 40 (6), 880-895 (2014)
   PUBMED   24882218
REFERENCE   7  (bases 1 to 3827)
  AUTHORS   Sato,T., Okumura,F., Ariga,T. and Hatakeyama,S.
  TITLE     TRIM6 interacts with Myc and maintains the pluripotency of mouse
            embryonic stem cells
  JOURNAL   J Cell Sci 125 (Pt 6), 1544-1555 (2012)
   PUBMED   22328504
  REMARK    GeneRIF: TRIM6 regulates the transcriptional activity of Myc during
            the maintenance of cell pluripotency, suggesting that TRIM6
            functions as a novel regulator for Myc-mediated transcription in
            embryonic stem cells.
REFERENCE   8  (bases 1 to 3827)
  AUTHORS   Tareen,S.U., Sawyer,S.L., Malik,H.S. and Emerman,M.
  TITLE     An expanded clade of rodent Trim5 genes
  JOURNAL   Virology 385 (2), 473-483 (2009)
   PUBMED   19147168
REFERENCE   9  (bases 1 to 3827)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB634731.1, AK049238.1 and AC123830.5.
            
            On Dec 19, 2006 this sequence version replaced NM_001013616.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049238.1, AK033396.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                BB634731.1         1-21
            22-1902             AK049238.1         2-1882
            1903-3653           AC123830.5         35168-36918         c
            3654-3827           AK049238.1         3635-3808
FEATURES             Location/Qualifiers
     source          1..3827
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 55.55 cM"
     gene            1..3827
                     /gene="Trim6"
                     /gene_synonym="C430046K18Rik; D7Ertd684e"
                     /note="tripartite motif-containing 6"
                     /db_xref="GeneID:94088"
                     /db_xref="MGI:MGI:2137352"
     exon            1..89
                     /gene="Trim6"
                     /gene_synonym="C430046K18Rik; D7Ertd684e"
                     /inference="alignment:Splign:2.1.0"
     exon            90..563
                     /gene="Trim6"
                     /gene_synonym="C430046K18Rik; D7Ertd684e"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1607
                     /gene="Trim6"
                     /gene_synonym="C430046K18Rik; D7Ertd684e"
                     /EC_number="2.3.2.27"
                     /note="tripartite motif protein 6; RING-type E3 ubiquitin
                     transferase TRIM6"
                     /codon_start=1
                     /product="tripartite motif-containing protein 6"
                     /protein_id="NP_001013637.1"
                     /db_xref="CCDS:CCDS40065.1"
                     /db_xref="GeneID:94088"
                     /db_xref="MGI:MGI:2137352"
                     /translation="MTSTVLVDIRDEVTCPICLELLTEPLSIDCGHSFCQVCIIGNSN
                     NSVFGQGGRSSCPVCRTSYQPGNLRPNRHLAAIVKRLREVALCPGKQLEVIFCALHGE
                     KLQLFCKEDGKLICWLCERSQEHRGHHTFLMEEVAQEYQDMFQESLKKLRREQQEAEK
                     LKALIQEKRESWKSQVEPEKRRIQTEFKQLRSILDREEQRELKKLEVEERKGLSIIEK
                     AEGDLIHQSQSLKDLISDLEHRCQGSTVELLQDVGDVTKRSEFWTLRKPQALPTKLKS
                     LFRAPDLRKMLKVFRELTDVQSYWVDVTLNPQTANLNLVLSKNRRQVRFVGAQLSEPS
                     SLEEHYDCSVLGSQHFSSGKYYWEVDVSKKTAWILGVCSTPVDPMFSFSQYSSKQGAY
                     SRYQPQCGYWVIGLQCKHEYRAYEDSSPSLLLSMTVPPRRIGIFLDCEAGTVSFYNVT
                     NHGLPIYTFSKYYFPSALCPYFNPCSCIVPMTLRRPTS"
     exon            564..659
                     /gene="Trim6"
                     /gene_synonym="C430046K18Rik; D7Ertd684e"
                     /inference="alignment:Splign:2.1.0"
     exon            660..890
                     /gene="Trim6"
                     /gene_synonym="C430046K18Rik; D7Ertd684e"
                     /inference="alignment:Splign:2.1.0"
     exon            891..913
                     /gene="Trim6"
                     /gene_synonym="C430046K18Rik; D7Ertd684e"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1014
                     /gene="Trim6"
                     /gene_synonym="C430046K18Rik; D7Ertd684e"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1041
                     /gene="Trim6"
                     /gene_synonym="C430046K18Rik; D7Ertd684e"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..3827
                     /gene="Trim6"
                     /gene_synonym="C430046K18Rik; D7Ertd684e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3561..3566
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim6"
                     /gene_synonym="C430046K18Rik; D7Ertd684e"
                     /note="hexamer: AATAAA"
     polyA_site      3582
                     /gene="Trim6"
                     /gene_synonym="C430046K18Rik; D7Ertd684e"
                     /note="major polyA site"
ORIGIN      
        1 tttttcctgg agtccggctt tagtactgga aggagccgtc tccttggctg caagtcctcg
       61 gcactgatcc aggcacggat tccagattgg attctttttc taagcaagct gggaaggtag
      121 gagacgagag agtggctaca atgacttcaa cagtcttggt ggacatccga gatgaagtaa
      181 cctgccctat ctgcttggag ctcctgacag aacccctgag cattgattgt ggccatagct
      241 tctgccaggt ctgcatcata ggaaacagta ataattcagt gttcggccaa ggagggagga
      301 gcagctgtcc tgtgtgccgg acctcctatc agcctgggaa cctccgtcct aatcggcacc
      361 tggccgccat agtgaagagg ctcagagagg ttgcgttgtg ccctggaaaa caactcgagg
      421 tcattttttg tgcgcttcat ggagagaaac tccagctctt ttgcaaggag gatgggaagt
      481 taatttgctg gctttgtgaa cgatctcagg agcaccgtgg tcatcacaca ttcctcatgg
      541 aggaggtggc ccaggagtac caggacatgt tccaggagtc tctgaagaaa ttgaggaggg
      601 agcagcagga agccgagaag ctaaaagctc ttatccagga gaagagggaa tcctggaaga
      661 gtcaggtgga gcctgagaaa cgccggatcc agacagagtt taagcagctc cgaagcatcc
      721 tggacaggga ggagcagcgg gaactgaaga aactggaagt ggaagagagg aaggggctga
      781 gcatcataga aaaggccgag ggtgacctga tccaccagag ccagtcactg aaggacctca
      841 tctcagacct ggagcaccgg tgccaggggt ccaccgtaga actgctgcag gatgtgggtg
      901 atgttacaaa aaggagtgag ttctggaccc tgaggaagcc ccaagctctc cccaccaagc
      961 tgaaaagttt gtttcgagca ccggatctga ggaagatgct aaaagtcttt agagagctga
     1021 cagatgtcca aagctattgg gtggacgtga cactgaatcc acagacggct aatttaaatc
     1081 ttgtcctgtc gaaaaatcgg agacaggtga ggtttgtggg tgcccagctg tccgagccat
     1141 ccagtctgga agaacattat gactgtagtg tcctgggctc tcagcacttc tcctcaggaa
     1201 aatactactg ggaagtggac gtgagcaaga agacggcatg gatcttgggt gtatgcagta
     1261 ccccggtgga tcccatgttc tctttcagcc agtactccag caagcagggc gcctactcca
     1321 ggtatcagcc acagtgtgga tactgggtga ttggcttgca gtgtaagcac gagtacagag
     1381 cctatgagga ttcctccccg tccctgctcc tctccatgac cgtgccacct cgacgcatag
     1441 ggattttctt agactgtgag gctggcacgg tctcctttta taatgtcaca aaccacggct
     1501 tgcccatcta caccttctcg aagtattact ttccttctgc cctttgtccc tattttaatc
     1561 cctgcagctg tatagtcccg atgaccctgc ggcggccaac ttcctgaggt ctgttacccc
     1621 tgcccacaac taagcagatt ccttcaaaca catgaatctc cattctctgt tctcctagta
     1681 ggataccttc cattgctaag agtgcgcacc cttaagccat ctcatggaaa agcatttagt
     1741 gttttggggt ttttgtattt ttgcttttgg gttgtttatt tttgtttttt gttttttatt
     1801 tttagagata gggtttctgg aactctgtag gtcaaactgg ccttaaactt ggagagatcc
     1861 gcttgcctct cctgagtgct gggacaccag tctagttgtg ttttggtttt gggttttttg
     1921 tttgtttgtt tgttttttgt ttgtttgtat ttttgaaaca ggctggcctt gaactctgtg
     1981 attgagaaac taactgagaa ctgatccaga gtcccgatta caagtggaca tcaccatacc
     2041 tggctgtgaa tttgttttag tgttgtttga gatagggtct ccataaatag cccaaactgg
     2101 ccacagactc agtccatttg cctcactccc aaatactgat tatagatcta cctcacagtg
     2161 cctgactgag ctcccaaata ctgattatag ctctacctca cagcacctga ctgagctccc
     2221 aaatactgat tatagatcta cctcacagtg cctgactgag ctcccaaata ctgattatag
     2281 atctacctca cagcgcctga ctgagctctc aaatactgat tatagctcta cctcacagcg
     2341 cctgactgag cacatttgac gacttttttc tttactaatg tctgtggtca aatgtaaaga
     2401 acctctgaat tagataggaa ttttttaata aatattgaat tcagtaattt tttttctcta
     2461 gttactgaga tacttgtgta tcctttctat tctgctcctg ggtcagcctc actgagttgt
     2521 ctcagttgtt acgtttacca ctgattcctg aagcaaaact gtcatgtgtt acattcagca
     2581 ctttatgttt gctgactcta ggtttggttt ttgtctcttt ataaacaaac tacctctaag
     2641 tttgcattct ttgttatctg tcaaggcata tcagaaagaa attatgggga agggcttatg
     2701 tatgtgtatt taggatcaca ataaatccta agtatgtata tttaggatta cagtaaaaat
     2761 aataaaatct ttggatggtt tcaagaagag attgtagctt tggttttaac aataaatgct
     2821 accacaacct tcagccttca gcataaaatt ttaagagtgg taataaaaac tagaaaatgc
     2881 tcttgaaagg gagataaagt aagataagga gaagacttca atcaaccagt atcagttatt
     2941 atttaggagg aggaagaaat tcagttaccc attctcacag tgagttattc tggtcccccc
     3001 agcccctctt atttcttctg tagagctagg tactgaactc ggctttttac ttcaagcaga
     3061 gacattttag caccaagctt aaccccattt ttgtgttttg tattgttatt attggggttt
     3121 gtttgtttgt ttgttttgtt ttgctgacac agggttttaa cacatttccc aggctggcct
     3181 tgagcttgct atcaagtgca ggctgacttt aagctttgcc tcagcatcct gagtaactag
     3241 gtgtttaggg taatactgac ttttcatctt agcctggacc ttctctttgt gctcatattc
     3301 aaattgcaaa tgagtgaacc gctttggctt tgctggaaag gtgcaacaaa ctttcatatt
     3361 caactgtgaa aaaagttata gctgtgaaga tggaaatgag tgtcggggga ggtgcagctg
     3421 gacttctgac actgcagaca agggctactc gtggcttttg gtactctcca atgtactgta
     3481 acagtgaaat actgaatttc cataaaagca atgtaaaata atctattatc ttacaatgat
     3541 ggtattttgg atatatttta aataaaatgt tttatttcag gatggagtct tcttactctg
     3601 tagcccaggc tcgccatcaa attgtagtgg tagcttcctg ccttagcctt tcaactgctg
     3661 gggttaaggc ataagccacc acaggcagtt ttccctgtat gttttaaatg tgggtactag
     3721 gaaattttca gttatacatt aactggcttc tgttacactt ctactgtcaa gatgaacttt
     3781 ctattcttgg gggaacccta gaataataaa gacttggcca gagaacc
//
