LOCUS       NM_021447               1548 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus tripartite motif-containing 54 (Trim54), mRNA.
ACCESSION   NM_021447
VERSION     NM_021447.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1548)
  AUTHORS   King,K.A., Benton,A.H., Caudill,M.T., Stoyanof,S.T., Kang,L.,
            Michalak,P., Lahmers,K.K., Dunman,P.M., DeHart,T.G., Ahmad,S.S.,
            Jutras,B.L., Poncin,K., De Bolle,X. and Caswell,C.C.
  TITLE     Post-transcriptional control of the essential enzyme MurF by a
            small regulatory RNA in Brucella abortus
  JOURNAL   Mol Microbiol 121 (1), 129-141 (2024)
   PUBMED   38082493
  REMARK    GeneRIF: Post-transcriptional control of the essential enzyme MurF
            by a small regulatory RNA in Brucella abortus.
REFERENCE   2  (bases 1 to 1548)
  AUTHORS   Wiederstein,J.L., Nolte,H., Gunther,S., Piller,T., Baraldo,M.,
            Kostin,S., Bloch,W., Schindler,N., Sandri,M., Blaauw,B., Braun,T.,
            Holper,S. and Kruger,M.
  TITLE     Skeletal Muscle-Specific Methyltransferase METTL21C Trimethylates
            p97 and Regulates Autophagy-Associated Protein Breakdown
  JOURNAL   Cell Rep 23 (5), 1342-1356 (2018)
   PUBMED   29719249
REFERENCE   3  (bases 1 to 1548)
  AUTHORS   Lodka,D., Pahuja,A., Geers-Knorr,C., Scheibe,R.J., Nowak,M.,
            Hamati,J., Kohncke,C., Purfurst,B., Kanashova,T., Schmidt,S.,
            Glass,D.J., Morano,I., Heuser,A., Kraft,T., Bassel-Duby,R.,
            Olson,E.N., Dittmar,G., Sommer,T. and Fielitz,J.
  TITLE     Muscle RING-finger 2 and 3 maintain striated-muscle structure and
            function
  JOURNAL   J Cachexia Sarcopenia Muscle 7 (2), 165-180 (2016)
   PUBMED   27493870
REFERENCE   4  (bases 1 to 1548)
  AUTHORS   Quintana,M.T., He,J., Sullivan,J., Grevengoed,T., Schisler,J.,
            Han,Y., Hill,J.A., Yates,C.C., Stansfield,W.E., Mapanga,R.F.,
            Essop,M.F., Muehlbauer,M.J., Newgard,C.B., Bain,J.R. and
            Willis,M.S.
  TITLE     Muscle ring finger-3 protects against diabetic cardiomyopathy
            induced by a high fat diet
  JOURNAL   BMC Endocr Disord 15, 36 (2015)
   PUBMED   26215257
  REMARK    GeneRIF: findings suggest that MuRF3 helps stabilize cardiac
            PPARalpha and PPARgamma1 in vivo to support resistance to the
            development of diabetic cardiomyopathy. MuRF3 also plays an
            unexpected role in regulating fat storage despite being found only
            in striated muscle.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1548)
  AUTHORS   Perera,S., Holt,M.R., Mankoo,B.S. and Gautel,M.
  TITLE     Developmental regulation of MURF ubiquitin ligases and autophagy
            proteins nbr1, p62/SQSTM1 and LC3 during cardiac myofibril assembly
            and turnover
  JOURNAL   Dev Biol 351 (1), 46-61 (2011)
   PUBMED   21185285
  REMARK    GeneRIF: Knockdown of both MURF2 and MURF3 severely disrupts the
            formation of ordered Z- and M-bands, likely by perturbed tubulin
            dynamics
REFERENCE   6  (bases 1 to 1548)
  AUTHORS   Koyama,S., Hata,S., Witt,C.C., Ono,Y., Lerche,S., Ojima,K.,
            Chiba,T., Doi,N., Kitamura,F., Tanaka,K., Abe,K., Witt,S.H.,
            Rybin,V., Gasch,A., Franz,T., Labeit,S. and Sorimachi,H.
  TITLE     Muscle RING-finger protein-1 (MuRF1) as a connector of muscle
            energy metabolism and protein synthesis
  JOURNAL   J Mol Biol 376 (5), 1224-1236 (2008)
   PUBMED   18222470
REFERENCE   7  (bases 1 to 1548)
  AUTHORS   Fielitz,J., Kim,M.S., Shelton,J.M., Latif,S., Spencer,J.A.,
            Glass,D.J., Richardson,J.A., Bassel-Duby,R. and Olson,E.N.
  TITLE     Myosin accumulation and striated muscle myopathy result from the
            loss of muscle RING finger 1 and 3
  JOURNAL   J Clin Invest 117 (9), 2486-2495 (2007)
   PUBMED   17786241
  REMARK    GeneRIF: muscle RING finger 1 and muscle RING finger 3 as key E3
            ubiquitin ligases for the ubiquitin proteasome system-dependent
            turnover of sarcomeric proteins and reveal a potential basis for
            myosin storage myopathies
REFERENCE   8  (bases 1 to 1548)
  AUTHORS   Fielitz,J., van Rooij,E., Spencer,J.A., Shelton,J.M., Latif,S., van
            der Nagel,R., Bezprozvannaya,S., de Windt,L., Richardson,J.A.,
            Bassel-Duby,R. and Olson,E.N.
  TITLE     Loss of muscle-specific RING-finger 3 predisposes the heart to
            cardiac rupture after myocardial infarction
  JOURNAL   Proc Natl Acad Sci U S A 104 (11), 4377-4382 (2007)
   PUBMED   17360532
  REMARK    GeneRIF: MuRF3 has an essential role in maintaining cardiac
            integrity and function after acute myocardial infarction and
            turnover of FHL2 and gamma-filamin contributes to this
            cardioprotective function of MuRF3
REFERENCE   9  (bases 1 to 1548)
  AUTHORS   Meroni,G. and Diez-Roux,G.
  TITLE     TRIM/RBCC, a novel class of 'single protein RING finger' E3
            ubiquitin ligases
  JOURNAL   Bioessays 27 (11), 1147-1157 (2005)
   PUBMED   16237670
  REMARK    Review article
REFERENCE   10 (bases 1 to 1548)
  AUTHORS   Spencer,J.A., Eliazer,S., Ilaria,R.L. Jr., Richardson,J.A. and
            Olson,E.N.
  TITLE     Regulation of microtubule dynamics and myogenic differentiation by
            MURF, a striated muscle RING-finger protein
  JOURNAL   J Cell Biol 150 (4), 771-784 (2000)
   PUBMED   10953002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY346743.1 and AF294790.1.
            
            On Dec 1, 2007 this sequence version replaced NM_021447.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF294790.1, SRR5189679.35961.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               BY346743.1         2-101
            101-1548            AF294790.1         1-1448
FEATURES             Location/Qualifiers
     source          1..1548
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.06 cM"
     gene            1..1548
                     /gene="Trim54"
                     /gene_synonym="4930486E09Rik; 4930566I02Rik; MURF; MURF-3;
                     MuRF3; Rnf30"
                     /note="tripartite motif-containing 54"
                     /db_xref="GeneID:58522"
                     /db_xref="MGI:MGI:1889623"
     exon            1..466
                     /gene="Trim54"
                     /gene_synonym="4930486E09Rik; 4930566I02Rik; MURF; MURF-3;
                     MuRF3; Rnf30"
                     /inference="alignment:Splign:2.1.0"
     CDS             299..1399
                     /gene="Trim54"
                     /gene_synonym="4930486E09Rik; 4930566I02Rik; MURF; MURF-3;
                     MuRF3; Rnf30"
                     /note="ring finger protein 30; muscle-specific RING finger
                     protein 3; muscle-specific RING-finger protein"
                     /codon_start=1
                     /product="tripartite motif-containing protein 54"
                     /protein_id="NP_067422.1"
                     /db_xref="CCDS:CCDS19173.1"
                     /db_xref="GeneID:58522"
                     /db_xref="MGI:MGI:1889623"
                     /translation="MNFTVGFKPLLGDAHNMDNLEKQLICPICLEMFSKPVVILPCQH
                     NLCRKCANDVFQASNPLWQSRGSTTVSSGGRFRCPSCRHEVVLDRHGVYGLQRNLLVE
                     NIIDIYKQESSRPLHAKAEQHLMCEEHEDEKINIYCLSCEVPTCSLCKVFGAHKDCEV
                     APLPTIYKRQKSELSDGIAMLVAGNDRVQAVITQMEEVCQTIEDNSRRQKQLLNQRFE
                     TLCAVLEERKGELLQALAREQEEKLQRVRGLIRQYGDHLEGSSKLVESAIQSMEEPQM
                     ALYLQQAKELINKVGAMSKVELAGRPEPGYESMEQFSVSVEHVAEMLRTIDFQPGAAG
                     DEEDDDMALDGEEGNAGLEEERLDVPEGSGLH"
     exon            467..639
                     /gene="Trim54"
                     /gene_synonym="4930486E09Rik; 4930566I02Rik; MURF; MURF-3;
                     MuRF3; Rnf30"
                     /inference="alignment:Splign:2.1.0"
     exon            640..811
                     /gene="Trim54"
                     /gene_synonym="4930486E09Rik; 4930566I02Rik; MURF; MURF-3;
                     MuRF3; Rnf30"
                     /inference="alignment:Splign:2.1.0"
     exon            812..907
                     /gene="Trim54"
                     /gene_synonym="4930486E09Rik; 4930566I02Rik; MURF; MURF-3;
                     MuRF3; Rnf30"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1141
                     /gene="Trim54"
                     /gene_synonym="4930486E09Rik; 4930566I02Rik; MURF; MURF-3;
                     MuRF3; Rnf30"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1164
                     /gene="Trim54"
                     /gene_synonym="4930486E09Rik; 4930566I02Rik; MURF; MURF-3;
                     MuRF3; Rnf30"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1289
                     /gene="Trim54"
                     /gene_synonym="4930486E09Rik; 4930566I02Rik; MURF; MURF-3;
                     MuRF3; Rnf30"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1382
                     /gene="Trim54"
                     /gene_synonym="4930486E09Rik; 4930566I02Rik; MURF; MURF-3;
                     MuRF3; Rnf30"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1532
                     /gene="Trim54"
                     /gene_synonym="4930486E09Rik; 4930566I02Rik; MURF; MURF-3;
                     MuRF3; Rnf30"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1511..1516
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim54"
                     /gene_synonym="4930486E09Rik; 4930566I02Rik; MURF; MURF-3;
                     MuRF3; Rnf30"
                     /note="hexamer: AATAAA"
     polyA_site      1532
                     /gene="Trim54"
                     /gene_synonym="4930486E09Rik; 4930566I02Rik; MURF; MURF-3;
                     MuRF3; Rnf30"
                     /note="major polyA site"
ORIGIN      
        1 agtgctgccc aaagagtgac caagagggtg gtttgggggg acaggaggag aatttcacag
       61 ggcaagataa agctacaagc gcctggtgag ggttctgagc aaggagtgta gacagagtgt
      121 ctggaaatag acaggggtga gaggagctgt taggggaagg gacaggactc ttccaagagg
      181 gagcaatagc cgggatccca agaatccagt cagcctaaac tgaccgagga agggtgcaca
      241 ggcaggggag aaggccaacg acagggccac agcgaggcag gctccagagc gccgcgggat
      301 gaacttcacg gtgggtttca agccgctgct aggggatgcg cacaacatgg acaacttgga
      361 gaagcagctc atttgcccca tctgcctgga gatgttctcc aagcccgtgg tgatcttgcc
      421 ctgccaacac aacctgtgcc gcaagtgtgc caacgacgtc ttccaggcct ctaatcctct
      481 gtggcaatcc cggggctcca caacggtgtc ttcaggagga cgtttccgat gcccatcttg
      541 taggcacgag gttgtcctgg acaggcatgg tgtctatggc ctgcagcgga acctgctagt
      601 ggagaacatc attgacatct acaagcagga gtcctcccgg ccactgcacg ccaaggctga
      661 acagcacctc atgtgtgagg agcacgagga cgagaagatc aacatctact gcctgagctg
      721 cgaggtgccc acctgctctc tctgcaaggt tttcggcgcc cacaaggact gtgaggtggc
      781 ccctctgccc accatttaca aacgccagaa gagtgagctg agcgatggca tcgcgatgct
      841 ggtggcgggc aatgaccgtg tgcaggcagt gatcacccag atggaggagg tgtgccagac
      901 cattgaggac aacagccgca gacagaagca actgttaaac cagaggttcg agaccctgtg
      961 cgcggttttg gaggagcgca agggcgaact gcttcaagca ctggcccggg agcaggagga
     1021 gaagttgcag cgcgtgcggg gcctcatccg ccagtacgga gaccacttgg agggctcctc
     1081 aaagctggtg gagtccgcca tccagtccat ggaggagccg cagatggctc tctacctcca
     1141 gcaggcaaag gagctgatca acaaggtcgg ggcaatgtcg aaggtggagc tggcaggacg
     1201 gccggagcca ggctatgaga gcatggagca attctctgtg agcgtggagc acgtggccga
     1261 aatgttgcga accatcgact tccagccggg cgccgctggg gatgaagagg atgacgacat
     1321 ggctttggat ggggaggagg gcaatgcggg gctggaggag gagcggctgg acgtgccaga
     1381 aggctcaggc ctgcactgac ccgactctga tccagagcgc acacccgaag cgggagccaa
     1441 gggatgctga ggatctgcgc agagaccacc gcgccaccaa gctcggcttc ccgcccccgg
     1501 gaaggttctc aataaaggac tcaagtgtcc caaaaaaaaa aaaaaaaa
//
