LOCUS       NM_178240               1453 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus tripartite motif-containing 50 (Trim50), transcript
            variant 1, mRNA.
ACCESSION   NM_178240
VERSION     NM_178240.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1453)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1453)
  AUTHORS   Lin,Y., Lv,X., Sun,C., Sun,Y., Yang,M., Ma,D., Jing,W., Zhao,Y.,
            Cheng,Y., Xuan,H. and Han,L.
  TITLE     TRIM50 promotes NLRP3 inflammasome activation by directly inducing
            NLRP3 oligomerization
  JOURNAL   EMBO Rep 23 (11), e54569 (2022)
   PUBMED   36178239
  REMARK    GeneRIF: TRIM50 promotes NLRP3 inflammasome activation by directly
            inducing NLRP3 oligomerization.
REFERENCE   3  (bases 1 to 1453)
  AUTHORS   Fusco,C., Mandriani,B., Di Rienzo,M., Micale,L., Malerba,N.,
            Cocciadiferro,D., Sjottem,E., Augello,B., Squeo,G.M., Pellico,M.T.,
            Jain,A., Johansen,T., Fimia,G.M. and Merla,G.
  TITLE     TRIM50 regulates Beclin 1 proautophagic activity
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1865 (6), 908-919 (2018)
   PUBMED   29604308
  REMARK    GeneRIF: TRIM50, via the RING domain, ubiquitinates Beclin 1 in a
            K63-dependent manner enhancing its binding with ULK1 and autophagy
            activity.
REFERENCE   4  (bases 1 to 1453)
  AUTHORS   Strogantsev,R., Krueger,F., Yamazawa,K., Shi,H., Gould,P.,
            Goldman-Roberts,M., McEwen,K., Sun,B., Pedersen,R. and
            Ferguson-Smith,A.C.
  TITLE     Allele-specific binding of ZFP57 in the epigenetic regulation of
            imprinted and non-imprinted monoallelic expression
  JOURNAL   Genome Biol 16 (1), 112 (2015)
   PUBMED   26025256
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1453)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 1453)
  AUTHORS   Nishi,M., Aoyama,F., Kisa,F., Zhu,H., Sun,M., Lin,P., Ohta,H.,
            Van,B., Yamamoto,S., Kakizawa,S., Sakai,H., Ma,J., Sawaguchi,A. and
            Takeshima,H.
  TITLE     TRIM50 protein regulates vesicular trafficking for acid secretion
            in gastric parietal cells
  JOURNAL   J Biol Chem 287 (40), 33523-33532 (2012)
   PUBMED   22872646
  REMARK    GeneRIF: TRIM50 protein regulates vesicular trafficking for acid
            secretion in gastric parietal cells
REFERENCE   7  (bases 1 to 1453)
  AUTHORS   Fusco,C., Micale,L., Egorov,M., Monti,M., D'Addetta,E.V.,
            Augello,B., Cozzolino,F., Calcagni,A., Fontana,A., Polishchuk,R.S.,
            Didelot,G., Reymond,A., Pucci,P. and Merla,G.
  TITLE     The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and
            promotes the sequestration and clearance of ubiquitinated proteins
            into the aggresome
  JOURNAL   PLoS One 7 (7), e40440 (2012)
   PUBMED   22792322
REFERENCE   8  (bases 1 to 1453)
  AUTHORS   Li,H.H., Roy,M., Kuscuoglu,U., Spencer,C.M., Halm,B.,
            Harrison,K.C., Bayle,J.H., Splendore,A., Ding,F., Meltzer,L.A.,
            Wright,E., Paylor,R., Deisseroth,K. and Francke,U.
  TITLE     Induced chromosome deletions cause hypersociability and other
            features of Williams-Beuren syndrome in mice
  JOURNAL   EMBO Mol Med 1 (1), 50-65 (2009)
   PUBMED   20049703
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC074359.2.
            
            On Mar 1, 2018 this sequence version replaced NM_178240.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY081947.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-400               AC074359.2         84448-84847
            401-496             AC074359.2         90008-90103
            497-727             AC074359.2         94881-95111
            728-747             AC074359.2         95206-95225
            748-872             AC074359.2         97694-97818
            873-1453            AC074359.2         98227-98807
FEATURES             Location/Qualifiers
     source          1..1453
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 75.15 cM"
     gene            1..1453
                     /gene="Trim50"
                     /note="tripartite motif-containing 50"
                     /db_xref="GeneID:215061"
                     /db_xref="MGI:MGI:2664992"
     exon            1..400
                     /gene="Trim50"
                     /inference="alignment:Splign:2.1.0"
     CDS             2..1453
                     /gene="Trim50"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     ubiquitin-protein ligase TRIM50; tripartite
                     motif-containing protein 50; RING-type E3 ubiquitin
                     transferase TRIM50"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM50 isoform 1"
                     /protein_id="NP_839971.1"
                     /db_xref="CCDS:CCDS19739.1"
                     /db_xref="GeneID:215061"
                     /db_xref="MGI:MGI:2664992"
                     /translation="MAWRLTVPELQDQLQCPICLEVFKEPLMLQCGHSYCKDCLDNLS
                     QHLDSELCCPVCRQSVDCSSSPPNVSLARVIDALRLPGDIEPTVCVHHRNPLSLFCEK
                     DQEFICGLCGLLGSHQHHRVTPVSTVYSRMKEELAGRISELKEEHRNVEEHIGKLVNN
                     RTRIINESDVFSWVIRREFQELHHLVDEEKARCLEGLEGHTRGLVASLDMQLEQAQGT
                     QERLAQAEQVLEQFGNESHHEFIRFHSVASRAEVQQARPLEGVFSPISFKPALHQADI
                     KLTVWKRLFRKVLPAPASLKLDPATAHPLLELSKGNTVVHCGLLAQRRASQPERFDYS
                     TCVLASKGFSWGRHYWEVVVGSKSDWRLGVIKGTASRKGKLNKSPEHGVWLIGLKEGR
                     VYEAFGCPRLPLPVAGHPHRIGVYLHYEQGELTFFDADRPDDLRTLYTFQADFQGKLY
                     PILDTCWHERGSNSLPMVLPPPSGPGHFTLGQV"
     exon            401..496
                     /gene="Trim50"
                     /inference="alignment:Splign:2.1.0"
     exon            497..727
                     /gene="Trim50"
                     /inference="alignment:Splign:2.1.0"
     exon            728..747
                     /gene="Trim50"
                     /inference="alignment:Splign:2.1.0"
     exon            748..872
                     /gene="Trim50"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1453
                     /gene="Trim50"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catggcgtgg cggctgactg tgccggaact ccaggaccag ctgcagtgtc ccatttgcct
       61 ggaggtcttc aaagagcctc tgatgctaca gtgcggccac tcctactgca aggactgcct
      121 ggataacttg tcccaacacc tggactccga gctatgctgt cctgtgtgtc gtcagtcagt
      181 agactgcagc agctccccgc ctaatgtctc cctggcccgg gtgatagatg ctctgaggct
      241 gccgggggac atagagccca ccgtctgcgt gcaccaccga aaccctctca gcctcttctg
      301 cgagaaagac caggaattca tctgtggtct ctgtggcctg ctgggctccc accaacacca
      361 ccgagtcaca ccagtctcca ccgtctacag ccgcatgaag gaagagcttg caggccgcat
      421 atctgagctg aaggaggagc acaggaacgt ggaggagcac atcggcaaac tggtgaacaa
      481 caggacccgg attattaatg agtccgatgt cttcagctgg gtgatccgaa gggagttcca
      541 ggaattgcac cacctggtgg acgaagagaa agcccgctgc ctggaggggc ttgagggcca
      601 tacgcgtggc ctggtggcct ccctggacat gcagctggag caggctcagg gtacacaaga
      661 gcgactggct caggcggagc aggtgctgga gcagtttggg aacgagagtc accatgagtt
      721 catccggttc cactctgtgg cctccagggc agaggtccag caggctcggc ctttggaagg
      781 cgtcttcagt cccatctcct tcaagccagc tctccaccag gctgacatca aactgaccgt
      841 gtggaagaga ctcttccgga aggttctgcc agctccagca tctctcaagc tggacccggc
      901 tactgcccac cctctgctgg agctctctaa gggcaacaca gtggtgcatt gtggcctcct
      961 tgcccagaga cgagccagcc aacccgagcg cttcgactat agcacctgtg tcctggctag
     1021 caagggcttc tcttggggtc gccactactg ggaagtggtg gtggggagca agagtgactg
     1081 gcgcttgggg gtcatcaagg gcacagccag ccgcaaaggc aagctgaaca agtccccaga
     1141 gcacggtgtg tggctaattg gcctgaaaga gggtcgggtg tatgaggctt ttggctgccc
     1201 acggctgcca ctgcctgtgg ctggccaccc tcatcgcatc ggcgtctact tacactatga
     1261 gcagggtgag ctcacgttct ttgacgctga ccgtcctgat gatctgcgga cactctatac
     1321 tttccaagct gacttccagg gcaagctgta ccctatcctg gacacatgtt ggcatgagag
     1381 gggcagcaac tcactgccca tggtattgcc cccacccagt gggcctgggc acttcacact
     1441 gggacaggta tag
//
