LOCUS       NM_025863               2920 bp    mRNA    linear   ROD 14-FEB-2024
DEFINITION  Mus musculus tripartite motif-containing 59 (Trim59), mRNA.
ACCESSION   NM_025863
VERSION     NM_025863.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2920)
  AUTHORS   Zhang,L., Li,G. and Li,Y.
  TITLE     TRIM59 suppresses the brain ischaemia/reperfusion injury and
            pyroptosis of microglial through mediating the ubiquitination of
            NLRP3
  JOURNAL   Sci Rep 14 (1), 2511 (2024)
   PUBMED   38291200
  REMARK    GeneRIF: TRIM59 suppresses the brain ischaemia/reperfusion injury
            and pyroptosis of microglial through mediating the ubiquitination
            of NLRP3.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2920)
  AUTHORS   Liu,B., Gao,Y., Liu,X., Lian,Q. and Li,Y.
  TITLE     Tripartite motif containing 59 mediates protective anti-oxidative
            effects in intestinal injury through Nrf2 signaling
  JOURNAL   Int Immunopharmacol 124 (Pt B), 110896 (2023)
   PUBMED   37729796
  REMARK    GeneRIF: Tripartite motif containing 59 mediates protective
            anti-oxidative effects in intestinal injury through Nrf2 signaling.
REFERENCE   3  (bases 1 to 2920)
  AUTHORS   Su,X., Zhang,Q., Yue,J., Wang,Y., Zhang,Y. and Yang,R.
  TITLE     TRIM59 suppresses NO production by promoting the binding of PIAS1
            and STAT1 in macrophages
  JOURNAL   Int Immunopharmacol 89 (Pt A), 107030 (2020)
   PUBMED   33045573
  REMARK    GeneRIF: TRIM59 suppresses NO production by promoting the binding
            of PIAS1 and STAT1 in macrophages.
REFERENCE   4  (bases 1 to 2920)
  AUTHORS   An,Y., Ni,Y., Xu,Z., Shi,S., He,J., Liu,Y., Deng,K.Y., Fu,M.,
            Jiang,M. and Xin,H.B.
  TITLE     TRIM59 expression is regulated by Sp1 and Nrf1 in LPS-activated
            macrophages through JNK signaling pathway
  JOURNAL   Cell Signal 67, 109522 (2020)
   PUBMED   31883458
  REMARK    GeneRIF: TRIM59 expression is regulated by Sp1 and Nrf1 in
            LPS-activated macrophages through JNK signaling pathway.
REFERENCE   5  (bases 1 to 2920)
  AUTHORS   Jin,Z., Zhu,Z., Liu,S., Hou,Y., Tang,M., Zhu,P., Tian,Y., Li,D.,
            Yan,D. and Zhu,X.
  TITLE     TRIM59 Protects Mice From Sepsis by Regulating Inflammation and
            Phagocytosis in Macrophages
  JOURNAL   Front Immunol 11, 263 (2020)
   PUBMED   32133014
  REMARK    GeneRIF: TRIM59 Protects Mice From Sepsis by Regulating
            Inflammation and Phagocytosis in Macrophages.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2920)
  AUTHORS   Uchil,P.D., Quinlan,B.D., Chan,W.T., Luna,J.M. and Mothes,W.
  TITLE     TRIM E3 ligases interfere with early and late stages of the
            retroviral life cycle
  JOURNAL   PLoS Pathog 4 (2), e16 (2008)
   PUBMED   18248090
REFERENCE   7  (bases 1 to 2920)
  AUTHORS   Bulfone,A., Carotenuto,P., Faedo,A., Aglio,V., Garzia,L.,
            Bello,A.M., Basile,A., Andre,A., Cocchia,M., Guardiola,O.,
            Ballabio,A., Rubenstein,J.L. and Zollo,M.
  TITLE     Telencephalic embryonic subtractive sequences: a unique collection
            of neurodevelopmental genes
  JOURNAL   J Neurosci 25 (33), 7586-7600 (2005)
   PUBMED   16107646
REFERENCE   8  (bases 1 to 2920)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 2920)
  AUTHORS   Chang,R., Xu,X. and Li,M.D.
  TITLE     Molecular cloning, mapping and characterization of a novel mouse
            RING finger gene, Mrf1
  JOURNAL   Gene 291 (1-2), 241-249 (2002)
   PUBMED   12095697
REFERENCE   10 (bases 1 to 2920)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK012269.1, AK016642.1, CD541510.1, AK009637.1 and BE847098.1.
            
            [WARNING] On Apr 1, 2024 this sequence was replaced by NM_025863.4.
            
            On Mar 19, 2008 this sequence version replaced NM_025863.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025430.1, BY711434.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               AK012269.1         2-120
            120-130             AK016642.1         112-122
            131-797             AK012269.1         132-798
            798-1236            CD541510.1         145-583
            1237-1757           AK009637.1         310-830
            1758-1992           BE847098.1         109-343
            1993-2920           AK009637.1         1066-1993
FEATURES             Location/Qualifiers
     source          1..2920
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 32.16 cM"
     gene            1..2920
                     /gene="Trim59"
                     /gene_synonym="2310035M22Rik; 2700022F13Rik; Mrf1; TSBF1"
                     /note="tripartite motif-containing 59"
                     /db_xref="GeneID:66949"
                     /db_xref="MGI:MGI:1914199"
     exon            1..130
                     /gene="Trim59"
                     /gene_synonym="2310035M22Rik; 2700022F13Rik; Mrf1; TSBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            131..205
                     /gene="Trim59"
                     /gene_synonym="2310035M22Rik; 2700022F13Rik; Mrf1; TSBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            206..2920
                     /gene="Trim59"
                     /gene_synonym="2310035M22Rik; 2700022F13Rik; Mrf1; TSBF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..1420
                     /gene="Trim59"
                     /gene_synonym="2310035M22Rik; 2700022F13Rik; Mrf1; TSBF1"
                     /EC_number="2.3.2.27"
                     /note="RING finger 1; tumor suppressor TSBF1 homolog; RING
                     finger protein 1"
                     /codon_start=1
                     /product="tripartite motif-containing protein 59"
                     /protein_id="NP_080139.3"
                     /db_xref="CCDS:CCDS17402.1"
                     /db_xref="GeneID:66949"
                     /db_xref="MGI:MGI:1914199"
                     /translation="MHNFEEELTCPICYSIFEDPRVLPCSHTFCRNCLENVLQASGNF
                     YIWRPLRIPLKCPNCRSIIEIASTGIESLPVNFALRAIIEKYQQEDHPDVVTCPEHYR
                     QPLNVYCLLDKKLVCGHCLTIGQHHGHPIDDLQSAYLKEKDTPQKLLKQLTDTHWTDI
                     TRLIEKLEEQKCHSEKIVQGDKEVVLQYFKELIDTLEQKKKYFLAALCDVGKMINQEY
                     TPQIQGMKEIREQQLELMTITTSLQDESPLKFLEKIDEVRQRVQMLKQRPLPEVQPVE
                     IYPRVSNVLKEEWSRIEIGRIKKAVIPEMRVSSKRTPCSWSDNDEKEMELFKILNIAI
                     VSLISVILMLILLFNHHIITFLNEITSICFSEVFLSVYQSLSKNLYDLNNTVCYTLYL
                     LKEFMWKIVSR"
     regulatory      2896..2901
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim59"
                     /gene_synonym="2310035M22Rik; 2700022F13Rik; Mrf1; TSBF1"
                     /note="putative"
     polyA_site      2920
                     /gene="Trim59"
                     /gene_synonym="2310035M22Rik; 2700022F13Rik; Mrf1; TSBF1"
                     /note="putative"
ORIGIN      
        1 acctgaagac tcgggcgagc gcctcgcagt gtccgcacca ggctgcccgg gagccctcgc
       61 cgtgcgcgcc gtcgcccgcc tcgcccgcct cgcccgcctc gcccgcctcg cccgcctcgc
      121 ccgcctcgcg aataacaaag gatcctggaa aagttggaga agataaagta cacccagtgt
      181 ccagatcagg agattgacag accaggaaat gcacaatttt gaggaggagt taacgtgtcc
      241 catctgttac agcatctttg aagatccccg tgtactacca tgctctcata cattttgtag
      301 aaactgtttg gaaaatgttc ttcaggcatc tggtaacttt tacatatgga ggcctctgcg
      361 aattccactc aagtgtccta actgcagaag tattattgaa attgcttcta ctggcataga
      421 atccttacct gtaaactttg cattacgagc aattattgaa aagtaccagc aagaagacca
      481 cccagatgtt gtcacctgcc ctgaacacta caggcaacca ttaaatgttt attgtctact
      541 agataagaaa ttagtttgtg gccattgtct tactataggc caacatcatg gccatcctat
      601 agatgacctt caaagtgcct atctgaaaga aaaggataca cctcagaagt tgttgaaaca
      661 gttaactgac acacattgga cagatatcac tcgccttatt gaaaagcttg aagaacagaa
      721 atgtcattct gagaaaatag ttcaaggtga taaggaagtt gttctccagt attttaagga
      781 gctaattgat acattagaac agaaaaaaaa gtattttttg gcagctcttt gtgatgttgg
      841 caaaatgatt aatcaagaat acactccaca gattcaagga atgaaggaga taagggaaca
      901 acaacttgaa ttaatgacaa taacgacatc tttacaagat gagtctccac ttaaatttct
      961 ggaaaaaatt gatgaagtcc gccaacgtgt gcagatgttg aaacagagac cacttcctga
     1021 ggtccagcct gttgaaattt atcctcgagt aagcaatgta ttaaaagaag agtggagcag
     1081 aatagaaatt ggacgtatta agaaagctgt tattcctgaa atgagagttt cttcaaaaag
     1141 aacgccatgt tcctggtctg ataatgatga aaaagaaatg gaacttttta aaattttaaa
     1201 cattgctata gtttcactca tttcagtgat actaatgttg atactccttt tcaaccatca
     1261 cataataaca ttcttaaatg aaatcacttc aatatgtttc tctgaagtct ttctctctgt
     1321 ttaccagagt ttatctaaga acttatatga cttaaacaat acagtgtgtt acactttata
     1381 tttgttaaag gaatttatgt ggaaaatagt ttctcgttga aaacctagaa tttccagttt
     1441 tatgtgggct tctgtatagc agaggctaag cattgattgc tagatggaaa gtcagggtgg
     1501 cataaacagc acatcaactt cacatcttac aacagatgca gagaaatacg ataaacttcc
     1561 catgcttggc tacaagtgct gtcagaaatg agacattacc tgaaagaaga ctaaaatcaa
     1621 attagaaaat gacaactttt gggttgaata ttaatacctt accctgtttt tattggcttg
     1681 ctagttaatg ttttattctg attaataagt ctttttcttt aactgttaca tgttatagtg
     1741 gctaacttgg cagttctttg tatatgtaga tataagattt ttaaacaaat gacaagatcc
     1801 ttgaggtcca caagcctatt ttgatgattt gaagctttcc aatgcacaga tggagaggat
     1861 ttataagttg ttttaaaaat ctaggccagg attgtttaaa cctttttttg gggtcaaggc
     1921 tattcatagg tttaggagca gtcatcccaa gtagcactgc ttgctgcttg tggataaact
     1981 gtctagtaca cttgagttta attcatcctt gatatcagtg aggtctcaaa aacccatcag
     2041 aaagtgtctg gactgctggc tctagcacca caaagcaaat caagtacata ttttgatttt
     2101 gtattttagc cttgttttta tatgaaaact atacgaaacg tacattggga caattatgtt
     2161 tatgtgattc atctaataga ttatgatgta aaaactatat tcatcttaaa atgttttcac
     2221 cctgtagctt gagtactggg attataagta tgagttgatg ctgtacctgt ttagttttaa
     2281 aagaggtcat taagtcagaa cctttaattt tgctcacttg acatggacta ccatgatgca
     2341 tgtggtagaa cttttggttc acagccattg aaatccccta cacaatgttt tccagaaacc
     2401 ccttatgaat gctcttgaat ggagacttta tttcaaataa aagctgtgtt tcttaaggtc
     2461 agaacaatgc tgacaagttt tatcactaaa gtccacttat cagacgcaaa atctaggcat
     2521 ggtaacaaaa tgaggtcatt ttgaagatgc aatgaaggtg aggggaaatt atgtaaatat
     2581 tagcaagcga agaatattgg aacatttttc aaggggttac tagcttcttt gtagagatga
     2641 ggaaacaaaa gtgccagtgt tagcaggtgg gaaagctcat tctattctgc ttataaacaa
     2701 cttgagtagg ctgatctatg taattaacgg aaacttctat ttcagtatgc ccagtattac
     2761 attgtaggct tgacgatttt gtgtacacaa ttatctttgt gttctgatat actgttttat
     2821 atctttgcca ggaggctgag tttgtacaac ttaaaagttt agaaattctg ggttttatgt
     2881 ataacaatat attttaataa atgatatttt attgaagtct
//
