LOCUS       NM_001039047            2298 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus tripartite motif-containing 58 (Trim58), mRNA.
ACCESSION   NM_001039047 XM_111186 XM_359262
VERSION     NM_001039047.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2298)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2298)
  AUTHORS   Eyking,A., Ferber,F., Kohler,S., Reis,H. and Cario,E.
  TITLE     TRIM58 Restrains Intestinal Mucosal Inflammation by Negatively
            Regulating TLR2 in Myeloid Cells
  JOURNAL   J Immunol 203 (6), 1636-1649 (2019)
   PUBMED   31383741
REFERENCE   3  (bases 1 to 2298)
  AUTHORS   Thom,C.S., Traxler,E.A., Khandros,E., Nickas,J.M., Zhou,O.Y.,
            Lazarus,J.E., Silva,A.P., Prabhu,D., Yao,Y., Aribeana,C.,
            Fuchs,S.Y., Mackay,J.P., Holzbaur,E.L. and Weiss,M.J.
  TITLE     Trim58 degrades Dynein and regulates terminal erythropoiesis
  JOURNAL   Dev Cell 30 (6), 688-700 (2014)
   PUBMED   25241935
  REMARK    GeneRIF: Trim58 binds dynein, promotes its proteasomal degradation
            and regulates terminal erythropoiesis.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645802.11.
            
            On Oct 27, 2022 this sequence version replaced NM_001039047.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC150936.1, SRR13422598.734819.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-479               AL645802.11        93747-94225
            480-575             AL645802.11        96380-96475
            576-806             AL645802.11        99237-99467
            807-829             AL645802.11        100274-100296
            830-930             AL645802.11        100393-100493
            931-2298            AL645802.11        104425-105792
FEATURES             Location/Qualifiers
     source          1..2298
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 36.23 cM"
     gene            1..2298
                     /gene="Trim58"
                     /gene_synonym="Gm16; Gm1783"
                     /note="tripartite motif-containing 58"
                     /db_xref="GeneID:216781"
                     /db_xref="MGI:MGI:2684862"
     exon            1..479
                     /gene="Trim58"
                     /gene_synonym="Gm16; Gm1783"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1520
                     /gene="Trim58"
                     /gene_synonym="Gm16; Gm1783"
                     /EC_number="2.3.2.27"
                     /note="tripartite motif-containing protein 58; RING-type
                     E3 ubiquitin transferase TRIM58"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM58"
                     /protein_id="NP_001034136.1"
                     /db_xref="CCDS:CCDS24738.1"
                     /db_xref="GeneID:216781"
                     /db_xref="MGI:MGI:2684862"
                     /translation="MATAPGERLQEEARCSVCLDFLQEPISVDCGHSFCLRCISEFCE
                     KSDSAQGVYACPQCRGPFRPASFRPNRQLASLVDSVRQLGLGTGHAGSRQCARHGEDL
                     SHFCEEDQTMLCWVCDTSPEHRSHRTETLQEAASRYQRMLRASLELVKKEMEEALTQE
                     ANVGKKTIIWKEKVEMQRQRFRLEFEKHRGFLAQEEQLQLRRLEEEERATLQRLRDSR
                     NRLAQQNKALKELAEELEERSQRPAPGLLEGARGVLTRCEAITRLEPEAVPMDLKTVC
                     RIPGMREMLRKFQVDVKLDPATAHPSLLLTADLRSVQDAEVWRDVPSNPERFDTWPCI
                     LGLQGFSSGRHYWEVIVGERAEWGLGVCRDSVLRKGETTPSPENGVWAMWLLRGNEYM
                     VLSSPSVPVLQDERPRRIGIFLDYEAGEISFYNVTNGSYIYTFNHLFSGVLRPYFFVC
                     DTTPLILPPMTEAAPGNWTPRGIFDLAAAARNEEY"
     exon            480..575
                     /gene="Trim58"
                     /gene_synonym="Gm16; Gm1783"
                     /inference="alignment:Splign:2.1.0"
     exon            576..806
                     /gene="Trim58"
                     /gene_synonym="Gm16; Gm1783"
                     /inference="alignment:Splign:2.1.0"
     exon            807..829
                     /gene="Trim58"
                     /gene_synonym="Gm16; Gm1783"
                     /inference="alignment:Splign:2.1.0"
     exon            830..930
                     /gene="Trim58"
                     /gene_synonym="Gm16; Gm1783"
                     /inference="alignment:Splign:2.1.0"
     exon            931..2298
                     /gene="Trim58"
                     /gene_synonym="Gm16; Gm1783"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggtttcctt ccttctatgc agaccgctag ggtaatagga gctgctgcca caagctaagg
       61 ccatggccac ggcacccggg gagcgactgc aggaggaggc gcggtgctcc gtgtgcctgg
      121 acttcctgca ggagcccatc agcgtggact gcggccacag tttctgtctg cggtgcatct
      181 cggagttctg cgagaagtcg gacagcgctc agggcgtcta cgcctgtccc cagtgcaggg
      241 gtcccttcag gcccgccagc ttcagaccca accggcagct ggccagcctg gtggacagcg
      301 tgcggcagct ggggctgggc acgggacacg cggggtcgcg tcagtgtgcg aggcacggtg
      361 aggacctgag ccacttctgt gaagaggacc agacgatgct gtgctgggtc tgcgatacca
      421 gccctgagca ccggagccac cgcacagaga cgctgcagga ggctgccagc cgctaccaga
      481 ggatgctccg agcgtctttg gaacttgtga agaaggaaat ggaggaggct ctgacccagg
      541 aggccaacgt gggaaaaaag accatcatct ggaaggagaa agtggagatg cagagacaac
      601 gtttcaggct ggagtttgag aaacacagag ggtttctggc ccaggaggag cagctgcagc
      661 tgaggcggct ggaagaggag gagagagcaa ccctgcagag actgcgtgac agtaggaaca
      721 ggctggccca acagaacaag gccctgaagg aactggctga ggagctggag gagaggagcc
      781 agcggccagc cccagggctg ctggagggag cgagaggagt cttgacacga tgtgaggcta
      841 tcacaaggct ggaaccagag gctgtcccta tggacctgaa gactgtgtgc cgcatccctg
      901 ggatgaggga gatgctgagg aagttccaag tcgacgtgaa gctggatccg gccactgctc
      961 acccaagctt gctcttaact gcggacctgc gcagtgtaca ggatgcggag gtctggaggg
     1021 atgttcccag caaccctgag cgctttgaca cctggccttg catcctgggc ctgcagggct
     1081 tctcttctgg gaggcattac tgggaagtca tcgtcgggga aagagcagag tgggggctag
     1141 gggtctgccg agactcagtg ctgagaaaag gggagaccac accgtcccca gagaacggcg
     1201 tctgggccat gtggctgctg agggggaacg agtacatggt cctgtcctct ccctcggtgc
     1261 ctgtgctcca agatgagcga cctcgccgca tcgggatctt tttggactac gaagctggtg
     1321 aaatctcctt ctacaatgtc acaaatgggt cttacatcta cacattcaac catctcttct
     1381 ccggcgttct caggccctac ttcttcgtct gcgacacgac tcctcttatc ttgcctccca
     1441 tgacagaagc agcgcctgga aactggacgc ccaggggtat ctttgatctt gctgctgctg
     1501 ccagaaatga ggaatactaa acccatccag aagtgctgtg cttcagggaa gtcctggatg
     1561 gatcgggagg cgtggctgtg ccctgcttcc ctaaaccaca ccaacgccta ttctgcaggc
     1621 ctgcacagga gggattctcc cagtgggact gatgagtggg tcccgggtgg ttcacattct
     1681 gaggaactca gtggagtaga tgactcagga aaggcagcag gctcatcaaa cactactgcc
     1741 cgaggcttca ttttttcctt ggtgcatctt cacagtgaaa agctagaatt aaatgttatt
     1801 cttgcaccct caaccctcca tacagagaga tttaggatta ttaattctac ttgtttctga
     1861 caagtagcca aggttatccc aataaccccc aataactcag tctcctgggt gcaggtgtgt
     1921 gccacaaagc ttagcttaga aataaggatg cttcaaaata acctttttct agtaaattcc
     1981 atttcattct ctctccctcc ctctccctct ctctccctcc ctctccctct ctctccctcc
     2041 ctctccctcc ctctccttct cccctccttc cccctctctc cctctccctc tctccctctc
     2101 ccccctctct ctcttccttc ctccctctcc cttccccctc cttattgctt tgtgttgtct
     2161 cttcctactt agtctcatag tccttctagt ttaatataac cagaatcatt ctgaatgtat
     2221 atttgcattt cctagcacta tgttcagtga catcctatcc tcttttctgt tgttgcattt
     2281 taaaagattt tattcttt
//
