LOCUS       NM_172570               2192 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus tripartite motif-containing 47 (Trim47), transcript
            variant 2, mRNA.
ACCESSION   NM_172570
VERSION     NM_172570.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2192)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2192)
  AUTHORS   Qian,Y., Wang,Z., Lin,H., Lei,T., Zhou,Z., Huang,W., Wu,X., Zuo,L.,
            Wu,J., Liu,Y., Wang,L.F., Guan,X.H., Deng,K.Y., Fu,M. and Xin,H.B.
  TITLE     TRIM47 is a novel endothelial activation factor that aggravates
            lipopolysaccharide-induced acute lung injury in mice via K63-linked
            ubiquitination of TRAF2
  JOURNAL   Signal Transduct Target Ther 7 (1), 148 (2022)
   PUBMED   35513381
  REMARK    GeneRIF: TRIM47 is a novel endothelial activation factor that
            aggravates lipopolysaccharide-induced acute lung injury in mice via
            K63-linked ubiquitination of TRAF2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2192)
  AUTHORS   Tang,J., Tu,S., Lin,G., Guo,H., Yan,C., Liu,Q., Huang,L., Tang,N.,
            Xiao,Y., Pope,R.M., Rajaram,M.V.S., Amer,A.O., Ahmer,B.M.,
            Gunn,J.S., Wozniak,D.J., Tao,L., Coppola,V., Zhang,L.,
            Langdon,W.Y., Torrelles,J.B., Lipkowitz,S. and Zhang,J.
  TITLE     Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b limits
            inflammasome activation and endotoxemia
  JOURNAL   J Exp Med 217 (4) (2020)
   PUBMED   31999304
REFERENCE   4  (bases 1 to 2192)
  AUTHORS   Yamamoto,H., Kon,T., Omori,Y. and Furukawa,T.
  TITLE     Functional and Evolutionary Diversification of Otx2 and Crx in
            Vertebrate Retinal Photoreceptor and Bipolar Cell Development
  JOURNAL   Cell Rep 30 (3), 658-671 (2020)
   PUBMED   31968244
REFERENCE   5  (bases 1 to 2192)
  AUTHORS   Ji,Y.X., Huang,Z., Yang,X., Wang,X., Zhao,L.P., Wang,P.X.,
            Zhang,X.J., Alves-Bezerra,M., Cai,L., Zhang,P., Lu,Y.X., Bai,L.,
            Gao,M.M., Zhao,H., Tian,S., Wang,Y., Huang,Z.X., Zhu,X.Y.,
            Zhang,Y., Gong,J., She,Z.G., Li,F., Cohen,D.E. and Li,H.
  TITLE     The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic
            steatohepatitis
  JOURNAL   Nat Med 24 (2), 213-223 (2018)
   PUBMED   29291351
REFERENCE   6  (bases 1 to 2192)
  AUTHORS   Balasubramanian,R., Bui,A., Ding,Q. and Gan,L.
  TITLE     Expression of LIM-homeodomain transcription factors in the
            developing and mature mouse retina
  JOURNAL   Gene Expr Patterns 14 (1), 1-8 (2014)
   PUBMED   24333658
REFERENCE   7  (bases 1 to 2192)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2192)
  AUTHORS   Munger,S.C., Aylor,D.L., Syed,H.A., Magwene,P.M., Threadgill,D.W.
            and Capel,B.
  TITLE     Elucidation of the transcription network governing mammalian sex
            determination by exploiting strain-specific susceptibility to sex
            reversal
  JOURNAL   Genes Dev 23 (21), 2521-2536 (2009)
   PUBMED   19884258
REFERENCE   9  (bases 1 to 2192)
  AUTHORS   Zhou,Q., Law,A.C., Rajagopal,J., Anderson,W.J., Gray,P.A. and
            Melton,D.A.
  TITLE     A multipotent progenitor domain guides pancreatic organogenesis
  JOURNAL   Dev Cell 13 (1), 103-114 (2007)
   PUBMED   17609113
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL607108.17, BC100317.1 and BG065693.2.
            
            On Mar 22, 2011 this sequence version replaced NM_172570.4.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 1. This
            results in a shorter protein (isoform 2), compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100317.1, AK031572.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN04095720 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AL607108.17        126577-126592       c
            17-2190             BC100317.1         1-2174
            2191-2192           BG065693.2         1-2                 c
FEATURES             Location/Qualifiers
     source          1..2192
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 80.91 cM"
     gene            1..2192
                     /gene="Trim47"
                     /gene_synonym="2210023F24Rik"
                     /note="tripartite motif-containing 47"
                     /db_xref="GeneID:217333"
                     /db_xref="MGI:MGI:1917374"
     exon            1..702
                     /gene="Trim47"
                     /gene_synonym="2210023F24Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1941
                     /gene="Trim47"
                     /gene_synonym="2210023F24Rik"
                     /EC_number="2.3.2.27"
                     /note="isoform 2 is encoded by transcript variant 2;
                     tripartite motif protein 47; tripartite motif-containing
                     protein 47; E3 ubiquitin-protein ligase TRIM47"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM47 isoform 2"
                     /protein_id="NP_766158.3"
                     /db_xref="CCDS:CCDS56822.1"
                     /db_xref="GeneID:217333"
                     /db_xref="MGI:MGI:1917374"
                     /translation="MDGSGPFSCPICLEPLREPVTLPCGHNFCLACLGALWPHRSAGG
                     TGGSGGPARCPLCQEPFPDGLQLRKNHTLSELLQLRQGSVPGPMSAPASGSTRGATPE
                     PSAPSAPPPAPEPSAPCAPEQWPAGEEPVRCDACPEGAALPAALSCLSCLASFCSAHL
                     APHERSPALRGHRLVPPLRRLEESLCPRHLRPLERYCRVERVCLCEACATQDHRGHEL
                     VPLEQERALQEVEQSKVLSAAEDRMDELGAGIAQSRRTVALIKSAAVAERERVSQMFA
                     EATATLQSFQNEVMGFIEEGEATMLGRSQGDLRRQEEQRSRLSKARHNLGQVPEADSV
                     SFLQELLALRLALEEGCGPGPGPPRELSFTKSSQVVKAVRDTLISACASQWEQLRGLG
                     SNEDGLQKLGSEDVESQDPDSTSLLESEAPRDYFLKFAYIVDLDSDTADKFLQLFGTK
                     GVKRVLCPINYPESPTRFTHCEQVLGEGALDRGTYYWEVEIIEGWVSVGVMAEGFSPQ
                     EPYDRGRLGRNAHSCCLQWNGRGFSVWFCGLEAPLPHAFSPTVGVCLEYADHALAFYA
                     VRDGKLSLLRRLKASRPRRSGALASPTDPFQSRLDSHFSGLFNHRLKPAFFLESVDAH
                     LQIGPLKKSCITVLKRR"
     exon            703..798
                     /gene="Trim47"
                     /gene_synonym="2210023F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            799..1029
                     /gene="Trim47"
                     /gene_synonym="2210023F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1228
                     /gene="Trim47"
                     /gene_synonym="2210023F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1300
                     /gene="Trim47"
                     /gene_synonym="2210023F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..2192
                     /gene="Trim47"
                     /gene_synonym="2210023F24Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2170..2175
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim47"
                     /gene_synonym="2210023F24Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2190
                     /gene="Trim47"
                     /gene_synonym="2210023F24Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggtagcggcg gagccatgga cggcagcggg cctttcagct gccccatctg cctggaaccg
       61 ctccgggagc cggtgacact accctgcggc cacaacttct gcctcgcttg cctgggcgct
      121 ctctggccgc accggagcgc gggcggcacc ggtggttccg gaggtccagc tcgctgtcca
      181 ctttgtcagg agcctttccc cgacggcctg cagctccgca agaaccacac gctgtccgag
      241 ttgctgcagc tccgccaggg ctcggtcccg ggacccatgt ccgccccggc ttcaggatcg
      301 acccggggcg ccacgcccga gccctccgcg cccagcgcac cacctccggc tccggaacca
      361 tcggctccct gcgcgccgga gcagtggccc gcgggtgagg agccggtgcg ctgcgacgcg
      421 tgccccgagg gcgccgccct gcccgccgcg ctctcttgcc tctcctgcct cgcctccttc
      481 tgctccgcgc atctggcccc ccacgaacgc agccccgccc tgcgcggcca ccgcctggtg
      541 cccccgctgc gccgacttga ggagagcctg tgtccgcgcc acctgcggcc tctggagcgc
      601 tactgtcgcg tggagcgtgt gtgcctttgc gaggcctgtg ccactcagga ccatcgcggc
      661 cacgagctcg tgccgctgga gcaggagcgc gcgcttcagg aggtggagca gtccaaagtc
      721 ctgagcgctg cggaggaccg catggatgaa ctgggtgccg gcatcgcaca gtcccgccgt
      781 actgtggccc tcatcaagag tgcagctgtg gcagagcggg agagggtgag ccagatgttt
      841 gccgaggcca cagccaccct tcagagtttc cagaacgagg tgatggggtt catcgaagag
      901 ggagaggcca caatgttggg ccggtcccag ggtgacctgc gtagacaaga ggaacagcgc
      961 agccgcctaa gcaaggcacg gcacaacctc ggtcaggttc cagaggcgga ttcagtcagc
     1021 tttctccagg agctcctggc actacggctg gccctggagg aggggtgcgg ccccgggcct
     1081 gggcccccca gggaactcag cttcaccaag tcctcccagg tggtcaaagc ggtgagagac
     1141 accctcatct cagcctgtgc cagccagtgg gagcagctgc gggggctggg cagcaatgag
     1201 gatgggctac agaaactcgg ctcagaagat gtggagtccc aggaccctga cagtaccagc
     1261 ctgctggaga gtgaggcccc cagggattac ttcctcaagt ttgcctacat cgtggacctg
     1321 gacagcgaca ccgcggacaa gttcctgcag ctttttggaa ctaaaggtgt caagagagta
     1381 ctgtgtccca tcaactaccc ggagtcaccc acccgcttca cacactgcga gcaggtgcta
     1441 ggagagggcg ccctggaccg gggcacctac tactgggagg tggagatcat cgaaggatgg
     1501 gtcagtgtgg gagtcatggc cgagggcttc tccccgcaag agccctatga ccggggccgg
     1561 ctgggccgca atgcacactc atgctgtctg cagtggaatg ggcgtggctt ctcagtctgg
     1621 ttctgcgggc tggaggcccc gctaccccat gccttttcgc ctacagtcgg ggtctgccta
     1681 gagtatgcag accatgccct ggccttctat gctgtccgag acggaaagct gagccttctt
     1741 cggaggctca aagcctcccg gcctcgccgc agcggtgctc tggcctcccc cactgaccct
     1801 tttcagagtc gcctggacag ccatttttcc gggctcttca accacaggct caagcctgcc
     1861 ttcttcctgg agagtgtgga cgcccatctg cagattggac ctctcaagaa atcgtgcata
     1921 accgtgctga agaggaggtg atgcacgccc ggctgggtca tcctgtggcg ccgttgccca
     1981 tatttgctag gggaaggcac tagcctcaga gactcccaca ctcctagcca cctcacttct
     2041 tgaggccttc tagaccttcc actttgcagg acttgttttg agaacagatc tttagctggg
     2101 acaactccag tctgccccag ccccttcttt tccaggtctc tagaactacc tggcacacag
     2161 taggtgctca ataaacattt gttaaatgaa tg
//
