LOCUS       NM_001081281            2772 bp    mRNA    linear   ROD 04-AUG-2024
DEFINITION  Mus musculus tripartite motif-containing 55 (Trim55), mRNA.
ACCESSION   NM_001081281 XM_884648
VERSION     NM_001081281.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2772)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2772)
  AUTHORS   Lin,L., Yu,H., Li,L., Yang,W., Chen,X., Gong,Y., Lei,Q., Li,Z.,
            Zhou,Z., Dai,L., Zhang,H. and Hu,H.
  TITLE     TRIM55 promotes noncanonical NF-kappaB signaling and B
            cell-mediated immune responses by coordinating p100 ubiquitination
            and processing
  JOURNAL   Sci Signal 16 (806), eabn5410 (2023)
   PUBMED   37816088
  REMARK    GeneRIF: TRIM55 promotes noncanonical NF-kappaB signaling and B
            cell-mediated immune responses by coordinating p100 ubiquitination
            and processing.
REFERENCE   3  (bases 1 to 2772)
  AUTHORS   Nguyen,T., Bowen,T.S., Augstein,A., Schauer,A., Gasch,A., Linke,A.,
            Labeit,S. and Adams,V.
  TITLE     Expression of MuRF1 or MuRF2 is essential for the induction of
            skeletal muscle atrophy and dysfunction in a murine pulmonary
            hypertension model
  JOURNAL   Skelet Muscle 10 (1), 12 (2020)
   PUBMED   32340625
  REMARK    GeneRIF: Expression of MuRF1 or MuRF2 is essential for the
            induction of skeletal muscle atrophy and dysfunction in a murine
            pulmonary hypertension model.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2772)
  AUTHORS   Bian,H., Gao,S., Zhang,D., Zhao,Q., Li,F., Li,X., Sun,S., Song,S.,
            Li,T., Zhu,Q., Ren,W., Qin,C. and Qi,J.
  TITLE     The E3 ubiquitin ligase MuRF2 attenuates LPS-induced macrophage
            activation by inhibiting production of inflammatory cytokines and
            migration
  JOURNAL   FEBS Open Bio 8 (2), 234-243 (2018)
   PUBMED   29435413
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2772)
  AUTHORS   Lodka,D., Pahuja,A., Geers-Knorr,C., Scheibe,R.J., Nowak,M.,
            Hamati,J., Kohncke,C., Purfurst,B., Kanashova,T., Schmidt,S.,
            Glass,D.J., Morano,I., Heuser,A., Kraft,T., Bassel-Duby,R.,
            Olson,E.N., Dittmar,G., Sommer,T. and Fielitz,J.
  TITLE     Muscle RING-finger 2 and 3 maintain striated-muscle structure and
            function
  JOURNAL   J Cachexia Sarcopenia Muscle 7 (2), 165-180 (2016)
   PUBMED   27493870
REFERENCE   6  (bases 1 to 2772)
  AUTHORS   Moriscot,A.S., Baptista,I.L., Bogomolovas,J., Witt,C., Hirner,S.,
            Granzier,H. and Labeit,S.
  TITLE     MuRF1 is a muscle fiber-type II associated factor and together with
            MuRF2 regulates type-II fiber trophicity and maintenance
  JOURNAL   J Struct Biol 170 (2), 344-353 (2010)
   PUBMED   20149877
  REMARK    GeneRIF: Data suggest that expression of MuRF1 is required for
            remodeling of type-II fibers under pathophysiological stress
            states, whereas MuRF1 and MuRF2 together are required for
            maintenance of type-II fibers, possibly via the regulation of
            myozenin-1.
REFERENCE   7  (bases 1 to 2772)
  AUTHORS   Witt,C.C., Witt,S.H., Lerche,S., Labeit,D., Back,W. and Labeit,S.
  TITLE     Cooperative control of striated muscle mass and metabolism by MuRF1
            and MuRF2
  JOURNAL   EMBO J 27 (2), 350-360 (2008)
   PUBMED   18157088
  REMARK    GeneRIF: Double knockout (dKO) mice obtained by the inactivation of
            all four MuRF1 and MuRF2 alleles developed extreme cardiac and
            milder skeletal muscle hypertrophy.
REFERENCE   8  (bases 1 to 2772)
  AUTHORS   Willis,M.S., Ike,C., Li,L., Wang,D.Z., Glass,D.J. and Patterson,C.
  TITLE     Muscle ring finger 1, but not muscle ring finger 2, regulates
            cardiac hypertrophy in vivo
  JOURNAL   Circ Res 100 (4), 456-459 (2007)
   PUBMED   17272810
REFERENCE   9  (bases 1 to 2772)
  AUTHORS   Weinert,S., Bergmann,N., Luo,X., Erdmann,B. and Gotthardt,M.
  TITLE     M line-deficient titin causes cardiac lethality through impaired
            maturation of the sarcomere
  JOURNAL   J Cell Biol 173 (4), 559-570 (2006)
   PUBMED   16702235
REFERENCE   10 (bases 1 to 2772)
  AUTHORS   Witt,S.H., Granzier,H., Witt,C.C. and Labeit,S.
  TITLE     MURF-1 and MURF-2 target a specific subset of myofibrillar proteins
            redundantly: towards understanding MURF-dependent muscle
            ubiquitination
  JOURNAL   J Mol Biol 350 (4), 713-722 (2005)
   PUBMED   15967462
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC141209.11.
            
            On Jun 20, 2019 this sequence version replaced NM_001081281.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849390,
                              SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-317               AC141209.11        90096-90412
            318-490             AC141209.11        90910-91082
            491-656             AC141209.11        104764-104929
            657-752             AC141209.11        107421-107516
            753-986             AC141209.11        116560-116793
            987-1009            AC141209.11        117043-117065
            1010-1134           AC141209.11        117166-117290
            1135-1376           AC141209.11        118392-118633
            1377-1664           AC141209.11        119890-120177
            1665-2772           AC141209.11        137113-138220
FEATURES             Location/Qualifiers
     source          1..2772
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 5.65 cM"
     gene            1..2772
                     /gene="Trim55"
                     /gene_synonym="D830041C10Rik; MuRF-2; Murf2; Rnf29"
                     /note="tripartite motif-containing 55"
                     /db_xref="GeneID:381485"
                     /db_xref="MGI:MGI:3036269"
     exon            1..317
                     /gene="Trim55"
                     /gene_synonym="D830041C10Rik; MuRF-2; Murf2; Rnf29"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..1787
                     /gene="Trim55"
                     /gene_synonym="D830041C10Rik; MuRF-2; Murf2; Rnf29"
                     /EC_number="2.3.2.27"
                     /note="ring finger protein 29; muscle-specific RING finger
                     protein 2; tripartite motif-containing protein 55"
                     /codon_start=1
                     /product="tripartite motif-containing 55"
                     /protein_id="NP_001074750.1"
                     /db_xref="CCDS:CCDS38399.1"
                     /db_xref="GeneID:381485"
                     /db_xref="MGI:MGI:3036269"
                     /translation="MSTSLNYKSFSKEQQTMDNLEKQLICPICLEMFTKPVVILPCQH
                     NLCRKCASDIFQASNPYLPTRGGTTVASGGRFRCPSCRHEVVLDRHGVYGLQRNLLVE
                     NIIDIYKQESTRPEKKLDQPMCEEHEEERINIYCLNCEVPTCSLCKVFGAHKDCQVAP
                     LTHVFQRQKSELSDGIAVLVGSNDRVQGVISQLEDTCKTIEECCRKQKQDLCEKFDHL
                     YGILEERKTEMTQAITRTQEEKLEHVRTLIRKYSDHLENVSKLVESGIQFMDEPEMAV
                     FLQNAKTLLQKIVEASKAFQMEKLEQGYEIMSNFTVNLNREEKIIREIDFSREEEEEE
                     DAGEIDEEGEGEDAVEVEEAENVQIASSGEEESLEKAAEPSQLPAELQVAPEPLPASS
                     PEPFSSMPPAADVLVTQGEVVPIGSQQTTQSETSGPSAAETADPLFYPSWYKGQSRKT
                     SSNPPCTHGSEGLGQIGPLGIEDSSVQSAEVAEAATNEQAAVSGKESSSTAATSQIGF
                     EAPSPQGQSAALGSGGGADPEPARHVFSFSWLNSLNE"
     exon            318..490
                     /gene="Trim55"
                     /gene_synonym="D830041C10Rik; MuRF-2; Murf2; Rnf29"
                     /inference="alignment:Splign:2.1.0"
     exon            491..656
                     /gene="Trim55"
                     /gene_synonym="D830041C10Rik; MuRF-2; Murf2; Rnf29"
                     /inference="alignment:Splign:2.1.0"
     exon            657..752
                     /gene="Trim55"
                     /gene_synonym="D830041C10Rik; MuRF-2; Murf2; Rnf29"
                     /inference="alignment:Splign:2.1.0"
     exon            753..986
                     /gene="Trim55"
                     /gene_synonym="D830041C10Rik; MuRF-2; Murf2; Rnf29"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1009
                     /gene="Trim55"
                     /gene_synonym="D830041C10Rik; MuRF-2; Murf2; Rnf29"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1134
                     /gene="Trim55"
                     /gene_synonym="D830041C10Rik; MuRF-2; Murf2; Rnf29"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1376
                     /gene="Trim55"
                     /gene_synonym="D830041C10Rik; MuRF-2; Murf2; Rnf29"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1664
                     /gene="Trim55"
                     /gene_synonym="D830041C10Rik; MuRF-2; Murf2; Rnf29"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..2772
                     /gene="Trim55"
                     /gene_synonym="D830041C10Rik; MuRF-2; Murf2; Rnf29"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcctggaa caatgtcctc cacagagaga gagacataaa ggacacttga tcatacagtc
       61 cttggaatta tttccaggaa ccacttacag aagccgttcg ggagcacctt tcccttggca
      121 gcacactcag ggacagggac ggcaaggaaa tgagcacttc tctgaattac aagtctttct
      181 ccaaagagca gcagaccatg gataacttgg aaaagcaact gatctgtccc atctgcctag
      241 agatgttcac gaagcctgtg gtcattctcc cttgccagca caacctgtgc aggaaatgtg
      301 ccagtgacat cttccaggcc tctaacccgt acttacccac aagaggaggc accaccgtgg
      361 catcaggggg ccgcttccgc tgtccctcct gcagacatga ggtggtgtta gacagacatg
      421 gggtctatgg actgcagagg aacctgctcg tggaaaacat tattgatatc tacaagcagg
      481 aatccaccag gccagaaaaa aaattggacc agcccatgtg tgaagagcat gaagaggaac
      541 gcatcaacat ctattgtctg aactgtgaag tgcccacctg ttccttgtgc aaggtttttg
      601 gcgcccataa ggactgccag gtggctcccc tgactcatgt gttccagagg cagaagtcag
      661 agctcagtga tggtattgct gtacttgtgg gaagcaacga tagagtccag ggtgtgatca
      721 gccagctgga ggacacctgt aaaactattg aggagtgctg cagaaagcag aaacaggacc
      781 tgtgtgagaa atttgatcac ctatacggca tcctggagga gaggaagact gaaatgaccc
      841 aagccatcac tcgaacacag gaggagaaac tggaacatgt ccgaactctt atcaggaagt
      901 attccgatca cctggagaac gtatccaagt tggtggagtc aggaatccag ttcatggatg
      961 agcccgaaat ggcagtattt ctgcagaatg ccaagaccct gttgcaaaag atcgtggaag
     1021 catcaaaggc gtttcagatg gagaaactag aacaaggtta tgagatcatg agcaacttca
     1081 ctgtcaatct caatagagaa gaaaaaatta tccgtgaaat tgacttttct agagaagagg
     1141 aagaggaaga agatgcagga gaaatagatg aagaaggaga aggagaggat gcagtagaag
     1201 tagaagaggc agaaaatgtt caaatagcat cttcagggga agaggagagt ctggagaaag
     1261 ctgcagagcc ctctcagctt cccgcagagc ttcaggtcgc cccagagcca ctacctgctt
     1321 cctctccaga accgttttca tccatgccac ctgctgcaga tgtcctggtg acacaggggg
     1381 aggtggtgcc cattggctct cagcagacca cacagtctga aacttcaggc ccttcagcag
     1441 cggaaactgc ggatcccttg ttttacccta gttggtataa aggccaaagc cggaaaacca
     1501 gctccaaccc accttgcact catgggagtg aaggtctggg tcaaataggg cctctgggca
     1561 ttgaggattc cagtgtgcag tccgcagaag tggcagaagc cgcaaccaat gagcaggcag
     1621 cagtgagtgg taaggagtct agttcaactg cagctacctc tcagattgga tttgaggccc
     1681 cttctcccca gggacagtct gcagccttgg ggagtggggg tggggctgat cctgagccag
     1741 ctcgccacgt cttctccttc tcctggttga attccctaaa tgaataatat ttattctcgt
     1801 tgctgccccc tgtctgcctg gctgagaagc acataggcag caggaaacag gtggaaattc
     1861 accacgattc atatgaaggg gacctctgga caggatttct gaaagcaaaa caaaacaata
     1921 caacaccacc accctttaat tccagatgac ttatctcact cattgagaaa atgattatgc
     1981 tcagaacaaa attacagaaa atactcttct gaagaaactt gatcttctgc aaatctttca
     2041 tttgtgtgag aaaccttctg aaggttgtgt aggtgtggtg catgcctgtg tatcagccat
     2101 aagtgccaag tggtaacaaa gtggcagaac actctcccag cctccctcag gcttctggtt
     2161 attttaggac gcttgtgcct tttgcttttc tccttagcat tgcaggtggt aggtgatgtt
     2221 cagtgtcagt tccaaactga ccgatttatc aaaatatgga gattggtcac tgaccaaagc
     2281 tatgtagggc actgtagagg ttcctttccc tatggatgcc atgggtgcgc agacaggact
     2341 ttcctttaca tgtggccaca cgtccatagt ccagaaggcc aaaaatctag ggcaactctt
     2401 ttgacatttt tctaacctta tttacatatc tcataatcat atccatgtat taggcatttt
     2461 aattgaattt caaagaggag ctgtctactt tcttaagtgt cctgccatag cagcaatctg
     2521 ataatctgtg gagcaactgc atggatttaa gtatacacac aattctcccc ctgtgtgcct
     2581 tctctctctc tctctctccc cctctctccc tctgtctctt ctctccccct ctgtctctcc
     2641 ctcctttcct ttcttcctcc ttccctccct ccctcccccc ccccccggtc tctctctctc
     2701 ctctctcctt ccttgccttc atcacataag tgtaacttta ctttaaatga actattaaat
     2761 aaatgttttt aa
//
