LOCUS       NM_001310602            2496 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus tripartite motif-containing 5 (Trim5), mRNA.
ACCESSION   NM_001310602 XM_011241954
VERSION     NM_001310602.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2496)
  AUTHORS   Schafer,A., Marzi,A., Furuyama,W., Catanzaro,N.J., Nguyen,C.,
            Haddock,E., Feldmann,F., Meade-White,K., Thomas,T., Hubbard,M.L.,
            Gully,K.L., Leist,S.R., Hock,P., Bell,T.A., De la Cruz,G.E.,
            Midkiff,B.R., Martinez,D.R., Shaw,G.D., Miller,D.R., Vernon,M.J.,
            Graham,R.L., Cowley,D.O., Montgomery,S.A., Schughart,K., de
            Villena,F.P.M., Wilkerson,G.K., Ferris,M.T., Feldmann,H. and
            Baric,R.S.
  TITLE     Mapping of susceptibility loci for Ebola virus pathogenesis in mice
  JOURNAL   Cell Rep 43 (5), 114127 (2024)
   PUBMED   38652660
REFERENCE   2  (bases 1 to 2496)
  AUTHORS   Fan,J., Campioli,E., Sottas,C., Zirkin,B. and Papadopoulos,V.
  TITLE     Amhr2-Cre-Mediated Global Tspo Knockout
  JOURNAL   J Endocr Soc 4 (2), bvaa001 (2020)
   PUBMED   32099945
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2496)
  AUTHORS   Boon,A.C., deBeauchamp,J., Hollmann,A., Luke,J., Kotb,M., Rowe,S.,
            Finkelstein,D., Neale,G., Lu,L., Williams,R.W. and Webby,R.J.
  TITLE     Host genetic variation affects resistance to infection with a
            highly pathogenic H5N1 influenza A virus in mice
  JOURNAL   J Virol 83 (20), 10417-10426 (2009)
   PUBMED   19706712
REFERENCE   4  (bases 1 to 2496)
  AUTHORS   Tareen,S.U., Sawyer,S.L., Malik,H.S. and Emerman,M.
  TITLE     An expanded clade of rodent Trim5 genes
  JOURNAL   Virology 385 (2), 473-483 (2009)
   PUBMED   19147168
REFERENCE   5  (bases 1 to 2496)
  AUTHORS   Johnson,W.E. and Sawyer,S.L.
  TITLE     Molecular evolution of the antiretroviral TRIM5 gene
  JOURNAL   Immunogenetics 61 (3), 163-176 (2009)
   PUBMED   19238338
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC142110.4 and AC123830.5.
            
            On Jul 16, 2015 this sequence version replaced XM_011241954.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments and paralogous data.
            
            CCDS Note: This gene lacks full-length transcript support.
            Therefore this CCDS representation has an inferred exon combination
            based on partial transcripts and paralogous transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849382
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AC142110.4         37087-37112         c
            27-502              AC142110.4         28319-28794         c
            503-598             AC142110.4         27422-27517         c
            599-829             AC142110.4         25612-25842         c
            830-852             AC142110.4         23779-23801         c
            853-950             AC123830.5         3580-3677
            951-977             AC123830.5         3910-3936
            978-2496            AC123830.5         4181-5699
FEATURES             Location/Qualifiers
     source          1..2496
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 55.69 cM"
     gene            1..2496
                     /gene="Trim5"
                     /gene_synonym="EG667823; Gm8833"
                     /note="tripartite motif-containing 5"
                     /db_xref="GeneID:667823"
                     /db_xref="MGI:MGI:3646853"
     exon            1..26
                     /gene="Trim5"
                     /gene_synonym="EG667823; Gm8833"
                     /inference="alignment:Splign:2.1.0"
     exon            27..502
                     /gene="Trim5"
                     /gene_synonym="EG667823; Gm8833"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1576
                     /gene="Trim5"
                     /gene_synonym="EG667823; Gm8833"
                     /codon_start=1
                     /product="tripartite motif-containing 5"
                     /protein_id="NP_001297531.1"
                     /db_xref="CCDS:CCDS80770.1"
                     /db_xref="GeneID:667823"
                     /db_xref="MGI:MGI:3646853"
                     /translation="MASQFMKNLKEEVTCPVCLNLMVKPVSADCGHTFCQGCITLYFE
                     SIKCDKEMFSCPVCRLSYQSSNLRPNLHVANIVERLKEFKPSPEEEQKVFNCARHGEK
                     LQLFCRKDMMAICWLCERSQEHRGHKTALIEEVAREYKEQLQVVLQRLMADKKEFENW
                     KDELQKDRTYWENQIQKDVENVQSEFKRMRDIIDSEEKNELQKLRQEKEDILNNLAES
                     ESEHAQQSKLLEDFISDVEHQLQCSDIEILQGVENIIKRSLTFSMKKPKTIAREQRKF
                     RAPDLQGMLQVLQEVTEAQRYWVQVTLVQNNHPNIAITDDKRQVRYEDHQASNLIHEC
                     ENSHEGVLGHPAIQSGKHYWEVDVSGKGAWVLGLSDGSYLFCPIFHSNAERNRLFCRG
                     IKNDSHYQPKYGFWVIGLWKKSVYNAFEECPFTGKPSVLTLSLMVPPCRVGVFLDYAA
                     GTLSFYNISNNGTLIYRFCTASFPDRVFPYFNPTGSSEPMTICWPDS"
     exon            503..598
                     /gene="Trim5"
                     /gene_synonym="EG667823; Gm8833"
                     /inference="alignment:Splign:2.1.0"
     exon            599..829
                     /gene="Trim5"
                     /gene_synonym="EG667823; Gm8833"
                     /inference="alignment:Splign:2.1.0"
     exon            830..852
                     /gene="Trim5"
                     /gene_synonym="EG667823; Gm8833"
                     /inference="alignment:Splign:2.1.0"
     exon            853..950
                     /gene="Trim5"
                     /gene_synonym="EG667823; Gm8833"
                     /inference="alignment:Splign:2.1.0"
     exon            951..977
                     /gene="Trim5"
                     /gene_synonym="EG667823; Gm8833"
                     /inference="alignment:Splign:2.1.0"
     exon            978..2496
                     /gene="Trim5"
                     /gene_synonym="EG667823; Gm8833"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2313..2318
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim5"
                     /gene_synonym="EG667823; Gm8833"
                     /note="hexamer: AAGAAA"
     polyA_site      2335
                     /gene="Trim5"
                     /gene_synonym="EG667823; Gm8833"
                     /note="major polyA site"
     regulatory      2439..2444
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim5"
                     /gene_synonym="EG667823; Gm8833"
                     /note="hexamer: AAGAAA"
     polyA_site      2464
                     /gene="Trim5"
                     /gene_synonym="EG667823; Gm8833"
                     /note="major polyA site"
ORIGIN      
        1 cggaaatacc ttgaagttct ggattggcac ctgagcagaa gtgcaaggag tccggacagt
       61 catacacagg atcacagcaa ctatggcttc acaattcatg aagaatttaa aggaggaggt
      121 gacctgtcct gtctgtctga acctgatggt gaaacctgtg agtgcagatt gtggtcacac
      181 cttctgccaa ggctgcatca cgttgtactt tgaatccatc aaatgtgata aggaaatgtt
      241 cagttgccct gtgtgccgac ttagttacca gtctagcaat ctgaggccta atctacatgt
      301 ggccaacata gtagagaggc tcaaagagtt caagcccagc ccagaagagg agcagaaagt
      361 gtttaactgt gcaagacatg gagagaaact ccagctcttc tgtaggaagg acatgatggc
      421 catctgctgg ctttgtgagc gatctcagga gcaccggggc cacaaaacag ctctcattga
      481 agaggtggcc cgggagtaca aggagcagct gcaggtagtt ctgcaaaggc tgatggcaga
      541 taagaaagaa tttgaaaact ggaaagatga acttcagaag gatagaactt actgggagaa
      601 tcaaatacag aaagatgtgg agaatgttca gtcagagttt aaacgaatga gggatatcat
      661 agactcagag gagaagaatg aattgcagaa gctgaggcaa gagaaggaag acattctcaa
      721 caacctggca gagtctgaaa gtgagcatgc tcagcagagc aagttgctag aagacttcat
      781 ctcagatgtg gaacatcagt tacagtgctc agacatagaa atactacagg gtgtggagaa
      841 catcataaaa cggagtctta ctttttcgat gaagaagccc aaaaccatcg ccagggaaca
      901 aagaaagttc cgagcccctg acctgcaagg catgctgcaa gtgctgcaag aggtcacaga
      961 ggctcaacgc tactgggttc aggtgaccct ggttcaaaat aaccatccaa acattgccat
     1021 tactgacgac aaaagacaag tacgatatga agaccaccaa gcaagtaatc ttatacacga
     1081 gtgtgaaaac tctcatgaag gcgtcctggg acatccagct atccaatctg gaaaacatta
     1141 ctgggaagta gatgtgtctg gaaaaggtgc ttgggttctg gggttaagtg atggaagcta
     1201 cctcttctgt ccaatatttc attcaaatgc tgaaagaaat cgtttatttt gtagggggat
     1261 taagaatgat tcacattatc aaccaaaata tggcttctgg gttatagggc tgtggaaaaa
     1321 gtctgtgtat aatgcttttg aggagtgtcc tttcacaggc aagcccagtg tcttgaccct
     1381 gtctctgatg gtcccgccct gtcgtgttgg tgttttcctt gactatgcag ctgggactct
     1441 ctcattttac aatatttcca acaatgggac tcttatctac agattctgca cagcttcctt
     1501 tcctgatagg gtttttccat attttaatcc cacgggaagt tcagagccga tgacaatttg
     1561 ctggccagac tcttaacatt tgcctgttta cttgcaaggt ctctggctct gatatgtata
     1621 tcatatgcct gagctcatca taccattttc tctctctttt ttttcctgac tctagtcttt
     1681 ctgtgtgaat gtctttcatt ggtaaaaaag gatatattca tttctctagg tcagattctt
     1741 ctcagtttct ttcagttttg ttttgtttta gatgagaata ttaaatcact tcccatttag
     1801 tcaaggaaaa gtgcctgagt gctcattgtg taagataaca ctgctgcaaa gttctcttat
     1861 tctttgcgcc agaggtggaa gccaaggcct tgtgcatggt gaggaggtgc tccacccctg
     1921 aggaggtgct ccaccactga gctaattacc tcagctctgt caggtctcta taacttcatc
     1981 ctgcccatca atgaaagaag attaaagaaa gatcttcaac aacttgtcca ttcattctga
     2041 aaattatagg taggaatctg tggttaagaa atgcaccctt agctataggc cagttttacc
     2101 aggatgcatc ttcatcaaag aatgaaggag aagcatcaca atgaggcata ctgtgttctt
     2161 gctcaggcat catatgtgcc caaagtagaa tgatcaggga atgttaatat ggcccctgct
     2221 catggatgac atgcgagttt atgaagcatt ccatattttt gaagagcatt gatagtctaa
     2281 atcatgttag agaggaggca gggggaaaga aaaagaaagg aaggaaggaa ggaaggaagg
     2341 aaggaaggaa ggaaggaagg aagagtaagg aaggaaggaa gggaaagaaa gaaagaaaga
     2401 aagaaagaaa gaaagaaaga aagaaagaaa gagaacaaaa gaaagaacga aagaaagaac
     2461 gaaagaaaga aagaaagaaa gaaagaaaga aagaaa
//
